EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000089195 (Gene tree)
Gene ID: 51605
Gene Symbol: TRMT6
Alias: GCD10|MGC5029|Gcd10p|CGI-09
Full Name: tRNA methyltransferase 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 13,324 bases
Position: chr20:5,937,235-5,950,558
Accession: 20900
RBP type: canonical RBP
Summary: This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000203001	Gcd10p	PF04189.13	5.4e-71	1	1
ENSP00000392070	Gcd10p	PF04189.13	4.4e-21	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000473131	TRMT6-204	3025	-	-	- (aa)	-	-
ENST00000203001	TRMT6-201	2327	-	ENSP00000203001	497 (aa)	-	Q9UJA5
ENST00000453074	TRMT6-202	2239	XM_017027875	ENSP00000392070	327 (aa)	XP_016883364	Q9UJA5
ENST00000466974	TRMT6-203	2976	-	-	- (aa)	-	-
ENST00000493972	TRMT6-205	778	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000089195's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000089195's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000089195	TRMT6	97	58.678	ENSAPOG00000008036	trmt6	98	59.175	Acanthochromis_polyacanthus
ENSG00000089195	TRMT6	100	94.567	ENSAMEG00000010635	TRMT6	100	94.567	Ailuropoda_melanoleuca
ENSG00000089195	TRMT6	96	55.208	ENSACIG00000004608	trmt6	97	55.094	Amphilophus_citrinellus
ENSG00000089195	TRMT6	97	56.341	ENSAOCG00000024322	trmt6	98	56.133	Amphiprion_ocellaris
ENSG00000089195	TRMT6	97	58.230	ENSAPEG00000017334	trmt6	98	58.230	Amphiprion_percula
ENSG00000089195	TRMT6	99	53.799	ENSATEG00000018498	trmt6	97	58.696	Anabas_testudineus
ENSG00000089195	TRMT6	99	72.171	ENSAPLG00000007761	TRMT6	99	75.930	Anas_platyrhynchos
ENSG00000089195	TRMT6	96	70.084	ENSACAG00000000575	TRMT6	98	70.084	Anolis_carolinensis
ENSG00000089195	TRMT6	100	98.189	ENSANAG00000021260	TRMT6	100	98.189	Aotus_nancymaae
ENSG00000089195	TRMT6	99	51.964	ENSACLG00000026034	trmt6	97	54.433	Astatotilapia_calliptera
ENSG00000089195	TRMT6	100	54.985	ENSAMXG00000017116	trmt6	96	58.264	Astyanax_mexicanus
ENSG00000089195	TRMT6	100	94.190	ENSBTAG00000001314	TRMT6	100	93.360	Bos_taurus
ENSG00000089195	TRMT6	100	97.988	ENSCJAG00000021296	TRMT6	100	97.988	Callithrix_jacchus
ENSG00000089195	TRMT6	100	93.578	ENSCAFG00000005969	TRMT6	100	93.360	Canis_familiaris
ENSG00000089195	TRMT6	100	93.360	ENSCAFG00020000777	TRMT6	100	93.360	Canis_lupus_dingo
ENSG00000089195	TRMT6	100	93.578	ENSCHIG00000010338	TRMT6	100	93.360	Capra_hircus
ENSG00000089195	TRMT6	100	95.413	ENSTSYG00000004286	TRMT6	100	95.372	Carlito_syrichta
ENSG00000089195	TRMT6	100	84.709	ENSCAPG00000015467	TRMT6	93	86.473	Cavia_aperea
ENSG00000089195	TRMT6	100	87.123	ENSCPOG00000013809	TRMT6	100	87.123	Cavia_porcellus
ENSG00000089195	TRMT6	100	96.982	ENSCCAG00000026939	TRMT6	100	96.982	Cebus_capucinus
ENSG00000089195	TRMT6	100	99.195	ENSCATG00000041111	TRMT6	100	99.195	Cercocebus_atys
ENSG00000089195	TRMT6	99	89.409	ENSCLAG00000013978	TRMT6	99	89.409	Chinchilla_lanigera
ENSG00000089195	TRMT6	100	98.793	ENSCSAG00000013461	TRMT6	100	98.793	Chlorocebus_sabaeus
ENSG00000089195	TRMT6	84	80.863	ENSCHOG00000012537	TRMT6	83	80.863	Choloepus_hoffmanni
ENSG00000089195	TRMT6	96	75.574	ENSCPBG00000023406	TRMT6	98	75.783	Chrysemys_picta_bellii
ENSG00000089195	TRMT6	90	34.979	ENSCING00000002472	-	96	34.071	Ciona_intestinalis
ENSG00000089195	TRMT6	88	37.838	ENSCSAVG00000001680	-	94	38.140	Ciona_savignyi
ENSG00000089195	TRMT6	100	98.592	ENSCANG00000002381	TRMT6	100	98.592	Colobus_angolensis_palliatus
ENSG00000089195	TRMT6	100	88.934	ENSCGRG00001003385	Trmt6	100	88.934	Cricetulus_griseus_chok1gshd
ENSG00000089195	TRMT6	100	88.934	ENSCGRG00000006540	Trmt6	100	88.934	Cricetulus_griseus_crigri
ENSG00000089195	TRMT6	96	58.212	ENSCSEG00000002228	trmt6	98	58.628	Cynoglossus_semilaevis
ENSG00000089195	TRMT6	100	54.242	ENSCVAG00000000341	trmt6	98	56.701	Cyprinodon_variegatus
ENSG00000089195	TRMT6	97	58.111	ENSDARG00000042344	trmt6	97	57.495	Danio_rerio
ENSG00000089195	TRMT6	100	83.532	ENSDNOG00000012785	TRMT6	100	83.532	Dasypus_novemcinctus
ENSG00000089195	TRMT6	100	88.531	ENSDORG00000006458	Trmt6	99	88.531	Dipodomys_ordii
ENSG00000089195	TRMT6	64	94.048	ENSETEG00000003490	-	60	92.424	Echinops_telfairi
ENSG00000089195	TRMT6	66	51.976	ENSETEG00000017282	-	96	51.976	Echinops_telfairi
ENSG00000089195	TRMT6	100	94.366	ENSEASG00005001411	TRMT6	99	94.512	Equus_asinus_asinus
ENSG00000089195	TRMT6	100	93.964	ENSECAG00000023914	TRMT6	100	93.964	Equus_caballus
ENSG00000089195	TRMT6	99	91.532	ENSEEUG00000006635	TRMT6	99	91.532	Erinaceus_europaeus
ENSG00000089195	TRMT6	96	59.751	ENSELUG00000013378	trmt6	79	61.454	Esox_lucius
ENSG00000089195	TRMT6	100	94.190	ENSFCAG00000003102	TRMT6	100	94.165	Felis_catus
ENSG00000089195	TRMT6	98	70.062	ENSFALG00000013575	TRMT6	97	75.442	Ficedula_albicollis
ENSG00000089195	TRMT6	100	89.135	ENSFDAG00000015117	TRMT6	100	89.135	Fukomys_damarensis
ENSG00000089195	TRMT6	96	56.933	ENSFHEG00000019957	trmt6	97	56.367	Fundulus_heteroclitus
ENSG00000089195	TRMT6	80	65.476	ENSGMOG00000011059	trmt6	96	65.476	Gadus_morhua
ENSG00000089195	TRMT6	95	73.950	ENSGALG00000009169	TRMT6	97	73.950	Gallus_gallus
ENSG00000089195	TRMT6	97	57.290	ENSGAFG00000008618	trmt6	98	56.198	Gambusia_affinis
ENSG00000089195	TRMT6	90	58.537	ENSGACG00000012471	trmt6	93	58.537	Gasterosteus_aculeatus
ENSG00000089195	TRMT6	96	75.574	ENSGAGG00000008464	TRMT6	98	75.824	Gopherus_agassizii
ENSG00000089195	TRMT6	100	99.598	ENSGGOG00000008597	TRMT6	100	99.598	Gorilla_gorilla
ENSG00000089195	TRMT6	99	51.964	ENSHBUG00000016631	trmt6	98	54.433	Haplochromis_burtoni
ENSG00000089195	TRMT6	100	87.525	ENSHGLG00000015405	TRMT6	100	87.525	Heterocephalus_glaber_female
ENSG00000089195	TRMT6	100	87.525	ENSHGLG00100004120	TRMT6	100	87.525	Heterocephalus_glaber_male
ENSG00000089195	TRMT6	99	55.183	ENSHCOG00000000118	trmt6	98	57.764	Hippocampus_comes
ENSG00000089195	TRMT6	98	57.585	ENSIPUG00000019365	trmt6	97	61.006	Ictalurus_punctatus
ENSG00000089195	TRMT6	100	90.520	ENSSTOG00000006863	TRMT6	100	90.141	Ictidomys_tridecemlineatus
ENSG00000089195	TRMT6	99	87.475	ENSJJAG00000007315	Trmt6	99	87.475	Jaculus_jaculus
ENSG00000089195	TRMT6	95	57.531	ENSKMAG00000001295	trmt6	97	58.750	Kryptolebias_marmoratus
ENSG00000089195	TRMT6	96	55.602	ENSLBEG00000025654	trmt6	98	55.602	Labrus_bergylta
ENSG00000089195	TRMT6	99	66.801	ENSLACG00000016478	TRMT6	99	66.801	Latimeria_chalumnae
ENSG00000089195	TRMT6	96	65.344	ENSLOCG00000016451	trmt6	97	65.344	Lepisosteus_oculatus
ENSG00000089195	TRMT6	100	91.743	ENSLAFG00000032216	TRMT6	99	90.927	Loxodonta_africana
ENSG00000089195	TRMT6	100	98.592	ENSMFAG00000044360	TRMT6	100	98.592	Macaca_fascicularis
ENSG00000089195	TRMT6	100	98.592	ENSMMUG00000013728	TRMT6	100	98.592	Macaca_mulatta
ENSG00000089195	TRMT6	100	98.390	ENSMNEG00000041831	TRMT6	100	98.390	Macaca_nemestrina
ENSG00000089195	TRMT6	100	98.793	ENSMLEG00000040762	TRMT6	100	98.793	Mandrillus_leucophaeus
ENSG00000089195	TRMT6	96	58.763	ENSMAMG00000012101	trmt6	98	58.763	Mastacembelus_armatus
ENSG00000089195	TRMT6	99	51.662	ENSMZEG00005010771	trmt6	97	54.433	Maylandia_zebra
ENSG00000089195	TRMT6	95	73.950	ENSMGAG00000007678	TRMT6	97	73.950	Meleagris_gallopavo
ENSG00000089195	TRMT6	100	88.330	ENSMAUG00000008719	Trmt6	100	88.330	Mesocricetus_auratus
ENSG00000089195	TRMT6	99	94.769	ENSMICG00000011626	TRMT6	99	94.769	Microcebus_murinus
ENSG00000089195	TRMT6	100	87.324	ENSMOCG00000022320	Trmt6	100	87.324	Microtus_ochrogaster
ENSG00000089195	TRMT6	96	53.750	ENSMMOG00000004412	trmt6	97	53.958	Mola_mola
ENSG00000089195	TRMT6	100	79.719	ENSMODG00000003784	TRMT6	99	79.719	Monodelphis_domestica
ENSG00000089195	TRMT6	96	54.451	ENSMALG00000018140	trmt6	97	54.451	Monopterus_albus
ENSG00000089195	TRMT6	100	84.538	MGP_CAROLIEiJ_G0024344	Trmt6	100	84.538	Mus_caroli
ENSG00000089195	TRMT6	100	85.341	ENSMUSG00000037376	Trmt6	100	85.341	Mus_musculus
ENSG00000089195	TRMT6	100	86.145	MGP_PahariEiJ_G0025789	Trmt6	100	86.145	Mus_pahari
ENSG00000089195	TRMT6	100	85.542	MGP_SPRETEiJ_G0025264	Trmt6	100	85.542	Mus_spretus
ENSG00000089195	TRMT6	87	92.627	ENSMPUG00000006317	TRMT6	93	92.627	Mustela_putorius_furo
ENSG00000089195	TRMT6	100	92.958	ENSMLUG00000006491	TRMT6	100	92.958	Myotis_lucifugus
ENSG00000089195	TRMT6	100	84.404	ENSNGAG00000015251	Trmt6	99	84.959	Nannospalax_galili
ENSG00000089195	TRMT6	96	53.222	ENSNBRG00000020261	trmt6	98	53.222	Neolamprologus_brichardi
ENSG00000089195	TRMT6	100	98.592	ENSNLEG00000013957	TRMT6	100	98.592	Nomascus_leucogenys
ENSG00000089195	TRMT6	85	82.185	ENSMEUG00000009179	TRMT6	100	82.185	Notamacropus_eugenii
ENSG00000089195	TRMT6	100	88.554	ENSOPRG00000008564	TRMT6	100	88.554	Ochotona_princeps
ENSG00000089195	TRMT6	100	88.732	ENSODEG00000005657	TRMT6	100	88.732	Octodon_degus
ENSG00000089195	TRMT6	99	53.313	ENSONIG00000000968	trmt6	98	56.148	Oreochromis_niloticus
ENSG00000089195	TRMT6	99	77.064	ENSOANG00000008403	-	99	80.659	Ornithorhynchus_anatinus
ENSG00000089195	TRMT6	100	92.757	ENSOCUG00000014669	TRMT6	100	92.757	Oryctolagus_cuniculus
ENSG00000089195	TRMT6	96	56.133	ENSORLG00000009862	trmt6	97	55.950	Oryzias_latipes
ENSG00000089195	TRMT6	96	55.187	ENSORLG00020001466	trmt6	97	55.000	Oryzias_latipes_hni
ENSG00000089195	TRMT6	96	55.925	ENSORLG00015015552	trmt6	97	56.133	Oryzias_latipes_hsok
ENSG00000089195	TRMT6	96	53.112	ENSOMEG00000019874	trmt6	97	53.320	Oryzias_melastigma
ENSG00000089195	TRMT6	100	91.365	ENSOGAG00000012950	TRMT6	99	91.365	Otolemur_garnettii
ENSG00000089195	TRMT6	100	93.578	ENSOARG00000017993	TRMT6	100	93.360	Ovis_aries
ENSG00000089195	TRMT6	100	98.996	ENSPPAG00000036809	TRMT6	100	98.996	Pan_paniscus
ENSG00000089195	TRMT6	100	94.190	ENSPPRG00000000424	TRMT6	100	94.165	Panthera_pardus
ENSG00000089195	TRMT6	100	94.190	ENSPTIG00000010629	TRMT6	100	94.165	Panthera_tigris_altaica
ENSG00000089195	TRMT6	100	99.598	ENSPTRG00000013231	TRMT6	100	99.598	Pan_troglodytes
ENSG00000089195	TRMT6	100	98.994	ENSPANG00000009284	TRMT6	100	98.994	Papio_anubis
ENSG00000089195	TRMT6	96	61.088	ENSPKIG00000003441	trmt6	97	59.414	Paramormyrops_kingsleyae
ENSG00000089195	TRMT6	98	74.390	ENSPSIG00000017048	TRMT6	98	74.390	Pelodiscus_sinensis
ENSG00000089195	TRMT6	89	54.828	ENSPMGG00000021074	trmt6	92	59.101	Periophthalmus_magnuspinnatus
ENSG00000089195	TRMT6	100	85.933	ENSPEMG00000023268	Trmt6	100	86.774	Peromyscus_maniculatus_bairdii
ENSG00000089195	TRMT6	100	80.321	ENSPCIG00000001546	TRMT6	96	80.321	Phascolarctos_cinereus
ENSG00000089195	TRMT6	97	56.646	ENSPFOG00000003037	trmt6	98	56.646	Poecilia_formosa
ENSG00000089195	TRMT6	97	56.495	ENSPLAG00000005143	trmt6	98	56.495	Poecilia_latipinna
ENSG00000089195	TRMT6	97	57.873	ENSPMEG00000014875	trmt6	98	57.873	Poecilia_mexicana
ENSG00000089195	TRMT6	97	54.470	ENSPREG00000016227	trmt6	97	54.262	Poecilia_reticulata
ENSG00000089195	TRMT6	100	98.793	ENSPPYG00000010691	TRMT6	100	98.793	Pongo_abelii
ENSG00000089195	TRMT6	100	89.336	ENSPCAG00000012098	TRMT6	100	89.336	Procavia_capensis
ENSG00000089195	TRMT6	100	95.181	ENSPCOG00000020723	TRMT6	100	95.181	Propithecus_coquereli
ENSG00000089195	TRMT6	99	92.638	ENSPVAG00000007539	TRMT6	99	89.718	Pteropus_vampyrus
ENSG00000089195	TRMT6	99	51.368	ENSPNYG00000000918	trmt6	98	54.262	Pundamilia_nyererei
ENSG00000089195	TRMT6	100	56.839	ENSPNAG00000019279	trmt6	96	59.834	Pygocentrus_nattereri
ENSG00000089195	TRMT6	99	85.830	ENSRNOG00000021270	Trmt6	99	85.830	Rattus_norvegicus
ENSG00000089195	TRMT6	100	97.384	ENSRBIG00000031132	TRMT6	100	97.384	Rhinopithecus_bieti
ENSG00000089195	TRMT6	100	98.777	ENSRROG00000045329	TRMT6	100	98.592	Rhinopithecus_roxellana
ENSG00000089195	TRMT6	100	96.942	ENSSBOG00000019803	-	99	97.319	Saimiri_boliviensis_boliviensis
ENSG00000089195	TRMT6	100	97.787	ENSSBOG00000033602	-	100	97.787	Saimiri_boliviensis_boliviensis
ENSG00000089195	TRMT6	99	78.672	ENSSHAG00000010754	TRMT6	97	78.672	Sarcophilus_harrisii
ENSG00000089195	TRMT6	96	62.971	ENSSFOG00015008429	trmt6	97	61.088	Scleropages_formosus
ENSG00000089195	TRMT6	96	56.522	ENSSMAG00000005352	trmt6	98	56.936	Scophthalmus_maximus
ENSG00000089195	TRMT6	96	58.471	ENSSDUG00000008294	trmt6	98	59.298	Seriola_dumerili
ENSG00000089195	TRMT6	96	58.884	ENSSLDG00000002180	trmt6	98	59.298	Seriola_lalandi_dorsalis
ENSG00000089195	TRMT6	100	85.915	ENSSARG00000005487	TRMT6	100	85.915	Sorex_araneus
ENSG00000089195	TRMT6	60	64.039	ENSSPUG00000006759	-	97	64.039	Sphenodon_punctatus
ENSG00000089195	TRMT6	96	57.261	ENSSPAG00000011628	trmt6	98	57.884	Stegastes_partitus
ENSG00000089195	TRMT6	100	93.578	ENSSSCG00000007046	TRMT6	72	93.159	Sus_scrofa
ENSG00000089195	TRMT6	96	73.958	ENSTGUG00000002195	TRMT6	98	75.208	Taeniopygia_guttata
ENSG00000089195	TRMT6	95	54.008	ENSTRUG00000007153	trmt6	97	53.445	Takifugu_rubripes
ENSG00000089195	TRMT6	96	55.992	ENSTNIG00000010726	TRMT6	98	55.992	Tetraodon_nigroviridis
ENSG00000089195	TRMT6	76	94.839	ENSTBEG00000016317	TRMT6	76	94.839	Tupaia_belangeri
ENSG00000089195	TRMT6	100	94.801	ENSTTRG00000012889	TRMT6	100	93.964	Tursiops_truncatus
ENSG00000089195	TRMT6	100	94.190	ENSUAMG00000008674	TRMT6	100	93.964	Ursus_americanus
ENSG00000089195	TRMT6	100	94.366	ENSUMAG00000004999	TRMT6	100	94.366	Ursus_maritimus
ENSG00000089195	TRMT6	100	93.272	ENSVPAG00000002371	TRMT6	100	92.231	Vicugna_pacos
ENSG00000089195	TRMT6	100	93.763	ENSVVUG00000023370	TRMT6	100	93.763	Vulpes_vulpes
ENSG00000089195	TRMT6	96	65.975	ENSXETG00000004501	trmt6	98	65.975	Xenopus_tropicalis
ENSG00000089195	TRMT6	97	52.599	ENSXCOG00000007761	trmt6	98	52.599	Xiphophorus_couchianus
ENSG00000089195	TRMT6	97	56.432	ENSXMAG00000008592	trmt6	98	56.432	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006400	tRNA modification	-	TAS	Process
GO:0016429	tRNA (adenine-N1-)-methyltransferase activity	21873635.	IBA	Function
GO:0030488	tRNA methylation	-	IEA	Process
GO:0031515	tRNA (m1A) methyltransferase complex	21873635.	IBA	Component
GO:0080009	mRNA methylation	29072297.29107537.	IDA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr20	5946458	Silent	NA	V68V	0.35
BLCA	chr20	5942438	Missense_Mutation	NA	K339R	0.6
BLCA	chr20	5944250	Missense_Mutation	NA	I124L	0.43
BLCA	chr20	5950412	5'UTR	rs754193939		0.16
BLCA	chr20	5944027	Nonsense_Mutation	novel	E155*	0.41
BLCA	chr20	5942595	Missense_Mutation	novel	E287K	0.15
BLCA	chr20	5943934	Intron	novel		0.17
BLCA	chr20	5942742	Missense_Mutation	rs544190283	R238W	0.15
BLCA	chr20	5950322	Silent	novel	L28L	0.04
BRCA	chr20	5941107	Silent	NA	E416E	0.22
BRCA	chr20	5938590	Missense_Mutation	novel	H480P	0.04
BRCA	chr20	5942742	Missense_Mutation	rs544190283	R238W	0.13
BRCA	chr20	5944858	Nonsense_Mutation	novel	K105*	0.06
BRCA	chr20	5944868	Silent	novel	G101G	0.09
BRCA	chr20	5938520	3'UTR	rs775785354		0.17
BRCA	chr20	5946474	Missense_Mutation	novel	G63A	0.07	Gcd10p
CESC	chr20	5950429	5'UTR	novel		0.21
CESC	chr20	5943919	Intron	NA		0.57
CESC	chr20	5950429	5'UTR	NA		0.2
CESC	chr20	5938561	Nonsense_Mutation	rs145935378	R490*	0.45
CESC	chr20	5950322	Silent	novel	L28L	0.1
COAD	chr20	5941855	Intron	novel		0.32
COAD	chr20	5943626	Silent	NA	G200G	0.22
COAD	chr20	5941886	Intron	novel		0.24
COAD	chr20	5946515	Frame_Shift_Del	novel	*K49Nfs20**	0.06	Gcd10p
COAD	chr20	5950281	Missense_Mutation	novel	R42K	0.26	Gcd10p
COAD	chr20	5941100	Missense_Mutation	novel	G419W	0.11
COAD	chr20	5944162	Frame_Shift_Del	rs780358338	*K153Nfs9**	0.53
COAD	chr20	5942569	Frame_Shift_Del	NA	*K295Nfs64**	0.37
COAD	chr20	5941959	Silent	novel	N368N	0.19
COAD	chr20	5944214	Nonsense_Mutation	novel	R136*	0.12
COAD	chr20	5943648	Missense_Mutation	rs766405213	T193M	0.48
COAD	chr20	5943847	Intron	novel		0.18
GBM	chr20	5942589	Missense_Mutation	novel	N289D	0.05
GBM	chr20	5944838	Frame_Shift_Del	NA	*I111Kfs9**	0.3
GBM	chr20	5941271	Missense_Mutation	rs574762537	P396L	0.24
HNSC	chr20	5944223	Missense_Mutation	novel	T133A	0.14
HNSC	chr20	5941308	Silent	novel	L384L	0.11
LGG	chr20	5942020	Missense_Mutation	novel	R348M	0.11
LGG	chr20	5946521	Silent	rs374176622	F47F	0.38
LIHC	chr20	5941920	Intron	novel		0.33
LIHC	chr20	5938621	Missense_Mutation	novel	L470F	0.26
LUAD	chr20	5942019	Missense_Mutation	NA	R348S	0.38
LUAD	chr20	5942677	Silent	NA	L259L	0.27
LUAD	chr20	5950334	In_Frame_Del	novel	R19_D24del	0.1	Gcd10p
LUAD	chr20	5941103	Nonsense_Mutation	NA	G418*	0.34
LUAD	chr20	5941892	Intron	novel		0.24
LUAD	chr20	5941252	Missense_Mutation	NA	Q402H	0.17
LUAD	chr20	5941086	Silent	NA	L423L	0.41
LUAD	chr20	5944900	Missense_Mutation	novel	G91C	0.21
LUAD	chr20	5942486	Missense_Mutation	NA	T323I	0.22
LUSC	chr20	5942661	Missense_Mutation	novel	L265F	0.19
LUSC	chr20	5938589	Silent	rs201035404	H480H	0.3
LUSC	chr20	5942493	Missense_Mutation	rs776097806	M321V	0.36
LUSC	chr20	5942022	Missense_Mutation	NA	Q347H	0.16
LUSC	chr20	5942625	Frame_Shift_Del	novel	*L275Ffs10**	0.12
LUSC	chr20	5943849	Intron	novel		1
LUSC	chr20	5943680	Silent	rs752056178	H182H	0.27
LUSC	chr20	5942035	Missense_Mutation	novel	I343T	0.12
LUSC	chr20	5944829	Silent	novel	L114L	0.11
LUSC	chr20	5942569	Silent	novel	K295K	0.51
LUSC	chr20	5942503	Silent	NA	D317D	0.24
OV	chr20	5942005	Frame_Shift_Ins	novel	*Q353Lfs14**	0.03
OV	chr20	5950305	Missense_Mutation	novel	F34S	0.04	Gcd10p
OV	chr20	5950394	Silent	novel	S4S	0.1
PAAD	chr20	5946486	Missense_Mutation	novel	G59D	0.06	Gcd10p
PRAD	chr20	5950405	Translation_Start_Site	NA	M1?	0.19
PRAD	chr20	5943944	Splice_Region	novel		0.21
SARC	chr20	5943915	Intron	novel		0.07
SKCM	chr20	5942761	Silent	rs762964729	Y231Y	0.75
SKCM	chr20	5941874	Intron	novel		0.34
SKCM	chr20	5938533	3'UTR	novel		0.1
SKCM	chr20	5946534	Splice_Site	NA	X43_splice	0.32
SKCM	chr20	5944870	Missense_Mutation	novel	G101W	0.47
SKCM	chr20	5938449	3'UTR	novel		0.46
SKCM	chr20	5946521	Silent	rs374176622	F47F	0.25
STAD	chr20	5950307	Silent	novel	V33V	0.09
STAD	chr20	5943978	Missense_Mutation	NA	M171K	0.25
STAD	chr20	5944167	Missense_Mutation	NA	K151N	0.21
STAD	chr20	5944805	Missense_Mutation	NA	E122D	0.13
STAD	chr20	5944243	Missense_Mutation	novel	Q126L	0.11
STAD	chr20	5942007	Silent	NA	E352E	0.12
STAD	chr20	5943863	Intron	novel		0.21
STAD	chr20	5944162	Frame_Shift_Del	rs780358338	*K153Nfs9**	0.52
TGCT	chr20	5942634	Missense_Mutation	rs760219917	M274V	0.62
THCA	chr20	5942566	Silent	NA	Q296Q	0.24
UCEC	chr20	5946521	Silent	rs374176622	F47F	0.27
UCEC	chr20	5946494	Silent	rs147507376	N56N	0.35
UCEC	chr20	5938666	Missense_Mutation	novel	S455P	0.38
UCEC	chr20	5943648	Missense_Mutation	rs766405213	T193M	0.45
UCEC	chr20	5943633	Missense_Mutation	rs769568000	R198H	0.29
UCEC	chr20	5938553	Silent	novel	C492C	0.37
UCEC	chr20	5941272	Missense_Mutation	novel	P396S	0.06
UCEC	chr20	5942434	Missense_Mutation	novel	K340N	0.2
UCEC	chr20	5941980	Silent	rs754563478	A361A	0.39
UCEC	chr20	5938499	3'UTR	rs781374629		0.38
UCEC	chr20	5938479	3'UTR	novel		0.43
UCEC	chr20	5946494	Silent	rs147507376	N56N	0.42
UCEC	chr20	5946442	Missense_Mutation	novel	L74I	0.5	Gcd10p
UCEC	chr20	5944888	Nonsense_Mutation	novel	R95*	0.06
UCEC	chr20	5942703	Missense_Mutation	novel	L251I	0.3
UCEC	chr20	5942436	Missense_Mutation	rs756068751	K340E	0.39
UCEC	chr20	5943878	Intron	novel		0.32
UCEC	chr20	5938658	Missense_Mutation	novel	F457L	0.52
UCEC	chr20	5944230	Missense_Mutation	novel	E130D	0.24
UCEC	chr20	5950405	Translation_Start_Site	rs766784956	M1?	0.36
UCEC	chr20	5938669	Missense_Mutation	novel	L454I	0.05
UCEC	chr20	5944162	Frame_Shift_Del	rs780358338	*K153Nfs9**	0.61
UCEC	chr20	5942548	Silent	novel	N302N	0.16
UCEC	chr20	5950311	Missense_Mutation	novel	D32G	0.34	Gcd10p
UCEC	chr20	5941932	Intron	novel		0.32
UCEC	chr20	5950491	5'UTR	novel		0.41
UCEC	chr20	5938511	3'UTR	novel		0.41
UCEC	chr20	5946486	Missense_Mutation	NA	G59V	0.07	Gcd10p
UCEC	chr20	5944215	Missense_Mutation	novel	F135L	0.29
UCEC	chr20	5941882	Intron	novel		0.24
UCEC	chr20	5942717	Missense_Mutation	novel	F246S	0.27
UCEC	chr20	5943592	Missense_Mutation	novel	L212V	0.23
UCEC	chr20	5943944	Splice_Region	novel		0.27
UCEC	chr20	5941272	Missense_Mutation	novel	P396S	0.42
UCEC	chr20	5943568	Nonsense_Mutation	novel	R220*	0.28
UCS	chr20	5938725	Missense_Mutation	novel	V435G	0.16

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1333	0.030954
LUAD	DEL	0.1996	0.15188
TGCT	DEL	0.1867	0.14117

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0068	Kaplan-Meier Survival Analysis
MESO	0.023	Kaplan-Meier Survival Analysis
ACC	0.021	Kaplan-Meier Survival Analysis
ESCA	0.033	Kaplan-Meier Survival Analysis
KIRP	0.0048	Kaplan-Meier Survival Analysis
COAD	0.019	Kaplan-Meier Survival Analysis
READ	0.00063	Kaplan-Meier Survival Analysis
LAML	0.0045	Kaplan-Meier Survival Analysis
UCEC	0.048	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LGG	0.00037	Kaplan-Meier Survival Analysis
LUAD	0.048	Kaplan-Meier Survival Analysis