EuRBPDB

Description

Ensembl ID: ENSG00000089597 (Gene tree)
Gene ID: 23193
Gene Symbol: GANAB
Alias: GluII|G2AN|KIAA0088|GIIA
Full Name: glucosidase II alpha subunit
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 21,901 bases
Position: chr11:62,624,826-62,646,726
Accession: 4138
RBP type: non-canonical RBP
Summary: This gene encodes the alpha subunit of glucosidase II and a member of the glycosyl hydrolase 31 family of proteins. The heterodimeric enzyme glucosidase II plays a role in protein folding and quality control by cleaving glucose residues from immature glycoproteins in the endoplasmic reticulum. Expression of the encoded protein is elevated in lung tumor tissue and in response to UV irradiation. Mutations in this gene cause autosomal-dominant polycystic kidney and liver disease. [provided by RefSeq, Jul 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000346178	GANAB-201	3906	-	ENSP00000340466	966 (aa)	-	Q14697
ENST00000648273	GANAB-217	3846	-	ENSP00000497655	847 (aa)	-	UPI00003B258F
ENST00000534779	GANAB-215	2626	-	ENSP00000435306	852 (aa)	-	E9PKU7
ENST00000529737	GANAB-209	577	-	ENSP00000432593	76 (aa)	-	E9PQ69
ENST00000534419	GANAB-212	640	-	-	- (aa)	-	-
ENST00000534613	GANAB-214	737	-	ENSP00000434921	52 (aa)	-	Q14697
ENST00000524437	GANAB-203	671	-	-	- (aa)	-	-
ENST00000526732	GANAB-207	824	-	-	- (aa)	-	-
ENST00000531563	GANAB-210	414	-	-	- (aa)	-	-
ENST00000526210	GANAB-205	533	-	ENSP00000433799	52 (aa)	-	Q14697
ENST00000532402	GANAB-211	3718	-	ENSP00000432181	52 (aa)	-	Q14697
ENST00000525994	GANAB-204	390	-	ENSP00000434805	119 (aa)	-	E9PNH1
ENST00000534422	GANAB-213	702	-	-	- (aa)	-	-
ENST00000528503	GANAB-208	608	-	-	- (aa)	-	-
ENST00000356638	GANAB-202	3608	-	ENSP00000349053	944 (aa)	-	Q14697
ENST00000526392	GANAB-206	257	-	-	- (aa)	-	-
ENST00000540933	GANAB-216	3836	XM_017017412	ENSP00000442962	847 (aa)	XP_016872901	F5H6X6

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa00510	N-Glycan biosynthesis	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04141	Protein processing in endoplasmic reticulum	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000089597	rs2956993	11	62638690	G	Waist-to-hip ratio adjusted for BMI	26426971	units increase	0.024	EFO_0007788
ENSG00000089597	rs118093058	11	62646201	T	Educational attainment (MTAG)	30038396	[0.011-0.019] unit increase	0.0153	EFO_0004784
ENSG00000089597	rs118093058	11	62646201	T	Highest math class taken (MTAG)	30038396	[0.012-0.021] unit increase	0.0165	EFO_0004875
ENSG00000089597	rs118093058	11	62646201	T	Cognitive performance (MTAG)	30038396	[0.014-0.027] unit increase	0.0205	EFO_0008354
ENSG00000089597	rs7949030	11	62627409	G	Waist-to-hip ratio adjusted for body mass index	28448500	[0.021-0.044] unit increase	0.0324	EFO_0007788\|EFO_0008002
ENSG00000089597	rs7949030	11	62627409	?	Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction)	28448500			EFO_0007788\|EFO_0008002
ENSG00000089597	rs2956993	11	62638690	G	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	26426971			EFO_0007788\|EFO_0008343\|EFO_0008007
ENSG00000089597	rs118093058	11	62646201	T	Educational attainment (years of education)	30038396	[0.01-0.019] unit increase	0.0146	EFO_0004784
ENSG00000089597	rs118093058	11	62646201	?	Educational attainment (years of education)	30595370			EFO_0004784

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000089597	GANAB	99	91.920	ENSMUSG00000071650	Ganab	99	91.920	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	10929008.	IPI	Function
GO:0005788	endoplasmic reticulum lumen	-	TAS	Component
GO:0005794	Golgi apparatus	-	IEA	Component
GO:0005975	carbohydrate metabolic process	-	IEA	Process
GO:0006457	protein folding	-	TAS	Process
GO:0006491	N-glycan processing	10929008.	IDA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0017177	glucosidase II complex	10929008.	IDA	Component
GO:0030246	carbohydrate binding	-	IEA	Function
GO:0033919	glucan 1,3-alpha-glucosidase activity	10929008.	IDA	Function
GO:0042470	melanosome	-	IEA	Component
GO:0043231	intracellular membrane-bounded organelle	10929008.	IMP	Component
GO:0070062	extracellular exosome	19056867.19199708.23533145.	HDA	Component
GO:0090599	alpha-glucosidase activity	28375157.	IDA	Function