EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000090060 (Gene tree)
Gene ID: 10914
Gene Symbol: PAPOLA
Alias: PAP
Full Name: poly(A) polymerase alpha
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 65,684 bases
Position: chr14:96,501,433-96,567,116
Accession: 14981
RBP type: canonical RBP
Summary: The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000450534	PAP_RNA-bind	PF04926.15	4.6e-23	1	1
ENSP00000376716	PAP_RNA-bind	PF04926.15	1.7e-22	1	1
ENSP00000216277	PAP_RNA-bind	PF04926.15	2.3e-22	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10742179	The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein.	Nat Struct Biol	2000 Apr	Varani L	-
9742111	Processivity of the Saccharomyces cerevisiae poly(A) polymerase requires interactions at the carboxyl-terminal RNA binding domain.	Mol Cell Biol	1998 Oct	Zhelkovsky A	-
7592899	Structure-function relationships in the Saccharomyces cerevisiae poly(A) polymerase. Identification of a novel RNA binding site and a domain that interacts with specificity factor(s).	J Biol Chem	1995 Nov 3	Zhelkovsky AM	-
8164653	Poly(A) polymerase contains multiple functional domains.	Mol Cell Biol	1994 May	Raabe T	-
10361280	Poly(A) polymerase I of Escherichia coli: characterization of the catalytic domain, an RNA binding site and regions for the interaction with proteins involved in mRNA degradation.	Mol Microbiol	1999 May	Raynal LC	-
12083511	Identification of new poly(A) polymerase-inhibitory proteins capable of regulating pre-mRNA polyadenylation.	J Mol Biol	2002 May 17	Ko B	-
15955317	Entamoeba histolytica: cloning and expression of the poly(A) polymerase EhPAP.	Exp Parasitol	2005 Jul	Garcia-Vivas J	-
14749727	Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.	EMBO J	2004 Feb 11	Kaufmann I	-
19460348	Antagonism between GLD-2 binding partners controls gamete sex.	Dev Cell	2009 May	Kim KW	doi: 10.1016/j.devcel.2009.04.002.
23219533	PARP1 represses PAP and inhibits polyadenylation during heat shock.	Mol Cell	2013 Jan 10	Di Giammartino DC	doi: 10.1016/j.molcel.2012.11.005
20855596	GLD-2/RNP-8 cytoplasmic poly(A) polymerase is a broad-spectrum regulator of the oogenesis program.	Proc Natl Acad Sci U S A	2010 Oct 5	Kim KW	doi: 10.1073/pnas.1012611107
23840799	The 25 kDa subunit of cleavage factor Im Is a RNA-binding protein that interacts with the poly(A) polymerase in Entamoeba histolytica.	PLoS One	2013 Jun 28	Pezet-Valdez M	doi: 10.1371/journal.pone.0067977
25896913	Poly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs.	Mol Cell Biol	2015 Jul	Muniz L	doi: 10.1128/MCB.00123-15
9087430	Involvement of the carboxyl terminus of vertebrate poly(A) polymerase in U1A autoregulation and in the coupling of splicing and polyadenylation.	Genes Dev	1997 Mar 15	Gunderson SI	-
12697817	Determinants within an 18-amino-acid U1A autoregulatory domain that uncouple cooperative RNA binding, inhibition of polyadenylation, and homodimerization.	Mol Cell Biol	2003 May	Guan F	-
17949481	Hfq stimulates the activity of the CCA-adding enzyme.	BMC Mol Biol	2007 Oct 18	Scheibe M	-
24146636	The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay.	PLoS Genet	2013	Bresson SM	doi: 10.1371/journal.pgen.1003893

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000553357	PAPOLA-203	585	-	ENSP00000452578	73 (aa)	-	H0YJZ9
ENST00000555626	PAPOLA-215	2272	-	ENSP00000450534	475 (aa)	-	G3V2A0
ENST00000555021	PAPOLA-211	547	-	-	- (aa)	-	-
ENST00000554887	PAPOLA-210	547	-	-	- (aa)	-	-
ENST00000557320	PAPOLA-223	3264	-	ENSP00000450437	285 (aa)	-	P51003
ENST00000554130	PAPOLA-207	848	-	-	- (aa)	-	-
ENST00000554135	PAPOLA-208	735	-	-	- (aa)	-	-
ENST00000392990	PAPOLA-202	2588	XM_005267281	ENSP00000376716	724 (aa)	XP_005267338	G3XAH6
ENST00000557406	PAPOLA-224	450	-	-	- (aa)	-	-
ENST00000555701	PAPOLA-216	1875	-	-	- (aa)	-	-
ENST00000553689	PAPOLA-205	2267	-	ENSP00000451600	111 (aa)	-	G3V457
ENST00000555508	PAPOLA-214	588	-	-	- (aa)	-	-
ENST00000556248	PAPOLA-218	652	-	-	- (aa)	-	-
ENST00000556459	PAPOLA-220	959	-	ENSP00000451757	181 (aa)	-	H0YJL4
ENST00000555912	PAPOLA-217	2277	-	-	- (aa)	-	-
ENST00000555131	PAPOLA-212	546	-	-	- (aa)	-	-
ENST00000556619	PAPOLA-221	584	-	ENSP00000451267	177 (aa)	-	G3V3I9
ENST00000557471	PAPOLA-225	1421	-	ENSP00000450812	238 (aa)	-	A0A0C4DGK1
ENST00000555224	PAPOLA-213	534	-	-	- (aa)	-	-
ENST00000553940	PAPOLA-206	454	-	-	- (aa)	-	-
ENST00000554666	PAPOLA-209	558	-	-	- (aa)	-	-
ENST00000556283	PAPOLA-219	644	-	-	- (aa)	-	-
ENST00000556787	PAPOLA-222	806	-	-	- (aa)	-	-
ENST00000216277	PAPOLA-201	4519	-	ENSP00000216277	745 (aa)	-	P51003
ENST00000553461	PAPOLA-204	892	-	ENSP00000450564	203 (aa)	-	H0YJ00

Gene Model

Click here to download ENSG00000090060's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000090060	Platelet Function Tests	1.2816700E-005	-
ENSG00000090060	Platelet Function Tests	1.2737700E-005	-
ENSG00000090060	Child Development Disorders, Pervasive	1.7736000E-006	-
ENSG00000090060	Child Development Disorders, Pervasive	1.6903000E-005	-
ENSG00000090060	Myoglobin	3.7930000E-005	-
ENSG00000090060	Suntan	9E-8	19340012
ENSG00000090060	Colonic Neoplasms	1E-7	25866641
ENSG00000090060	Disease-Free Survival	1E-7	25866641
ENSG00000090060	Cognition	8E-6	24684796
ENSG00000090060	Colonic Neoplasms	4E-6	25866641
ENSG00000090060	Survival Rate	4E-6	25866641

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000090060's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000090060	PAPOLA	94	83.158	ENSG00000115421	PAPOLG	100	81.197
ENSG00000090060	PAPOLA	98	92.115	ENSG00000218823	PAPOLB	98	86.080

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000090060	PAPOLA	99	97.715	ENSAMEG00000014142	PAPOLA	99	97.715	Ailuropoda_melanoleuca
ENSG00000090060	PAPOLA	97	96.390	ENSAPLG00000006645	PAPOLA	99	90.579	Anas_platyrhynchos
ENSG00000090060	PAPOLA	98	97.849	ENSACAG00000013474	PAPOLA	99	94.737	Anolis_carolinensis
ENSG00000090060	PAPOLA	100	99.597	ENSANAG00000018274	PAPOLA	100	99.597	Aotus_nancymaae
ENSG00000090060	PAPOLA	99	96.364	ENSANAG00000027941	-	98	91.760	Aotus_nancymaae
ENSG00000090060	PAPOLA	94	95.263	ENSAMXG00000018141	papola	99	85.099	Astyanax_mexicanus
ENSG00000090060	PAPOLA	100	97.514	ENSBTAG00000004054	PAPOLA	100	97.514	Bos_taurus
ENSG00000090060	PAPOLA	100	99.597	ENSCJAG00000006512	PAPOLA	100	99.597	Callithrix_jacchus
ENSG00000090060	PAPOLA	100	97.071	ENSCAFG00000017783	PAPOLA	100	97.071	Canis_familiaris
ENSG00000090060	PAPOLA	100	97.652	ENSCAFG00020011550	PAPOLA	100	97.652	Canis_lupus_dingo
ENSG00000090060	PAPOLA	82	89.157	ENSCHIG00000009834	-	66	98.148	Capra_hircus
ENSG00000090060	PAPOLA	100	97.181	ENSCHIG00000025004	-	100	97.181	Capra_hircus
ENSG00000090060	PAPOLA	100	96.421	ENSTSYG00000012384	PAPOLA	99	97.226	Carlito_syrichta
ENSG00000090060	PAPOLA	100	96.632	ENSCPOG00000002648	PAPOLA	100	93.826	Cavia_porcellus
ENSG00000090060	PAPOLA	100	99.789	ENSCCAG00000025120	PAPOLA	100	99.732	Cebus_capucinus
ENSG00000090060	PAPOLA	100	100.000	ENSCATG00000018815	PAPOLA	100	99.866	Cercocebus_atys
ENSG00000090060	PAPOLA	99	99.091	ENSCLAG00000016342	PAPOLA	100	97.790	Chinchilla_lanigera
ENSG00000090060	PAPOLA	100	100.000	ENSCSAG00000010516	PAPOLA	100	99.866	Chlorocebus_sabaeus
ENSG00000090060	PAPOLA	99	97.273	ENSCHOG00000001115	PAPOLA	72	83.110	Choloepus_hoffmanni
ENSG00000090060	PAPOLA	98	96.774	ENSCPBG00000024125	PAPOLA	100	92.627	Chrysemys_picta_bellii
ENSG00000090060	PAPOLA	100	100.000	ENSCANG00000000159	PAPOLA	100	94.616	Colobus_angolensis_palliatus
ENSG00000090060	PAPOLA	98	98.925	ENSCGRG00001022693	-	100	95.718	Cricetulus_griseus_chok1gshd
ENSG00000090060	PAPOLA	100	86.526	ENSCGRG00001002732	-	99	83.871	Cricetulus_griseus_chok1gshd
ENSG00000090060	PAPOLA	100	87.785	ENSCGRG00001000229	-	99	90.032	Cricetulus_griseus_chok1gshd
ENSG00000090060	PAPOLA	100	82.735	ENSCGRG00000000257	-	100	82.735	Cricetulus_griseus_crigri
ENSG00000090060	PAPOLA	94	86.316	ENSCGRG00000001888	-	96	80.191	Cricetulus_griseus_crigri
ENSG00000090060	PAPOLA	97	98.913	ENSCGRG00000003664	-	100	95.700	Cricetulus_griseus_crigri
ENSG00000090060	PAPOLA	92	64.516	ENSCSEG00000001841	-	71	53.734	Cynoglossus_semilaevis
ENSG00000090060	PAPOLA	94	93.158	ENSDARG00000009585	papola	100	69.867	Danio_rerio
ENSG00000090060	PAPOLA	100	86.316	ENSDORG00000013415	-	100	90.586	Dipodomys_ordii
ENSG00000090060	PAPOLA	99	83.580	ENSETEG00000004889	PAPOLA	100	83.445	Echinops_telfairi
ENSG00000090060	PAPOLA	94	92.105	ENSELUG00000018972	papola	100	68.966	Esox_lucius
ENSG00000090060	PAPOLA	100	98.343	ENSFCAG00000006784	PAPOLA	100	98.343	Felis_catus
ENSG00000090060	PAPOLA	97	96.739	ENSFALG00000002547	PAPOLA	98	87.337	Ficedula_albicollis
ENSG00000090060	PAPOLA	97	99.275	ENSFDAG00000010370	PAPOLA	100	95.973	Fukomys_damarensis
ENSG00000090060	PAPOLA	100	62.526	ENSGMOG00000010209	papola	100	65.863	Gadus_morhua
ENSG00000090060	PAPOLA	98	96.774	ENSGALG00000033099	PAPOLA	100	89.946	Gallus_gallus
ENSG00000090060	PAPOLA	94	63.158	ENSGACG00000006142	-	100	53.958	Gasterosteus_aculeatus
ENSG00000090060	PAPOLA	98	96.774	ENSGAGG00000020500	PAPOLA	99	94.760	Gopherus_agassizii
ENSG00000090060	PAPOLA	100	100.000	ENSGGOG00000006287	PAPOLA	100	100.000	Gorilla_gorilla
ENSG00000090060	PAPOLA	100	96.961	ENSHGLG00000007909	-	100	96.961	Heterocephalus_glaber_female
ENSG00000090060	PAPOLA	100	85.684	ENSHGLG00000017457	-	100	84.324	Heterocephalus_glaber_female
ENSG00000090060	PAPOLA	99	90.909	ENSHGLG00000007467	-	100	78.523	Heterocephalus_glaber_female
ENSG00000090060	PAPOLA	98	98.925	ENSHGLG00100017273	PAPOLA	100	96.823	Heterocephalus_glaber_male
ENSG00000090060	PAPOLA	94	94.211	ENSIPUG00000005919	papola	100	67.254	Ictalurus_punctatus
ENSG00000090060	PAPOLA	99	99.091	ENSSTOG00000011471	PAPOLA	100	98.066	Ictidomys_tridecemlineatus
ENSG00000090060	PAPOLA	97	98.913	ENSJJAG00000024340	Papola	100	96.533	Jaculus_jaculus
ENSG00000090060	PAPOLA	95	95.312	ENSLACG00000018136	PAPOLA	99	76.707	Latimeria_chalumnae
ENSG00000090060	PAPOLA	99	90.594	ENSLOCG00000008632	papola	99	65.824	Lepisosteus_oculatus
ENSG00000090060	PAPOLA	97	98.913	ENSLAFG00000000946	PAPOLA	99	96.631	Loxodonta_africana
ENSG00000090060	PAPOLA	100	100.000	ENSMFAG00000001792	PAPOLA	100	99.866	Macaca_fascicularis
ENSG00000090060	PAPOLA	100	100.000	ENSMMUG00000018610	PAPOLA	100	99.866	Macaca_mulatta
ENSG00000090060	PAPOLA	100	100.000	ENSMNEG00000043747	PAPOLA	100	99.866	Macaca_nemestrina
ENSG00000090060	PAPOLA	100	100.000	ENSMLEG00000032066	PAPOLA	100	99.866	Mandrillus_leucophaeus
ENSG00000090060	PAPOLA	92	97.849	ENSMGAG00000013228	-	100	88.854	Meleagris_gallopavo
ENSG00000090060	PAPOLA	98	99.283	ENSMAUG00000017178	Papola	100	95.994	Mesocricetus_auratus
ENSG00000090060	PAPOLA	100	98.343	ENSMICG00000010347	PAPOLA	100	98.343	Microcebus_murinus
ENSG00000090060	PAPOLA	98	99.283	ENSMOCG00000021670	Papola	100	95.856	Microtus_ochrogaster
ENSG00000090060	PAPOLA	99	98.182	ENSMODG00000012887	-	100	96.242	Monodelphis_domestica
ENSG00000090060	PAPOLA	99	93.636	ENSMODG00000001969	-	99	81.868	Monodelphis_domestica
ENSG00000090060	PAPOLA	98	99.283	MGP_CAROLIEiJ_G0018093	Papola	100	95.168	Mus_caroli
ENSG00000090060	PAPOLA	98	99.283	ENSMUSG00000021111	Papola	100	95.442	Mus_musculus
ENSG00000090060	PAPOLA	98	99.283	MGP_PahariEiJ_G0029850	Papola	100	95.442	Mus_pahari
ENSG00000090060	PAPOLA	98	99.283	MGP_SPRETEiJ_G0018943	Papola	100	95.580	Mus_spretus
ENSG00000090060	PAPOLA	99	99.091	ENSMPUG00000003054	PAPOLA	100	97.987	Mustela_putorius_furo
ENSG00000090060	PAPOLA	98	99.283	ENSMLUG00000010922	PAPOLA	100	95.570	Myotis_lucifugus
ENSG00000090060	PAPOLA	98	98.566	ENSNGAG00000022172	Papola	100	96.133	Nannospalax_galili
ENSG00000090060	PAPOLA	97	99.639	ENSNLEG00000000625	PAPOLA	100	94.681	Nomascus_leucogenys
ENSG00000090060	PAPOLA	77	86.029	ENSMEUG00000007831	-	74	85.714	Notamacropus_eugenii
ENSG00000090060	PAPOLA	100	95.368	ENSOPRG00000007625	PAPOLA	100	91.736	Ochotona_princeps
ENSG00000090060	PAPOLA	94	62.105	ENSONIG00000001062	-	96	54.202	Oreochromis_niloticus
ENSG00000090060	PAPOLA	97	98.195	ENSOANG00000013812	PAPOLA	99	93.075	Ornithorhynchus_anatinus
ENSG00000090060	PAPOLA	97	98.913	ENSOCUG00000011531	PAPOLA	99	94.616	Oryctolagus_cuniculus
ENSG00000090060	PAPOLA	99	99.091	ENSOGAG00000004611	PAPOLA	100	97.852	Otolemur_garnettii
ENSG00000090060	PAPOLA	100	97.450	ENSOARG00000016579	-	100	97.450	Ovis_aries
ENSG00000090060	PAPOLA	100	100.000	ENSPPAG00000030505	PAPOLA	100	100.000	Pan_paniscus
ENSG00000090060	PAPOLA	100	98.343	ENSPPRG00000008616	PAPOLA	100	98.343	Panthera_pardus
ENSG00000090060	PAPOLA	100	97.474	ENSPTIG00000018852	PAPOLA	99	98.336	Panthera_tigris_altaica
ENSG00000090060	PAPOLA	100	100.000	ENSPTRG00000006704	PAPOLA	100	100.000	Pan_troglodytes
ENSG00000090060	PAPOLA	100	100.000	ENSPANG00000025582	PAPOLA	100	99.866	Papio_anubis
ENSG00000090060	PAPOLA	94	95.263	ENSPKIG00000014471	papola	100	69.909	Paramormyrops_kingsleyae
ENSG00000090060	PAPOLA	98	96.774	ENSPSIG00000014157	PAPOLA	87	92.895	Pelodiscus_sinensis
ENSG00000090060	PAPOLA	98	98.925	ENSPEMG00000000043	Papola	100	95.994	Peromyscus_maniculatus_bairdii
ENSG00000090060	PAPOLA	99	99.091	ENSPCIG00000013234	PAPOLA	100	95.845	Phascolarctos_cinereus
ENSG00000090060	PAPOLA	100	100.000	ENSPPYG00000006128	PAPOLA	100	97.584	Pongo_abelii
ENSG00000090060	PAPOLA	94	99.474	ENSPCAG00000004199	PAPOLA	100	90.030	Procavia_capensis
ENSG00000090060	PAPOLA	98	99.283	ENSPCOG00000022117	PAPOLA	99	94.875	Propithecus_coquereli
ENSG00000090060	PAPOLA	98	98.925	ENSPVAG00000013925	PAPOLA	100	96.510	Pteropus_vampyrus
ENSG00000090060	PAPOLA	94	93.684	ENSPNAG00000010467	papola	100	70.201	Pygocentrus_nattereri
ENSG00000090060	PAPOLA	98	99.283	ENSRNOG00000004827	Papola	100	95.034	Rattus_norvegicus
ENSG00000090060	PAPOLA	99	97.507	ENSRBIG00000038490	PAPOLA	100	97.507	Rhinopithecus_bieti
ENSG00000090060	PAPOLA	100	99.789	ENSRROG00000025545	PAPOLA	100	99.732	Rhinopithecus_roxellana
ENSG00000090060	PAPOLA	100	99.579	ENSSBOG00000024061	PAPOLA	100	99.462	Saimiri_boliviensis_boliviensis
ENSG00000090060	PAPOLA	97	98.913	ENSSHAG00000015211	PAPOLA	99	95.957	Sarcophilus_harrisii
ENSG00000090060	PAPOLA	94	95.263	ENSSFOG00015004431	papola	99	84.991	Scleropages_formosus
ENSG00000090060	PAPOLA	94	66.492	ENSSDUG00000018247	-	72	57.851	Seriola_dumerili
ENSG00000090060	PAPOLA	98	97.849	ENSSPUG00000005835	PAPOLA	100	92.359	Sphenodon_punctatus
ENSG00000090060	PAPOLA	100	98.121	ENSSSCG00000002505	-	100	98.121	Sus_scrofa
ENSG00000090060	PAPOLA	97	96.739	ENSTGUG00000012687	PAPOLA	99	90.162	Taeniopygia_guttata
ENSG00000090060	PAPOLA	94	98.947	ENSTBEG00000000194	PAPOLA	75	88.043	Tupaia_belangeri
ENSG00000090060	PAPOLA	96	98.131	ENSTTRG00000005717	PAPOLA	80	98.701	Tursiops_truncatus
ENSG00000090060	PAPOLA	95	98.893	ENSUAMG00000025737	PAPOLA	98	99.289	Ursus_americanus
ENSG00000090060	PAPOLA	100	96.421	ENSVPAG00000006464	PAPOLA	100	97.170	Vicugna_pacos
ENSG00000090060	PAPOLA	99	99.091	ENSVVUG00000028340	PAPOLA	100	97.928	Vulpes_vulpes
ENSG00000090060	PAPOLA	98	93.907	ENSXETG00000013949	papola	100	82.819	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	-	ISS	Function
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	-	IEA	Function
GO:0004652	polynucleotide adenylyltransferase activity	21873635.	IBA	Function
GO:0004652	polynucleotide adenylyltransferase activity	7590244.	IDA	Function
GO:0004652	polynucleotide adenylyltransferase activity	-	ISS	Function
GO:0004652	polynucleotide adenylyltransferase activity	-	TAS	Function
GO:0005515	protein binding	7590244.19224921.	IPI	Function
GO:0005524	ATP binding	-	ISS	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	8302877.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	8302877.	TAS	Component
GO:0006369	termination of RNA polymerase II transcription	-	TAS	Process
GO:0006378	mRNA polyadenylation	21873635.	IBA	Process
GO:0006378	mRNA polyadenylation	7590244.19224921.	IDA	Process
GO:0030145	manganese ion binding	-	ISS	Function
GO:0031124	mRNA 3'-end processing	-	TAS	Process
GO:0031440	regulation of mRNA 3'-end processing	19224921.	IDA	Process
GO:0043631	RNA polyadenylation	-	ISS	Process