EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000088930 (Gene tree)
Gene ID: 22803
Gene Symbol: XRN2
Alias: N
Full Name: 5'-3' exoribonuclease 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 86,524 bases
Position: chr20:21,303,304-21,389,827
Accession: 12836
RBP type: canonical RBP
Summary: This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000366396	XRN_N	PF03159.18	3.4e-102	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30374086	SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation.	Nat Struct Mol Biol	2018 Nov	Vendramin R	doi: 10.1038/s41594-018-0143-4
25110015	Regulation of miRNA strand selection: follow the leader?	Biochem Soc Trans	2014 Aug	Meijer HA	doi: 10.1042/BST20140142.
23857582	Heterogeneous nuclear ribonucleoprotein (HnRNP) K genome-wide binding survey reveals its role in regulating 3'-end RNA processing and transcription termination at the early growth response 1 (EGR1) gene through XRN2 exonuclease.	J Biol Chem	2013 Aug 23	Mikula M	doi: 10.1074/jbc.M113.496679
27331609	Regulation of alternative polyadenylation by Nkx2-5 and Xrn2 during mouse heart development.	Elife	2016 Jun 22	Nimura K	doi: 10.7554/eLife.16030.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000377191	XRN2-201	3437	XM_017027723	ENSP00000366396	950 (aa)	XP_016883212	Q9H0D6

Gene Model

Click here to download ENSG00000088930's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03008	Ribosome biogenesis in eukaryotes	KEGG
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000088930	Child Development Disorders, Pervasive	2.0376000E-005	-
ENSG00000088930	Blood Pressure	1.2358817E-005	-
ENSG00000088930	Blood Pressure	1.2453503E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000088930	rs9917457	20	21349312	G	Mean corpuscular hemoglobin	27863252	[0.032-0.063] unit increase	0.04755121	EFO_0004527
ENSG00000088930	rs62217959	20	21382323	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000088930's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000088930	XRN2	71	39.912	ENSG00000114127	XRN1	96	50.820

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000088930	XRN2	97	71.596	ENSAPOG00000009818	xrn2	100	70.438	Acanthochromis_polyacanthus
ENSG00000088930	XRN2	100	97.895	ENSAMEG00000012581	XRN2	100	97.895	Ailuropoda_melanoleuca
ENSG00000088930	XRN2	90	70.535	ENSACIG00000015047	xrn2	95	74.280	Amphilophus_citrinellus
ENSG00000088930	XRN2	97	71.902	ENSAOCG00000023632	xrn2	100	70.761	Amphiprion_ocellaris
ENSG00000088930	XRN2	97	71.732	ENSAPEG00000014871	xrn2	100	70.570	Amphiprion_percula
ENSG00000088930	XRN2	95	71.506	ENSATEG00000001273	xrn2	97	70.825	Anabas_testudineus
ENSG00000088930	XRN2	97	82.885	ENSAPLG00000013869	XRN2	99	83.333	Anas_platyrhynchos
ENSG00000088930	XRN2	100	80.538	ENSACAG00000005565	XRN2	100	80.538	Anolis_carolinensis
ENSG00000088930	XRN2	100	98.632	ENSANAG00000020126	XRN2	100	98.632	Aotus_nancymaae
ENSG00000088930	XRN2	90	73.757	ENSACLG00000010522	xrn2	96	75.833	Astatotilapia_calliptera
ENSG00000088930	XRN2	100	71.617	ENSAMXG00000018301	xrn2	100	71.617	Astyanax_mexicanus
ENSG00000088930	XRN2	100	95.794	ENSBTAG00000011304	XRN2	100	95.794	Bos_taurus
ENSG00000088930	XRN2	87	55.814	WBGene00006964	xrn-2	89	55.090	Caenorhabditis_elegans
ENSG00000088930	XRN2	100	98.737	ENSCJAG00000005611	XRN2	100	98.737	Callithrix_jacchus
ENSG00000088930	XRN2	100	98.000	ENSCAFG00000005185	XRN2	100	98.000	Canis_familiaris
ENSG00000088930	XRN2	100	98.000	ENSCAFG00020027479	XRN2	100	98.000	Canis_lupus_dingo
ENSG00000088930	XRN2	100	96.320	ENSCHIG00000006921	XRN2	100	96.320	Capra_hircus
ENSG00000088930	XRN2	100	97.053	ENSTSYG00000008315	XRN2	100	97.053	Carlito_syrichta
ENSG00000088930	XRN2	97	81.985	ENSCAPG00000010773	XRN2	99	81.985	Cavia_aperea
ENSG00000088930	XRN2	100	97.579	ENSCPOG00000009407	XRN2	100	97.579	Cavia_porcellus
ENSG00000088930	XRN2	100	99.684	ENSCATG00000040350	XRN2	100	99.684	Cercocebus_atys
ENSG00000088930	XRN2	100	97.895	ENSCLAG00000013419	XRN2	100	97.895	Chinchilla_lanigera
ENSG00000088930	XRN2	100	99.684	ENSCSAG00000011094	XRN2	100	99.684	Chlorocebus_sabaeus
ENSG00000088930	XRN2	68	98.925	ENSCHOG00000013404	XRN2	70	98.925	Choloepus_hoffmanni
ENSG00000088930	XRN2	100	84.271	ENSCPBG00000023533	XRN2	100	84.896	Chrysemys_picta_bellii
ENSG00000088930	XRN2	86	60.143	ENSCING00000022336	-	100	60.501	Ciona_intestinalis
ENSG00000088930	XRN2	87	58.831	ENSCSAVG00000011217	-	100	61.407	Ciona_savignyi
ENSG00000088930	XRN2	100	99.684	ENSCANG00000040240	XRN2	100	99.684	Colobus_angolensis_palliatus
ENSG00000088930	XRN2	98	96.878	ENSCGRG00001010676	Xrn2	99	96.878	Cricetulus_griseus_chok1gshd
ENSG00000088930	XRN2	97	96.009	ENSCGRG00000006378	Xrn2	99	96.009	Cricetulus_griseus_crigri
ENSG00000088930	XRN2	54	72.157	ENSCSEG00000005628	xrn2	100	72.157	Cynoglossus_semilaevis
ENSG00000088930	XRN2	89	71.494	ENSCVAG00000018999	xrn2	98	76.762	Cyprinodon_variegatus
ENSG00000088930	XRN2	100	69.815	ENSDARG00000101900	xrn2	96	77.629	Danio_rerio
ENSG00000088930	XRN2	100	97.474	ENSDNOG00000001895	XRN2	100	97.474	Dasypus_novemcinctus
ENSG00000088930	XRN2	100	95.684	ENSDORG00000005434	Xrn2	100	95.684	Dipodomys_ordii
ENSG00000088930	XRN2	87	56.832	FBgn0031868	Rat1	87	56.711	Drosophila_melanogaster
ENSG00000088930	XRN2	100	83.684	ENSETEG00000001740	XRN2	100	83.684	Echinops_telfairi
ENSG00000088930	XRN2	84	71.636	ENSEBUG00000016136	xrn2	100	71.636	Eptatretus_burgeri
ENSG00000088930	XRN2	100	97.684	ENSEASG00005002484	XRN2	100	97.684	Equus_asinus_asinus
ENSG00000088930	XRN2	99	97.888	ENSECAG00000018988	XRN2	96	100.000	Equus_caballus
ENSG00000088930	XRN2	80	100.000	ENSEEUG00000009265	XRN2	80	100.000	Erinaceus_europaeus
ENSG00000088930	XRN2	100	70.389	ENSELUG00000000552	xrn2	100	70.799	Esox_lucius
ENSG00000088930	XRN2	100	97.789	ENSFCAG00000007970	XRN2	100	97.789	Felis_catus
ENSG00000088930	XRN2	100	82.390	ENSFALG00000004508	XRN2	100	82.827	Ficedula_albicollis
ENSG00000088930	XRN2	100	97.684	ENSFDAG00000016311	XRN2	100	97.684	Fukomys_damarensis
ENSG00000088930	XRN2	54	69.466	ENSFHEG00000013039	xrn2	98	69.466	Fundulus_heteroclitus
ENSG00000088930	XRN2	86	72.661	ENSGMOG00000013436	xrn2	100	72.661	Gadus_morhua
ENSG00000088930	XRN2	100	82.513	ENSGALG00000008372	XRN2	100	82.513	Gallus_gallus
ENSG00000088930	XRN2	89	73.721	ENSGAFG00000014284	xrn2	98	73.721	Gambusia_affinis
ENSG00000088930	XRN2	87	74.519	ENSGACG00000011870	xrn2	100	74.519	Gasterosteus_aculeatus
ENSG00000088930	XRN2	100	84.062	ENSGAGG00000004884	XRN2	100	84.688	Gopherus_agassizii
ENSG00000088930	XRN2	100	99.789	ENSGGOG00000013738	XRN2	100	99.789	Gorilla_gorilla
ENSG00000088930	XRN2	54	74.280	ENSHBUG00000005077	xrn2	96	75.833	Haplochromis_burtoni
ENSG00000088930	XRN2	100	96.526	ENSHGLG00000014831	XRN2	100	96.526	Heterocephalus_glaber_female
ENSG00000088930	XRN2	100	96.526	ENSHGLG00100013130	XRN2	100	96.526	Heterocephalus_glaber_male
ENSG00000088930	XRN2	99	68.016	ENSHCOG00000011994	xrn2	99	68.927	Hippocampus_comes
ENSG00000088930	XRN2	100	70.031	ENSIPUG00000006639	xrn2	100	70.031	Ictalurus_punctatus
ENSG00000088930	XRN2	100	98.316	ENSSTOG00000000589	XRN2	100	98.316	Ictidomys_tridecemlineatus
ENSG00000088930	XRN2	100	97.474	ENSJJAG00000022128	Xrn2	100	97.474	Jaculus_jaculus
ENSG00000088930	XRN2	54	79.492	ENSLBEG00000010041	xrn2	100	79.492	Labrus_bergylta
ENSG00000088930	XRN2	94	76.752	ENSLACG00000008307	XRN2	99	79.264	Latimeria_chalumnae
ENSG00000088930	XRN2	99	72.803	ENSLOCG00000016874	xrn2	100	72.803	Lepisosteus_oculatus
ENSG00000088930	XRN2	100	96.316	ENSLAFG00000014624	XRN2	100	96.316	Loxodonta_africana
ENSG00000088930	XRN2	100	99.684	ENSMFAG00000038122	XRN2	100	99.684	Macaca_fascicularis
ENSG00000088930	XRN2	100	99.684	ENSMMUG00000011405	XRN2	100	99.684	Macaca_mulatta
ENSG00000088930	XRN2	100	99.579	ENSMNEG00000040626	XRN2	100	99.579	Macaca_nemestrina
ENSG00000088930	XRN2	100	99.579	ENSMLEG00000041897	XRN2	100	99.579	Mandrillus_leucophaeus
ENSG00000088930	XRN2	95	72.579	ENSMAMG00000008633	xrn2	98	71.069	Mastacembelus_armatus
ENSG00000088930	XRN2	90	75.607	ENSMZEG00005022362	xrn2	97	75.607	Maylandia_zebra
ENSG00000088930	XRN2	99	81.042	ENSMGAG00000003196	XRN2	99	81.042	Meleagris_gallopavo
ENSG00000088930	XRN2	100	96.947	ENSMAUG00000021842	Xrn2	100	96.947	Mesocricetus_auratus
ENSG00000088930	XRN2	100	97.368	ENSMICG00000008126	XRN2	100	97.368	Microcebus_murinus
ENSG00000088930	XRN2	100	96.211	ENSMOCG00000012588	Xrn2	100	96.211	Microtus_ochrogaster
ENSG00000088930	XRN2	89	73.769	ENSMMOG00000017576	xrn2	96	74.053	Mola_mola
ENSG00000088930	XRN2	100	91.158	ENSMODG00000006163	XRN2	100	91.158	Monodelphis_domestica
ENSG00000088930	XRN2	91	72.022	ENSMALG00000011355	xrn2	99	72.022	Monopterus_albus
ENSG00000088930	XRN2	100	95.794	MGP_CAROLIEiJ_G0024400	Xrn2	100	95.794	Mus_caroli
ENSG00000088930	XRN2	100	96.004	ENSMUSG00000027433	Xrn2	100	96.004	Mus_musculus
ENSG00000088930	XRN2	100	95.794	MGP_PahariEiJ_G0025843	Xrn2	100	95.794	Mus_pahari
ENSG00000088930	XRN2	100	96.004	MGP_SPRETEiJ_G0025318	Xrn2	100	96.004	Mus_spretus
ENSG00000088930	XRN2	100	96.381	ENSMPUG00000001198	XRN2	93	96.381	Mustela_putorius_furo
ENSG00000088930	XRN2	100	97.789	ENSMLUG00000001536	XRN2	100	97.789	Myotis_lucifugus
ENSG00000088930	XRN2	100	97.474	ENSNGAG00000018138	Xrn2	100	97.474	Nannospalax_galili
ENSG00000088930	XRN2	90	75.810	ENSNBRG00000008062	xrn2	97	75.810	Neolamprologus_brichardi
ENSG00000088930	XRN2	100	99.579	ENSNLEG00000009991	XRN2	100	99.579	Nomascus_leucogenys
ENSG00000088930	XRN2	66	97.778	ENSMEUG00000008622	-	67	97.778	Notamacropus_eugenii
ENSG00000088930	XRN2	75	78.534	ENSOPRG00000001397	-	77	78.534	Ochotona_princeps
ENSG00000088930	XRN2	100	97.579	ENSODEG00000010745	-	100	97.579	Octodon_degus
ENSG00000088930	XRN2	98	88.565	ENSODEG00000000860	-	99	88.997	Octodon_degus
ENSG00000088930	XRN2	100	71.753	ENSONIG00000018720	xrn2	100	71.959	Oreochromis_niloticus
ENSG00000088930	XRN2	100	90.966	ENSOANG00000015673	XRN2	100	90.966	Ornithorhynchus_anatinus
ENSG00000088930	XRN2	100	98.316	ENSOCUG00000013468	XRN2	100	98.316	Oryctolagus_cuniculus
ENSG00000088930	XRN2	98	70.301	ENSORLG00000017213	xrn2	97	74.942	Oryzias_latipes
ENSG00000088930	XRN2	98	70.301	ENSORLG00020001824	xrn2	100	70.000	Oryzias_latipes_hni
ENSG00000088930	XRN2	98	70.093	ENSORLG00015019747	xrn2	100	69.796	Oryzias_latipes_hsok
ENSG00000088930	XRN2	90	73.988	ENSOMEG00000019820	xrn2	100	69.543	Oryzias_melastigma
ENSG00000088930	XRN2	100	97.476	ENSOGAG00000001068	XRN2	100	97.476	Otolemur_garnettii
ENSG00000088930	XRN2	97	96.220	ENSOARG00000004443	XRN2	100	96.220	Ovis_aries
ENSG00000088930	XRN2	100	99.789	ENSPPAG00000033549	XRN2	100	99.789	Pan_paniscus
ENSG00000088930	XRN2	100	97.789	ENSPPRG00000008732	XRN2	100	97.789	Panthera_pardus
ENSG00000088930	XRN2	97	97.730	ENSPTIG00000015683	XRN2	97	97.730	Panthera_tigris_altaica
ENSG00000088930	XRN2	100	99.789	ENSPTRG00000013308	XRN2	100	99.789	Pan_troglodytes
ENSG00000088930	XRN2	100	99.684	ENSPANG00000018088	XRN2	100	99.684	Papio_anubis
ENSG00000088930	XRN2	100	70.727	ENSPKIG00000016889	xrn2	100	70.727	Paramormyrops_kingsleyae
ENSG00000088930	XRN2	81	86.849	ENSPSIG00000014666	XRN2	100	86.849	Pelodiscus_sinensis
ENSG00000088930	XRN2	100	96.211	ENSPEMG00000000111	Xrn2	100	96.211	Peromyscus_maniculatus_bairdii
ENSG00000088930	XRN2	100	69.990	ENSPFOG00000004182	xrn2	99	70.393	Poecilia_formosa
ENSG00000088930	XRN2	89	74.419	ENSPLAG00000007351	xrn2	96	74.419	Poecilia_latipinna
ENSG00000088930	XRN2	94	68.335	ENSPMEG00000011798	xrn2	99	69.206	Poecilia_mexicana
ENSG00000088930	XRN2	89	74.302	ENSPREG00000012452	xrn2	99	72.727	Poecilia_reticulata
ENSG00000088930	XRN2	100	99.158	ENSPPYG00000010755	XRN2	100	99.158	Pongo_abelii
ENSG00000088930	XRN2	100	91.387	ENSPCAG00000011191	XRN2	100	91.387	Procavia_capensis
ENSG00000088930	XRN2	100	90.947	ENSPCOG00000016468	XRN2	100	90.947	Propithecus_coquereli
ENSG00000088930	XRN2	93	96.049	ENSPVAG00000004596	XRN2	93	96.049	Pteropus_vampyrus
ENSG00000088930	XRN2	90	73.757	ENSPNYG00000001765	xrn2	97	73.757	Pundamilia_nyererei
ENSG00000088930	XRN2	100	71.633	ENSPNAG00000010956	xrn2	99	71.633	Pygocentrus_nattereri
ENSG00000088930	XRN2	100	96.740	ENSRNOG00000011785	Xrn2	100	96.740	Rattus_norvegicus
ENSG00000088930	XRN2	86	99.633	ENSRBIG00000036193	XRN2	100	99.633	Rhinopithecus_bieti
ENSG00000088930	XRN2	100	99.684	ENSRROG00000044400	XRN2	90	99.684	Rhinopithecus_roxellana
ENSG00000088930	XRN2	77	48.069	YOR048C	RAT1	63	53.846	Saccharomyces_cerevisiae
ENSG00000088930	XRN2	100	98.947	ENSSBOG00000021014	XRN2	100	98.947	Saimiri_boliviensis_boliviensis
ENSG00000088930	XRN2	100	71.827	ENSSFOG00015001091	xrn2	100	71.827	Scleropages_formosus
ENSG00000088930	XRN2	92	72.686	ENSSMAG00000007834	xrn2	100	68.389	Scophthalmus_maximus
ENSG00000088930	XRN2	91	71.946	ENSSDUG00000012802	xrn2	99	72.285	Seriola_dumerili
ENSG00000088930	XRN2	93	73.559	ENSSLDG00000021273	xrn2	100	73.559	Seriola_lalandi_dorsalis
ENSG00000088930	XRN2	76	100.000	ENSSARG00000005859	-	76	100.000	Sorex_araneus
ENSG00000088930	XRN2	98	79.274	ENSSPUG00000005485	XRN2	96	79.380	Sphenodon_punctatus
ENSG00000088930	XRN2	100	70.522	ENSSPAG00000016027	xrn2	99	70.522	Stegastes_partitus
ENSG00000088930	XRN2	100	95.579	ENSSSCG00000007109	XRN2	100	95.579	Sus_scrofa
ENSG00000088930	XRN2	100	81.211	ENSTGUG00000007535	XRN2	100	81.648	Taeniopygia_guttata
ENSG00000088930	XRN2	100	68.214	ENSTRUG00000015489	xrn2	100	68.586	Takifugu_rubripes
ENSG00000088930	XRN2	100	71.340	ENSTNIG00000010712	xrn2	100	71.340	Tetraodon_nigroviridis
ENSG00000088930	XRN2	100	97.053	ENSTBEG00000004119	XRN2	100	97.053	Tupaia_belangeri
ENSG00000088930	XRN2	93	97.477	ENSTTRG00000009087	XRN2	93	97.477	Tursiops_truncatus
ENSG00000088930	XRN2	100	98.000	ENSUAMG00000024634	XRN2	100	98.000	Ursus_americanus
ENSG00000088930	XRN2	97	97.730	ENSUMAG00000004012	XRN2	95	97.730	Ursus_maritimus
ENSG00000088930	XRN2	89	89.586	ENSVPAG00000010694	XRN2	91	89.586	Vicugna_pacos
ENSG00000088930	XRN2	100	98.105	ENSVVUG00000012178	XRN2	100	98.105	Vulpes_vulpes
ENSG00000088930	XRN2	100	74.453	ENSXETG00000023501	xrn2	100	75.078	Xenopus_tropicalis
ENSG00000088930	XRN2	100	68.551	ENSXMAG00000000242	xrn2	92	78.589	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000175	3'-5'-exoribonuclease activity	23482395.	EXP	Function
GO:0000738	DNA catabolic process, exonucleolytic	15565158.	IDA	Process
GO:0001147	transcription termination site sequence-specific DNA binding	21700224.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0004518	nuclease activity	10409438.	TAS	Function
GO:0004534	5'-3' exoribonuclease activity	10409438.	TAS	Function
GO:0005515	protein binding	23125361.26496610.26700805.26779609.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	12429849.	IDA	Component
GO:0006353	DNA-templated transcription, termination	-	IEA	Process
GO:0006364	rRNA processing	-	TAS	Process
GO:0006396	RNA processing	10409438.	TAS	Process
GO:0006397	mRNA processing	-	IEA	Process
GO:0006401	RNA catabolic process	10409438.	TAS	Process
GO:0007283	spermatogenesis	10409438.	IEP	Process
GO:0008409	5'-3' exonuclease activity	15565158.	IDA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016070	RNA metabolic process	-	ISS	Process
GO:0016235	aggresome	-	IDA	Component
GO:0021766	hippocampus development	-	IEA	Process
GO:0030182	neuron differentiation	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0060041	retina development in camera-type eye	-	IEA	Process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19915612	Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor.	Oncogene	2010 Feb 18	Lu Y	doi: 10.1038/onc.2009.396
16147866	A novel splice variant of human XRN2 gene is mainly expressed in blood leukocyte.	DNA Seq	2005 Apr	Li J	-
28319071	XRN2 promotes EMT and metastasis through regulating maturation of miR-10a.	Oncogene	2017 Jul 6	Zhang H	doi: 10.1038/onc.2017.39

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr20	21334075	Splice_Region	novel		0.22
BLCA	chr20	21331608	Missense_Mutation	novel	I208M	0.45	XRN_N
BLCA	chr20	21340768	Silent	novel	A442A	0.19
BLCA	chr20	21340738	Silent	novel	F432F	0.05
BLCA	chr20	21354828	Missense_Mutation	novel	R659Q	0.21
BLCA	chr20	21386959	Missense_Mutation	novel	G914W	0.12
BLCA	chr20	21382029	Missense_Mutation	novel	P874S	0.17
BLCA	chr20	21332347	Missense_Mutation	NA	F255L	0.1
BLCA	chr20	21328565	Missense_Mutation	NA	R108C	0.21	XRN_N
BRCA	chr20	21326596	Missense_Mutation	NA	G104R	0.35	XRN_N
BRCA	chr20	21333703	Splice_Site	NA	X312_splice	0.17
BRCA	chr20	21333781	Silent	novel	F337F	0.09
BRCA	chr20	21348411	Missense_Mutation	rs376273044	R615Q	0.2
BRCA	chr20	21332440	Frame_Shift_Ins	novel	*H287Ifs6**	0.06
BRCA	chr20	21303387	5'UTR	rs769034938		0.3
CESC	chr20	21328608	Nonsense_Mutation	NA	S122*	0.24	XRN_N
CESC	chr20	21354799	Silent	NA	L649L	0.57
CESC	chr20	21333774	Nonsense_Mutation	NA	W335*	0.32
CESC	chr20	21386974	Missense_Mutation	NA	P919A	0.46
CESC	chr20	21346441	Missense_Mutation	NA	R519Q	0.41
CESC	chr20	21365657	Silent	novel	R803R	0.25
CESC	chr20	21382001	Silent	novel	R864R	0.3
CESC	chr20	21386953	Silent	novel	L912L	0.38
CESC	chr20	21389465	3'UTR	rs111427369		0.36
CESC	chr20	21365450	Missense_Mutation	novel	E762V	0.09
CESC	chr20	21348247	Silent	rs138790989	T589T	0.17
CESC	chr20	21303455	Silent	NA	V19V	0.36
COAD	chr20	21348410	Missense_Mutation	rs753036714	R615W	0.24
COAD	chr20	21356646	Nonsense_Mutation	NA	E727*	0.41
COAD	chr20	21326316	Missense_Mutation	novel	A38V	0.07	XRN_N
COAD	chr20	21333550	Nonsense_Mutation	novel	E289*	0.15
COAD	chr20	21389400	3'UTR	novel		0.07
COAD	chr20	21331782	Missense_Mutation	novel	D222Y	0.22	XRN_N
COAD	chr20	21330668	Missense_Mutation	NA	D180V	0.32	XRN_N
COAD	chr20	21365625	Missense_Mutation	rs377677641	R793W	0.34
COAD	chr20	21328565	Missense_Mutation	NA	R108C	0.45	XRN_N
COAD	chr20	21333952	Silent	NA	D361D	0.53
COAD	chr20	21356109	Silent	novel	L684L	0.04
COAD	chr20	21328587	Missense_Mutation	NA	R115H	0.27	XRN_N
COAD	chr20	21332320	Silent	rs774996547	P246P	0.35
COAD	chr20	21346460	Silent	novel	F525F	0.21
COAD	chr20	21340813	Silent	rs372167550	P457P	0.38
COAD	chr20	21339068	Nonsense_Mutation	NA	E420*	0.2
ESCA	chr20	21386902	Missense_Mutation	rs769237988	R895W	0.08
GBM	chr20	21386983	Silent	NA	R922R	0.3
GBM	chr20	21389403	3'UTR	novel		0.17
GBM	chr20	21328644	Missense_Mutation	novel	R134Q	0.38	XRN_N
GBM	chr20	21344124	Missense_Mutation	novel	S482Y	0.21
GBM	chr20	21332320	Silent	rs774996547	P246P	0.21
GBM	chr20	21348200	Missense_Mutation	novel	D574Y	0.21
GBM	chr20	21333968	Nonsense_Mutation	novel	Y367*	0.04
HNSC	chr20	21386903	Missense_Mutation	rs771948880	R895Q	0.19
HNSC	chr20	21348231	Missense_Mutation	novel	D584A	0.1
HNSC	chr20	21326279	Missense_Mutation	novel	P26S	0.11	XRN_N
HNSC	chr20	21333547	Missense_Mutation	novel	D288N	0.12
HNSC	chr20	21333548	Missense_Mutation	novel	D288V	0.12
HNSC	chr20	21356095	Missense_Mutation	novel	L679P	0.11
HNSC	chr20	21344119	Missense_Mutation	novel	F480L	0.39
HNSC	chr20	21365588	Silent	novel	V780V	0.23
HNSC	chr20	21331598	Missense_Mutation	novel	E205G	0.3	XRN_N
HNSC	chr20	21354861	Missense_Mutation	novel	T670I	0.14
KIRC	chr20	21356106	Missense_Mutation	NA	V683L	0.32
KIRC	chr20	21333775	Missense_Mutation	NA	W335C	0.28
KIRC	chr20	21333723	Frame_Shift_Ins	novel	*M319Kfs12**	0.04
KIRC	chr20	21340822	Silent	NA	A460A	0.26
KIRP	chr20	21340788	Missense_Mutation	novel	P449R	0.31
LAML	chr20	21365444	Missense_Mutation	novel	F760Y	0.11
LGG	chr20	21346414	Splice_Site	novel	X510_splice	0.11
LGG	chr20	21356119	Missense_Mutation	NA	G687E	0.11
LIHC	chr20	21389308	Silent	NA	P941P	0.49
LIHC	chr20	21382043	Silent	novel	Q878Q	0.16
LIHC	chr20	21365437	Missense_Mutation	NA	P758S	0.42
LIHC	chr20	21332300	Missense_Mutation	novel	G240S	0.4	XRN_N
LIHC	chr20	21303372	5'UTR	novel		0.34
LIHC	chr20	21348389	Missense_Mutation	novel	N608Y	0.28
LIHC	chr20	21331782	Missense_Mutation	novel	D222Y	0.45	XRN_N
LUAD	chr20	21357738	Missense_Mutation	novel	I734K	0.06
LUAD	chr20	21348206	Missense_Mutation	novel	E576Q	0.27
LUAD	chr20	21389281	Silent	novel	P932P	0.24
LUAD	chr20	21356626	Missense_Mutation	novel	G720E	0.2
LUAD	chr20	21346537	Missense_Mutation	NA	R551K	0.22
LUAD	chr20	21368526	Frame_Shift_Del	novel	*Y841Tfs10**	0.16
LUAD	chr20	21333583	Missense_Mutation	NA	E300Q	0.12
LUAD	chr20	21386876	Missense_Mutation	novel	G886V	0.17
LUAD	chr20	21365614	Missense_Mutation	NA	S789C	0.16
LUAD	chr20	21348395	Missense_Mutation	NA	L610I	0.4
LUSC	chr20	21328628	Missense_Mutation	novel	A129T	0.26	XRN_N
LUSC	chr20	21389420	3'UTR	novel		0.5
LUSC	chr20	21346491	Missense_Mutation	rs148676805	R536W	0.05
LUSC	chr20	21344138	Missense_Mutation	novel	S487P	0.11
LUSC	chr20	21332415	Missense_Mutation	novel	G278V	0.2
LUSC	chr20	21326293	Silent	novel	N30N	0.21
LUSC	chr20	21382016	Missense_Mutation	novel	W869C	0.48
LUSC	chr20	21365605	Missense_Mutation	novel	W786L	0.24
LUSC	chr20	21334104	Silent	NA	V384V	0.1
LUSC	chr20	21333563	Missense_Mutation	novel	S293I	0.51
LUSC	chr20	21326313	Missense_Mutation	novel	D37G	0.09	XRN_N
LUSC	chr20	21368569	Nonsense_Mutation	NA	Q855*	0.35
LUSC	chr20	21346500	Missense_Mutation	novel	V539M	0.08
LUSC	chr20	21331594	Missense_Mutation	novel	G204R	0.1	XRN_N
LUSC	chr20	21344148	Missense_Mutation	novel	G490A	0.26
LUSC	chr20	21326569	Missense_Mutation	novel	R95G	0.27	XRN_N
LUSC	chr20	21356158	Missense_Mutation	novel	Y700C	0.42
LUSC	chr20	21331571	Missense_Mutation	novel	S196F	0.23	XRN_N
OV	chr20	21346460	Missense_Mutation	novel	F525L	0.04
PAAD	chr20	21326289	Missense_Mutation	rs373315919	C29Y	0.15	XRN_N
PAAD	chr20	21333762	Missense_Mutation	novel	S331I	0.19
PAAD	chr20	21365580	Missense_Mutation	novel	A778S	0.16
READ	chr20	21332320	Silent	rs774996547	P246P	0.3
READ	chr20	21339060	Missense_Mutation	NA	R417Q	0.15
READ	chr20	21303341	5'UTR	novel		0.52
READ	chr20	21389382	3'UTR	novel		0.28
READ	chr20	21333580	Nonsense_Mutation	novel	G299*	0.38
READ	chr20	21386989	Missense_Mutation	NA	D924Y	0.1
READ	chr20	21330515	Missense_Mutation	NA	R154S	0.43	XRN_N
READ	chr20	21348413	Missense_Mutation	NA	K616E	0.52
SKCM	chr20	21354836	Silent	NA	L662L	0.17
SKCM	chr20	21389340	3'UTR	novel		0.23
SKCM	chr20	21333613	Missense_Mutation	NA	R310C	0.29
SKCM	chr20	21330506	Silent	novel	I151I	0.31
SKCM	chr20	21382026	Missense_Mutation	novel	P873S	0.21
SKCM	chr20	21333960	Missense_Mutation	novel	V364A	0.29
SKCM	chr20	21368534	Missense_Mutation	NA	G843A	0.27
SKCM	chr20	21333753	Missense_Mutation	NA	V328A	0.3
SKCM	chr20	21348225	Missense_Mutation	NA	P582L	0.32
SKCM	chr20	21389278	Nonsense_Mutation	NA	Y931*	0.09
SKCM	chr20	21333825	Missense_Mutation	NA	S352L	0.11
SKCM	chr20	21354850	Silent	NA	Y666Y	0.25
SKCM	chr20	21330627	Silent	NA	F166F	0.15
STAD	chr20	21332347	Silent	NA	F255F	0.18
STAD	chr20	21332346	Missense_Mutation	novel	F255Y	0.41
STAD	chr20	21326312	Missense_Mutation	NA	D37N	0.15	XRN_N
STAD	chr20	21389326	Silent	novel	Y947Y	0.24
STAD	chr20	21348365	Missense_Mutation	NA	G600R	0.03
STAD	chr20	21365638	Missense_Mutation	NA	P797R	0.17
STAD	chr20	21326491	Missense_Mutation	NA	P69A	0.11	XRN_N
STAD	chr20	21331583	Missense_Mutation	NA	A200V	0.41	XRN_N
STAD	chr20	21389283	Missense_Mutation	rs774005334	R933K	0.34
STAD	chr20	21357751	Silent	novel	P738P	0.16
STAD	chr20	21386897	Missense_Mutation	NA	W893L	0.1
STAD	chr20	21365607	Frame_Shift_Ins	novel	*S789Ifs14**	0.19
STAD	chr20	21348253	Splice_Region	NA	P591P	0.16
STAD	chr20	21344094	Missense_Mutation	NA	P472L	0.31
STAD	chr20	21340751	Missense_Mutation	NA	I437L	0.13
STAD	chr20	21334077	Splice_Site	NA	X376_splice	0.07
STAD	chr20	21386902	Missense_Mutation	rs769237988	R895W	0.32
STAD	chr20	21326520	Missense_Mutation	NA	M78I	0.11	XRN_N
STAD	chr20	21326580	Silent	NA	L98L	0.58
STAD	chr20	21328656	Missense_Mutation	NA	E138G	0.13	XRN_N
STAD	chr20	21326356	Silent	novel	L51L	0.35
TGCT	chr20	21339060	Missense_Mutation	NA	R417Q	0.27
UCEC	chr20	21339075	Missense_Mutation	NA	R422I	0.31
UCEC	chr20	21389322	Missense_Mutation	NA	R946K	0.3
UCEC	chr20	21332342	Nonsense_Mutation	NA	E254*	0.27	XRN_N
UCEC	chr20	21344137	Silent	rs201613539	P486P	0.4
UCEC	chr20	21348179	Missense_Mutation	NA	H567N	0.38
UCEC	chr20	21357773	Missense_Mutation	novel	T746P	0.29
UCEC	chr20	21333825	Missense_Mutation	NA	S352L	0.4
UCEC	chr20	21328612	Silent	novel	K123K	0.4
UCEC	chr20	21328566	Missense_Mutation	NA	R108H	0.57	XRN_N
UCEC	chr20	21326285	Nonsense_Mutation	NA	E28*	0.43	XRN_N
UCEC	chr20	21326319	Missense_Mutation	NA	S39N	0.2	XRN_N
UCEC	chr20	21330702	Silent	NA	L191L	0.2
UCEC	chr20	21333954	Missense_Mutation	rs371978482	R362H	0.41
UCEC	chr20	21326310	Missense_Mutation	NA	V36A	0.36	XRN_N
UCEC	chr20	21326403	Missense_Mutation	NA	D67G	0.14	XRN_N
UCEC	chr20	21356631	Missense_Mutation	NA	F722L	0.24
UCEC	chr20	21344094	Missense_Mutation	NA	P472L	0.57
UCEC	chr20	21389311	Silent	novel	P942P	0.19
UCEC	chr20	21346441	Missense_Mutation	NA	R519Q	0.33
UCEC	chr20	21389728	3'UTR	novel		0.31
UCEC	chr20	21332426	Nonsense_Mutation	novel	E282*	0.16
UCEC	chr20	21346537	Missense_Mutation	NA	R551I	0.19
UCEC	chr20	21356635	Missense_Mutation	NA	S723Y	0.12
UCEC	chr20	21332320	Silent	rs774996547	P246P	0.42
UCEC	chr20	21339068	Nonsense_Mutation	NA	E420*	0.4
UCEC	chr20	21357735	Splice_Site	novel	X733_splice	0.45
UCEC	chr20	21382046	Missense_Mutation	novel	Q879H	0.06
UCEC	chr20	21389778	3'UTR	novel		0.06
UCEC	chr20	21333750	Missense_Mutation	novel	D327A	0.39
UCEC	chr20	21346522	Missense_Mutation	novel	L546R	0.43
UCEC	chr20	21356092	Missense_Mutation	novel	S678N	0.32
UCEC	chr20	21333716	Nonsense_Mutation	novel	E316*	0.41
UCEC	chr20	21357740	Missense_Mutation	novel	V735I	0.38
UCEC	chr20	21389441	3'UTR	novel		0.4
UCEC	chr20	21389795	3'UTR	novel		0.46
UCEC	chr20	21326302	Missense_Mutation	NA	K33N	0.48	XRN_N
UCEC	chr20	21348367	Silent	rs776581644	G600G	0.26
UCEC	chr20	21365647	Missense_Mutation	NA	G800D	0.4
UCEC	chr20	21346511	Silent	rs143832454	Y542Y	0.47
UCEC	chr20	21332426	Nonsense_Mutation	novel	E282*	0.32
UCEC	chr20	21333579	Silent	rs199788463	E298E	0.18
UCEC	chr20	21333560	Missense_Mutation	novel	D292A	0.44
UCEC	chr20	21333608	Missense_Mutation	novel	V308D	0.07
UCEC	chr20	21340812	Missense_Mutation	rs139083502	P457L	0.49
UCEC	chr20	21328642	Silent	novel	Q133Q	0.3
UCEC	chr20	21368498	Missense_Mutation	novel	Y831C	0.37
UCEC	chr20	21389322	Missense_Mutation	novel	R946I	0.5
UCEC	chr20	21389795	3'UTR	novel		0.49
UCEC	chr20	21344098	Silent	rs535403975	S473S	0.37
UCEC	chr20	21389585	3'UTR	novel		0.36
UCEC	chr20	21331804	Missense_Mutation	novel	L229S	0.07	XRN_N
UCEC	chr20	21332320	Silent	rs774996547	P246P	0.31
UCEC	chr20	21326600	Missense_Mutation	NA	V105A	0.17	XRN_N
UCEC	chr20	21389795	3'UTR	novel		0.25
UCEC	chr20	21328628	Missense_Mutation	NA	A129S	0.29	XRN_N
UCEC	chr20	21356159	Silent	NA	Y700Y	0.3
UCEC	chr20	21328608	Missense_Mutation	novel	S122L	0.44	XRN_N
UCEC	chr20	21365635	In_Frame_Ins	novel	L799_G800insTASSASQVHAIPLPQL	0.02
UCEC	chr20	21389795	3'UTR	novel		0.36
UCEC	chr20	21346451	Missense_Mutation	rs138301797	K522N	0.39
UCEC	chr20	21346537	Missense_Mutation	NA	R551I	0.17
UCEC	chr20	21332320	Silent	rs774996547	P246P	0.15
UCEC	chr20	21356635	Missense_Mutation	NA	S723Y	0.34
UCEC	chr20	21389557	3'UTR	novel		0.4
UCEC	chr20	21326596	Missense_Mutation	NA	G104R	0.26	XRN_N
UCEC	chr20	21382017	Nonsense_Mutation	rs756100274	R870*	0.21
UCEC	chr20	21389484	3'UTR	novel		0.43
UCEC	chr20	21344145	Missense_Mutation	novel	L489S	0.33
UCEC	chr20	21389795	3'UTR	novel		0.38
UCEC	chr20	21331781	Silent	NA	H221H	0.36
UCEC	chr20	21333991	Silent	NA	T374T	0.32
UCEC	chr20	21348416	Missense_Mutation	NA	L617I	0.27
UCEC	chr20	21389327	Missense_Mutation	novel	N948D	0.04
UCEC	chr20	21365680	Missense_Mutation	novel	D811G	0.28
UCEC	chr20	21389741	3'UTR	novel		0.41
UCEC	chr20	21389405	3'UTR	novel		0.48

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1222	0.030954
PAAD	AMP	0.125	0.0668

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0022	Kaplan-Meier Survival Analysis
SARC	0.0062	Kaplan-Meier Survival Analysis
MESO	0.037	Kaplan-Meier Survival Analysis
SKCM	0.0031	Kaplan-Meier Survival Analysis
PAAD	0.0058	Kaplan-Meier Survival Analysis
READ	0.0022	Kaplan-Meier Survival Analysis
KICH	0.011	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis