EuRBPDB

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  • Basic Information
  • Cancer Related Information

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000089159 (Gene tree)
Gene ID
5829
Gene Symbol
PXN
Alias
N
Full Name
paxillin
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
55,333 bases
Position
chr12:120,210,439-120,265,771
Accession
9718
RBP type
non-canonical RBP
Summary
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
18077133Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration.Cell Signal2008 FebLukong KE-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000547772PXN-213584--- (aa)--
ENST00000323871PXN-2035457-ENSP00000489977706 (aa)-A0A1B0GU60
ENST00000637386PXN-220621-ENSP00000490352207 (aa)-A0A1B0GV30
ENST00000637624PXN-2224132XM_005253917ENSP00000490896192 (aa)XP_005253974A0A1B0GWE7
ENST00000546532PXN-211729-ENSP0000044718037 (aa)-F8W0K8
ENST00000424649PXN-2043683-ENSP00000391283557 (aa)-P49023
ENST00000547983PXN-2141004-ENSP0000044689391 (aa)-F8VZ39
ENST00000552550PXN-219588-ENSP0000044665031 (aa)-F8W1E0
ENST00000550795PXN-217513--- (aa)--
ENST00000547746PXN-212579--- (aa)--
ENST00000458477PXN-2063807XM_017019735ENSP00000395536424 (aa)XP_016875224P49023
ENST00000637617PXN-2213246XM_006719532ENSP000004898401081 (aa)XP_006719595A0A1B0GTU4
ENST00000440827PXN-205516--- (aa)--
ENST00000267257PXN-2023835XM_017019739ENSP00000267257605 (aa)XP_016875228P49023
ENST00000538144PXN-2081805--- (aa)--
ENST00000228307PXN-2013785-ENSP00000228307591 (aa)-P49023
ENST00000551327PXN-218588--- (aa)--
ENST00000540221PXN-209550--- (aa)--
ENST00000536957PXN-2074112XM_017019733ENSP00000443887589 (aa)XP_016875222F5GZ78
ENST00000548912PXN-215655-ENSP0000044660736 (aa)-F8W0G0
ENST00000550205PXN-216547--- (aa)--
ENST00000543331PXN-210957-ENSP00000443745176 (aa)-F5H836
Gene Model
Click here to download ENSG00000089159's gene model file
Pathways
Pathway IDPathway NameSource
hsa04062Chemokine signaling pathwayKEGG
hsa04370VEGF signaling pathwayKEGG
hsa04510Focal adhesionKEGG
hsa04670Leukocyte transendothelial migrationKEGG
hsa04810Regulation of actin cytoskeletonKEGG
hsa05100Bacterial invasion of epithelial cellsKEGG
hsa05163Human cytomegalovirus infectionKEGG
hsa05165Human papillomavirus infectionKEGG
hsa05170Human immunodeficiency virus 1 infectionKEGG
hsa05203Viral carcinogenesisKEGG
hsa05205Proteoglycans in cancerKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000089159rs1258198312120233163?Platelet count29403010[0.017-0.034] unit decrease novel0.02531EFO_0004309
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000089159's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001725stress fiber24036928.IDAComponent
GO:0005178integrin binding-IEAFunction
GO:0005515protein binding7561682.9756887.10604475.10814581.11035932.12861019.14665621.14688263.15572663.16478788.16628223.17082770.20489202.21034468.21173240.21741599.22270917.22728435.23393263.23397142.24694988.24863063.25241761.IPIFunction
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005875microtubule associated complex10840040.TASComponent
GO:0005886plasma membrane17449030.IDAComponent
GO:0005886plasma membrane-TASComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0005925focal adhesion12686598.20086044.24863063.IDAComponent
GO:0005938cell cortex-IEAComponent
GO:0006936muscle contraction-TASProcess
GO:0007155cell adhesion10840040.NASProcess
GO:0007160cell-matrix adhesion-IEAProcess
GO:0007165signal transduction7534286.TASProcess
GO:0007172signal complex assembly9054445.TASProcess
GO:0007179transforming growth factor beta receptor signaling pathway24036928.IDAProcess
GO:0008013beta-catenin binding17513457.IPIFunction
GO:0017166vinculin binding9054445.IPIFunction
GO:0019901protein kinase binding-IEAFunction
GO:0019903protein phosphatase binding28759036.IPIFunction
GO:0030027lamellipodium12686598.IDAComponent
GO:0031625ubiquitin protein ligase binding-IEAFunction
GO:0034614cellular response to reactive oxygen species12686598.IEPProcess
GO:0038191neuropilin binding24863063.IPIFunction
GO:0043542endothelial cell migration24863063.IMPProcess
GO:0046872metal ion binding-IEAFunction
GO:0048010vascular endothelial growth factor receptor signaling pathway-TASProcess
GO:0051496positive regulation of stress fiber assembly24863063.IMPProcess
GO:0060396growth hormone receptor signaling pathway10925297.IDAProcess

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25973017MicroRNA-145 suppresses cell migration and invasion by targeting paxillin in human colorectal cancer cells.Int J Clin Exp Pathol2015 Feb 1Qin J-
24180516Abnormal expression of paxillin correlates with tumor progression and poor survival in patients with gastric cancer.J Transl Med2013 Nov 2Chen DLdoi: 10.1186/1479-5876-11-277.
23275153Overexpression of paxillin induced by miR-137 suppression promotes tumor progression and metastasis in colorectal cancer.Carcinogenesis2013 AprChen DLdoi: 10.1093/carcin/bgs400
29318915The overexpression of PXN promotes tumor progression and leads to radioresistance in cervical cancer.Future Oncol2018 FebLiu Qdoi: 10.2217/fon-2017-0474
29494963miR-24 inhibited the killing effect of natural killer cells to colorectal cancer cells by downregulating Paxillin.Biomed Pharmacother2018 MayZhang LLdoi: 10.1016/j.biopha.2018.02.024
21868260Decreased ezrin and paxillin expression in human urothelial bladder tumors correlate with tumor progression.Urol Oncol2013 AugAthanasopoulou Adoi: 10.1016/j.urolonc.2011.07.003
26349603Cytoskeletal Focal Adhesion Proteins Fascin-1 and Paxillin Are Predictors of Malignant Progression and Poor Prognosis in Human Breast Cancer.J Environ Pathol Toxicol Oncol2015Omran OM-
21614903The value of TOP2A, EZH2 and paxillin expression as markers of aggressive breast cancer: relationship with other prognostic factors.Eur J Gynaecol Oncol2011Panousis D-
25826088Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERK-mediated stabilization of Bcl-2 protein by phosphorylation at Serine 87.Oncotarget2015 Apr 20Huang CC-
11759057Paxillin: application of immunohistochemistry to the diagnosis of chromophobe renal cell carcinoma and oncocytoma.Appl Immunohistochem Mol Morphol2001 DecKuroda N-
19353596No somatic genetic change in the paxillin gene in nonsmall-cell lung cancer.Mol Carcinog2009 JulPallier Kdoi: 10.1002/mc.20538.
24395444The roles of Wnt5a, JNK and paxillin in the occurrence of metastasis of pancreatic adenocarcinoma.Int J Clin Oncol2014 DecLu Wdoi: 10.1007/s10147-013-0648-0
23588386Contribution of the PI3K/MMPs/Ln-5γ2 and EphA2/FAK/Paxillin signaling pathways to tumor growth and vasculogenic mimicry of gallbladder carcinomas.Int J Oncol2013 JunLu XSdoi: 10.3892/ijo.2013.1897
21042764Growth and differentiation factor-9 promotes adhesive and motile capacity of prostate cancer cells by up-regulating FAK and Paxillin via Smad dependent pathway.Oncol Rep2010 DecBokobza SM-
27035282Anticancer effect of docetaxel induces apoptosis of prostate cancer via the cofilin-1 and paxillin signaling pathway.Mol Med Rep2016 MayXiao Pdoi: 10.3892/mmr.2016.5000
26159303Expression of Paxillin is Correlated with Clinical Prognosis in Colorectal Cancer Patients.Med Sci Monit2015 Jul 10Zhao CJdoi: 10.12659/MSM.893832.
23792636Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: relevance to lung cancer.Cancer Biol Ther2013 JulKawada Idoi: 10.4161/cbt.25091
21617717Absence of paxillin gene mutation in lung cancer and other common solid cancers.Tumori2011 Mar-AprKim MSdoi: 10.1700/667.7785.
16552730Paxillin modulates squamous cancer cell adhesion and is important in pressure-augmented adhesion.J Cell Biochem2006 Aug 15Conway WC-
18632638Activation of platelet-activating factor receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer.Cancer Res2008 Jul 15Aponte Mdoi: 10.1158/0008-5472.CAN-07-5771.
21270128Calpain-mediated proteolysis of paxillin negatively regulates focal adhesion dynamics and cell migration.J Biol Chem2011 Mar 25Cortesio CLdoi: 10.1074/jbc.M110.187294
24096476Phosphorylation of paxillin confers cisplatin resistance in non-small cell lung cancer via activating ERK-mediated Bcl-2 expression.Oncogene2014 Aug 28Wu DWdoi: 10.1038/onc.2013.389
20628053Paxillin regulates androgen- and epidermal growth factor-induced MAPK signaling and cell proliferation in prostate cancer cells.J Biol Chem2010 Sep 10Sen Adoi: 10.1074/jbc.M110.134064
22700880MLK3 regulates paxillin phosphorylation in chemokine-mediated breast cancer cell migration and invasion to drive metastasis.Cancer Res2012 Aug 15Chen Jdoi: 10.1158/0008-5472.CAN-12-0655
25190348MEKK2 regulates paxillin ubiquitylation and localization in MDA-MB 231 breast cancer cells.Biochem J2014 Nov 15Ameka Mdoi: 10.1042/BJ20140420.
21940355Effects of paxillin on HCT-8 human colorectal cancer cells.Hepatogastroenterology2011 Nov-DecJun Qdoi: 10.5754/hge11352.
24885567Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway.Mol Cancer2014 May 4Du Tdoi: 10.1186/1476-4598-13-100.
18449907Genetic upregulation of matriptase-2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisation.J Cell Physiol2008 SepSanders AJdoi: 10.1002/jcp.21460.
24344012Prognostic value of EZH2, paxillin expression and DNA ploidy of breast adenocarcinoma: correlation to pathologic predictors.J BUON2013 Oct-DecPanousis D-
25182764Paxillin and steroid signaling: from frog to human.Methods Mol Biol2014Hammes SRdoi: 10.1007/978-1-4939-1346-6_9.
25323586Bcl-2 stabilization by paxillin confers 5-fluorouracil resistance in colorectal cancer.Cell Death Differ2015 MayWu DWdoi: 10.1038/cdd.2014.170
20127017Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin beta1-mediated paxillin and AKT activation.Oncol Rep2010 MarLee M-
25873394Phosphatase and Tensin Homolog (PTEN) Represses Colon Cancer Progression through Inhibiting Paxillin Transcription via PI3K/AKT/NF-??B Pathway.J Biol Chem2015 Jun 12Zhang LLdoi: 10.1074/jbc.M115.641407
20369478[Expression of paxillin in breast cancer cell with high and low metastatic potentiality].Sichuan Da Xue Xue Bao Yi Xue Ban2010 JanCai H-
18172305Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion.Cancer Res2008 Jan 1Jagadeeswaran Rdoi: 10.1158/0008-5472.CAN-07-1998.
20395438The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin.Am J Pathol2010 JunMetalli Ddoi: 10.2353/ajpath.2010.090904
28100775Cool-associated Tyrosine-phosphorylated Protein 1 Is Required for the Anchorage-independent Growth of Cervical Carcinoma Cells by Binding Paxillin and Promoting AKT Activation.J Biol Chem2017 Mar 3Yoo SMdoi: 10.1074/jbc.M116.769190
28739717Potential Implication of Paxillin in Cancer Establishment Within the Bone Environment.Anticancer Res2017 AugSobkowicz AD-
27130522Retinoic acid induces nuclear FAK translocation and reduces breast cancer cell adhesion through Moesin, FAK, and Paxillin.Mol Cell Endocrinol2016 Jul 15Sanchez AMdoi: 10.1016/j.mce.2016.04.021
27095481Paxillin, a novel controller in the signaling of estrogen to FAK/N-WASP/Arp2/3 complex in breast cancer cells.Mol Cell Endocrinol2016 Jul 15Shortrede JEdoi: 10.1016/j.mce.2016.04.007
28656206Nicotinic acid impairs assembly of leading edge in glioma cells.Oncol Rep2017 AugYang Xdoi: 10.3892/or.2017.5757
29337100Knockdown of long non-coding RNA XIST inhibits cell viability and invasion by regulating miR-137/PXN axis in non-small cell lung cancer.Int J Biol Macromol2018 MayJiang Hdoi: 10.1016/j.ijbiomac.2018.01.022

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr121202120613'UTRnovel0.19
BLCAchr12120219896Intronnovel0.23
BLCAchr12120222564Missense_MutationNAS227F0.31
BLCAchr12120219970Intronnovel0.18
BLCAchr12120216681Intronnovel0.18
BLCAchr12120212320Missense_MutationnovelF590L0.24
BLCAchr12120213885Missense_MutationnovelS489L0.24
BLCAchr12120219953Intronnovel0.25
BLCAchr121202120753'UTRnovel0.08
BRCAchr121202122943'UTRnovel0.18
BRCAchr12120265618Splice_RegionnovelL4L1
CESCchr12120214192Missense_MutationnovelT435M0.38
CESCchr12120215934Intronrs7455930400.45
CESCchr12120214960Missense_MutationnovelH381Q0.1
CESCchr121202120303'UTRrs7620128660.14
CESCchr121202122853'UTRnovel0.33
CESCchr121202123083'UTRnovel0.33
CESCchr12120212545Silentrs759575217F515F0.1
CESCchr121202108143'UTRnovel0.46
CESCchr12120215122Missense_Mutationrs201427575K362R0.36
CESCchr12120219789Intronnovel0.38
CHOLchr121202121293'UTRnovel0.59
COADchr12120213974Silentrs755276611D459D0.4
COADchr12120219390Intronnovel0.31
COADchr12120224375Missense_Mutationrs748821995A6T0.31
COADchr12120213872Silentrs772494174T493T0.1
COADchr12120212514Missense_MutationNAH526Y0.46
COADchr12120214924SilentNAS393S0.08
COADchr12120222879Silentrs374969563P159P0.51
COADchr12120223774SilentNAP100P0.33
COADchr12120221712Missense_MutationNAV248I0.11
COADchr12120212530Missense_MutationNAQ520H0.35
COADchr12120215229Frame_Shift_DelNAP328Rfs*180.42
COADchr12120224376Splice_Regionrs200236405D5D0.11
COADchr121202122633'UTRnovel0.69
COADchr12120214891Nonsense_MutationNAY404*0.15
COADchr12120214955Missense_MutationNAV383A0.22
COADchr121202122773'UTRnovel0.17
COADchr12120212368SilentNAK574K0.4
COADchr12120214956Missense_Mutationrs766354430V383I0.09
COADchr12120221734SilentNAG240G0.14
COADchr12120215182Missense_MutationNAQ342R0.11
ESCAchr12120214912Silentrs746357371F397F0.55
ESCAchr12120216527Intronnovel0.11
ESCAchr12120214201Missense_MutationnovelL432H0.55
ESCAchr121202110313'UTRnovel0.73
ESCAchr12120214187Missense_MutationnovelH437Y0.47
GBMchr12120213886Missense_MutationNAS489A0.3
GBMchr121202119053'UTRnovel0.2
GBMchr12120219238Intronnovel0.47
GBMchr12120222564Missense_MutationNAS227F0.2
GBMchr12120212463Missense_MutationnovelT543P0.35
HNSCchr12120216826Intronnovel0.35
HNSCchr12120215156Missense_Mutationrs757931149A351T0.37
HNSCchr12120219449Intronnovel0.48
HNSCchr12120213932SilentNAA473A0.25
HNSCchr12120219408Intronnovel0.42
HNSCchr12120214954SilentnovelV383V0.14
HNSCchr12120214989Missense_Mutationrs770437521A372T0.63
HNSCchr12120220042Intronnovel0.58
KIRCchr12120222639Missense_Mutationrs766497021P202L0.25
KIRCchr121202119803'UTRnovel0.3
KIRPchr12120222978SilentnovelS126S0.26
KIRPchr12120215596Silentrs374919882G299G0.24
KIRPchr12120215210Frame_Shift_DelnovelQ333Sfs*130.46
LUADchr12120212458SilentnovelG544G0.19
LUADchr12120212506Silentrs548963687H528H0.14
LUADchr12120215938Intronnovel0.3
LUADchr12120213878SilentNAL491L0.13
LUADchr12120212525Missense_MutationnovelY522C0.25
LUADchr121202121313'UTRnovel0.14
LUADchr12120219731Intronnovel0.24
LUADchr12120219212Intronnovel0.06
LUSCchr12120222954Missense_MutationNAM134I0.25
LUSCchr12120215652SilentnovelL281L0.33
LUSCchr12120215590Silentrs757891043R301R0.34
LUSCchr121202122583'UTRnovel0.21
LUSCchr12120215614Silentrs188662174A293A0.48
LUSCchr12120212343Missense_MutationnovelQ583E0.09
LUSCchr121202120103'UTRnovel0.3
OVchr12120215613Missense_Mutationrs770650321G294S0.56
OVchr12120214884Missense_MutationnovelK407E0.65
OVchr12120214885SilentnovelE406E0.61
OVchr12120214208Missense_MutationnovelT430S0.22
OVchr12120214983Missense_MutationnovelG374W0.28
OVchr12120221731Missense_MutationNAE241D0.57
OVchr12120214912Missense_MutationnovelF397L0.21
OVchr12120224370SilentNAL7L0.56
OVchr12120212483Missense_MutationNAS536Y0.33
PAADchr12120212323SilentnovelL589L0.23
PAADchr12120222896Missense_Mutationrs757867300A154T0.21
PRADchr12120220020Intronnovel0.1
READchr12120222914Frame_Shift_DelnovelL148Cfs*50.71
READchr12120215662Splice_SitenovelX278_splice0.44
SKCMchr12120219733Intronnovel0.2
SKCMchr12120216964Intronnovel0.8
SKCMchr12120219996IntronNA0.3
SKCMchr12120219572Intronnovel0.64
SKCMchr12120215129Missense_MutationnovelA360T0.14
SKCMchr12120215130SilentnovelG359G0.13
SKCMchr12120215581Silentrs543388127P304P0.22
SKCMchr12120215582Missense_MutationnovelP304R0.21
SKCMchr121202122873'UTRnovel0.32
SKCMchr12120220088IntronNA0.31
SKCMchr12120214928Missense_MutationNAG392E0.26
SKCMchr12120214867Silentrs371009984L412L0.4
STADchr12120219467Intronnovel0.27
STADchr12120222898Missense_MutationNAN153I0.28
STADchr12120222996SilentNAF120F0.28
STADchr121202120983'UTRnovel0.35
STADchr12120213910Missense_Mutationrs768579833R481W0.5
STADchr12120219363Intronrs7480418920.34
STADchr12120220042Intronnovel0.44
STADchr12120219950Intronnovel0.06
STADchr12120216646Intronnovel0.5
STADchr12120219651Intronnovel0.15
STADchr12120213871Missense_MutationNAL494M0.16
STADchr12120214942SilentnovelC387C0.27
STADchr12120212651Intronnovel0.13
STADchr12120224233Frame_Shift_DelnovelP53Rfs*140.5
STADchr121202118993'UTRnovel0.11
STADchr121202119543'UTRnovel0.17
STADchr12120224247Frame_Shift_Delrs758654594V49Sfs*180.33
STADchr12120222944Missense_MutationNAL138M0.17
STADchr12120212696Intronrs7461102690.43
THCAchr12120220086Intronnovel0.13
THCAchr12120220027Intronnovel0.07
UCECchr12120213935Silentrs773831994F472F0.26
UCECchr12120215224Frame_Shift_DelnovelP328Rfs*180.25
UCECchr121202108423'UTRnovel0.08
UCECchr12120215141Nonsense_MutationnovelG356*0.23
UCECchr12120221744Missense_MutationnovelV237A0.32
UCECchr12120212353SilentNAK579K0.45
UCECchr12120215236Frame_Shift_DelNAP324Lfs*220.25
UCECchr12120213840Splice_SitenovelX503_splice0.19
UCECchr12120215133Silentrs753461695C358C0.3
UCECchr12120221652Missense_MutationnovelE268K0.13
UCECchr121202116283'UTRnovel0.41
UCECchr121202121923'UTRrs5419078340.59
UCECchr12120219759Intronnovel0.41
UCECchr12120222974Missense_MutationnovelE128K0.23
UCECchr12120221714Missense_Mutationrs201921559R247H0.28
UCECchr12120222633Missense_Mutationrs750675975R204Q0.26
UCECchr12120212397Missense_MutationNAL565I0.33
UCECchr12120212551SilentNAS513S0.4
UCECchr12120216488Intronrs7657964290.48
UCECchr12120216465Intronnovel0.25
UCECchr121202107993'UTRnovel0.35
UCECchr121202120603'UTRnovel0.36
UCECchr12120212533Silentrs779572205G519G0.28
UCECchr12120216046Intronnovel0.32
UCECchr12120216482Intronnovel0.24
UCECchr12120219747Intronnovel0.28
UCECchr12120216317Intronrs5553133760.33
UCECchr12120216606Intronnovel0.21
UCECchr12120219520Intronnovel0.33
UCECchr121202121843'UTRnovel0.78
UCECchr121202106493'UTRnovel0.94
UCECchr12120214139Missense_MutationnovelE453K0.4
UCECchr121202116623'UTRnovel0.37
UCECchr12120212444Missense_MutationNAA549V0.26
UCECchr121202106993'UTRnovel0.28
UCECchr12120215124SilentnovelC361C0.25
UCECchr12120216449Intronnovel0.36
UCECchr12120219759Intronnovel0.44
UCECchr12120222954Missense_MutationnovelM134I0.41
UCECchr121202115313'UTRnovel0.26
UCECchr12120216358Intronnovel0.49
UCECchr12120219588Intronnovel0.31
UCECchr121202122193'UTRnovel0.31
UCECchr121202117233'UTRnovel0.5
UCECchr121202113583'UTRnovel0.52
UCECchr12120219984Intronnovel0.55
UCECchr12120216071Intronnovel0.27
UCECchr12120219371Intronrs1868268270.39
UCECchr121202118313'UTRnovel0.29
UCECchr12120215387Intronnovel0.24
UCECchr12120219278Intronnovel0.33
UCECchr12120219887Intronnovel0.31
UCECchr12120216436Intronnovel0.26
UCECchr12120216898Intronrs7741219920.33
UCECchr12120214140Silentrs558454285P452P0.38
UCECchr12120221633Missense_MutationnovelS274L0.28
UCECchr12120213957Missense_Mutationrs372866217R465H0.27
UCECchr12120222921Silentrs774463797L145L0.45
UCECchr12120216792Intronnovel0.27
UCECchr12120224364Silentrs377690617A9A0.14
UCECchr121202110193'UTRnovel0.3
UCECchr12120213943Missense_Mutationrs759270858D470N0.32
UCECchr12120222916Missense_Mutationrs749697934R147H0.28
UCECchr12120216720Intronnovel0.08
UCECchr121202118103'UTRnovel0.37
UCECchr12120212538Missense_Mutationrs370330317D518N0.4
UCECchr12120224330Missense_Mutationrs751358222R21W0.34
UCSchr12120214975Silentrs747813672T376T0.14
UCSchr12120222984Missense_MutationnovelQ124H0.48

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BRCADEL0.15936.3933e-07
CHOLDEL0.19440.067545
HNSCDEL0.05360.22646
LUADDEL0.14150.0059643
LUSCDEL0.10580.038823
PAADDEL0.17390.0030251
PRADAMP0.05490.016187
SKCMDEL0.17980.00079981

Survival Analysis
CancerP-value Q-value
THYM0.044

Kaplan-Meier Survival Analysis

KIRC0.0024

Kaplan-Meier Survival Analysis

MESO0.00011

Kaplan-Meier Survival Analysis

ACC0.034

Kaplan-Meier Survival Analysis

UCS0.034

Kaplan-Meier Survival Analysis

HNSC0.0014

Kaplan-Meier Survival Analysis

SKCM0.031

Kaplan-Meier Survival Analysis

LUSC0.0056

Kaplan-Meier Survival Analysis

LAML0.0071

Kaplan-Meier Survival Analysis

UCEC0.028

Kaplan-Meier Survival Analysis

GBM0.0001

Kaplan-Meier Survival Analysis

LIHC0.0021

Kaplan-Meier Survival Analysis

DLBC0.027

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

LUAD0.0014

Kaplan-Meier Survival Analysis

UVM0.036

Kaplan-Meier Survival Analysis

OV0.0068

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742


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