EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000087365 (Gene tree)
Gene ID
10992
Gene Symbol
SF3B2
Alias
SAP145|SF3b1|Cus1|SF3b145
Full Name
splicing factor 3b subunit 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
18,580 bases
Position
chr11:66,050,729-66,069,308
Accession
10769
RBP type
canonical RBP
Summary
This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000432655DUF382PF04037.134.3e-5911
ENSP00000318861DUF382PF04037.134.4e-5911
ENSP00000432655SAPPF02037.277.3e-0811
ENSP00000318861SAPPF02037.277.5e-0811
ENSP00000435495SAPPF02037.275.7e-0711
ENSP00000431908SAPPF02037.277.9e-0711
ENSP00000431520SAPPF02037.279.1e-0711
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
9436903Conservation of structure and subunit interactions in yeast homologues of splicing factor 3b (SF3b) subunits.RNA1998 JanIgel H-
28348170Crystal structure of U2 snRNP SF3b components: Hsh49p in complex with Cus1p-binding domain.RNA2017 Junvan Roon AMdoi: 10.1261/rna.059378.116
7958871The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site.Genes Dev1994 Aug 15Champion-Arnaud P-
25645911Anti-tumoral effects of miR-3189-3p in glioblastoma.J Biol Chem2015 Mar 27Jeansonne Ddoi: 10.1074/jbc.M114.633081
9601606New nuclear functions for calmodulin.Cell Calcium1998 Feb-MarAgell N-
25737013PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145.Nat Commun2015 Mar 4Yang Ydoi: 10.1038/ncomms7428.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000322535SF3B2-2012903XM_005273726ENSP00000318861895 (aa)XP_005273783Q13435
ENST00000526653SF3B2-205329--- (aa)--
ENST00000524475SF3B2-202432-ENSP0000043576580 (aa)-E9PIL8
ENST00000530981SF3B2-2101080-ENSP00000436757315 (aa)-H0YEX5
ENST00000525207SF3B2-204493--- (aa)--
ENST00000524627SF3B2-203841-ENSP00000435495273 (aa)-E9PJT3
ENST00000528302SF3B2-2063254-ENSP00000432655878 (aa)-E9PPJ0
ENST00000533421SF3B2-213407--- (aa)--
ENST00000534765SF3B2-2163932--- (aa)--
ENST00000531589SF3B2-212616--- (aa)--
ENST00000531041SF3B2-2111440--- (aa)--
ENST00000529577SF3B2-207606--- (aa)--
ENST00000529994SF3B2-2081004--- (aa)--
ENST00000530322SF3B2-2091163-ENSP00000431520387 (aa)-H0YCG1
ENST00000533595SF3B2-2141081-ENSP00000431908353 (aa)-E9PJ04
ENST00000534307SF3B2-215625--- (aa)--
Gene Model
Click here to download ENSG00000087365's gene model file
Pathways
Pathway IDPathway NameSource
hsa03040SpliceosomeKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000087365rs107918451166066869?Body mass index30595370EFO_0004340
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000087365's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000087365SF3B29289.796ENSAPOG00000001974sf3b28274.394Acanthochromis_polyacanthus
ENSG00000087365SF3B29999.367ENSAMEG00000017206SF3B210098.000Ailuropoda_melanoleuca
ENSG00000087365SF3B29989.905ENSACIG00000000624sf3b28774.572Amphilophus_citrinellus
ENSG00000087365SF3B29990.536ENSAOCG00000009207sf3b28675.065Amphiprion_ocellaris
ENSG00000087365SF3B29990.221ENSAPEG00000002762sf3b28773.205Amphiprion_percula
ENSG00000087365SF3B210065.642ENSACAG00000008615SF3B210066.040Anolis_carolinensis
ENSG00000087365SF3B210099.107ENSANAG00000029120SF3B210099.107Aotus_nancymaae
ENSG00000087365SF3B29990.536ENSACLG00000014771sf3b28774.708Astatotilapia_calliptera
ENSG00000087365SF3B29989.206ENSAMXG00000007929sf3b28677.237Astyanax_mexicanus
ENSG00000087365SF3B29999.683ENSBTAG00000002778SF3B210097.108Bos_taurus
ENSG00000087365SF3B29950.000WBGene00021004sftb-28951.825Caenorhabditis_elegans
ENSG00000087365SF3B210099.330ENSCJAG00000001656SF3B210099.330Callithrix_jacchus
ENSG00000087365SF3B29999.683ENSCAFG00000013033SF3B210098.107Canis_familiaris
ENSG00000087365SF3B29999.683ENSCAFG00020015382SF3B210098.107Canis_lupus_dingo
ENSG00000087365SF3B29999.683ENSCHIG00000011211SF3B210097.327Capra_hircus
ENSG00000087365SF3B210098.883ENSTSYG00000000959SF3B210098.883Carlito_syrichta
ENSG00000087365SF3B29596.053ENSCAPG00000006065SF3B293100.000Cavia_aperea
ENSG00000087365SF3B210096.250ENSCPOG00000008294SF3B210097.111Cavia_porcellus
ENSG00000087365SF3B210099.330ENSCCAG00000035256SF3B210099.330Cebus_capucinus
ENSG00000087365SF3B2100100.000ENSCATG00000042240SF3B210099.888Cercocebus_atys
ENSG00000087365SF3B29999.683ENSCLAG00000016852SF3B210098.064Chinchilla_lanigera
ENSG00000087365SF3B2100100.000ENSCSAG00000008121SF3B210099.888Chlorocebus_sabaeus
ENSG00000087365SF3B29199.485ENSCHOG00000001476SF3B27791.237Choloepus_hoffmanni
ENSG00000087365SF3B29996.825ENSCPBG00000022465SF3B28788.401Chrysemys_picta_bellii
ENSG00000087365SF3B29968.025ENSCING00000005665-9960.063Ciona_intestinalis
ENSG00000087365SF3B29968.750ENSCSAVG00000002029-9959.779Ciona_savignyi
ENSG00000087365SF3B2100100.000ENSCANG00000039680SF3B210099.888Colobus_angolensis_palliatus
ENSG00000087365SF3B29999.683ENSCGRG00001015741Sf3b210097.950Cricetulus_griseus_chok1gshd
ENSG00000087365SF3B29999.683ENSCGRG00000018110Sf3b210097.950Cricetulus_griseus_crigri
ENSG00000087365SF3B29984.906ENSCSEG00000000230sf3b27877.129Cynoglossus_semilaevis
ENSG00000087365SF3B29990.159ENSCVAG00000003357sf3b28574.934Cyprinodon_variegatus
ENSG00000087365SF3B29988.199ENSDARG00000018049sf3b28674.145Danio_rerio
ENSG00000087365SF3B29999.683ENSDNOG00000009484SF3B210096.996Dasypus_novemcinctus
ENSG00000087365SF3B29999.683ENSDORG00000002495Sf3b210097.725Dipodomys_ordii
ENSG00000087365SF3B210083.453ENSETEG00000020284SF3B28588.759Echinops_telfairi
ENSG00000087365SF3B29983.175ENSEBUG00000013703sf3b29960.174Eptatretus_burgeri
ENSG00000087365SF3B29999.683ENSEASG00005004508SF3B210097.998Equus_asinus_asinus
ENSG00000087365SF3B29999.683ENSECAG00000024461SF3B210097.998Equus_caballus
ENSG00000087365SF3B251100.000ENSEEUG00000003836-54100.000Erinaceus_europaeus
ENSG00000087365SF3B26994.915ENSEEUG00000014278-60100.000Erinaceus_europaeus
ENSG00000087365SF3B29989.873ENSELUG00000005586sf3b28671.499Esox_lucius
ENSG00000087365SF3B29999.683ENSFCAG00000013289SF3B210098.218Felis_catus
ENSG00000087365SF3B29979.365ENSFALG00000014653SF3B29869.014Ficedula_albicollis
ENSG00000087365SF3B29999.683ENSFDAG00000019806SF3B210097.556Fukomys_damarensis
ENSG00000087365SF3B29989.841ENSFHEG00000020968sf3b28672.000Fundulus_heteroclitus
ENSG00000087365SF3B29988.438ENSGMOG00000012131sf3b29680.975Gadus_morhua
ENSG00000087365SF3B29989.841ENSGAFG00000001675sf3b28673.386Gambusia_affinis
ENSG00000087365SF3B29988.571ENSGACG00000019012sf3b29680.159Gasterosteus_aculeatus
ENSG00000087365SF3B29996.825ENSGAGG00000023916SF3B28686.078Gopherus_agassizii
ENSG00000087365SF3B2100100.000ENSGGOG00000028448SF3B2100100.000Gorilla_gorilla
ENSG00000087365SF3B29990.536ENSHBUG00000017349sf3b28774.708Haplochromis_burtoni
ENSG00000087365SF3B29999.683ENSHGLG00000010807SF3B210097.950Heterocephalus_glaber_female
ENSG00000087365SF3B29999.683ENSHGLG00100006361SF3B210097.989Heterocephalus_glaber_male
ENSG00000087365SF3B29986.751ENSHCOG00000016203sf3b28771.056Hippocampus_comes
ENSG00000087365SF3B29985.802ENSIPUG00000009383sf3b28571.748Ictalurus_punctatus
ENSG00000087365SF3B29999.683ENSSTOG00000028892SF3B210098.436Ictidomys_tridecemlineatus
ENSG00000087365SF3B29999.683ENSJJAG00000018193Sf3b210097.957Jaculus_jaculus
ENSG00000087365SF3B29989.905ENSKMAG00000020181sf3b28474.079Kryptolebias_marmoratus
ENSG00000087365SF3B29990.221ENSLBEG00000027739sf3b28878.268Labrus_bergylta
ENSG00000087365SF3B29993.651ENSLACG00000010429SF3B29374.679Latimeria_chalumnae
ENSG00000087365SF3B29999.365ENSLAFG00000002128SF3B210097.616Loxodonta_africana
ENSG00000087365SF3B2100100.000ENSMFAG00000003064SF3B210099.777Macaca_fascicularis
ENSG00000087365SF3B2100100.000ENSMMUG00000011743SF3B210095.419Macaca_mulatta
ENSG00000087365SF3B210099.777ENSMNEG00000034437SF3B210099.777Macaca_nemestrina
ENSG00000087365SF3B210099.665ENSMLEG00000029373SF3B210099.665Mandrillus_leucophaeus
ENSG00000087365SF3B29990.536ENSMAMG00000014103sf3b28675.000Mastacembelus_armatus
ENSG00000087365SF3B29990.536ENSMZEG00005020789sf3b28674.708Maylandia_zebra
ENSG00000087365SF3B29999.683ENSMAUG00000017040Sf3b210098.333Mesocricetus_auratus
ENSG00000087365SF3B29997.785ENSMICG00000016942-10093.068Microcebus_murinus
ENSG00000087365SF3B29999.683ENSMICG00000008565-10098.547Microcebus_murinus
ENSG00000087365SF3B29999.365ENSMOCG00000003136Sf3b210097.836Microtus_ochrogaster
ENSG00000087365SF3B29999.683ENSMODG00000008490-9293.369Monodelphis_domestica
ENSG00000087365SF3B29992.063ENSMODG00000025020-9987.402Monodelphis_domestica
ENSG00000087365SF3B29986.792ENSMALG00000015137sf3b28473.297Monopterus_albus
ENSG00000087365SF3B29999.683MGP_CAROLIEiJ_G0022539Sf3b210096.925Mus_caroli
ENSG00000087365SF3B29999.683ENSMUSG00000024853Sf3b210097.722Mus_musculus
ENSG00000087365SF3B29999.683MGP_PahariEiJ_G0014036Sf3b210097.722Mus_pahari
ENSG00000087365SF3B29999.683MGP_SPRETEiJ_G0023453Sf3b210097.608Mus_spretus
ENSG00000087365SF3B29999.683ENSMPUG00000011349SF3B210097.996Mustela_putorius_furo
ENSG00000087365SF3B29999.365ENSMLUG00000011136SF3B210097.108Myotis_lucifugus
ENSG00000087365SF3B29999.683ENSNGAG00000012103Sf3b210097.950Nannospalax_galili
ENSG00000087365SF3B29995.860ENSNLEG00000006007SF3B210094.469Nomascus_leucogenys
ENSG00000087365SF3B29992.698ENSMEUG00000000019SF3B28093.466Notamacropus_eugenii
ENSG00000087365SF3B210095.000ENSODEG00000017764SF3B210094.191Octodon_degus
ENSG00000087365SF3B29990.536ENSONIG00000013068sf3b28775.758Oreochromis_niloticus
ENSG00000087365SF3B29995.873ENSOANG00000012482SF3B29781.867Ornithorhynchus_anatinus
ENSG00000087365SF3B29999.683ENSOCUG00000015722-10093.073Oryctolagus_cuniculus
ENSG00000087365SF3B26265.804ENSOCUG00000024154-10065.989Oryctolagus_cuniculus
ENSG00000087365SF3B29991.483ENSORLG00000008235sf3b28574.607Oryzias_latipes
ENSG00000087365SF3B29991.483ENSORLG00020005357sf3b28874.607Oryzias_latipes_hni
ENSG00000087365SF3B29991.483ENSORLG00015022454sf3b28278.323Oryzias_latipes_hsok
ENSG00000087365SF3B29990.221ENSOMEG00000017480sf3b28873.822Oryzias_melastigma
ENSG00000087365SF3B29999.683ENSOGAG00000005799SF3B210092.961Otolemur_garnettii
ENSG00000087365SF3B29999.683ENSOARG00000002125SF3B210098.103Ovis_aries
ENSG00000087365SF3B2100100.000ENSPPAG00000007359SF3B2100100.000Pan_paniscus
ENSG00000087365SF3B29999.683ENSPPRG00000013334SF3B210098.218Panthera_pardus
ENSG00000087365SF3B29999.683ENSPTIG00000015022SF3B210098.107Panthera_tigris_altaica
ENSG00000087365SF3B2100100.000ENSPTRG00000003912SF3B2100100.000Pan_troglodytes
ENSG00000087365SF3B2100100.000ENSPANG00000008593SF3B210099.888Papio_anubis
ENSG00000087365SF3B29990.536ENSPKIG00000016576sf3b28681.359Paramormyrops_kingsleyae
ENSG00000087365SF3B29996.508ENSPSIG00000003158SF3B210088.493Pelodiscus_sinensis
ENSG00000087365SF3B29982.812ENSPMGG00000000819sf3b28667.759Periophthalmus_magnuspinnatus
ENSG00000087365SF3B29992.063ENSPEMG00000015451-10083.578Peromyscus_maniculatus_bairdii
ENSG00000087365SF3B29999.683ENSPEMG00000015437Sf3b210098.064Peromyscus_maniculatus_bairdii
ENSG00000087365SF3B29999.365ENSPCIG00000008381SF3B210088.111Phascolarctos_cinereus
ENSG00000087365SF3B29990.159ENSPFOG00000002552sf3b28672.991Poecilia_formosa
ENSG00000087365SF3B29990.476ENSPLAG00000001471sf3b28673.123Poecilia_latipinna
ENSG00000087365SF3B29990.159ENSPMEG00000013180sf3b28674.308Poecilia_mexicana
ENSG00000087365SF3B29990.159ENSPREG00000002665sf3b28674.113Poecilia_reticulata
ENSG00000087365SF3B2100100.000ENSPPYG00000003034-9998.212Pongo_abelii
ENSG00000087365SF3B29999.683ENSPCAG00000005129SF3B210097.216Procavia_capensis
ENSG00000087365SF3B210099.106ENSPCOG00000025375SF3B210099.106Propithecus_coquereli
ENSG00000087365SF3B29999.365ENSPVAG00000016975-5599.299Pteropus_vampyrus
ENSG00000087365SF3B29592.405ENSPVAG00000005466-8899.561Pteropus_vampyrus
ENSG00000087365SF3B29988.088ENSPNYG00000023594sf3b29273.735Pundamilia_nyererei
ENSG00000087365SF3B29987.267ENSPNAG00000001891sf3b28673.214Pygocentrus_nattereri
ENSG00000087365SF3B210098.750ENSRNOG00000020412Sf3b210097.950Rattus_norvegicus
ENSG00000087365SF3B2100100.000ENSRBIG00000034065SF3B210099.777Rhinopithecus_bieti
ENSG00000087365SF3B2100100.000ENSRROG00000034496SF3B210099.777Rhinopithecus_roxellana
ENSG00000087365SF3B29999.683ENSSBOG00000026337SF3B210093.709Saimiri_boliviensis_boliviensis
ENSG00000087365SF3B29981.056ENSSHAG00000018043-10069.884Sarcophilus_harrisii
ENSG00000087365SF3B29999.365ENSSHAG00000010933-8486.815Sarcophilus_harrisii
ENSG00000087365SF3B29990.852ENSSFOG00015021125sf3b28674.708Scleropages_formosus
ENSG00000087365SF3B29990.221ENSSMAG00000004079sf3b28875.065Scophthalmus_maximus
ENSG00000087365SF3B29990.536ENSSDUG00000008499sf3b28571.484Seriola_dumerili
ENSG00000087365SF3B29990.536ENSSLDG00000006838sf3b28675.163Seriola_lalandi_dorsalis
ENSG00000087365SF3B210077.617ENSSARG00000003707-5399.206Sorex_araneus
ENSG00000087365SF3B29996.825ENSSPUG00000009198SF3B28584.554Sphenodon_punctatus
ENSG00000087365SF3B29990.536ENSSPAG00000004406sf3b28675.032Stegastes_partitus
ENSG00000087365SF3B29999.683ENSSSCG00000012957SF3B210097.216Sus_scrofa
ENSG00000087365SF3B29978.261ENSTRUG00000007611sf3b28871.763Takifugu_rubripes
ENSG00000087365SF3B29986.751ENSTNIG00000007441sf3b28869.612Tetraodon_nigroviridis
ENSG00000087365SF3B29191.860ENSTBEG00000004258SF3B28299.286Tupaia_belangeri
ENSG00000087365SF3B29999.683ENSTTRG00000014339SF3B210097.550Tursiops_truncatus
ENSG00000087365SF3B210096.218ENSUAMG00000020754SF3B29997.558Ursus_americanus
ENSG00000087365SF3B29999.683ENSUMAG00000010994SF3B210098.218Ursus_maritimus
ENSG00000087365SF3B210092.771ENSVPAG00000008695SF3B26399.153Vicugna_pacos
ENSG00000087365SF3B29999.683ENSVVUG00000027029SF3B210097.996Vulpes_vulpes
ENSG00000087365SF3B29991.111ENSXETG00000008422sf3b28778.540Xenopus_tropicalis
ENSG00000087365SF3B29990.159ENSXCOG00000008943sf3b28478.095Xiphophorus_couchianus
ENSG00000087365SF3B29990.159ENSXMAG00000008467sf3b28672.608Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000398mRNA splicing, via spliceosome21873635.IBAProcess
GO:0000398mRNA splicing, via spliceosome9731529.11991638.ICProcess
GO:0000398mRNA splicing, via spliceosome29360106.IDAProcess
GO:0000398mRNA splicing, via spliceosome-TASProcess
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding16189514.22365833.23455924.24965446.25737013.27905398.IPIFunction
GO:0005634nucleus29360106.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005681spliceosomal complex9731529.IDAComponent
GO:0005686U2 snRNP21873635.IBAComponent
GO:0005689U12-type spliceosomal complex21873635.IBAComponent
GO:0005689U12-type spliceosomal complex15146077.IDAComponent
GO:0006397mRNA processing8566756.TASProcess
GO:0008380RNA splicing8566756.TASProcess
GO:0016032viral process-IEAProcess
GO:0016607nuclear speck-IDAComponent
GO:0071005U2-type precatalytic spliceosome29360106.IDAComponent
GO:0071013catalytic step 2 spliceosome21873635.IBAComponent
GO:0071013catalytic step 2 spliceosome11991638.IDAComponent

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us