EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000089048 (Gene tree)
Gene ID: 51575
Gene Symbol: ESF1
Alias: bA526K24.1|C20orf6
Full Name: ESF1 nucleolar pre-rRNA processing protein homolog
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 70,612 bases
Position: chr20:13,714,322-13,784,933
Accession: 15898
RBP type: canonical RBP
Summary: (ESF1 Nucleolar Pre-RRNA Processing Protein Homolog) is a Protein Coding gene.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000202816	NUC153	PF08159.12	6.5e-11	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000617257	ESF1-202	1470	-	ENSP00000480783	456 (aa)	-	A0A087WX71
ENST00000202816	ESF1-201	3216	XM_017027874	ENSP00000202816	851 (aa)	XP_016883363	Q9H501

Gene Model

Click here to download ENSG00000089048's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000089048	Intelligence	7E-6	23358156

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000089048	rs6042314	20	13715482	C	Intelligence (childhood)	23358156	[0.033-0.083] unit increase	0.058	EFO_0004337

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000089048's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000089048	ESF1	62	59.170	ENSAPOG00000003004	esf1	99	53.905	Acanthochromis_polyacanthus
ENSG00000089048	ESF1	99	89.207	ENSAMEG00000008830	ESF1	100	82.360	Ailuropoda_melanoleuca
ENSG00000089048	ESF1	76	70.667	ENSACIG00000018305	esf1	91	70.513	Amphilophus_citrinellus
ENSG00000089048	ESF1	75	74.026	ENSAOCG00000006033	esf1	99	60.714	Amphiprion_ocellaris
ENSG00000089048	ESF1	75	74.026	ENSAPEG00000022385	esf1	90	69.318	Amphiprion_percula
ENSG00000089048	ESF1	76	72.973	ENSATEG00000016321	esf1	87	67.816	Anabas_testudineus
ENSG00000089048	ESF1	80	77.322	ENSAPLG00000012113	ESF1	100	59.725	Anas_platyrhynchos
ENSG00000089048	ESF1	100	62.238	ENSACAG00000000963	ESF1	100	62.093	Anolis_carolinensis
ENSG00000089048	ESF1	100	92.597	ENSANAG00000036778	ESF1	100	91.774	Aotus_nancymaae
ENSG00000089048	ESF1	76	70.130	ENSACLG00000002972	esf1	90	64.773	Astatotilapia_calliptera
ENSG00000089048	ESF1	73	66.279	ENSAMXG00000001172	esf1	91	63.668	Astyanax_mexicanus
ENSG00000089048	ESF1	99	88.184	ENSBTAG00000007130	ESF1	100	83.314	Bos_taurus
ENSG00000089048	ESF1	100	91.539	ENSCJAG00000004640	ESF1	100	91.304	Callithrix_jacchus
ENSG00000089048	ESF1	99	88.326	ENSCAFG00000005587	ESF1	100	83.372	Canis_familiaris
ENSG00000089048	ESF1	99	88.326	ENSCAFG00020027530	ESF1	100	83.372	Canis_lupus_dingo
ENSG00000089048	ESF1	99	87.800	ENSCHIG00000021188	ESF1	100	84.070	Capra_hircus
ENSG00000089048	ESF1	99	91.410	ENSTSYG00000009956	ESF1	100	87.089	Carlito_syrichta
ENSG00000089048	ESF1	80	83.333	ENSCAPG00000010333	-	97	84.127	Cavia_aperea
ENSG00000089048	ESF1	100	69.330	ENSCAPG00000010466	-	100	68.508	Cavia_aperea
ENSG00000089048	ESF1	99	84.735	ENSCPOG00000014027	-	100	80.634	Cavia_porcellus
ENSG00000089048	ESF1	99	95.604	ENSCCAG00000024521	ESF1	100	91.657	Cebus_capucinus
ENSG00000089048	ESF1	99	95.604	ENSCATG00000042792	ESF1	100	92.254	Cercocebus_atys
ENSG00000089048	ESF1	99	84.513	ENSCLAG00000013266	-	100	82.532	Chinchilla_lanigera
ENSG00000089048	ESF1	100	91.667	ENSCSAG00000011777	ESF1	100	91.901	Chlorocebus_sabaeus
ENSG00000089048	ESF1	68	45.260	ENSCING00000020446	-	89	50.746	Ciona_intestinalis
ENSG00000089048	ESF1	69	47.692	ENSCSAVG00000009015	-	88	50.000	Ciona_savignyi
ENSG00000089048	ESF1	100	91.559	ENSCANG00000030674	ESF1	100	91.794	Colobus_angolensis_palliatus
ENSG00000089048	ESF1	98	87.946	ENSCGRG00001018257	Esf1	100	81.243	Cricetulus_griseus_chok1gshd
ENSG00000089048	ESF1	80	58.824	ENSCSEG00000001159	esf1	86	60.563	Cynoglossus_semilaevis
ENSG00000089048	ESF1	72	75.385	ENSCVAG00000007894	esf1	91	74.648	Cyprinodon_variegatus
ENSG00000089048	ESF1	74	67.568	ENSDARG00000008740	esf1	87	68.831	Danio_rerio
ENSG00000089048	ESF1	99	85.903	ENSDNOG00000019409	ESF1	100	82.807	Dasypus_novemcinctus
ENSG00000089048	ESF1	95	87.586	ENSDORG00000016313	Esf1	100	81.967	Dipodomys_ordii
ENSG00000089048	ESF1	68	51.807	FBgn0024364	CG11417	81	51.807	Drosophila_melanogaster
ENSG00000089048	ESF1	79	84.861	ENSETEG00000004471	ESF1	79	84.861	Echinops_telfairi
ENSG00000089048	ESF1	80	53.786	ENSEBUG00000015161	esf1	87	49.053	Eptatretus_burgeri
ENSG00000089048	ESF1	99	88.742	ENSEASG00005001777	ESF1	100	83.705	Equus_asinus_asinus
ENSG00000089048	ESF1	99	88.767	ENSECAG00000019188	ESF1	100	83.822	Equus_caballus
ENSG00000089048	ESF1	98	52.784	ENSEEUG00000015837	-	99	59.969	Erinaceus_europaeus
ENSG00000089048	ESF1	74	67.949	ENSELUG00000000408	esf1	83	67.949	Esox_lucius
ENSG00000089048	ESF1	99	89.956	ENSFCAG00000000919	ESF1	100	85.565	Felis_catus
ENSG00000089048	ESF1	80	76.648	ENSFALG00000010914	ESF1	99	61.298	Ficedula_albicollis
ENSG00000089048	ESF1	99	84.292	ENSFDAG00000014777	ESF1	100	81.786	Fukomys_damarensis
ENSG00000089048	ESF1	68	65.079	ENSFHEG00000014984	esf1	99	60.552	Fundulus_heteroclitus
ENSG00000089048	ESF1	100	61.645	ENSGALG00000034768	ESF1	100	60.710	Gallus_gallus
ENSG00000089048	ESF1	80	61.680	ENSGAFG00000000540	esf1	90	67.568	Gambusia_affinis
ENSG00000089048	ESF1	100	98.002	ENSGGOG00000006692	ESF1	100	98.002	Gorilla_gorilla
ENSG00000089048	ESF1	81	71.429	ENSHBUG00000001890	esf1	90	65.909	Haplochromis_burtoni
ENSG00000089048	ESF1	99	85.398	ENSHGLG00000011505	ESF1	100	81.669	Heterocephalus_glaber_female
ENSG00000089048	ESF1	99	85.398	ENSHGLG00100015045	ESF1	100	81.669	Heterocephalus_glaber_male
ENSG00000089048	ESF1	74	67.949	ENSIPUG00000006507	esf1	87	62.500	Ictalurus_punctatus
ENSG00000089048	ESF1	95	89.425	ENSSTOG00000009846	ESF1	100	82.573	Ictidomys_tridecemlineatus
ENSG00000089048	ESF1	100	80.445	ENSJJAG00000012570	Esf1	100	80.445	Jaculus_jaculus
ENSG00000089048	ESF1	80	71.968	ENSLACG00000016439	ESF1	66	68.430	Latimeria_chalumnae
ENSG00000089048	ESF1	74	67.949	ENSLOCG00000015979	esf1	83	67.949	Lepisosteus_oculatus
ENSG00000089048	ESF1	100	82.201	ENSLAFG00000005479	ESF1	100	82.201	Loxodonta_africana
ENSG00000089048	ESF1	99	95.824	ENSMFAG00000036841	ESF1	100	92.606	Macaca_fascicularis
ENSG00000089048	ESF1	99	95.824	ENSMNEG00000044042	ESF1	100	92.488	Macaca_nemestrina
ENSG00000089048	ESF1	99	95.604	ENSMLEG00000037121	ESF1	100	92.254	Mandrillus_leucophaeus
ENSG00000089048	ESF1	75	72.973	ENSMAMG00000018648	esf1	99	60.827	Mastacembelus_armatus
ENSG00000089048	ESF1	62	64.664	ENSMZEG00005013912	esf1	99	58.730	Maylandia_zebra
ENSG00000089048	ESF1	87	74.623	ENSMGAG00000004291	ESF1	100	59.725	Meleagris_gallopavo
ENSG00000089048	ESF1	99	85.872	ENSMAUG00000015975	Esf1	100	80.657	Mesocricetus_auratus
ENSG00000089048	ESF1	99	89.231	ENSMICG00000010711	ESF1	100	87.588	Microcebus_murinus
ENSG00000089048	ESF1	99	84.176	ENSMOCG00000005902	Esf1	100	78.781	Microtus_ochrogaster
ENSG00000089048	ESF1	62	64.164	ENSMMOG00000018693	esf1	99	59.770	Mola_mola
ENSG00000089048	ESF1	99	78.146	ENSMODG00000005066	ESF1	100	70.258	Monodelphis_domestica
ENSG00000089048	ESF1	71	68.919	ENSMALG00000007338	esf1	81	63.636	Monopterus_albus
ENSG00000089048	ESF1	99	84.989	MGP_CAROLIEiJ_G0024365	Esf1	100	79.859	Mus_caroli
ENSG00000089048	ESF1	99	85.872	ENSMUSG00000045624	Esf1	100	80.328	Mus_musculus
ENSG00000089048	ESF1	99	86.313	MGP_PahariEiJ_G0025810	Esf1	100	80.399	Mus_pahari
ENSG00000089048	ESF1	99	85.651	MGP_SPRETEiJ_G0025285	Esf1	100	80.070	Mus_spretus
ENSG00000089048	ESF1	99	90.969	ENSMPUG00000001450	ESF1	100	84.211	Mustela_putorius_furo
ENSG00000089048	ESF1	99	86.564	ENSMLUG00000013080	ESF1	100	84.075	Myotis_lucifugus
ENSG00000089048	ESF1	100	94.595	ENSNLEG00000014563	ESF1	100	94.242	Nomascus_leucogenys
ENSG00000089048	ESF1	58	100.000	ENSMEUG00000005061	-	72	59.627	Notamacropus_eugenii
ENSG00000089048	ESF1	70	83.648	ENSOPRG00000004862	ESF1	100	84.387	Ochotona_princeps
ENSG00000089048	ESF1	99	84.292	ENSODEG00000006824	ESF1	100	81.477	Octodon_degus
ENSG00000089048	ESF1	77	71.429	ENSONIG00000006804	esf1	89	66.292	Oreochromis_niloticus
ENSG00000089048	ESF1	96	72.973	ENSOANG00000008432	-	100	67.955	Ornithorhynchus_anatinus
ENSG00000089048	ESF1	100	80.351	ENSOCUG00000005414	ESF1	100	80.468	Oryctolagus_cuniculus
ENSG00000089048	ESF1	62	61.888	ENSORLG00000018625	esf1	99	54.340	Oryzias_latipes
ENSG00000089048	ESF1	74	70.513	ENSORLG00015022826	esf1	92	70.513	Oryzias_latipes_hsok
ENSG00000089048	ESF1	62	62.718	ENSOMEG00000009311	esf1	99	56.897	Oryzias_melastigma
ENSG00000089048	ESF1	98	84.753	ENSOGAG00000016912	ESF1	100	81.712	Otolemur_garnettii
ENSG00000089048	ESF1	99	84.937	ENSOARG00000011158	ESF1	100	81.684	Ovis_aries
ENSG00000089048	ESF1	100	97.415	ENSPPAG00000024379	ESF1	100	97.415	Pan_paniscus
ENSG00000089048	ESF1	99	90.549	ENSPPRG00000012007	ESF1	100	84.696	Panthera_pardus
ENSG00000089048	ESF1	99	90.969	ENSPTIG00000020063	ESF1	100	86.199	Panthera_tigris_altaica
ENSG00000089048	ESF1	100	98.357	ENSPTRG00000013258	ESF1	100	98.357	Pan_troglodytes
ENSG00000089048	ESF1	74	68.750	ENSPKIG00000024448	esf1	79	68.750	Paramormyrops_kingsleyae
ENSG00000089048	ESF1	76	63.636	ENSPMGG00000016911	esf1	82	61.250	Periophthalmus_magnuspinnatus
ENSG00000089048	ESF1	100	69.849	ENSPCIG00000019331	ESF1	100	69.383	Phascolarctos_cinereus
ENSG00000089048	ESF1	80	60.574	ENSPFOG00000010101	esf1	90	57.955	Poecilia_formosa
ENSG00000089048	ESF1	62	65.385	ENSPLAG00000006452	esf1	99	56.890	Poecilia_latipinna
ENSG00000089048	ESF1	82	63.049	ENSPMEG00000000713	esf1	89	64.865	Poecilia_mexicana
ENSG00000089048	ESF1	75	64.865	ENSPREG00000004431	esf1	87	62.821	Poecilia_reticulata
ENSG00000089048	ESF1	100	97.183	ENSPPYG00000010715	ESF1	100	97.183	Pongo_abelii
ENSG00000089048	ESF1	100	76.464	ENSPCAG00000006881	ESF1	100	77.049	Procavia_capensis
ENSG00000089048	ESF1	83	93.056	ENSPVAG00000001295	ESF1	85	87.500	Pteropus_vampyrus
ENSG00000089048	ESF1	81	68.831	ENSPNYG00000015735	esf1	90	63.953	Pundamilia_nyererei
ENSG00000089048	ESF1	74	64.865	ENSPNAG00000014721	esf1	85	63.750	Pygocentrus_nattereri
ENSG00000089048	ESF1	98	85.111	ENSRNOG00000004777	Esf1	100	79.883	Rattus_norvegicus
ENSG00000089048	ESF1	99	95.165	ENSRBIG00000035763	ESF1	100	92.371	Rhinopithecus_bieti
ENSG00000089048	ESF1	99	95.604	ENSRROG00000032022	ESF1	100	93.662	Rhinopithecus_roxellana
ENSG00000089048	ESF1	68	37.318	YDR365C	-	73	35.294	Saccharomyces_cerevisiae
ENSG00000089048	ESF1	99	93.392	ENSSBOG00000030387	ESF1	100	90.739	Saimiri_boliviensis_boliviensis
ENSG00000089048	ESF1	100	68.409	ENSSHAG00000000449	ESF1	100	68.445	Sarcophilus_harrisii
ENSG00000089048	ESF1	76	71.622	ENSSDUG00000019460	esf1	93	67.059	Seriola_dumerili
ENSG00000089048	ESF1	89	73.039	ENSSPUG00000012635	ESF1	69	73.968	Sphenodon_punctatus
ENSG00000089048	ESF1	75	71.795	ENSSPAG00000019077	esf1	89	66.667	Stegastes_partitus
ENSG00000089048	ESF1	100	87.879	ENSSSCG00000007077	ESF1	100	84.750	Sus_scrofa
ENSG00000089048	ESF1	100	59.080	ENSTGUG00000002450	ESF1	100	60.274	Taeniopygia_guttata
ENSG00000089048	ESF1	84	61.183	ENSTRUG00000009445	esf1	88	65.385	Takifugu_rubripes
ENSG00000089048	ESF1	71	90.062	ENSTBEG00000008552	ESF1	76	89.051	Tupaia_belangeri
ENSG00000089048	ESF1	99	89.868	ENSTTRG00000005335	ESF1	100	84.895	Tursiops_truncatus
ENSG00000089048	ESF1	99	90.749	ENSUMAG00000008579	ESF1	100	85.263	Ursus_maritimus
ENSG00000089048	ESF1	100	77.986	ENSVPAG00000005291	ESF1	100	77.635	Vicugna_pacos
ENSG00000089048	ESF1	99	87.225	ENSVVUG00000014318	ESF1	93	83.138	Vulpes_vulpes
ENSG00000089048	ESF1	74	71.681	ENSXETG00000008079	esf1	100	55.275	Xenopus_tropicalis
ENSG00000089048	ESF1	75	67.568	ENSXMAG00000017651	esf1	88	67.568	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0005615	extracellular space	23580065.	HDA	Component
GO:0005654	nucleoplasm	-	IEA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0006364	rRNA processing	21873635.	IBA	Process