EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000089127 (Gene tree)
Gene ID: 4938
Gene Symbol: OAS1
Alias: OIASI|IFI-4|OIAS
Full Name: 2'-5'-oligoadenylate synthetase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 26,446 bases
Position: chr12:112,906,777-112,933,222
Accession: 8086
RBP type: canonical RBP
Summary: This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, Feb 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000415721	OAS1_C	PF10421.9	3.2e-86	1	1
ENSP00000448790	OAS1_C	PF10421.9	3.2e-86	1	1
ENSP00000202917	OAS1_C	PF10421.9	4.1e-86	1	1
ENSP00000388001	OAS1_C	PF10421.9	4.7e-86	1	1
ENSP00000448348	OAS1_C	PF10421.9	4.4e-62	1	1
ENSP00000449053	OAS1_C	PF10421.9	3.3e-38	1	1
ENSP00000450286	OAS1_C	PF10421.9	9.3e-07	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26156123	Contrasted patterns of variation and evolutionary convergence at the antiviral OAS1 gene in old world primates.	Immunogenetics	2015 Sep	Fish I	doi: 10.1007/s00251-015-0855-0
30965010	Impact of double-stranded RNA characteristics on the activation of human 2'-5'-oligoadenylate synthetase 2 (OAS2).	Biochem Cell Biol	2019 Apr 9	Koul A	doi: 10.1139/bcb-2019-0060
22104212	Long-term balancing selection at the antiviral gene OAS1 in Central African chimpanzees.	Mol Biol Evol	2012 Apr	Ferguson W	doi: 10.1093/molbev/msr247
24651762	Activation of 2' 5'-oligoadenylate synthetase by stem loops at the 5'-end of the West Nile virus genome.	PLoS One	2014 Mar 20	Deo S	doi: 10.1371/journal.pone.0092545
27393659	Functional evolution of the OAS1 viral sensor: Insights from old world primates.	Infect Genet Evol	2016 Oct	Fish I	doi: 10.1016/j.meegid.2016.07.005
23319625	Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1.	Proc Natl Acad Sci U S A	2013 Jan 29	Donovan J	doi: 10.1073/pnas.1218528110
26061044	The Tumor Suppressive Effects of HPP1 Are Mediated Through JAK-STAT-Interferon Signaling Pathways.	DNA Cell Biol	2015 Aug	Hernandez JM	doi: 10.1089/dna.2014.2730

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000553185	OAS1-211	664	-	ENSP00000448001	177 (aa)	-	F8VUC8
ENST00000445409	OAS1-202	1684	XM_011538413	ENSP00000388001	414 (aa)	XP_011536715	P00973
ENST00000202917	OAS1-201	1816	XM_017019361	ENSP00000202917	400 (aa)	XP_016874850	P00973
ENST00000452357	OAS1-203	1990	XM_006719434	ENSP00000415721	364 (aa)	XP_006719497	P00973
ENST00000553152	OAS1-210	890	-	ENSP00000449053	130 (aa)	-	H0YIB8
ENST00000551241	OAS1-208	2416	-	ENSP00000448790	360 (aa)	-	F8VXY3
ENST00000550883	OAS1-207	324	-	ENSP00000450286	83 (aa)	-	F8VPW7
ENST00000552526	OAS1-209	309	-	ENSP00000475139	15 (aa)	-	C6EMZ7
ENST00000540589	OAS1-204	395	-	ENSP00000474083	22 (aa)	-	S4R3A5
ENST00000549820	OAS1-205	1121	-	-	- (aa)	-	-
ENST00000550689	OAS1-206	950	-	ENSP00000448348	302 (aa)	-	H0YI20

Gene Model

Click here to download ENSG00000089127's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04621	NOD-like receptor signaling pathway	KEGG
hsa05160	Hepatitis C	KEGG
hsa05162	Measles	KEGG
hsa05164	Influenza A	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG
hsa05169	Epstein-Barr virus infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000089127	gamma-Glutamyltransferase	6E-44	21909109
ENSG00000089127	Diabetes Mellitus, Type 2	5E-9	23575436

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000089127	rs11066453	12	112927816	G	Glycemic traits	23575436	[0.16-0.32] mmol-1 decrease	0.242	EFO_0001360
ENSG00000089127	rs4767027	12	112921352	C	Blood protein levels	29875488	[0.21-0.33] unit decrease	0.27	EFO_0007937
ENSG00000089127	rs11066453	12	112927816	G	Gamma glutamyl transpeptidase	21909109	[0.0083-0.0111] IU/L increase	0.0097	EFO_0004532
ENSG00000089127	rs11066452	12	112923769	T	Blood protein levels	30072576	[0.094-0.2] unit decrease	0.147	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000089127's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000089127	OAS1	97	39.667	ENSG00000135114	OASL	85	36.486
ENSG00000089127	OAS1	97	53.199	ENSG00000111335	OAS2	99	53.429
ENSG00000089127	OAS1	98	61.824	ENSG00000111331	OAS3	93	59.884

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000089127	OAS1	100	88.000	ENSAMEG00000008654	OAS1	100	66.584	Ailuropoda_melanoleuca
ENSG00000089127	OAS1	97	54.392	ENSAMEG00000008674	OAS2	96	55.367	Ailuropoda_melanoleuca
ENSG00000089127	OAS1	97	45.485	ENSAMEG00000008347	-	95	47.302	Ailuropoda_melanoleuca
ENSG00000089127	OAS1	96	49.288	ENSACAG00000009153	-	96	49.288	Anolis_carolinensis
ENSG00000089127	OAS1	100	86.667	ENSANAG00000028558	OAS1	100	86.427	Aotus_nancymaae
ENSG00000089127	OAS1	98	60.135	ENSANAG00000013699	OAS3	94	58.430	Aotus_nancymaae
ENSG00000089127	OAS1	97	52.189	ENSANAG00000029234	OAS2	97	52.676	Aotus_nancymaae
ENSG00000089127	OAS1	97	51.178	ENSBTAG00000014628	OAS2	96	51.412	Bos_taurus
ENSG00000089127	OAS1	99	87.500	ENSBTAG00000039861	OAS1Y	100	67.830	Bos_taurus
ENSG00000089127	OAS1	97	38.742	ENSBTAG00000003297	OASL	98	38.527	Bos_taurus
ENSG00000089127	OAS1	97	73.810	ENSBTAG00000053807	-	99	70.940	Bos_taurus
ENSG00000089127	OAS1	97	68.136	ENSBTAG00000037527	OAS1Z	97	67.236	Bos_taurus
ENSG00000089127	OAS1	98	60.811	ENSCJAG00000012642	OAS3	93	59.012	Callithrix_jacchus
ENSG00000089127	OAS1	97	52.189	ENSCJAG00000012666	OAS2	99	52.000	Callithrix_jacchus
ENSG00000089127	OAS1	99	39.674	ENSCJAG00000043836	OASL	70	39.674	Callithrix_jacchus
ENSG00000089127	OAS1	100	84.488	ENSCJAG00000012624	OAS1	100	84.488	Callithrix_jacchus
ENSG00000089127	OAS1	100	92.000	ENSCAFG00000023556	OAS1	100	68.317	Canis_familiaris
ENSG00000089127	OAS1	97	43.000	ENSCAFG00000010511	OASL	66	43.266	Canis_familiaris
ENSG00000089127	OAS1	99	54.237	ENSCAFG00000023107	OAS2	96	54.802	Canis_familiaris
ENSG00000089127	OAS1	98	58.446	ENSCAFG00000008929	OAS3	89	57.267	Canis_familiaris
ENSG00000089127	OAS1	97	45.151	ENSCAFG00000024447	OASL	66	45.507	Canis_familiaris
ENSG00000089127	OAS1	98	58.446	ENSCAFG00020017605	OAS3	93	57.267	Canis_lupus_dingo
ENSG00000089127	OAS1	100	92.000	ENSCAFG00020017601	OAS1	100	68.069	Canis_lupus_dingo
ENSG00000089127	OAS1	97	42.667	ENSCAFG00020020845	OASL	66	42.980	Canis_lupus_dingo
ENSG00000089127	OAS1	99	54.942	ENSCAFG00020017625	OAS2	98	56.401	Canis_lupus_dingo
ENSG00000089127	OAS1	97	45.485	ENSCAFG00020020855	-	66	45.797	Canis_lupus_dingo
ENSG00000089127	OAS1	97	70.085	ENSCHIG00000017038	-	95	63.158	Capra_hircus
ENSG00000089127	OAS1	96	34.278	ENSCHIG00000017422	-	99	34.270	Capra_hircus
ENSG00000089127	OAS1	100	87.500	ENSCHIG00000019892	OAS1	99	70.655	Capra_hircus
ENSG00000089127	OAS1	97	51.178	ENSCHIG00000023778	-	96	51.989	Capra_hircus
ENSG00000089127	OAS1	97	48.136	ENSTSYG00000009240	OAS2	94	48.711	Carlito_syrichta
ENSG00000089127	OAS1	97	40.397	ENSTSYG00000009320	OASL	67	40.857	Carlito_syrichta
ENSG00000089127	OAS1	96	75.652	ENSTSYG00000003983	OAS1	99	75.652	Carlito_syrichta
ENSG00000089127	OAS1	98	60.067	ENSTSYG00000009231	OAS3	95	59.302	Carlito_syrichta
ENSG00000089127	OAS1	98	59.396	ENSCAPG00000013382	OAS3	92	58.721	Cavia_aperea
ENSG00000089127	OAS1	83	43.750	ENSCAPG00000006829	-	68	43.750	Cavia_aperea
ENSG00000089127	OAS1	99	79.167	ENSCAPG00000012425	OAS1	99	68.300	Cavia_aperea
ENSG00000089127	OAS1	86	62.963	ENSCAPG00000008640	OAS2	99	48.611	Cavia_aperea
ENSG00000089127	OAS1	96	67.335	ENSCPOG00000037062	OAS1	99	60.396	Cavia_porcellus
ENSG00000089127	OAS1	96	38.926	ENSCPOG00000007251	OASL	64	39.368	Cavia_porcellus
ENSG00000089127	OAS1	97	49.495	ENSCPOG00000034890	OAS2	99	49.722	Cavia_porcellus
ENSG00000089127	OAS1	98	59.396	ENSCPOG00000004153	OAS3	92	58.000	Cavia_porcellus
ENSG00000089127	OAS1	97	37.793	ENSCCAG00000028044	OASL	84	33.636	Cebus_capucinus
ENSG00000089127	OAS1	98	60.294	ENSCCAG00000018803	OAS3	94	59.903	Cebus_capucinus
ENSG00000089127	OAS1	100	84.488	ENSCCAG00000018223	OAS1	100	84.488	Cebus_capucinus
ENSG00000089127	OAS1	97	52.862	ENSCCAG00000023534	OAS2	99	52.857	Cebus_capucinus
ENSG00000089127	OAS1	97	40.333	ENSCATG00000034860	OASL	67	40.857	Cercocebus_atys
ENSG00000089127	OAS1	97	52.247	ENSCATG00000041022	OAS2	96	52.329	Cercocebus_atys
ENSG00000089127	OAS1	98	61.149	ENSCATG00000034991	OAS3	93	59.302	Cercocebus_atys
ENSG00000089127	OAS1	98	100.000	ENSCATG00000038529	OAS1	100	93.611	Cercocebus_atys
ENSG00000089127	OAS1	97	57.576	ENSCLAG00000013028	OAS2	87	56.164	Chinchilla_lanigera
ENSG00000089127	OAS1	72	47.872	ENSCLAG00000015572	-	72	49.474	Chinchilla_lanigera
ENSG00000089127	OAS1	97	39.333	ENSCLAG00000013631	OASL	66	40.230	Chinchilla_lanigera
ENSG00000089127	OAS1	97	68.456	ENSCLAG00000011485	OAS1	85	68.876	Chinchilla_lanigera
ENSG00000089127	OAS1	78	44.554	ENSCLAG00000012712	-	62	43.165	Chinchilla_lanigera
ENSG00000089127	OAS1	98	60.811	ENSCSAG00000002467	OAS3	99	59.012	Chlorocebus_sabaeus
ENSG00000089127	OAS1	98	100.000	ENSCSAG00000002468	OAS1	89	90.000	Chlorocebus_sabaeus
ENSG00000089127	OAS1	97	52.862	ENSCSAG00000002459	OAS2	99	53.258	Chlorocebus_sabaeus
ENSG00000089127	OAS1	97	40.667	ENSCSAG00000002221	OASL	67	41.143	Chlorocebus_sabaeus
ENSG00000089127	OAS1	97	41.391	ENSCHOG00000003162	OASL	66	41.143	Choloepus_hoffmanni
ENSG00000089127	OAS1	63	67.308	ENSCHOG00000000337	-	54	70.000	Choloepus_hoffmanni
ENSG00000089127	OAS1	68	47.191	ENSCHOG00000000146	-	53	49.275	Choloepus_hoffmanni
ENSG00000089127	OAS1	97	54.817	ENSCPBG00000007403	-	99	53.221	Chrysemys_picta_bellii
ENSG00000089127	OAS1	95	30.303	ENSCPBG00000015725	-	69	30.792	Chrysemys_picta_bellii
ENSG00000089127	OAS1	100	49.724	ENSCPBG00000007398	-	99	49.724	Chrysemys_picta_bellii
ENSG00000089127	OAS1	80	30.154	ENSCING00000024111	-	97	30.154	Ciona_intestinalis
ENSG00000089127	OAS1	97	40.333	ENSCANG00000029168	OASL	67	40.286	Colobus_angolensis_palliatus
ENSG00000089127	OAS1	100	95.833	ENSCANG00000013673	OAS1	100	90.000	Colobus_angolensis_palliatus
ENSG00000089127	OAS1	98	60.473	ENSCANG00000027783	OAS3	95	59.012	Colobus_angolensis_palliatus
ENSG00000089127	OAS1	92	74.074	ENSCANG00000003465	OAS2	96	52.329	Colobus_angolensis_palliatus
ENSG00000089127	OAS1	97	62.245	ENSCGRG00001017712	-	93	62.500	Cricetulus_griseus_chok1gshd
ENSG00000089127	OAS1	87	53.247	ENSCGRG00001000233	-	95	56.522	Cricetulus_griseus_chok1gshd
ENSG00000089127	OAS1	98	61.149	ENSCGRG00001015857	Oas3	91	58.960	Cricetulus_griseus_chok1gshd
ENSG00000089127	OAS1	99	60.882	ENSCGRG00001012905	-	88	60.882	Cricetulus_griseus_chok1gshd
ENSG00000089127	OAS1	98	54.131	ENSCGRG00001022495	Oas2	94	55.043	Cricetulus_griseus_chok1gshd
ENSG00000089127	OAS1	96	87.500	ENSCGRG00001012014	-	97	69.101	Cricetulus_griseus_chok1gshd
ENSG00000089127	OAS1	96	91.667	ENSCGRG00001014499	-	89	62.147	Cricetulus_griseus_chok1gshd
ENSG00000089127	OAS1	95	38.040	ENSCGRG00001021080	Oasl1	67	37.607	Cricetulus_griseus_chok1gshd
ENSG00000089127	OAS1	96	91.667	ENSCGRG00001016802	-	86	69.364	Cricetulus_griseus_chok1gshd
ENSG00000089127	OAS1	96	91.667	ENSCGRG00001008178	-	97	63.636	Cricetulus_griseus_chok1gshd
ENSG00000089127	OAS1	93	83.333	ENSCGRG00001001797	-	98	69.960	Cricetulus_griseus_chok1gshd
ENSG00000089127	OAS1	97	43.478	ENSCGRG00001017055	Oasl2	68	44.160	Cricetulus_griseus_chok1gshd
ENSG00000089127	OAS1	96	61.565	ENSCGRG00000014000	-	97	61.159	Cricetulus_griseus_crigri
ENSG00000089127	OAS1	93	83.333	ENSCGRG00000010108	-	98	69.170	Cricetulus_griseus_crigri
ENSG00000089127	OAS1	96	38.926	ENSCGRG00000006960	Oasl1	67	38.857	Cricetulus_griseus_crigri
ENSG00000089127	OAS1	97	58.879	ENSCGRG00000007538	Oas2	95	58.796	Cricetulus_griseus_crigri
ENSG00000089127	OAS1	99	60.882	ENSCGRG00000011004	-	88	60.882	Cricetulus_griseus_crigri
ENSG00000089127	OAS1	97	43.478	ENSCGRG00000015082	Oasl2	68	44.160	Cricetulus_griseus_crigri
ENSG00000089127	OAS1	96	91.667	ENSCGRG00000014155	-	86	69.364	Cricetulus_griseus_crigri
ENSG00000089127	OAS1	97	61.149	ENSCGRG00000006846	-	98	59.026	Cricetulus_griseus_crigri
ENSG00000089127	OAS1	96	91.667	ENSCGRG00000006049	-	98	83.333	Cricetulus_griseus_crigri
ENSG00000089127	OAS1	95	95.652	ENSCGRG00000009555	-	94	63.260	Cricetulus_griseus_crigri
ENSG00000089127	OAS1	100	84.000	ENSDNOG00000036996	OAS1	98	71.429	Dasypus_novemcinctus
ENSG00000089127	OAS1	97	41.806	ENSDNOG00000048828	-	61	43.440	Dasypus_novemcinctus
ENSG00000089127	OAS1	97	41.333	ENSDNOG00000035785	OASL	66	41.667	Dasypus_novemcinctus
ENSG00000089127	OAS1	98	60.544	ENSETEG00000010911	OAS3	79	60.678	Echinops_telfairi
ENSG00000089127	OAS1	97	39.000	ENSETEG00000015102	OASL	66	38.793	Echinops_telfairi
ENSG00000089127	OAS1	85	47.529	ENSEASG00005004436	-	63	46.106	Equus_asinus_asinus
ENSG00000089127	OAS1	99	88.000	ENSEASG00005009520	OAS1	100	71.000	Equus_asinus_asinus
ENSG00000089127	OAS1	97	43.000	ENSEASG00005004445	OASL	66	42.816	Equus_asinus_asinus
ENSG00000089127	OAS1	98	59.797	ENSEASG00005009518	OAS3	89	59.130	Equus_asinus_asinus
ENSG00000089127	OAS1	99	55.331	ENSEASG00005009515	OAS2	99	55.331	Equus_asinus_asinus
ENSG00000089127	OAS1	97	46.823	ENSECAG00000012132	-	68	45.706	Equus_caballus
ENSG00000089127	OAS1	99	88.000	ENSECAG00000013435	OAS1	100	72.886	Equus_caballus
ENSG00000089127	OAS1	98	59.459	ENSECAG00000008809	OAS3	94	58.721	Equus_caballus
ENSG00000089127	OAS1	99	55.043	ENSECAG00000014422	OAS2	99	55.043	Equus_caballus
ENSG00000089127	OAS1	97	42.333	ENSECAG00000014645	OASL	66	42.529	Equus_caballus
ENSG00000089127	OAS1	98	55.862	ENSEEUG00000004682	OAS3	95	55.631	Erinaceus_europaeus
ENSG00000089127	OAS1	79	69.136	ENSEEUG00000003781	-	68	70.039	Erinaceus_europaeus
ENSG00000089127	OAS1	69	57.377	ENSEEUG00000011762	-	63	57.377	Erinaceus_europaeus
ENSG00000089127	OAS1	97	42.000	ENSFCAG00000009641	OASL	67	42.571	Felis_catus
ENSG00000089127	OAS1	97	46.154	ENSFCAG00000032891	-	66	46.552	Felis_catus
ENSG00000089127	OAS1	99	55.085	ENSFCAG00000000322	OAS2	96	55.650	Felis_catus
ENSG00000089127	OAS1	98	58.446	ENSFCAG00000000320	OAS3	95	57.267	Felis_catus
ENSG00000089127	OAS1	92	91.667	ENSFCAG00000000318	OAS1	99	68.500	Felis_catus
ENSG00000089127	OAS1	98	44.444	ENSFALG00000008796	OASL	67	44.444	Ficedula_albicollis
ENSG00000089127	OAS1	79	39.806	ENSFDAG00000012294	-	52	45.415	Fukomys_damarensis
ENSG00000089127	OAS1	99	75.000	ENSFDAG00000001534	OAS1	99	70.085	Fukomys_damarensis
ENSG00000089127	OAS1	97	41.000	ENSFDAG00000014734	OASL	66	40.805	Fukomys_damarensis
ENSG00000089127	OAS1	96	45.302	ENSGALG00000013723	OASL	70	46.000	Gallus_gallus
ENSG00000089127	OAS1	96	55.137	ENSGAGG00000014588	-	80	50.000	Gopherus_agassizii
ENSG00000089127	OAS1	96	45.548	ENSGAGG00000013495	-	69	44.751	Gopherus_agassizii
ENSG00000089127	OAS1	100	48.753	ENSGAGG00000014599	-	99	48.753	Gopherus_agassizii
ENSG00000089127	OAS1	96	37.604	ENSGAGG00000013488	-	75	36.885	Gopherus_agassizii
ENSG00000089127	OAS1	97	52.189	ENSGGOG00000008149	OAS2	99	52.571	Gorilla_gorilla
ENSG00000089127	OAS1	97	40.000	ENSGGOG00000012123	OASL	85	37.387	Gorilla_gorilla
ENSG00000089127	OAS1	100	100.000	ENSGGOG00000008132	OAS1	100	98.792	Gorilla_gorilla
ENSG00000089127	OAS1	98	61.824	ENSGGOG00000008139	OAS3	93	59.884	Gorilla_gorilla
ENSG00000089127	OAS1	97	42.475	ENSHGLG00000011274	-	67	43.103	Heterocephalus_glaber_female
ENSG00000089127	OAS1	98	54.515	ENSHGLG00000016098	OAS2	96	54.455	Heterocephalus_glaber_female
ENSG00000089127	OAS1	97	40.333	ENSHGLG00000011746	OASL	66	40.805	Heterocephalus_glaber_female
ENSG00000089127	OAS1	99	75.000	ENSHGLG00000016286	OAS1	100	63.789	Heterocephalus_glaber_female
ENSG00000089127	OAS1	97	55.219	ENSHGLG00100017742	OAS2	96	54.416	Heterocephalus_glaber_male
ENSG00000089127	OAS1	99	75.000	ENSHGLG00100018718	OAS1	100	63.789	Heterocephalus_glaber_male
ENSG00000089127	OAS1	97	40.000	ENSHGLG00100016878	OASL	66	40.517	Heterocephalus_glaber_male
ENSG00000089127	OAS1	97	42.475	ENSHGLG00100014127	-	67	43.103	Heterocephalus_glaber_male
ENSG00000089127	OAS1	67	47.126	ENSSTOG00000032078	-	90	48.739	Ictidomys_tridecemlineatus
ENSG00000089127	OAS1	98	57.807	ENSSTOG00000003957	OAS3	92	56.772	Ictidomys_tridecemlineatus
ENSG00000089127	OAS1	97	73.220	ENSSTOG00000024010	OAS1	100	68.250	Ictidomys_tridecemlineatus
ENSG00000089127	OAS1	97	55.782	ENSSTOG00000009831	OAS2	99	56.000	Ictidomys_tridecemlineatus
ENSG00000089127	OAS1	93	66.667	ENSJJAG00000004385	Oas2	94	55.114	Jaculus_jaculus
ENSG00000089127	OAS1	78	68.293	ENSJJAG00000005317	-	99	67.568	Jaculus_jaculus
ENSG00000089127	OAS1	96	38.926	ENSJJAG00000022289	Oasl1	67	38.857	Jaculus_jaculus
ENSG00000089127	OAS1	97	52.159	ENSLACG00000017511	-	65	52.395	Latimeria_chalumnae
ENSG00000089127	OAS1	96	48.288	ENSLACG00000018284	-	96	47.564	Latimeria_chalumnae
ENSG00000089127	OAS1	97	42.333	ENSLAFG00000017892	OASL	66	42.529	Loxodonta_africana
ENSG00000089127	OAS1	98	55.285	ENSLAFG00000014069	OAS2	99	56.410	Loxodonta_africana
ENSG00000089127	OAS1	100	84.000	ENSLAFG00000005549	OAS1	99	73.547	Loxodonta_africana
ENSG00000089127	OAS1	98	63.176	ENSLAFG00000013640	OAS3	95	60.920	Loxodonta_africana
ENSG00000089127	OAS1	97	52.862	ENSMFAG00000000924	OAS2	99	52.975	Macaca_fascicularis
ENSG00000089127	OAS1	97	40.333	ENSMFAG00000043280	OASL	67	40.571	Macaca_fascicularis
ENSG00000089127	OAS1	100	95.833	ENSMFAG00000015570	OAS1	100	92.500	Macaca_fascicularis
ENSG00000089127	OAS1	98	61.486	ENSMFAG00000039534	OAS3	93	59.593	Macaca_fascicularis
ENSG00000089127	OAS1	97	40.333	ENSMMUG00000006441	OASL	96	36.957	Macaca_mulatta
ENSG00000089127	OAS1	98	61.486	ENSMMUG00000046639	OAS3	94	59.312	Macaca_mulatta
ENSG00000089127	OAS1	100	92.500	ENSMMUG00000012782	OAS1	100	92.500	Macaca_mulatta
ENSG00000089127	OAS1	97	52.862	ENSMMUG00000008505	OAS2	98	53.623	Macaca_mulatta
ENSG00000089127	OAS1	100	95.000	ENSMNEG00000044618	OAS1	100	93.056	Macaca_nemestrina
ENSG00000089127	OAS1	98	61.486	ENSMNEG00000044713	OAS3	93	59.593	Macaca_nemestrina
ENSG00000089127	OAS1	97	53.199	ENSMNEG00000030874	OAS2	99	53.258	Macaca_nemestrina
ENSG00000089127	OAS1	97	40.333	ENSMNEG00000029657	OASL	67	40.571	Macaca_nemestrina
ENSG00000089127	OAS1	98	61.149	ENSMLEG00000040673	OAS3	94	58.908	Mandrillus_leucophaeus
ENSG00000089127	OAS1	100	95.833	ENSMLEG00000005932	OAS1	100	94.167	Mandrillus_leucophaeus
ENSG00000089127	OAS1	97	52.862	ENSMLEG00000007181	OAS2	96	52.877	Mandrillus_leucophaeus
ENSG00000089127	OAS1	97	40.333	ENSMLEG00000037980	OASL	67	40.857	Mandrillus_leucophaeus
ENSG00000089127	OAS1	68	48.315	ENSMAUG00000018493	-	56	45.714	Mesocricetus_auratus
ENSG00000089127	OAS1	95	60.764	ENSMAUG00000007782	-	99	60.068	Mesocricetus_auratus
ENSG00000089127	OAS1	97	56.566	ENSMAUG00000009993	Oas2	95	56.111	Mesocricetus_auratus
ENSG00000089127	OAS1	88	58.065	ENSMAUG00000002119	-	98	59.813	Mesocricetus_auratus
ENSG00000089127	OAS1	72	50.000	ENSMAUG00000014013	-	94	54.400	Mesocricetus_auratus
ENSG00000089127	OAS1	97	39.000	ENSMICG00000046728	OASL	67	39.714	Microcebus_murinus
ENSG00000089127	OAS1	99	52.199	ENSMICG00000008532	OAS2	97	52.199	Microcebus_murinus
ENSG00000089127	OAS1	98	58.784	ENSMICG00000008519	OAS3	95	57.558	Microcebus_murinus
ENSG00000089127	OAS1	100	87.500	ENSMICG00000032537	OAS1	97	77.247	Microcebus_murinus
ENSG00000089127	OAS1	96	87.500	ENSMOCG00000014860	-	96	58.192	Microtus_ochrogaster
ENSG00000089127	OAS1	97	43.854	ENSMOCG00000019431	Oasl2	71	42.857	Microtus_ochrogaster
ENSG00000089127	OAS1	96	39.933	ENSMOCG00000013643	Oasl1	66	39.943	Microtus_ochrogaster
ENSG00000089127	OAS1	97	57.227	ENSMODG00000023765	-	94	57.227	Monodelphis_domestica
ENSG00000089127	OAS1	96	66.667	ENSMODG00000003252	OAS1	96	61.453	Monodelphis_domestica
ENSG00000089127	OAS1	98	59.596	ENSMODG00000003328	OAS3	95	58.841	Monodelphis_domestica
ENSG00000089127	OAS1	97	39.073	ENSMODG00000002922	-	64	39.828	Monodelphis_domestica
ENSG00000089127	OAS1	97	53.767	MGP_CAROLIEiJ_G0027669	Oas2	97	56.828	Mus_caroli
ENSG00000089127	OAS1	97	39.130	MGP_CAROLIEiJ_G0027609	Oasl1	66	40.230	Mus_caroli
ENSG00000089127	OAS1	97	45.000	MGP_CAROLIEiJ_G0027608	Oasl2	98	44.850	Mus_caroli
ENSG00000089127	OAS1	98	58.389	MGP_CAROLIEiJ_G0027670	Oas3	96	53.906	Mus_caroli
ENSG00000089127	OAS1	95	53.925	MGP_CAROLIEiJ_G0027671	-	100	69.231	Mus_caroli
ENSG00000089127	OAS1	68	70.787	MGP_CAROLIEiJ_G0027672	-	94	69.307	Mus_caroli
ENSG00000089127	OAS1	68	70.787	MGP_CAROLIEiJ_G0027673	-	94	69.307	Mus_caroli
ENSG00000089127	OAS1	98	56.140	MGP_CAROLIEiJ_G0027674	-	95	50.000	Mus_caroli
ENSG00000089127	OAS1	79	56.401	MGP_CAROLIEiJ_G0027675	-	98	56.401	Mus_caroli
ENSG00000089127	OAS1	96	53.716	ENSMUSG00000032623	Oas1d	97	52.422	Mus_musculus
ENSG00000089127	OAS1	98	57.383	ENSMUSG00000032661	Oas3	96	53.906	Mus_musculus
ENSG00000089127	OAS1	97	43.667	ENSMUSG00000029561	Oasl2	65	45.401	Mus_musculus
ENSG00000089127	OAS1	95	53.584	ENSMUSG00000001166	Oas1c	100	69.231	Mus_musculus
ENSG00000089127	OAS1	97	53.041	ENSMUSG00000032690	Oas2	98	56.410	Mus_musculus
ENSG00000089127	OAS1	98	48.860	ENSMUSG00000001168	Oas1h	94	52.023	Mus_musculus
ENSG00000089127	OAS1	96	91.667	ENSMUSG00000053765	Oas1f	95	57.925	Mus_musculus
ENSG00000089127	OAS1	97	70.508	ENSMUSG00000052776	Oas1a	96	69.492	Mus_musculus
ENSG00000089127	OAS1	96	52.862	ENSMUSG00000066867	Oas1e	97	52.149	Mus_musculus
ENSG00000089127	OAS1	97	71.186	ENSMUSG00000066861	Oas1g	96	70.056	Mus_musculus
ENSG00000089127	OAS1	99	87.500	ENSMUSG00000029605	Oas1b	99	58.661	Mus_musculus
ENSG00000089127	OAS1	96	38.926	ENSMUSG00000041827	Oasl1	66	39.655	Mus_musculus
ENSG00000089127	OAS1	95	39.655	MGP_PahariEiJ_G0024189	Oasl1	66	39.655	Mus_pahari
ENSG00000089127	OAS1	94	51.445	MGP_PahariEiJ_G0024255	Oas1h	94	51.445	Mus_pahari
ENSG00000089127	OAS1	100	64.286	MGP_PahariEiJ_G0024254	-	96	58.955	Mus_pahari
ENSG00000089127	OAS1	97	54.730	MGP_PahariEiJ_G0024251	-	98	57.083	Mus_pahari
ENSG00000089127	OAS1	98	59.589	MGP_PahariEiJ_G0024252	Oas3	96	55.469	Mus_pahari
ENSG00000089127	OAS1	95	53.082	MGP_PahariEiJ_G0024253	Oas1c	98	52.125	Mus_pahari
ENSG00000089127	OAS1	96	38.926	MGP_SPRETEiJ_G0028607	Oasl1	66	39.655	Mus_spretus
ENSG00000089127	OAS1	97	43.667	MGP_SPRETEiJ_G0028606	Oasl2	68	44.034	Mus_spretus
ENSG00000089127	OAS1	98	58.389	MGP_SPRETEiJ_G0028670	Oas3	96	53.906	Mus_spretus
ENSG00000089127	OAS1	51	53.416	MGP_SPRETEiJ_G0028671	-	100	71.795	Mus_spretus
ENSG00000089127	OAS1	68	58.427	MGP_SPRETEiJ_G0028673	-	83	61.582	Mus_spretus
ENSG00000089127	OAS1	97	53.041	MGP_SPRETEiJ_G0028669	Oas2	99	56.410	Mus_spretus
ENSG00000089127	OAS1	97	41.137	ENSMPUG00000003306	OASL	66	41.092	Mustela_putorius_furo
ENSG00000089127	OAS1	100	88.000	ENSMPUG00000002543	OAS1	100	64.428	Mustela_putorius_furo
ENSG00000089127	OAS1	98	59.122	ENSMPUG00000002547	OAS3	84	57.558	Mustela_putorius_furo
ENSG00000089127	OAS1	97	52.667	ENSMPUG00000002550	OAS2	96	53.714	Mustela_putorius_furo
ENSG00000089127	OAS1	97	45.819	ENSMPUG00000003310	-	67	46.243	Mustela_putorius_furo
ENSG00000089127	OAS1	98	59.797	ENSMLUG00000015773	OAS3	95	58.430	Myotis_lucifugus
ENSG00000089127	OAS1	99	83.333	ENSMLUG00000027019	-	99	64.951	Myotis_lucifugus
ENSG00000089127	OAS1	97	43.434	ENSMLUG00000015795	-	98	43.768	Myotis_lucifugus
ENSG00000089127	OAS1	97	38.816	ENSMLUG00000009136	OASL	67	39.660	Myotis_lucifugus
ENSG00000089127	OAS1	98	84.000	ENSMLUG00000015764	-	99	70.317	Myotis_lucifugus
ENSG00000089127	OAS1	91	42.342	ENSNGAG00000019818	Oasl2	67	42.342	Nannospalax_galili
ENSG00000089127	OAS1	98	60.403	ENSNGAG00000005163	Oas3	94	56.800	Nannospalax_galili
ENSG00000089127	OAS1	97	39.799	ENSNGAG00000016822	Oasl1	67	40.286	Nannospalax_galili
ENSG00000089127	OAS1	97	52.349	ENSNGAG00000000513	Oas2	90	54.030	Nannospalax_galili
ENSG00000089127	OAS1	97	63.390	ENSNGAG00000012028	-	97	64.535	Nannospalax_galili
ENSG00000089127	OAS1	97	70.169	ENSNGAG00000011017	-	97	68.436	Nannospalax_galili
ENSG00000089127	OAS1	97	53.199	ENSNLEG00000000137	OAS2	96	53.039	Nomascus_leucogenys
ENSG00000089127	OAS1	100	95.000	ENSNLEG00000000109	OAS1	100	94.444	Nomascus_leucogenys
ENSG00000089127	OAS1	97	39.667	ENSNLEG00000027642	OASL	85	36.036	Nomascus_leucogenys
ENSG00000089127	OAS1	98	60.811	ENSNLEG00000000121	OAS3	95	59.012	Nomascus_leucogenys
ENSG00000089127	OAS1	68	59.551	ENSMEUG00000012164	-	51	65.254	Notamacropus_eugenii
ENSG00000089127	OAS1	80	62.656	ENSMEUG00000012122	-	90	60.764	Notamacropus_eugenii
ENSG00000089127	OAS1	68	43.820	ENSMEUG00000002104	-	55	46.316	Notamacropus_eugenii
ENSG00000089127	OAS1	98	59.504	ENSOPRG00000011885	OAS3	74	57.840	Ochotona_princeps
ENSG00000089127	OAS1	100	87.500	ENSOPRG00000011867	OAS1	99	67.784	Ochotona_princeps
ENSG00000089127	OAS1	78	42.308	ENSOPRG00000010324	-	63	42.509	Ochotona_princeps
ENSG00000089127	OAS1	95	87.500	ENSODEG00000011899	OAS1	100	69.591	Octodon_degus
ENSG00000089127	OAS1	98	57.667	ENSODEG00000013221	OAS3	90	57.225	Octodon_degus
ENSG00000089127	OAS1	97	38.667	ENSODEG00000006970	OASL	66	39.080	Octodon_degus
ENSG00000089127	OAS1	97	53.872	ENSODEG00000013276	OAS2	96	53.509	Octodon_degus
ENSG00000089127	OAS1	97	41.528	ENSODEG00000006462	-	71	40.274	Octodon_degus
ENSG00000089127	OAS1	97	42.475	ENSOCUG00000029637	-	63	43.149	Oryctolagus_cuniculus
ENSG00000089127	OAS1	96	36.789	ENSOCUG00000029328	OASL	65	37.644	Oryctolagus_cuniculus
ENSG00000089127	OAS1	93	74.074	ENSOCUG00000015823	OAS2	98	54.678	Oryctolagus_cuniculus
ENSG00000089127	OAS1	98	59.396	ENSOCUG00000027849	OAS3	96	58.140	Oryctolagus_cuniculus
ENSG00000089127	OAS1	97	73.220	ENSOGAG00000014935	OAS1	97	71.196	Otolemur_garnettii
ENSG00000089127	OAS1	97	39.677	ENSOGAG00000009076	OASL	98	40.166	Otolemur_garnettii
ENSG00000089127	OAS1	98	51.841	ENSOGAG00000004204	OAS2	99	51.841	Otolemur_garnettii
ENSG00000089127	OAS1	98	61.149	ENSOGAG00000004202	OAS3	95	59.593	Otolemur_garnettii
ENSG00000089127	OAS1	99	87.500	ENSOARG00000009097	-	88	72.303	Ovis_aries
ENSG00000089127	OAS1	68	62.921	ENSOARG00000002881	-	70	66.387	Ovis_aries
ENSG00000089127	OAS1	96	36.338	ENSOARG00000013935	OASL	81	34.975	Ovis_aries
ENSG00000089127	OAS1	97	53.199	ENSPPAG00000034636	OAS2	96	53.591	Pan_paniscus
ENSG00000089127	OAS1	98	61.824	ENSPPAG00000042797	OAS3	93	59.884	Pan_paniscus
ENSG00000089127	OAS1	97	39.667	ENSPPAG00000036073	OASL	85	36.486	Pan_paniscus
ENSG00000089127	OAS1	100	98.333	ENSPPAG00000029859	OAS1	100	97.230	Pan_paniscus
ENSG00000089127	OAS1	99	54.237	ENSPPRG00000012740	OAS2	95	54.802	Panthera_pardus
ENSG00000089127	OAS1	98	58.446	ENSPPRG00000011430	OAS3	95	57.267	Panthera_pardus
ENSG00000089127	OAS1	97	46.154	ENSPPRG00000023601	-	66	46.552	Panthera_pardus
ENSG00000089127	OAS1	98	87.500	ENSPPRG00000009508	OAS1	99	71.930	Panthera_pardus
ENSG00000089127	OAS1	97	42.000	ENSPPRG00000023710	OASL	67	42.286	Panthera_pardus
ENSG00000089127	OAS1	97	42.000	ENSPTIG00000017787	OASL	67	42.286	Panthera_tigris_altaica
ENSG00000089127	OAS1	97	46.154	ENSPTIG00000020051	-	66	46.552	Panthera_tigris_altaica
ENSG00000089127	OAS1	99	54.237	ENSPTIG00000013464	OAS2	96	54.802	Panthera_tigris_altaica
ENSG00000089127	OAS1	98	91.667	ENSPTIG00000011938	OAS3	100	66.492	Panthera_tigris_altaica
ENSG00000089127	OAS1	98	61.824	ENSPTRG00000005478	OAS3	93	59.884	Pan_troglodytes
ENSG00000089127	OAS1	97	39.333	ENSPTRG00000005553	OASL	85	36.036	Pan_troglodytes
ENSG00000089127	OAS1	97	53.535	ENSPTRG00000005479	OAS2	96	53.867	Pan_troglodytes
ENSG00000089127	OAS1	100	95.845	ENSPTRG00000005477	OAS1	100	95.845	Pan_troglodytes
ENSG00000089127	OAS1	97	52.528	ENSPANG00000008227	OAS2	95	52.732	Papio_anubis
ENSG00000089127	OAS1	100	95.833	ENSPANG00000007338	OAS1	100	93.333	Papio_anubis
ENSG00000089127	OAS1	97	40.333	ENSPANG00000002378	OASL	67	40.857	Papio_anubis
ENSG00000089127	OAS1	97	62.821	ENSPANG00000017167	OAS3	93	59.302	Papio_anubis
ENSG00000089127	OAS1	93	30.314	ENSPSIG00000013108	-	100	30.678	Pelodiscus_sinensis
ENSG00000089127	OAS1	97	54.967	ENSPSIG00000005272	-	86	52.547	Pelodiscus_sinensis
ENSG00000089127	OAS1	99	44.262	ENSPSIG00000008634	OASL	70	41.551	Pelodiscus_sinensis
ENSG00000089127	OAS1	98	60.403	ENSPEMG00000016340	Oas3	91	58.671	Peromyscus_maniculatus_bairdii
ENSG00000089127	OAS1	96	39.262	ENSPEMG00000016063	Oasl1	67	39.429	Peromyscus_maniculatus_bairdii
ENSG00000089127	OAS1	65	46.429	ENSPEMG00000002563	-	58	43.262	Peromyscus_maniculatus_bairdii
ENSG00000089127	OAS1	93	87.500	ENSPEMG00000016414	-	98	58.566	Peromyscus_maniculatus_bairdii
ENSG00000089127	OAS1	96	41.060	ENSPCIG00000018622	-	94	40.761	Phascolarctos_cinereus
ENSG00000089127	OAS1	96	44.224	ENSPCIG00000007839	-	66	43.889	Phascolarctos_cinereus
ENSG00000089127	OAS1	95	40.970	ENSPCIG00000007837	-	70	40.476	Phascolarctos_cinereus
ENSG00000089127	OAS1	94	31.594	ENSPCIG00000007830	-	64	31.594	Phascolarctos_cinereus
ENSG00000089127	OAS1	96	74.074	ENSPCIG00000018633	-	96	59.050	Phascolarctos_cinereus
ENSG00000089127	OAS1	99	61.111	ENSPCIG00000018844	OAS1	100	56.716	Phascolarctos_cinereus
ENSG00000089127	OAS1	88	46.835	ENSPCIG00000018842	-	98	47.964	Phascolarctos_cinereus
ENSG00000089127	OAS1	99	93.970	ENSPPYG00000004977	-	88	94.000	Pongo_abelii
ENSG00000089127	OAS1	97	40.333	ENSPPYG00000005044	OASL	67	40.857	Pongo_abelii
ENSG00000089127	OAS1	97	50.685	ENSPPYG00000004979	-	98	50.450	Pongo_abelii
ENSG00000089127	OAS1	98	61.824	ENSPPYG00000004978	OAS3	94	59.429	Pongo_abelii
ENSG00000089127	OAS1	97	60.481	ENSPCAG00000009610	OAS3	70	60.204	Procavia_capensis
ENSG00000089127	OAS1	97	40.667	ENSPCAG00000013000	OASL	67	41.261	Procavia_capensis
ENSG00000089127	OAS1	97	54.153	ENSPCAG00000009686	OAS2	88	54.571	Procavia_capensis
ENSG00000089127	OAS1	97	40.066	ENSPCOG00000026188	OASL	67	40.793	Propithecus_coquereli
ENSG00000089127	OAS1	99	52.339	ENSPCOG00000023904	OAS2	96	52.113	Propithecus_coquereli
ENSG00000089127	OAS1	78	53.957	ENSPVAG00000008047	OASL	56	51.087	Pteropus_vampyrus
ENSG00000089127	OAS1	97	71.088	ENSPVAG00000017339	OAS1	92	68.633	Pteropus_vampyrus
ENSG00000089127	OAS1	99	61.538	ENSPVAG00000017340	OAS3	87	61.538	Pteropus_vampyrus
ENSG00000089127	OAS1	99	55.650	ENSPVAG00000017341	OAS2	77	53.947	Pteropus_vampyrus
ENSG00000089127	OAS1	97	41.806	ENSRNOG00000028814	Oasl2	73	41.129	Rattus_norvegicus
ENSG00000089127	OAS1	97	54.422	ENSRNOG00000031726	Oas1e	98	53.509	Rattus_norvegicus
ENSG00000089127	OAS1	97	70.508	ENSRNOG00000001369	Oas1a	99	68.347	Rattus_norvegicus
ENSG00000089127	OAS1	95	83.333	ENSRNOG00000024462	LOC103689988	96	53.757	Rattus_norvegicus
ENSG00000089127	OAS1	99	53.947	ENSRNOG00000049282	Oas2	94	56.047	Rattus_norvegicus
ENSG00000089127	OAS1	96	83.333	ENSRNOG00000057769	Oas1h	96	53.026	Rattus_norvegicus
ENSG00000089127	OAS1	97	59.060	ENSRNOG00000059207	Oas3	86	58.430	Rattus_norvegicus
ENSG00000089127	OAS1	99	91.667	ENSRNOG00000033220	Oas1f	99	67.919	Rattus_norvegicus
ENSG00000089127	OAS1	95	83.333	ENSRNOG00000048485	LOC103689988	96	53.757	Rattus_norvegicus
ENSG00000089127	OAS1	96	40.132	ENSRNOG00000001187	Oasl	67	40.000	Rattus_norvegicus
ENSG00000089127	OAS1	96	91.667	ENSRNOG00000047076	Oas1g	89	68.035	Rattus_norvegicus
ENSG00000089127	OAS1	96	91.667	ENSRNOG00000037744	Oas1i	89	68.035	Rattus_norvegicus
ENSG00000089127	OAS1	100	91.489	ENSRBIG00000001529	OAS1	100	86.779	Rhinopithecus_bieti
ENSG00000089127	OAS1	97	52.862	ENSRBIG00000036628	OAS2	99	52.691	Rhinopithecus_bieti
ENSG00000089127	OAS1	98	61.149	ENSRBIG00000027541	OAS3	94	58.908	Rhinopithecus_bieti
ENSG00000089127	OAS1	78	42.739	ENSRBIG00000008349	OASL	62	42.308	Rhinopithecus_bieti
ENSG00000089127	OAS1	98	61.149	ENSRROG00000029907	OAS3	94	58.908	Rhinopithecus_roxellana
ENSG00000089127	OAS1	97	40.333	ENSRROG00000035890	OASL	67	40.286	Rhinopithecus_roxellana
ENSG00000089127	OAS1	100	100.000	ENSRROG00000044255	OAS1	100	89.807	Rhinopithecus_roxellana
ENSG00000089127	OAS1	97	52.862	ENSRROG00000041077	OAS2	99	52.691	Rhinopithecus_roxellana
ENSG00000089127	OAS1	100	91.667	ENSSBOG00000035808	OAS1	100	83.934	Saimiri_boliviensis_boliviensis
ENSG00000089127	OAS1	98	59.797	ENSSBOG00000025552	OAS3	95	58.430	Saimiri_boliviensis_boliviensis
ENSG00000089127	OAS1	97	52.703	ENSSBOG00000031252	OAS2	99	53.009	Saimiri_boliviensis_boliviensis
ENSG00000089127	OAS1	97	39.130	ENSSBOG00000035582	OASL	66	39.080	Saimiri_boliviensis_boliviensis
ENSG00000089127	OAS1	98	60.452	ENSSHAG00000017661	-	89	61.449	Sarcophilus_harrisii
ENSG00000089127	OAS1	98	57.912	ENSSHAG00000016172	-	99	56.522	Sarcophilus_harrisii
ENSG00000089127	OAS1	97	34.219	ENSSHAG00000014676	-	67	35.345	Sarcophilus_harrisii
ENSG00000089127	OAS1	98	53.390	ENSSHAG00000016373	-	95	53.390	Sarcophilus_harrisii
ENSG00000089127	OAS1	99	42.617	ENSSHAG00000014420	-	99	42.424	Sarcophilus_harrisii
ENSG00000089127	OAS1	97	38.667	ENSSARG00000010081	OASL	70	40.774	Sorex_araneus
ENSG00000089127	OAS1	97	62.207	ENSSARG00000005259	OAS1	90	60.763	Sorex_araneus
ENSG00000089127	OAS1	96	47.475	ENSSPUG00000001562	OASL	67	48.286	Sphenodon_punctatus
ENSG00000089127	OAS1	97	53.716	ENSSPUG00000007383	-	97	52.422	Sphenodon_punctatus
ENSG00000089127	OAS1	97	55.034	ENSSSCG00000009881	OAS2	98	55.072	Sus_scrofa
ENSG00000089127	OAS1	97	39.799	ENSSSCG00000009921	OASL	99	38.904	Sus_scrofa
ENSG00000089127	OAS1	97	42.384	ENSTGUG00000006574	OASL	68	42.980	Taeniopygia_guttata
ENSG00000089127	OAS1	76	43.434	ENSTBEG00000007593	OASL	62	30.742	Tupaia_belangeri
ENSG00000089127	OAS1	97	51.626	ENSTBEG00000000579	OAS2	90	52.234	Tupaia_belangeri
ENSG00000089127	OAS1	96	83.333	ENSTBEG00000017586	-	99	59.130	Tupaia_belangeri
ENSG00000089127	OAS1	97	52.862	ENSTTRG00000002406	OAS2	97	52.958	Tursiops_truncatus
ENSG00000089127	OAS1	100	91.667	ENSTTRG00000002404	OAS1	100	66.024	Tursiops_truncatus
ENSG00000089127	OAS1	95	33.811	ENSTTRG00000001955	-	98	34.097	Tursiops_truncatus
ENSG00000089127	OAS1	78	41.319	ENSUAMG00000022495	-	56	41.343	Ursus_americanus
ENSG00000089127	OAS1	97	41.137	ENSUAMG00000022496	OASL	66	41.547	Ursus_americanus
ENSG00000089127	OAS1	97	54.698	ENSUAMG00000028391	OAS2	99	55.714	Ursus_americanus
ENSG00000089127	OAS1	100	80.000	ENSUAMG00000028393	OAS1	100	66.085	Ursus_americanus
ENSG00000089127	OAS1	98	58.446	ENSUAMG00000028392	OAS3	92	57.267	Ursus_americanus
ENSG00000089127	OAS1	97	33.108	ENSUMAG00000005863	OASL	66	34.682	Ursus_maritimus
ENSG00000089127	OAS1	97	54.545	ENSUMAG00000010148	OAS2	98	53.867	Ursus_maritimus
ENSG00000089127	OAS1	97	47.333	ENSUMAG00000005858	-	67	47.953	Ursus_maritimus
ENSG00000089127	OAS1	100	80.000	ENSUMAG00000009975	OAS1	100	66.085	Ursus_maritimus
ENSG00000089127	OAS1	98	58.784	ENSUMAG00000009998	OAS3	93	57.478	Ursus_maritimus
ENSG00000089127	OAS1	98	58.784	ENSVVUG00000010348	OAS3	93	57.558	Vulpes_vulpes
ENSG00000089127	OAS1	97	46.000	ENSVVUG00000021631	-	66	46.398	Vulpes_vulpes
ENSG00000089127	OAS1	100	91.667	ENSVVUG00000010357	OAS1	100	72.394	Vulpes_vulpes
ENSG00000089127	OAS1	97	42.667	ENSVVUG00000021628	OASL	66	42.980	Vulpes_vulpes
ENSG00000089127	OAS1	99	55.233	ENSVVUG00000010321	OAS2	96	55.085	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001730	2'-5'-oligoadenylate synthetase activity	21873635.	IBA	Function
GO:0001730	2'-5'-oligoadenylate synthetase activity	12799444.	IDA	Function
GO:0003725	double-stranded RNA binding	21873635.	IBA	Function
GO:0003725	double-stranded RNA binding	12799444.23319625.	IDA	Function
GO:0005515	protein binding	15039538.23455924.25416956.	IPI	Function
GO:0005524	ATP binding	21142819.	TAS	Function
GO:0005576	extracellular region	-	IEA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	21245038.	IDA	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0005783	endoplasmic reticulum	-	IEA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006006	glucose metabolic process	23575436.	IMP	Process
GO:0009615	response to virus	18931074.	IDA	Process
GO:0042593	glucose homeostasis	23575436.	IMP	Process
GO:0045071	negative regulation of viral genome replication	21873635.	IBA	Process
GO:0045071	negative regulation of viral genome replication	18931074.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051607	defense response to virus	21873635.	IBA	Process
GO:0051607	defense response to virus	-	TAS	Process
GO:0060333	interferon-gamma-mediated signaling pathway	-	TAS	Process
GO:0060337	type I interferon signaling pathway	-	TAS	Process
GO:0060700	regulation of ribonuclease activity	21873635.	IBA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21638280	2'-5' oligoadenylate synthetase 1 polymorphism is associated with prostate cancer.	Cancer	2011 Dec 15	Mandal S	doi: 10.1002/cncr.26219

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr12	112911070	Nonsense_Mutation	NA	Y163*	0.37
BLCA	chr12	112908751	Silent	novel	L132L	0.43
BLCA	chr12	112916729	Missense_Mutation	rs778367989	T292M	0.24
BLCA	chr12	112917626	Missense_Mutation	novel	E322Q	0.13
BLCA	chr12	112911175	Silent	NA	L198L	0.16
BLCA	chr12	112919482	Missense_Mutation	novel	H378Y	0.48
BLCA	chr12	112917703	Splice_Region	novel		0.04
BLCA	chr12	112908644	Missense_Mutation	novel	E97K	0.12
BLCA	chr12	112919527	Missense_Mutation	novel	E393Q	0.22
BLCA	chr12	112907016	5'UTR	novel		0.13
BRCA	chr12	112919669	3'UTR	novel		0.14
CESC	chr12	112907022	5'UTR	novel		0.46
CESC	chr12	112916704	Missense_Mutation	NA	E284K	0.26
CESC	chr12	112919524	Missense_Mutation	novel	E392K	0.39
CESC	chr12	112916517	Missense_Mutation	NA	K221N	0.34
CESC	chr12	112917666	Missense_Mutation	NA	W335S	0.41
COAD	chr12	112908796	Silent	NA	F147F	0.29
COAD	chr12	112911104	Missense_Mutation	rs148820389	E175K	0.14
COAD	chr12	112919422	Missense_Mutation	novel	D358N	0.34
COAD	chr12	112916689	Frame_Shift_Del	novel	*N280Tfs8**	0.07
COAD	chr12	112911160	Silent	NA	L193L	0.42
COAD	chr12	112917596	Missense_Mutation	novel	D312Y	0.13
COAD	chr12	112907031	5'UTR	novel		0.04
ESCA	chr12	112917725	Intron	novel		0.12
GBM	chr12	112907121	Missense_Mutation	novel	M28L	0.07
GBM	chr12	112908744	Missense_Mutation	NA	R130H	0.47
GBM	chr12	112919664	3'UTR	novel		0.33
GBM	chr12	112908686	Missense_Mutation	novel	R111G	0.05
GBM	chr12	112908635	Missense_Mutation	novel	R94S	0.16
HNSC	chr12	112916678	Missense_Mutation	novel	Y275C	0.47
HNSC	chr12	112911080	Missense_Mutation	novel	P167S	0.09
HNSC	chr12	112908779	Missense_Mutation	rs779611860	G142R	0.19
HNSC	chr12	112919386	Splice_Region	novel		0.42
HNSC	chr12	112908819	Missense_Mutation	novel	A155V	0.11
KICH	chr12	112908743	Missense_Mutation	rs776426424	R130C	0.37
KIRC	chr12	112908725	Missense_Mutation	NA	P124T	0.11
KIRC	chr12	112917893	Intron	novel		0.43
KIRC	chr12	112916626	Frame_Shift_Ins	novel	*P281Lfs19**	0.27
KIRC	chr12	112919768	3'UTR	novel		0.25
KIRC	chr12	112919440	Frame_Shift_Del	novel	*K364Ifs8**	0.21
KIRP	chr12	112908641	Nonsense_Mutation	novel	G96*	0.06
LAML	chr12	112911143	Missense_Mutation	rs774905171	T188A	0.22
LGG	chr12	112916688	Frame_Shift_Ins	novel	*N280Kfs5**	0.42
LIHC	chr12	112917927	Intron	novel		0.56
LIHC	chr12	112919459	Missense_Mutation	novel	T370K	0.23
LIHC	chr12	112907166	Nonsense_Mutation	NA	E43*	0.29
LUAD	chr12	112916606	Missense_Mutation	NA	T251K	0.67
LUAD	chr12	112919422	Missense_Mutation	novel	D358N	0.43
LUAD	chr12	112919530	Missense_Mutation	NA	D394N	0.2
LUAD	chr12	112907185	Missense_Mutation	novel	S49T	0.06
LUAD	chr12	112919464	Missense_Mutation	novel	E372K	0.42
LUAD	chr12	112911185	Missense_Mutation	novel	P202S	0.2
LUAD	chr12	112906984	5'UTR	novel		0.19
LUSC	chr12	112908772	Silent	rs754283775	L139L	0.19
LUSC	chr12	112907111	Silent	novel	T24T	0.27
LUSC	chr12	112908780	Missense_Mutation	NA	G142A	0.16
LUSC	chr12	112908746	Missense_Mutation	NA	A131P	0.39
LUSC	chr12	112911216	Missense_Mutation	novel	V212D	0.25
LUSC	chr12	112917599	Missense_Mutation	NA	P313S	0.2
LUSC	chr12	112908744	Missense_Mutation	NA	R130L	0.43
LUSC	chr12	112907002	5'UTR	novel		0.31
LUSC	chr12	112917738	Intron	novel		0.12
OV	chr12	112906995	5'UTR	novel		0.06
OV	chr12	112919418	Silent	rs376225547	T356T	0.26
OV	chr12	112917674	Missense_Mutation	novel	S338T	0.05
OV	chr12	112917766	Intron	novel		0.19
OV	chr12	112911104	Missense_Mutation	rs148820389	E175K	0.12
PRAD	chr12	112907025	5'UTR	novel		0.25
READ	chr12	112907097	Missense_Mutation	NA	L20I	0.2
READ	chr12	112917668	Missense_Mutation	NA	D336N	0.19
READ	chr12	112907167	Missense_Mutation	novel	E43G	0.08
SKCM	chr12	112907078	Missense_Mutation	NA	D13E	0.4
SKCM	chr12	112919480	Missense_Mutation	novel	S377F	0.68
SKCM	chr12	112916632	Missense_Mutation	novel	E260K	0.24
SKCM	chr12	112916765	Intron	novel		0.55
SKCM	chr12	112917808	Intron	novel		0.41
SKCM	chr12	112908543	Missense_Mutation	rs752541022	S63F	0.32	OAS1_C
SKCM	chr12	112908706	Silent	NA	V117V	0.21
SKCM	chr12	112916831	Intron	novel		0.3
SKCM	chr12	112907027	5'UTR	novel		0.69
SKCM	chr12	112919456	Missense_Mutation	novel	G369E	0.25
SKCM	chr12	112911163	Silent	novel	Q194Q	0.38
SKCM	chr12	112908580	Missense_Mutation	rs142809544	D75E	0.33	OAS1_C
SKCM	chr12	112907059	Missense_Mutation	NA	T7I	0.33
SKCM	chr12	112907191	Missense_Mutation	NA	Y51C	0.43
SKCM	chr12	112919455	Missense_Mutation	novel	G369R	0.32
SKCM	chr12	112908757	Silent	NA	F134F	0.33
SKCM	chr12	112917820	Intron	novel		0.29
SKCM	chr12	112907061	Missense_Mutation	rs776721646	P8S	0.46
SKCM	chr12	112919386	Splice_Region	novel		0.51
SKCM	chr12	112908757	Silent	NA	F134F	0.29
SKCM	chr12	112906981	5'UTR	novel		0.72
SKCM	chr12	112919422	Missense_Mutation	novel	D358N	0.4
SKCM	chr12	112908656	Missense_Mutation	NA	E101K	0.31
SKCM	chr12	112908726	Missense_Mutation	NA	P124L	0.89
SKCM	chr12	112919514	Silent	novel	T388T	0.26
SKCM	chr12	112916807	Intron	novel		0.31
STAD	chr12	112916548	Silent	novel	L232L	0.27
STAD	chr12	112916730	Silent	rs144257676	T292T	0.12
STAD	chr12	112916658	Silent	novel	L268L	0.17
STAD	chr12	112911133	Silent	rs773579176	G184G	0.21
STAD	chr12	112908796	Silent	NA	F147F	0.31
STAD	chr12	112919431	Missense_Mutation	novel	R361W	0.08
STAD	chr12	112911191	Missense_Mutation	NA	K204E	0.28
STAD	chr12	112908637	Silent	novel	R94R	0.05
STAD	chr12	112911113	Missense_Mutation	NA	T178A	0.07
STAD	chr12	112917742	Intron	novel		0.38
STAD	chr12	112908748	Silent	rs147639145	A131A	0.16
STAD	chr12	112916666	Missense_Mutation	NA	Y271C	0.13
UCEC	chr12	112907128	Missense_Mutation	NA	I30T	0.3
UCEC	chr12	112911139	Silent	NA	F186F	0.3
UCEC	chr12	112919566	3'UTR	NA		0.38
UCEC	chr12	112907065	Missense_Mutation	novel	A9V	0.33
UCEC	chr12	112911209	Missense_Mutation	rs754280709	R210C	0.34
UCEC	chr12	112907029	5'UTR	novel		0.25
UCEC	chr12	112916848	Intron	novel		0.29
UCEC	chr12	112908796	Silent	NA	F147F	0.5
UCEC	chr12	112917861	Intron	novel		0.6
UCEC	chr12	112911184	Silent	novel	R201R	0.46
UCEC	chr12	112908622	Missense_Mutation	novel	Q89H	0.16
UCEC	chr12	112911207	Missense_Mutation	novel	I209N	0.25
UCEC	chr12	112916607	Silent	novel	T251T	0.43
UCEC	chr12	112916509	Missense_Mutation	novel	C219R	0.3
UCEC	chr12	112916644	Missense_Mutation	novel	N264D	0.42
UCEC	chr12	112907016	5'UTR	novel		0.56
UCEC	chr12	112919765	3'UTR	novel		0.6
UCEC	chr12	112908595	Silent	NA	V80V	0.47
UCEC	chr12	112919433	Silent	rs766895329	R361R	0.46
UCEC	chr12	112916670	Nonsense_Mutation	novel	W272*	0.42
UCEC	chr12	112908636	Missense_Mutation	novel	R94H	0.33
UCEC	chr12	112911134	Missense_Mutation	rs766882379	E185K	0.32
UCEC	chr12	112911209	Missense_Mutation	rs754280709	R210C	0.44
UCEC	chr12	112908562	Silent	novel	T69T	0.08
UCEC	chr12	112917621	Missense_Mutation	rs370539671	A320V	0.42
UCEC	chr12	112916624	Missense_Mutation	rs766223435	T257M	0.24
UCEC	chr12	112906934	5'UTR	novel		0.5
UCEC	chr12	112919603	3'UTR	novel		0.17
UCEC	chr12	112908687	Missense_Mutation	NA	R111K	0.27
UCEC	chr12	112919422	Missense_Mutation	novel	D358N	0.13
UCEC	chr12	112919635	3'UTR	NA		0.33
UCEC	chr12	112916799	Intron	novel		0.33
UCEC	chr12	112911115	Silent	rs199685456	T178T	0.46
UCEC	chr12	112907116	Missense_Mutation	novel	F26Y	0.28
UCEC	chr12	112919630	3'UTR	NA		0.26

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.2222	0.067545
HNSC	DEL	0.0594	0.22646
LUAD	DEL	0.1453	0.0059643
LUSC	DEL	0.0898	0.038823
PAAD	DEL	0.1793	0.0030251
PRAD	AMP	0.0508	0.016187
SKCM	DEL	0.188	0.00079981

Survival Analysis

Cancer	P-value	Q-value
THYM	0.019	Kaplan-Meier Survival Analysis
SARC	0.019	Kaplan-Meier Survival Analysis
MESO	0.00019	Kaplan-Meier Survival Analysis
ACC	0.0013	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
TGCT	0.049	Kaplan-Meier Survival Analysis
PAAD	0.00014	Kaplan-Meier Survival Analysis
BLCA	0.00011	Kaplan-Meier Survival Analysis
LAML	0.0021	Kaplan-Meier Survival Analysis
UCEC	0.0071	Kaplan-Meier Survival Analysis
LIHC	0.022	Kaplan-Meier Survival Analysis
CHOL	0.045	Kaplan-Meier Survival Analysis
THCA	0.026	Kaplan-Meier Survival Analysis
LUAD	0.0036	Kaplan-Meier Survival Analysis
UVM	0.018	Kaplan-Meier Survival Analysis
OV	0.05	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742