EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000089154 (Gene tree)
Gene ID: 10985
Gene Symbol: GCN1
Alias: KIAA0219|GCN1L|GCN1L1
Full Name: GCN1 activator of EIF2AK4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 67,508 bases
Position: chr12:120,127,203-120,194,710
Accession: 4199
RBP type: non-canonical RBP
Summary: (GCN1 Activator Of EIF2AK4) is a Protein Coding gene. Diseases associated with GCN1 include Neuroblastoma. An important paralog of this gene is ECPAS.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000548821	GCN1-205	504	-	-	- (aa)	-	-
ENST00000549815	GCN1-206	543	-	-	- (aa)	-	-
ENST00000551549	GCN1-208	258	-	-	- (aa)	-	-
ENST00000300648	GCN1-201	8675	-	ENSP00000300648	2671 (aa)	-	Q92616
ENST00000551920	GCN1-209	558	-	-	- (aa)	-	-
ENST00000550471	GCN1-207	918	-	-	- (aa)	-	-
ENST00000547263	GCN1-202	366	-	-	- (aa)	-	-
ENST00000547369	GCN1-203	595	-	-	- (aa)	-	-
ENST00000548132	GCN1-204	498	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000089154's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000089154	Body Height	5.2510000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000089154's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000089154	GCN1	99	43.368	FBgn0039959	CG17514	99	43.331	Drosophila_melanogaster
ENSG00000089154	GCN1	100	94.010	ENSMUSG00000041638	Gcn1l1	100	94.010	Mus_musculus
ENSG00000089154	GCN1	67	34.053	YGL195W	GCN1	67	34.070	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005737	cytoplasm	9234705.	NAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005840	ribosome	9234705.	NAS	Component
GO:0005844	polysome	-	ISS	Component
GO:0006412	translation	-	IEA	Process
GO:0006417	regulation of translation	-	IEA	Process
GO:0008135	translation factor activity, RNA binding	9234705.	NAS	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0019887	protein kinase regulator activity	-	IEA	Function
GO:0019901	protein kinase binding	-	IEA	Function
GO:0033674	positive regulation of kinase activity	-	IEA	Process
GO:0034198	cellular response to amino acid starvation	-	ISS	Process
GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	-	ISS	Process
GO:0043022	ribosome binding	-	IEA	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045859	regulation of protein kinase activity	-	IEA	Process
GO:1990253	cellular response to leucine starvation	-	ISS	Process