EuRBPDB

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  • RBDs
  • RBPome
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Description
Ensembl ID
ENSG00000089280 (Gene tree)
Gene ID
2521
Gene Symbol
FUS
Alias
TLS|FUS1|hnRNP-P2|HNRNPP2|ALS6
Full Name
FUS RNA binding protein
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
15,168 bases
Position
chr16:31,179,704-31,194,871
Accession
4010
RBP type
canonical RBP
Summary
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000369594zf-RanBPPF00641.181.5e-1111
ENSP00000254108zf-RanBPPF00641.181.5e-1111
ENSP00000455282zf-RanBPPF00641.181.5e-1111
ENSP00000254108RRM_1PF00076.222.1e-1011
ENSP00000369594RRM_1PF00076.222.1e-1011
ENSP00000455282RRM_1PF00076.222.2e-1011
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
28980860 behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.Autophagy2017Uversky VNdoi: 10.1080/15548627.2017.1384889
9000615Molecular cloning and subcellular localisation of the snRNP-associated protein 69KD, a structural homologue of the proto-oncoproteins TLS and EWS with RNA and DNA-binding properties.J Mol Biol1996 Dec 20Hackl W-
27033831Mechanisms of FUS mutations in familial amyotrophic lateral sclerosis.Brain Res2016 Sep 15Shang Ydoi: 10.1016/j.brainres.2016.03.036
23257289RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations.Hum Mol Genet2013 Mar 15Daigle JGdoi: 10.1093/hmg/dds526
21256132Characterization of a family of RanBP2-type zinc fingers that can recognize single-stranded RNA.J Mol Biol2011 Mar 25Nguyen CDdoi: 10.1016/j.jmb.2010.12.041
28090150M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b.Mediators Inflamm2016Parisi Cdoi: 10.1155/2016/2989548
23474849RNA dysfunction and aggrephagy at the centre of an amyotrophic lateral sclerosis/frontotemporal dementia disease continuum.Brain2013 MayThomas Mdoi: 10.1093/brain/awt030
9440806TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors.Mol Endocrinol1998 JanPowers CA-
30939964Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation.Autophagy2019 Apr 2:1-19Catanese Adoi: 10.1080/15548627.2019.1589257
8890175hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II.EMBO J1996 Sep 16Bertolotti A-
31309752[Identification of differentially expressed genes in peripheral blood mononuclear cells of patients with hepatocellular carcinoma and its regulatory network analysis].Zhejiang Da Xue Xue Bao Yi Xue Ban2019 Apr 25Lun Y-
18509338Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.Nature2008 Jul 3Wang Xdoi: 10.1038/nature06992
23975767catRAPID omics: a web server for large-scale prediction of protein-RNA interactions.Bioinformatics2013 Nov 15Agostini Fdoi: 10.1093/bioinformatics/btt495
31132467Cytoplasmic functions of TDP-43 and FUS and their role in ALS.Semin Cell Dev Biol2019 Jun 4Birsa Ndoi: 10.1016/j.semcdb.2019.05.023
9795213Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.Gene1998 Oct 23Morohoshi F-
8954779Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins.Genomics1996 Nov 15Morohoshi F-
7970732TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain.Oncogene1994 DecPrasad DD-
7623847Association of SARFH (sarcoma-associated RNA-binding fly homolog) with regions of chromatin transcribed by RNA polymerase II.Mol Cell Biol1995 AugImmanuel D-
10602519Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11).Oncogene1999 Dec 9Panagopoulos I-
19593125Recent advances in motor neuron disease.Curr Opin Neurol2009 OctVan Damme Pdoi: 10.1097/WCO.0b013e32832ffbe3.
22079416Neurodegeneration the RNA way.Prog Neurobiol2012 MayRenoux AJdoi: 10.1016/j.pneurobio.2011.10.006
23280309RNA-mediated toxicity in neurodegenerative disease.Mol Cell Neurosci2013 SepBelzil VVdoi: 10.1016/j.mcn.2012.12.006
28072389Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106.Elife2017 Jan 10Celona Bdoi: 10.7554/eLife.19032.
26056265Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1.Proc Natl Acad Sci U S A2015 Jun 23Barmada SJdoi: 10.1073/pnas.1509744112
29866190A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy.J Hematol Oncol2018 Jun 4Liu Cdoi: 10.1186/s13045-018-0619-z.
29916022Mechanisms Associated with TDP-43 Neurotoxicity in ALS/FTLD.Adv Neurobiol2018Shenouda Mdoi: 10.1007/978-3-319-89689-2_9.
11098054Identification of an RNA binding specificity for the potential splicing factor TLS.J Biol Chem2001 Mar 2Lerga A-
23046583Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.Mol Neurodegener2012 Oct 10Verbeeck Cdoi: 10.1186/1750-1326-7-53.
22444279Misregulated RNA processing in amyotrophic lateral sclerosis.Brain Res2012 Jun 26Polymenidou Mdoi: 10.1016/j.brainres.2012.02.059
22342159FUS-related proteinopathies: lessons from animal models.Brain Res2012 Jun 26Lanson NA Jrdoi: 10.1016/j.brainres.2012.01.039
23834335FUsed in sarcoma is a novel regulator of manganese superoxide dismutase gene transcription.Antioxid Redox Signal2014 Apr 1Dhar SKdoi: 10.1089/ars.2012.4984
24268778RNA seeds higher-order assembly of FUS protein.Cell Rep2013 Nov 27Schwartz JCdoi: 10.1016/j.celrep.2013.11.017
27252488Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants.EMBO J2016 Jul 15Reber Sdoi: 10.15252/embj.201593791
29774215Importance of Functional Loss of FUS in FTLD/ALS.Front Mol Biosci2018 May 3Ishigaki Sdoi: 10.3389/fmolb.2018.00044
30736838FUS/circ_002136/miR-138-5p/SOX13 feedback loop regulates angiogenesis in Glioma.J Exp Clin Cancer Res2019 Feb 8He Zdoi: 10.1186/s13046-019-1065-7.
27838743Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis.Cell Mol Life Sci2017 AprSantamaria Ndoi: 10.1007/s00018-016-2416-6
23041957How do the RNA-binding proteins TDP-43 and FUS relate to amyotrophic lateral sclerosis and frontotemporal degeneration, and to each other?Curr Opin Neurol2012 DecBaloh RHdoi: 10.1097/WCO.0b013e32835a269b.
22934129Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain.Sci Rep2012Rogelj Bdoi: 10.1038/srep00603
22113303Promoter-associated noncoding RNA from the CCND1 promoter.Methods Mol Biol2012Song Xdoi: 10.1007/978-1-61779-376-9_39.
21956718Conjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUS.Neurology2011 Oct 25Ito Ddoi: 10.1212/WNL.0b013e3182343365
21487023A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43.Hum Mol Genet2011 Jul 1Lanson NA Jrdoi: 10.1093/hmg/ddr150
21412718RNA-binding proteins and RNA metabolism: a new scenario in the pathogenesis of Amyotrophic lateral sclerosis.Arch Ital Biol2011 MarColombrita Cdoi: 10.4449/aib.v149i1.1261.
23172908Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models.Hum Mol Genet2013 Feb 15Tauffenberger Adoi: 10.1093/hmg/dds485
23196570[Conjoint pathological cascades mediated by RNA-binding proteins, TDP-43, FUS and ataxin-2].Rinsho Shinkeigaku2012Ito D-
24013423Recruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasm.Cell Cycle2013 Oct 1Shelkovnikova TAdoi: 10.4161/cc.26241
23431168Reactive astrocytes secrete lcn2 to promote neuron death.Proc Natl Acad Sci U S A2013 Mar 5Bi Fdoi: 10.1073/pnas.1218497110
28265061Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons.Proc Natl Acad Sci U S A2017 Mar 21Gopal PPdoi: 10.1073/pnas.1614462114
27368346Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice.Brain2016 SepShiihashi Gdoi: 10.1093/brain/aww161
27015757Physiological functions and pathobiology of TDP-43 and FUS/TLS proteins.J Neurochem2016 AugRatti Adoi: 10.1111/jnc.13625
30367664Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease.Acta Neuropathol Commun2018 Oct 26Sengupta Udoi: 10.1186/s40478-018-0615-0.
30486313Perturbations in Traffic: Aberrant Nucleocytoplasmic Transport at the Heart of Neurodegeneration.Cells2018 Nov 26Fahrenkrog Bdoi: 10.3390/cells7120232.
9506449Localization and characterization of the RNA binding protein TLS in skin and stratified mucosa.J Invest Dermatol1998 MarChampliaud MF-
15843054Delocalization of the multifunctional RNA splicing factor TLS/FUS in hippocampal neurones: exclusion from the nucleus and accumulation in dendritic granules and spine heads.Neurosci Lett2005 May 13Belly A-
15094065Stimulation of hTAFII68 (NTD)-mediated transactivation by v-Src.FEBS Lett2004 Apr 23Lee HJ-
22608070Rodent models of TDP-43: recent advances.Brain Res2012 Jun 26Tsao Wdoi: 10.1016/j.brainres.2012.04.031
22563080Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43).J Biol Chem2012 Jun 29Bentmann Edoi: 10.1074/jbc.M111.328757
23301088RNA-Seq profiling of spinal cord motor neurons from a presymptomatic SOD1 ALS mouse.PLoS One2013Bandyopadhyay Udoi: 10.1371/journal.pone.0053575
22065782A yeast functional screen predicts new candidate ALS disease genes.Proc Natl Acad Sci U S A2011 Dec 27Couthouis Jdoi: 10.1073/pnas.1109434108
22081015RNA targets of wild-type and mutant FET family proteins.Nat Struct Mol Biol2011 Nov 13Hoell JIdoi: 10.1038/nsmb.2163.
20864052TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia.Lancet Neurol2010 OctMackenzie IRdoi: 10.1016/S1474-4422(10)70195-2.
20541619Fused in sarcoma/translocated in liposarcoma: a multifunctional DNA/RNA binding protein.Int J Biochem Cell Biol2010 SepYang Sdoi: 10.1016/j.biocel.2010.06.003
20349096RNA processing pathways in amyotrophic lateral sclerosis.Neurogenetics2010 Julvan Blitterswijk Mdoi: 10.1007/s10048-010-0239-4
28358055FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons.Nat Commun2017 Mar 30Errichelli Ldoi: 10.1038/ncomms14741.
25503099 [FEBS Open Bio 4 (2014) 1-10].FEBS Open Bio2014 Nov 22Honda Ddoi: 10.1016/j.fob.2014.11.007
25338097Presynaptic localization of Smn and hnRNP R in axon terminals of embryonic and postnatal mouse motoneurons.PLoS One2014 Oct 22Dombert Bdoi: 10.1371/journal.pone.0110846
25289647Functions of FUS/TLS from DNA repair to stress response: implications for ALS.ASN Neuro2014 Jun 1Sama RRdoi: 10.1177/1759091414544472.
25173930Aggregation of ALS-linked FUS mutant sequesters RNA binding proteins and impairs RNA granules formation.Biochem Biophys Res Commun2014 Sep 26Takanashi Kdoi: 10.1016/j.bbrc.2014.08.115
24353314NKAP is a novel RS-related protein that interacts with RNA and RNA binding proteins.Nucleic Acids Res2014 MarBurgute BDdoi: 10.1093/nar/gkt1311
24319651The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons.FEBS Open Bio2013 Nov 20Honda Ddoi: 10.1016/j.fob.2013.11.001
23474818ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules.Hum Mol Genet2013 Jul 1Vance Cdoi: 10.1093/hmg/ddt117
27600654Pathogenesis of FUS-associated ALS and FTD: insights from rodent models.Acta Neuropathol Commun2016 Sep 6Nolan Mdoi: 10.1186/s40478-016-0358-8.
27151080Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts.Acta Neuropathol Commun2016 May 5Onesto Edoi: 10.1186/s40478-016-0316-5.
26514432From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.Biochim Biophys Acta2015 DecColombrita Cdoi: 10.1016/j.bbagrm.2015.10.015
26461404Oxidative stress affects FET proteins localization and alternative pre-mRNA processing in cellular models of ALS.Free Radic Biol Med2014 OctSvetoni Fdoi: 10.1016/j.freeradbiomed.2014.10.820
26102026A phosphomimetic mutant TDP-43 (S409/410E) induces Drosha instability and cytotoxicity in Neuro 2A cells.Biochem Biophys Res Commun2015 Aug 14Kim KYdoi: 10.1016/j.bbrc.2015.06.125
28707655[The FUS protein: Physiological functions and a role in amyotrophic lateral sclerosis].Mol Biol (Mosk)2017 May-JunEfimova ADdoi: 10.7868/S0026898417020094.
28860970Failure to Deliver and Translate-New Insights into RNA Dysregulation in ALS.Front Cell Neurosci2017 Aug 17Coyne ANdoi: 10.3389/fncel.2017.00243
29610493Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation.Nat Struct Mol Biol2018 AprLuo Fdoi: 10.1038/s41594-018-0050-8
29728455Microtubules as platforms for probing liquid-liquid phase separation in cells - application to RNA-binding proteins.J Cell Sci2018 Jun 11Maucuer Adoi: 10.1242/jcs.214692.
30308519A FUS-LATS1/2 Axis Inhibits Hepatocellular Carcinoma Progression via Activating Hippo Pathway.Cell Physiol Biochem2018Bao Ldoi: 10.1159/000494155
30375034Does ALS-FUS without FUS mutation represent ALS-FET? Report of three cases.Neuropathol Appl Neurobiol2019 JunBorrego-ecija Sdoi: 10.1111/nan.12527
30581145The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity.Mol Cell2019 Feb 7Loughlin FEdoi: 10.1016/j.molcel.2018.11.012
31022909Fused in Sarcoma: Properties, Self-Assembly and Correlation with Neurodegenerative Diseases.Molecules2019 Apr 24Chen Cdoi: 10.3390/molecules24081622.
31272829Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD.Neuron2019 Jun 18Fang MYdoi: 10.1016/j.neuron.2019.05.048
8510758Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.Nature1993 Jun 17Crozat A-
7987849Characterization of the CHOP breakpoints and fusion transcripts in myxoid liposarcomas with the 12;16 translocation.Cancer Res1994 Dec 15Panagopoulos I-
19781443Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics.Cancer Genet Cytogenet2009 Oct 15Kim Jdoi: 10.1016/j.cancergencyto.2009.06.010.
23389473FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved introns.RNA2013 AprNakaya Tdoi: 10.1261/rna.037804.112
22261247FET proteins in frontotemporal dementia and amyotrophic lateral sclerosis.Brain Res2012 Jun 26Mackenzie IRdoi: 10.1016/j.brainres.2011.12.010
23291981Characterization of Ewing sarcoma associated cancer/testis antigens.Cancer Biol Ther2013 MarMahlendorf DEdoi: 10.4161/cbt.23298
20720006Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.J Biol Chem2010 Oct 29Kim SHdoi: 10.1074/jbc.M110.154831
20624952ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.Proc Natl Acad Sci U S A2010 Jul 27Ling SCdoi: 10.1073/pnas.1008227107
25453086Self-assembled FUS binds active chromatin and regulates gene transcription.Proc Natl Acad Sci U S A2014 Dec 16Yang Ldoi: 10.1073/pnas.1414004111
24716897The voltage-gated calcium channel blocker lomerizine is neuroprotective in motor neurons expressing mutant SOD1, but not TDP-43.J Neurochem2014 AugTran LTdoi: 10.1111/jnc.12738
27632209Mutation Frequency of the Major Frontotemporal Dementia Genes, MAPT, GRN and C9ORF72 in a Turkish Cohort of Dementia Patients.PLoS One2016 Sep 15Guven Gdoi: 10.1371/journal.pone.0162592
23835137The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis.Mol Brain2013 Jul 8Nishimoto Ydoi: 10.1186/1756-6606-6-31.
23644307Protein aggregates and regional disease spread in ALS is reminiscent of prion-like pathogenesis.Neurol India2013 Mar-AprVerma Adoi: 10.4103/0028-3886.111109.
25792726Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations.Hum Mol Genet2015 Jun 15Finelli MJdoi: 10.1093/hmg/ddv104
28575444Intrinsically disordered RGG/RG domains mediate degenerate specificity in RNA binding.Nucleic Acids Res2017 Jul 27Ozdilek BAdoi: 10.1093/nar/gkx460.
30287867Long noncoding RNA Meg3 regulates cardiomyocyte apoptosis in myocardial infarction.Gene Ther2018 DecWu Hdoi: 10.1038/s41434-018-0045-4
7493135The emerging molecular genetics of sarcoma translocations.Diagn Mol Pathol1995 SepLadanyi M-
10220412Induction of a secreted protein by the myxoid liposarcoma oncogene.Proc Natl Acad Sci U S A1999 Apr 27Kuroda M-
9687511TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis.EMBO J1998 Aug 3Perrotti D-
9478924The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS.J Biol Chem1998 Feb 27Hallier M-
9341188The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain.J Biol Chem1997 Oct 24Deloulme JC-
10448063CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability.Biochem Biophys Res Commun1999 Aug 19Ubeda M-
9053842A topogenic role for the oncogenic N-terminus of TLS: nucleolar localization when transcription is inhibited.Oncogene1997 Jan 30Zinszner H-
8187069An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation.Cancer Res1994 Jun 1Ichikawa H-
7958914A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP.Genes Dev1994 Nov 1Zinszner H-
7708500Cabeza, a Drosophila gene encoding a novel RNA binding protein, shares homology with EWS and TLS, two genes involved in human sarcoma formation.Nucleic Acids Res1995 Mar 11Stolow DT-
12907633FUS/ERG gene fusions in Ewing's tumors.Cancer Res2003 Aug 1Shing DC-
12476304Post-transcriptional mechanisms in BCR/ABL leukemogenesis: role of shuttling RNA-binding proteins.Oncogene2002 Dec 9Perrotti D-
11162437A novel FUS/CHOP chimera in myxoid liposarcoma.Biochem Biophys Res Commun2000 Dec 29Panagopoulos I-
10654943Male sterility and enhanced radiation sensitivity in TLS(-/-) mice.EMBO J2000 Feb 1Kuroda M-
16230076Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing.Gastroenterology2005 OctSato S-
15797031The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology.Curr Biol2005 Mar 29Fujii R-
15299008Domain architectures and characterization of an RNA-binding protein, TLS.J Biol Chem2004 Oct 22Iko Y-
16769671TLS, EWS and TAF15: a model for transcriptional integration of gene expression.Brief Funct Genomic Proteomic2006 MarLaw WJ-
14595851Naphthalene exposure: effects on gene expression and proliferation in human cord blood cells.J Biochem Mol Toxicol2003Diodovich C-
23128393TAF15 is important for cellular proliferation and regulates the expression of a subset of cell cycle genes through miRNAs.Oncogene2013 Sep 26Ballarino Mdoi: 10.1038/onc.2012.490
19833157The RNA-binding protein FUS/TLS is a common aggregate-interacting protein in polyglutamine diseases.Neurosci Res2010 JanDoi Hdoi: 10.1016/j.neures.2009.10.004
19558455A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus.J Neurochem2009 SepTakarada Tdoi: 10.1111/j.1471-4159.2009.06225.x
23048034Roles of ataxin-2 in pathological cascades mediated by TAR DNA-binding protein 43 (TDP-43) and Fused in Sarcoma (FUS).J Biol Chem2012 Nov 30Nihei Ydoi: 10.1074/jbc.M112.398099
23049996Gene expression responses to FUS, EWS, and TAF15 reduction and stress granule sequestration analyses identifies FET-protein non-redundant functions.PLoS One2012Blechingberg Jdoi: 10.1371/journal.pone.0046251
19303844Rethinking ALS: the FUS about TDP-43.Cell2009 Mar 20Lagier-Tourenne Cdoi: 10.1016/j.cell.2009.03.006.
23022481FUS-SMN protein interactions link the motor neuron diseases ALS and SMA.Cell Rep2012 Oct 25Yamazaki Tdoi: 10.1016/j.celrep.2012.08.025
22993125The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients.Acta Neuropathol2012 NovCollins Mdoi: 10.1007/s00401-012-1045-x
18776329Identification of RNA binding specificity for the TET-family proteins.Nucleic Acids Symp Ser (Oxf)2008Takahama Kdoi: 10.1093/nass/nrn108.
18620564The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response.BMC Cell Biol2008 Jul 11Andersson MKdoi: 10.1186/1471-2121-9-37.
22961620Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion.Acta Neuropathol2013 FebMitchell JCdoi: 10.1007/s00401-012-1043-z
18453593The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (csf1r) gene.J Immunol2008 May 15Hume DA-
18167354RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells.J Biol Chem2008 Mar 7Doi Hdoi: 10.1074/jbc.M705306200
17633521[Spine biology in psychiatric diseases].Nihon Shinkei Seishin Yakurigaku Zasshi2007 JunTakumi T-
22842875Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.Acta Neuropathol2012 NovNeumann Mdoi: 10.1007/s00401-012-1020-6
22848727Methylene blue protects against TDP-43 and FUS neuronal toxicity in C. elegans and D. rerio.PLoS One2012Vaccaro Adoi: 10.1371/journal.pone.0042117
17363515From mRNA metabolism to cancer therapy: chronic myelogenous leukemia shows the way.Clin Cancer Res2007 Mar 15Perrotti D-
22829983Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions.Sci Rep2012Ishigaki Sdoi: 10.1038/srep00529
22771914Domains involved in TAF15 subcellular localisation: dependence on cell type and ongoing transcription.Gene2012 Sep 15Marko Mdoi: 10.1016/j.gene.2012.06.088
22792076TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans.PLoS Genet2012 JulVaccaro Adoi: 10.1371/journal.pgen.1002806
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31039132HPV shapes tumor transcriptome by globally modifying the pool of RNA binding protein-binding motif.Aging (Albany NY)2019 Apr 29Wu Ydoi: 10.18632/aging.101927.
31092554The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing.J Biol Chem2019 Jun 28Tischbein Mdoi: 10.1074/jbc.RA118.005933
31171724Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma.J Biol Chem2019 Jul 19Ryan JJdoi: 10.1074/jbc.RA119.009494
31242416Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis.Cell Rep2019 Jun 25De Santis Rdoi: 10.1016/j.celrep.2019.05.085.
31270472Molecular interactions underlying liquid-liquid phase separation of the FUS low-complexity domain.Nat Struct Mol Biol2019 JulMurthy ACdoi: 10.1038/s41594-019-0250-x
31290213Parkin expression reverses mitochondrial dysfunction in fused in sarcoma-induced amyotrophic lateral sclerosis.Insect Mol Biol2019 Jul 10Cha SJdoi: 10.1111/imb.12608
30808650FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I-induced DNA breakage and transcriptional stress.Life Sci Alliance2019 Feb 26Martinez-Macias MIdoi: 10.26508/lsa.201800222
21881207The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span.J Clin Invest2011 OctWang JWdoi: 10.1172/JCI57883
12168660RNA splicing mediated by YB-1 is inhibited by TLS/CHOP in human myxoid liposarcoma cells.J Orthop Res2002 JulRapp TB-
18954305Structural basis and specificity of human otubain 1-mediated deubiquitination.Biochem J2009 Mar 1Edelmann MJdoi: 10.1042/BJ20081318.
26816614The binding specificity of Translocated in LipoSarcoma/FUsed in Sarcoma with lncRNA transcribed from the promoter region of cyclin D1.Cell Biosci2016 Jan 25Yoneda Rdoi: 10.1186/s13578-016-0068-8
28421535MicroRNA Metabolism and Dysregulation in Amyotrophic Lateral Sclerosis.Mol Neurobiol2018 MarRinchetti Pdoi: 10.1007/s12035-017-0537-z
15312650Kinesin transports RNA: isolation and characterization of an RNA-transporting granule.Neuron2004 Aug 19Kanai Y-
14709340Translocated in liposarcoma (TLS) is a substrate for fibroblast growth factor receptor-1.Cell Signal2004 AprKlint P-
21603978FUS immunogold labeling TEM analysis of the neuronal cytoplasmic inclusions of neuronal intermediate filament inclusion disease: a frontotemporal lobar degeneration with FUS proteinopathy.J Mol Neurosci2011 NovPage Tdoi: 10.1007/s12031-011-9549-8
21287132Long noncoding RNA as a regulator for transcription.Prog Mol Subcell Biol2011Kurokawa Rdoi: 10.1007/978-3-642-16502-3_2.
21109527Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations.Nucleic Acids Res2011 AprKino Ydoi: 10.1093/nar/gkq1162
20400460TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration.Hum Mol Genet2010 Apr 15Lagier-Tourenne Cdoi: 10.1093/hmg/ddq137
20406185Neuronal death in amyotrophic lateral sclerosis (ALS): what can we learn from genetics?CNS Neurol Disord Drug Targets2010 JulSreedharan J-
25501833A loss of FUS/TLS function leads to impaired cellular proliferation.Cell Death Dis2014 Dec 11Ward CLdoi: 10.1038/cddis.2014.508.
24509083ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.J Clin Invest2014 MarQiu Hdoi: 10.1172/JCI72723
24251952Specific binding of modified RGG domain in TLS/FUS to G-quadruplex RNA: tyrosines in RGG domain recognize 2'-OH of the riboses of loops in G-quadruplex.J Am Chem Soc2013 Dec 4Takahama Kdoi: 10.1021/ja4086929
24036913Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons.Nat Neurosci2013 OctWang WYdoi: 10.1038/nn.3514
27164932Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways.Acta Neuropathol2016 AugBlokhuis AMdoi: 10.1007/s00401-016-1575-8
26360301G-Quadruplex DNA- and RNA-Specific-Binding Proteins Engineered from the RGG Domain of TLS/FUS.ACS Chem Biol2015 Nov 20Takahama Kdoi: 10.1021/acschembio.5b00566
26251528ALS mutations in TLS/FUS disrupt target gene expression.Genes Dev2015 Aug 15Coady THdoi: 10.1101/gad.267286.115
25995189Position-specific binding of FUS to nascent RNA regulates mRNA length.Genes Dev2015 May 15Masuda Adoi: 10.1101/gad.255737.114.
25968143FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization.Nat Commun2015 May 13Udagawa Tdoi: 10.1038/ncomms8098.
25949136Fus expression patterns in developing tooth.Dev Reprod2013 SepKim EJdoi: 10.12717/DR.2013.17.3.215.
30206235Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis.Nat Commun2018 Sep 11Wang Hdoi: 10.1038/s41467-018-06111-6.
30398641The neurodegenerative diseases ALS and SMA are linked at the molecular level via the ASC-1 complex.Nucleic Acids Res2018 Dec 14Chi Bdoi: 10.1093/nar/gky1093.
30488693Transcription-Dependent Formation of Nuclear Granules Containing FUS and RNA Pol II.Biochemistry2018 Dec 26Thompson VFdoi: 10.1021/acs.biochem.8b01097
30770445Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects.Proc Natl Acad Sci U S A2019 Feb 15Mitra Jdoi: 10.1073/pnas.1818415116
31217692New Mechanisms of DNA Repair Defects in Fused in Sarcoma-Associated Neurodegeneration: Stage Set for DNA Repair-Based Therapeutics?J Exp Neurosci2019 Jun 10Wang Hdoi: 10.1177/1179069519856358
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000568901FUS-211521--- (aa)--
ENST00000487045FUS-205952--- (aa)--
ENST00000254108FUS-2015119XM_011545781ENSP00000254108526 (aa)XP_011544083P35637
ENST00000380244FUS-2021818XM_005255233ENSP00000369594525 (aa)XP_005255290P35637
ENST00000568685FUS-2101785-ENSP00000455282527 (aa)-H3BPE7
ENST00000487974FUS-207643--- (aa)--
ENST00000487509FUS-2064920--- (aa)--
ENST00000570090FUS-213544--- (aa)--
ENST00000564766FUS-208791--- (aa)--
ENST00000569760FUS-212639--- (aa)--
ENST00000483853FUS-204778--- (aa)--
ENST00000474990FUS-203827--- (aa)--
ENST00000566605FUS-2091787-ENSP00000455073263 (aa)-H3BNZ4
Gene Model
Click here to download ENSG00000089280's gene model file
Pathways
Pathway IDPathway NameSource
hsa05202Transcriptional misregulation in cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000089280Platelet Function Tests1.6900000E-006-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000089280's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000089280FUS57100.000ENSAMEG00000007181FUS5290.189Ailuropoda_melanoleuca
ENSG00000089280FUS5065.809ENSAPEG00000006451fus5066.300Amphiprion_percula
ENSG00000089280FUS6983.957ENSANAG00000021591-50100.000Aotus_nancymaae
ENSG00000089280FUS7186.631ENSBTAG00000005757FUS52100.000Bos_taurus
ENSG00000089280FUS9990.737ENSCJAG00000003169FUS51100.000Callithrix_jacchus
ENSG00000089280FUS7087.166ENSCAFG00000016862FUS5199.245Canis_familiaris
ENSG00000089280FUS7082.888ENSCAFG00020018210FUS5299.623Canis_lupus_dingo
ENSG00000089280FUS6191.925ENSCHIG00000004508FUS52100.000Capra_hircus
ENSG00000089280FUS50100.000ENSTSYG00000011757FUS52100.000Carlito_syrichta
ENSG00000089280FUS63100.000ENSCPOG00000038302FUS96100.000Cavia_porcellus
ENSG00000089280FUS6192.025ENSCCAG00000019778FUS51100.000Cebus_capucinus
ENSG00000089280FUS6295.679ENSCATG00000034413FUS50100.000Cercocebus_atys
ENSG00000089280FUS10095.085ENSCLAG00000010457FUS10095.085Chinchilla_lanigera
ENSG00000089280FUS6290.741ENSCSAG00000005711FUS50100.000Chlorocebus_sabaeus
ENSG00000089280FUS10094.329ENSCGRG00001016216Fus10094.329Cricetulus_griseus_chok1gshd
ENSG00000089280FUS7090.909ENSCGRG00000012106Fus9687.195Cricetulus_griseus_crigri
ENSG00000089280FUS7086.631ENSDNOG00000017091FUS5199.623Dasypus_novemcinctus
ENSG00000089280FUS7090.909ENSDORG00000014218Fus5199.623Dipodomys_ordii
ENSG00000089280FUS10087.879ENSEASG00005011180-5192.481Equus_asinus_asinus
ENSG00000089280FUS10085.227ENSEEUG00000004934FUS10085.227Erinaceus_europaeus
ENSG00000089280FUS5099.623ENSFCAG00000027928FUS5199.623Felis_catus
ENSG00000089280FUS6987.432ENSFDAG00000007552FUS5799.242Fukomys_damarensis
ENSG00000089280FUS10098.482ENSGGOG00000003707FUS10098.482Gorilla_gorilla
ENSG00000089280FUS63100.000ENSHGLG00000017008-96100.000Heterocephalus_glaber_female
ENSG00000089280FUS63100.000ENSHGLG00100006254-96100.000Heterocephalus_glaber_male
ENSG00000089280FUS10093.774ENSJJAG00000011802Fus96100.000Jaculus_jaculus
ENSG00000089280FUS10080.943ENSLAFG00000001643FUS96100.000Loxodonta_africana
ENSG00000089280FUS6295.679ENSMMUG00000019637FUS55100.000Macaca_mulatta
ENSG00000089280FUS10094.259ENSMNEG00000027646FUS10094.259Macaca_nemestrina
ENSG00000089280FUS10096.395ENSMLEG00000038040FUS10096.395Mandrillus_leucophaeus
ENSG00000089280FUS7090.374ENSMAUG00000009599Fus9696.262Mesocricetus_auratus
ENSG00000089280FUS10093.750ENSMICG00000033962FUS10093.750Microcebus_murinus
ENSG00000089280FUS10094.329ENSMOCG00000006871-10094.329Microtus_ochrogaster
ENSG00000089280FUS8289.362ENSMOCG00000019180-5095.259Microtus_ochrogaster
ENSG00000089280FUS10090.566ENSMODG00000001889FUS5098.868Monodelphis_domestica
ENSG00000089280FUS10094.518MGP_CAROLIEiJ_G0030533Fus10099.038Mus_caroli
ENSG00000089280FUS10094.707ENSMUSG00000030795Fus9999.038Mus_musculus
ENSG00000089280FUS10094.518MGP_PahariEiJ_G0013740Fus10099.038Mus_pahari
ENSG00000089280FUS10094.518MGP_SPRETEiJ_G0031647Fus10099.038Mus_spretus
ENSG00000089280FUS5799.623ENSMPUG00000011426-5199.623Mustela_putorius_furo
ENSG00000089280FUS5099.245ENSMLUG00000004806-5299.245Myotis_lucifugus
ENSG00000089280FUS5093.962ENSNGAG00000023361-9696.262Nannospalax_galili
ENSG00000089280FUS9995.810ENSNLEG00000016218FUS10095.810Nomascus_leucogenys
ENSG00000089280FUS5697.872ENSMEUG00000000968FUS5797.872Notamacropus_eugenii
ENSG00000089280FUS50100.000ENSODEG00000015325-51100.000Octodon_degus
ENSG00000089280FUS10081.439ENSODEG00000007263-5290.226Octodon_degus
ENSG00000089280FUS5095.849ENSOANG00000005606FUS5189.434Ornithorhynchus_anatinus
ENSG00000089280FUS10076.525ENSOCUG00000021526FUS5279.931Oryctolagus_cuniculus
ENSG00000089280FUS6853.425ENSORLG00020014824-5456.929Oryzias_latipes_hni
ENSG00000089280FUS6852.877ENSORLG00015022673-5456.554Oryzias_latipes_hsok
ENSG00000089280FUS10098.861ENSPPAG00000029090FUS10098.861Pan_paniscus
ENSG00000089280FUS7090.323ENSPPRG00000004170FUS5199.623Panthera_pardus
ENSG00000089280FUS7090.323ENSPTIG00000012151FUS5198.868Panthera_tigris_altaica
ENSG00000089280FUS10098.677ENSPTRG00000008038FUS10098.677Pan_troglodytes
ENSG00000089280FUS7092.432ENSPANG00000021275FUS50100.000Papio_anubis
ENSG00000089280FUS7090.909ENSPEMG00000023119Fus5198.491Peromyscus_maniculatus_bairdii
ENSG00000089280FUS10091.082ENSPPYG00000007311FUS10091.082Pongo_abelii
ENSG00000089280FUS6785.994ENSPCAG00000007167FUS5286.339Procavia_capensis
ENSG00000089280FUS6281.098ENSPCOG00000022295FUS9599.623Propithecus_coquereli
ENSG00000089280FUS7079.570ENSPVAG00000003097FUS5298.864Pteropus_vampyrus
ENSG00000089280FUS7090.909ENSRNOG00000023360Fus5198.113Rattus_norvegicus
ENSG00000089280FUS10096.964ENSRBIG00000042196FUS10096.964Rhinopithecus_bieti
ENSG00000089280FUS10088.469ENSSBOG00000034540FUS50100.000Saimiri_boliviensis_boliviensis
ENSG00000089280FUS8188.346ENSSHAG00000011874FUS5687.970Sarcophilus_harrisii
ENSG00000089280FUS7351.000ENSSPUG00000007180-5362.814Sphenodon_punctatus
ENSG00000089280FUS7089.785ENSSSCG00000030798FUS5399.623Sus_scrofa
ENSG00000089280FUS61100.000ENSTTRG00000015559FUS67100.000Tursiops_truncatus
ENSG00000089280FUS5099.623ENSUAMG00000008533FUS5299.623Ursus_americanus
ENSG00000089280FUS6986.885ENSVVUG00000027797-5186.545Vulpes_vulpes
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000398mRNA splicing, via spliceosome-TASProcess
GO:0003677DNA binding-IEAFunction
GO:0003682chromatin binding25453086.27731383.IDAFunction
GO:0003713transcription coactivator activity21909421.IDAFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding9774382.18509338.18954305.20085233.21988832.22240165.22778397.23232809.23975937.26124092.27731383.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus16365397.21909421.27731383.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005844polysome-IEAComponent
GO:0006355regulation of transcription, DNA-templated26124092.IDAProcess
GO:0006357regulation of transcription by RNA polymerase II25453086.IDAProcess
GO:0008380RNA splicing26124092.IDAProcess
GO:0030331estrogen receptor binding-IEAFunction
GO:0031489myosin V binding-IEAFunction
GO:0035255ionotropic glutamate receptor binding-IEAFunction
GO:0042802identical protein binding18509338.23975937.IPIFunction
GO:0043204perikaryon-IEAComponent
GO:0043484regulation of RNA splicing25453086.27731383.IDAProcess
GO:0044327dendritic spine head-IEAComponent
GO:0046872metal ion binding-IEAFunction
GO:0046965retinoid X receptor binding-IEAFunction
GO:0046966thyroid hormone receptor binding-IEAFunction
GO:0048471perinuclear region of cytoplasm-IEAComponent
GO:0051260protein homooligomerization25453086.IDAProcess
GO:0071277cellular response to calcium ion-IEAProcess
GO:1903508positive regulation of nucleic acid-templated transcription-IEAProcess
GO:1905168positive regulation of double-strand break repair via homologous recombination10567410.IDAProcess

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26081814FUS1 acts as a tumor-suppressor gene by upregulating miR-197 in human glioblastoma.Oncol Rep2015 AugXin Jdoi: 10.3892/or.2015.4069
24285420A mechanistic study on the metastasis inducing function of FUS-CHOP fusion protein in liposarcoma.Int J Cancer2014 Jun 15Patil Ndoi: 10.1002/ijc.28638
21327980Extraskeletal Ewing's sarcoma in a 67-year-old man.J Orthop Sci2011 MarHanaoka Ndoi: 10.1007/s00776-011-0024-8
28505004A Subset of Malignant Mesotheliomas in Young Adults Are Associated With Recurrent EWSR1/FUS-ATF1 Fusions.Am J Surg Pathol2017 JulDesmeules Pdoi: 10.1097/PAS.0000000000000864.
29380416Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha.Glia2018 MayKia Adoi: 10.1002/glia.23298
26246474Mitochondria, calcium, and tumor suppressor Fus1: At the crossroad of cancer, inflammation, and autoimmunity.Oncotarget2015 Aug 28Uzhachenko R-
16230076Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing.Gastroenterology2005 OctSato S-
21909421FUS/TLS is a co-activator of androgen receptor in prostate cancer cells.PLoS One2011Haile Sdoi: 10.1371/journal.pone.0024197
21169411FUS/TLS is a novel mediator of androgen-dependent cell-cycle progression and prostate cancer growth.Cancer Res2011 Feb 1Brooke GNdoi: 10.1158/0008-5472.CAN-10-0874
24410728Cationic liposome mediated delivery of FUS1 and hIL-12 coexpression plasmid demonstrates enhanced activity against human lung cancer.Curr Cancer Drug Targets2014Ren J-

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1631184225Nonsense_MutationnovelQ118*0.38
BLCAchr1631184330Nonsense_MutationNAQ153*0.12
BLCAchr1631182783Intronrs7602196580.3
BLCAchr1631184330Nonsense_MutationNAQ153*0.25
BLCAchr1631190073Nonsense_MutationNAS367*0.13
BLCAchr1631190981Missense_MutationNAD471G0.34
BLCAchr1631189779Missense_MutationnovelI351V0.43zf-RanBP
BLCAchr1631183940Nonsense_MutationNAY91*0.39
BLCAchr1631184388Missense_Mutationrs374434160G172A0.18
BLCAchr1631191403Missense_MutationnovelE516Q0.28
BRCAchr1631191099Missense_MutationNAK510N0.35
BRCAchr16311801815'UTRrs7659457960.18
BRCAchr1631190776Missense_MutationnovelE443K0.32
BRCAchr16311801445'UTRnovel0.28
BRCAchr16311801995'UTRnovel0.2
BRCAchr1631183926Missense_MutationNAS87T0.31
CESCchr16311801575'UTRrs1426840660.44
CHOLchr1631189774Missense_MutationnovelA349G0.44zf-RanBP
COADchr1631185099Silentrs151073460G228G0.34
COADchr1631182541Nonsense_MutationNAQ23*0.15
COADchr16311915353'UTRnovel0.38
COADchr1631185099Silentrs151073460G228G0.29
COADchr16311915343'UTRrs7658058200.35
COADchr16311915343'UTRrs7658058200.27
COADchr1631184324Frame_Shift_DelNAP152Lfs*330.31
COADchr1631185099Silentrs151073460G228G0.37
COADchr1631185099Silentrs151073460G228G0.43
COADchr1631185116Missense_Mutationrs749434237R234H0.28
COADchr16311801965'UTRnovel0.3
COADchr1631191069SilentnovelG500G0.39
ESCAchr1631190301In_Frame_DelnovelS402_G406del0.33
ESCAchr1631182610Missense_MutationNAD46H0.08
GBMchr1631190987Missense_Mutationrs777102516R473H0.48
GBMchr1631185113Missense_MutationnovelN233S0.25
GBMchr16311914973'UTRnovel0.4
GBMchr1631183931Missense_MutationnovelQ88H0.09
HNSCchr1631190378SilentnovelG424G0.25
HNSCchr1631190999Missense_MutationnovelG477A0.13
HNSCchr1631190759Missense_MutationnovelN437S0.14
KIRCchr16311915013'UTRnovel0.23
KIRCchr1631190303SilentNAG399G0.41
KIRCchr1631185055Missense_MutationNAG214R0.14
KIRCchr1631182609SilentNAT45T0.15
KIRCchr1631182610Missense_MutationNAD46H0.15
LAMLchr1631191027SilentNAG486G0.06
LGGchr1631184280Missense_MutationnovelY136C0.24
LGGchr1631188324Splice_SitenovelX267_splice0.38
LIHCchr1631185087Silentrs533399799G224G0.43
LIHCchr1631182784Intronnovel0.19
LIHCchr1631190287Missense_MutationNAR394L0.17
LIHCchr1631190287Missense_MutationNAR394L0.05
LUADchr1631185032Missense_MutationNAG206A0.38
LUADchr1631191398Splice_SiteNAX514_splice0.22
LUADchr1631185133Missense_MutationnovelE240K0.17
LUADchr1631189721SilentNAG331G0.09
LUADchr1631182761Intronnovel0.15
LUADchr1631189122Splice_SitenovelX278_splice0.12
LUADchr1631191031Missense_MutationNAG488C0.24
LUSCchr1631190065SilentnovelI364I0.23
LUSCchr1631182677Intronnovel0.25
LUSCchr1631191053Missense_MutationnovelR495L0.29
LUSCchr1631191403Nonsense_MutationnovelE516*0.77
LUSCchr1631191404Missense_MutationnovelE516A0.77
OVchr1631190347Missense_MutationnovelG414A0.06
PAADchr1631189164SilentnovelL292L0.19
PAADchr1631191015Silentrs112061837G482G0.17
READchr1631185099Silentrs151073460G228G0.52
SARCchr1631183990Missense_MutationnovelS108I0.06
SKCMchr1631190050SilentNAF359F0.25
SKCMchr1631189136SilentNAS282S0.06
SKCMchr1631183952SilentNAS95S0.14
SKCMchr1631186823SilentNAF262F0.49
SKCMchr1631190285SilentNAG393G0.31
SKCMchr1631183856Splice_SiteNAX64_splice0.16
SKCMchr1631189147Missense_MutationnovelT286I0.4
SKCMchr1631182727Intronrs7498528460.33
SKCMchr1631183877SilentNAS70S0.44
SKCMchr1631189151SilentNAI287I0.11
SKCMchr1631189147Missense_MutationnovelT286I0.28
SKCMchr1631191027SilentNAG486G0.4
SKCMchr1631184325Missense_Mutationrs144342946P151L0.25
SKCMchr1631191418Missense_Mutationrs121909668R521C0.13
SKCMchr1631191072SilentNAG501G0.27
SKCMchr1631190060Missense_MutationNAP363S0.08zf-RanBP
STADchr1631188357Missense_MutationnovelE278K0.15
STADchr1631185084Silentrs767226101G223G0.5
STADchr1631182727Intronrs7498528460.4
STADchr1631185102Silentrs781445592G229G0.3
STADchr1631185099Silentrs151073460G228G0.38
STADchr1631186803Missense_MutationNAG256R0.32
STADchr1631185081Silentrs61732969G222G0.5
UCECchr1631190088Missense_MutationnovelR372Q0.23
UCECchr16311915473'UTRrs7646424590.45
UCECchr1631190053SilentNAS360S0.41
UCECchr1631191062Missense_Mutationrs781554309R498Q0.26
UCECchr1631190310Missense_MutationnovelS402G0.26
UCECchr1631182727Intronrs7498528460.4
UCECchr1631191419Missense_Mutationrs121909671R521H0.34
UCECchr1631189685Missense_MutationnovelQ319H0.32zf-RanBP
UCECchr1631190776Nonsense_MutationnovelE443*0.29
UCECchr1631190127Missense_MutationnovelG385D0.33
UCECchr1631190355Missense_Mutationrs768259829G417S0.07
UCECchr16311916453'UTRrs7656845960.2
UCECchr1631182708Intronnovel0.31
UCECchr1631190395Missense_MutationNAN430T0.45
UCECchr1631182727Intronrs7498528460.13
UCECchr1631183990Missense_MutationNAS108N0.07
UCECchr1631190120Missense_Mutationrs776191869R383C0.41
UCECchr1631189679Silentrs771216742T317T0.4
UCECchr1631191031Missense_Mutationrs200903051G488S0.26
UCECchr1631184371Silentrs757247898G166G0.34
UCECchr1631182712Intronnovel0.31
UCECchr1631182632Missense_MutationnovelS53I0.45
UCECchr1631183901Silentrs780032205T78T0.36
UCECchr1631185096Silentrs755321560G227G0.39
UCECchr16311915353'UTRnovel0.14
UCECchr1631185102Silentrs781445592G229G0.09
UCECchr16311915673'UTRnovel0.33
UCECchr1631185099Silentrs151073460G228G0.28
UCECchr1631190984Missense_MutationnovelR472H0.39
UCECchr1631185099Silentrs151073460G228G0.28
UCECchr1631182560Missense_MutationnovelS29N0.52
UCECchr1631191410Missense_MutationnovelR518I0.51
UCECchr16311801625'UTRrs7596682560.08
UCECchr1631191419Missense_Mutationrs121909671R521H0.24
UCECchr1631185099Silentrs151073460G228G0.34
UCECchr1631185084Silentrs767226101G223G0.39
UCECchr1631190338Frame_Shift_InsnovelS412Efs*240.03
UCECchr1631190286Missense_Mutationrs781216283R394C0.5
UCECchr1631188356Splice_Regionrs138746304S277S0.16
UCECchr1631182632Missense_MutationnovelS53N0.48
UCECchr1631185094Missense_Mutationrs752125355G227S0.39
UCECchr1631190806Missense_MutationnovelD453N0.38
UVMchr1631182623Missense_MutationnovelY50C0.54

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CHOLDEL0.05560.23475
LUADAMP0.24810.20955

Survival Analysis
CancerP-value Q-value
THYM0.017

Kaplan-Meier Survival Analysis

SARC0.048

Kaplan-Meier Survival Analysis

ACC0.00057

Kaplan-Meier Survival Analysis

HNSC0.044

Kaplan-Meier Survival Analysis

SKCM0.011

Kaplan-Meier Survival Analysis

PRAD0.0053

Kaplan-Meier Survival Analysis

COAD0.027

Kaplan-Meier Survival Analysis

LIHC0.0045

Kaplan-Meier Survival Analysis

UVM0.043

Kaplan-Meier Survival Analysis

OV0.027

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742


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