EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000088986 (Gene tree)
Gene ID: 8655
Gene Symbol: DYNLL1
Alias: hdlc1|DLC1|PIN|LC8|DLC8|DNCL1
Full Name: dynein light chain LC8-type 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 28,646 bases
Position: chr12:120,469,850-120,498,495
Accession: 15476
RBP type: non-canonical RBP
Summary: Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27864381	Dynein light chain DLC-1 promotes localization and function of the PUF protein FBF-2 in germline progenitor cells.	Development	2016 Dec 15	Wang X	-
26459761	Dynein Light Chain LC8 Is Required for RNA Polymerase I-Mediated Transcription in Trypanosoma brucei, Facilitating Assembly and Promoter Binding of Class I Transcription Factor A.	Mol Cell Biol	2015 Oct 12	Kirkham JK	doi: 10.1128/MCB.00705-15
28566454	Correction for Kirkham et al., Dynein Light Chain LC8 Is Required for RNA Polymerase I-Mediated Transcription in Trypanosoma brucei, Facilitating Assembly and Promoter Binding of Class I Transcription Factor A	Mol Cell Biol	2017 May 31	Kirkham JK	doi: 10.1128/MCB.00166-17

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000549649	DYNLL1-206	794	-	ENSP00000448834	42 (aa)	-	F8VXI7
ENST00000548214	DYNLL1-204	616	-	ENSP00000448608	67 (aa)	-	F8VRV5
ENST00000242577	DYNLL1-201	720	-	ENSP00000242577	89 (aa)	-	P63167
ENST00000392508	DYNLL1-202	697	-	ENSP00000376296	89 (aa)	-	P63167
ENST00000392509	DYNLL1-203	814	-	ENSP00000376297	89 (aa)	-	P63167
ENST00000549989	DYNLL1-207	719	-	ENSP00000446614	89 (aa)	-	P63167
ENST00000550178	DYNLL1-208	581	-	ENSP00000446596	67 (aa)	-	F8VRV5
ENST00000552870	DYNLL1-211	595	-	ENSP00000449088	47 (aa)	-	F8VXL2
ENST00000552316	DYNLL1-210	670	-	-	- (aa)	-	-
ENST00000550845	DYNLL1-209	1376	-	ENSP00000447494	67 (aa)	-	F8VRV5
ENST00000548342	DYNLL1-205	662	-	ENSP00000447907	89 (aa)	-	P63167

Gene Model

Click here to download ENSG00000088986's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04962	Vasopressin-regulated water reabsorption	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000088986	Heart Rate	8.833e-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000088986	rs4767902	12	120472201	T	High light scatter reticulocyte percentage of red cells	27863252	[0.066-0.081] unit decrease	0.07385731	EFO_0007986
ENSG00000088986	rs11352199	12	120482340	A	High light scatter reticulocyte percentage of red cells	27863252	[0.062-0.076] unit decrease	0.06871397	EFO_0007986
ENSG00000088986	rs4767902	12	120472201	T	Reticulocyte count	27863252	[0.058-0.073] unit decrease	0.06562033	EFO_0007986
ENSG00000088986	rs17431717	12	120474407	A	Self-reported math ability (MTAG)	30038396	[0.011-0.02] unit increase	0.0154	EFO_0004875
ENSG00000088986	rs17431717	12	120474407	G	Highest math class taken	30038396	[0.012-0.023] unit decrease	0.0174	EFO_0004875
ENSG00000088986	rs616157	12	120487992	T	Educational attainment (MTAG)	30038396	[0.01-0.017] unit decrease	0.0134	EFO_0004784
ENSG00000088986	rs17431717	12	120474407	A	Highest math class taken (MTAG)	30038396	[0.013-0.022] unit increase	0.0174	EFO_0004875
ENSG00000088986	rs17431717	12	120474407	A	Cognitive performance (MTAG)	30038396	[0.011-0.023] unit increase	0.0174	EFO_0008354
ENSG00000088986	rs11352199	12	120482340	A	Reticulocyte fraction of red cells	27863252	[0.056-0.071] unit decrease	0.0633918	EFO_0007986
ENSG00000088986	rs558163981	12	120472178	CA	Immature fraction of reticulocytes	27863252	[0.055-0.069] unit decrease	0.06199417	EFO_0007986
ENSG00000088986	rs11352199	12	120482340	A	High light scatter reticulocyte count	27863252	[0.061-0.075] unit decrease	0.06803904	EFO_0007986

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000088986's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0000776	kinetochore	20133940.	IDA	Component
GO:0005515	protein binding	14607844.15891768.16684779.18420585.18579519.20133940.20412299.20562859.21094642.22167198.25416956.25852190.26496610.27173435.	IPI	Function
GO:0005634	nucleus	15891768.	IDA	Component
GO:0005737	cytoplasm	8628263.15891768.	IDA	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0005813	centrosome	21399614.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005868	cytoplasmic dynein complex	21873635.	IBA	Component
GO:0005868	cytoplasmic dynein complex	25830415.	IDA	Component
GO:0005868	cytoplasmic dynein complex	-	ISS	Component
GO:0005874	microtubule	-	IEA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005929	cilium	-	TAS	Component
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0006915	apoptotic process	-	IEA	Process
GO:0007286	spermatid development	-	IEA	Process
GO:0008022	protein C-terminus binding	-	IEA	Function
GO:0008180	COP9 signalosome	18850735.	IDA	Component
GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	21873635.	IBA	Function
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0016236	macroautophagy	-	TAS	Process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0019899	enzyme binding	-	IEA	Function
GO:0019904	protein domain specific binding	-	IEA	Function
GO:0021762	substantia nigra development	22926577.	HEP	Process
GO:0030235	nitric-oxide synthase regulator activity	-	IEA	Function
GO:0030286	dynein complex	21873635.	IBA	Component
GO:0035721	intraciliary retrograde transport	-	IEA	Process
GO:0035735	intraciliary transport involved in cilium assembly	-	TAS	Process
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	-	IEA	Process
GO:0042326	negative regulation of phosphorylation	18579519.	IDA	Process
GO:0042803	protein homodimerization activity	-	IEA	Function
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0044458	motile cilium assembly	-	IEA	Process
GO:0045505	dynein intermediate chain binding	21873635.	IBA	Function
GO:0046982	protein heterodimerization activity	-	IEA	Function
GO:0051959	dynein light intermediate chain binding	21873635.	IBA	Function
GO:0070821	tertiary granule membrane	-	TAS	Component
GO:0072686	mitotic spindle	20133940.	IDA	Component
GO:0097110	scaffold protein binding	-	IEA	Function
GO:0097542	ciliary tip	-	TAS	Component
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	Process
GO:0101003	ficolin-1-rich granule membrane	-	TAS	Component
GO:1902857	positive regulation of non-motile cilium assembly	-	IEA	Process
GO:1904115	axon cytoplasm	-	IEA	Component
GO:2000582	positive regulation of ATP-dependent microtubule motor activity, plus-end-directed	21873635.	IBA	Process