EuRBPDB

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  • Description
  • RBDs
  • RBPome
  • PRI
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000090861 (Gene tree)
Gene ID
16
Gene Symbol
AARS
Alias
CMT2N|AlaRS
Full Name
alanyl-tRNA synthetase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
37,256 bases
Position
chr16:70,252,295-70,289,550
Accession
20
RBP type
canonical RBP
Summary
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000455360tRNA_SADPF07973.143.1e-1711
ENSP00000261772tRNA_SADPF07973.141.7e-1611
ENSP00000261772tRNA-synt_2cPF01411.193.7e-22711
ENSP00000261772DHHA1PF02272.191.1e-1811
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
14999004A hamster temperature-sensitive alanyl-tRNA synthetase mutant causes degradation of cell-cycle related proteins and apoptosis.J Biochem2004 JanWang Y-
9736622Functional analysis of peptide motif for RNA microhelix binding suggests new family of RNA-binding domains.EMBO J1998 Sep 15Ribas de Pouplana L-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000566969AARS-204610--- (aa)--
ENST00000567490AARS-205533--- (aa)--
ENST00000565361AARS-203839-ENSP00000455360280 (aa)-H3BPK7
ENST00000261772AARS-2013477-ENSP00000261772968 (aa)-P49588
ENST00000569790AARS-206528--- (aa)--
ENST00000569825AARS-207871--- (aa)--
ENST00000564359AARS-202590--- (aa)--
Gene Model
Click here to download ENSG00000090861's gene model file
Pathways
Pathway IDPathway NameSource
hsa00970Aminoacyl-tRNA biosynthesisKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000090861rs121496601670275334?Body mass index30595370EFO_0004340
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000090861's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000090861AARS9845.946ENSG00000124608AARS29645.924
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000090861AARS9980.207ENSAPOG00000022413aars9980.207Acanthochromis_polyacanthus
ENSG00000090861AARS10095.661ENSAMEG00000004815AARS10095.661Ailuropoda_melanoleuca
ENSG00000090861AARS9979.793ENSACIG00000016586aars9979.793Amphilophus_citrinellus
ENSG00000090861AARS9980.311ENSAOCG00000007036aars9980.311Amphiprion_ocellaris
ENSG00000090861AARS9980.207ENSAPEG00000022892aars9980.207Amphiprion_percula
ENSG00000090861AARS9980.415ENSATEG00000013826aars9980.415Anabas_testudineus
ENSG00000090861AARS7990.364ENSAPLG00000008519AARS8489.964Anas_platyrhynchos
ENSG00000090861AARS10085.759ENSACAG00000002808AARS10085.759Anolis_carolinensis
ENSG00000090861AARS10088.374ENSANAG00000029082AARS9898.214Aotus_nancymaae
ENSG00000090861AARS9980.518ENSACLG00000022314aars9980.518Astatotilapia_calliptera
ENSG00000090861AARS9982.139ENSAMXG00000003368aars9982.139Astyanax_mexicanus
ENSG00000090861AARS10095.455ENSBTAG00000019810AARS10095.455Bos_taurus
ENSG00000090861AARS9957.704WBGene00000197aars-29957.704Caenorhabditis_elegans
ENSG00000090861AARS10097.624ENSCJAG00000014562AARS10098.802Callithrix_jacchus
ENSG00000090861AARS10095.971ENSCAFG00000020132AARS10095.971Canis_familiaris
ENSG00000090861AARS10095.971ENSCAFG00020020967AARS10095.971Canis_lupus_dingo
ENSG00000090861AARS10095.351ENSCHIG00000015632AARS10095.351Capra_hircus
ENSG00000090861AARS10097.211ENSTSYG00000010987AARS10098.381Carlito_syrichta
ENSG00000090861AARS9196.411ENSCAPG00000013564AARS10096.411Cavia_aperea
ENSG00000090861AARS10096.384ENSCPOG00000002373AARS10096.384Cavia_porcellus
ENSG00000090861AARS10097.831ENSCCAG00000001818AARS10097.831Cebus_capucinus
ENSG00000090861AARS10099.174ENSCATG00000032821AARS10099.595Cercocebus_atys
ENSG00000090861AARS10095.764ENSCLAG00000004366AARS10095.764Chinchilla_lanigera
ENSG00000090861AARS10099.174ENSCSAG00000004476AARS10099.174Chlorocebus_sabaeus
ENSG00000090861AARS6587.330ENSCHOG00000000347-7587.330Choloepus_hoffmanni
ENSG00000090861AARS10086.983ENSCPBG00000002995AARS10086.983Chrysemys_picta_bellii
ENSG00000090861AARS9959.217ENSCING00000024107-9959.217Ciona_intestinalis
ENSG00000090861AARS10059.179ENSCSAVG00000000721-9959.179Ciona_savignyi
ENSG00000090861AARS10095.971ENSCANG00000040257AARS10099.190Colobus_angolensis_palliatus
ENSG00000090861AARS10096.488ENSCGRG00001014390AARS10096.488Cricetulus_griseus_chok1gshd
ENSG00000090861AARS10096.488ENSCGRG00000017420AARS10096.488Cricetulus_griseus_crigri
ENSG00000090861AARS9979.275ENSCSEG00000014258aars9979.275Cynoglossus_semilaevis
ENSG00000090861AARS8978.629ENSCVAG00000000882aars9979.497Cyprinodon_variegatus
ENSG00000090861AARS9981.969ENSDARG00000069142aars9489.681Danio_rerio
ENSG00000090861AARS10091.189ENSDNOG00000004586AARS10091.189Dasypus_novemcinctus
ENSG00000090861AARS10096.591ENSDORG00000004110Aars10096.591Dipodomys_ordii
ENSG00000090861AARS9960.933FBgn0027094AlaRS9960.933Drosophila_melanogaster
ENSG00000090861AARS10088.017ENSETEG00000002451AARS10088.017Echinops_telfairi
ENSG00000090861AARS9973.493ENSEBUG00000004521aars9974.127Eptatretus_burgeri
ENSG00000090861AARS10096.798ENSEASG00005013408AARS9196.798Equus_asinus_asinus
ENSG00000090861AARS10096.901ENSECAG00000008561AARS9596.901Equus_caballus
ENSG00000090861AARS9397.500ENSEEUG00000006335AARS9397.500Erinaceus_europaeus
ENSG00000090861AARS9981.969ENSELUG00000015496aars9981.969Esox_lucius
ENSG00000090861AARS10096.591ENSFCAG00000009482AARS10096.591Felis_catus
ENSG00000090861AARS10086.983ENSFALG00000007196AARS10086.983Ficedula_albicollis
ENSG00000090861AARS10095.248ENSFDAG00000011896AARS10095.248Fukomys_damarensis
ENSG00000090861AARS5781.736ENSFHEG00000004067aars9181.736Fundulus_heteroclitus
ENSG00000090861AARS9974.301ENSGMOG00000008147aars9974.301Gadus_morhua
ENSG00000090861AARS10087.293ENSGALG00000001965AARS10087.293Gallus_gallus
ENSG00000090861AARS9980.933ENSGAFG00000015182aars9980.933Gambusia_affinis
ENSG00000090861AARS9974.383ENSGACG00000002667aars9974.383Gasterosteus_aculeatus
ENSG00000090861AARS10086.674ENSGAGG00000014004AARS10086.674Gopherus_agassizii
ENSG00000090861AARS91100.000ENSGGOG00000008737AARS100100.000Gorilla_gorilla
ENSG00000090861AARS9975.026ENSHBUG00000011211aars9975.026Haplochromis_burtoni
ENSG00000090861AARS10095.868ENSHGLG00000011756AARS10095.868Heterocephalus_glaber_female
ENSG00000090861AARS10095.764ENSHGLG00100011337AARS10095.764Heterocephalus_glaber_male
ENSG00000090861AARS9978.031ENSHCOG00000012089aars9978.031Hippocampus_comes
ENSG00000090861AARS9980.809ENSIPUG00000020538aars9980.809Ictalurus_punctatus
ENSG00000090861AARS10097.314ENSSTOG00000006856AARS10097.314Ictidomys_tridecemlineatus
ENSG00000090861AARS10096.591ENSJJAG00000008731Aars10096.591Jaculus_jaculus
ENSG00000090861AARS9979.689ENSKMAG00000009832aars9979.689Kryptolebias_marmoratus
ENSG00000090861AARS9978.653ENSLBEG00000018551aars9978.653Labrus_bergylta
ENSG00000090861AARS10081.508ENSLACG00000004892AARS9981.508Latimeria_chalumnae
ENSG00000090861AARS10093.952ENSLAFG00000006645AARS10093.952Loxodonta_africana
ENSG00000090861AARS10098.967ENSMFAG00000002309AARS10098.967Macaca_fascicularis
ENSG00000090861AARS10098.760ENSMMUG00000021653AARS10098.785Macaca_mulatta
ENSG00000090861AARS10093.492ENSMNEG00000014902AARS10097.546Macaca_nemestrina
ENSG00000090861AARS9595.109ENSMLEG00000035037AARS10095.109Mandrillus_leucophaeus
ENSG00000090861AARS9979.482ENSMAMG00000016945aars9979.482Mastacembelus_armatus
ENSG00000090861AARS9980.415ENSMZEG00005010733aars9980.415Maylandia_zebra
ENSG00000090861AARS10087.397ENSMGAG00000002038AARS9987.397Meleagris_gallopavo
ENSG00000090861AARS10096.074ENSMAUG00000021342Aars10096.074Mesocricetus_auratus
ENSG00000090861AARS10097.730ENSMICG00000000255AARS10098.381Microcebus_murinus
ENSG00000090861AARS10096.074ENSMOCG00000005336Aars10096.074Microtus_ochrogaster
ENSG00000090861AARS9978.446ENSMMOG00000002584aars9978.446Mola_mola
ENSG00000090861AARS10089.420ENSMODG00000014518AARS10089.420Monodelphis_domestica
ENSG00000090861AARS9980.207ENSMALG00000007912aars9980.207Monopterus_albus
ENSG00000090861AARS10095.558ENSMUSG00000031960Aars10095.558Mus_musculus
ENSG00000090861AARS10096.178ENSMPUG00000010060AARS10096.178Mustela_putorius_furo
ENSG00000090861AARS10096.074ENSMLUG00000007431AARS10096.074Myotis_lucifugus
ENSG00000090861AARS10096.591ENSNGAG00000003676Aars10096.591Nannospalax_galili
ENSG00000090861AARS9980.415ENSNBRG00000007321aars9980.415Neolamprologus_brichardi
ENSG00000090861AARS9479.052ENSMEUG00000016034-10079.052Notamacropus_eugenii
ENSG00000090861AARS6289.017ENSMEUG00000006934-10091.504Notamacropus_eugenii
ENSG00000090861AARS10092.975ENSOPRG00000003373AARS10092.975Ochotona_princeps
ENSG00000090861AARS10089.153ENSODEG00000014435-10089.153Octodon_degus
ENSG00000090861AARS8993.145ENSODEG00000014606-6792.903Octodon_degus
ENSG00000090861AARS9980.725ENSONIG00000011185aars9980.725Oreochromis_niloticus
ENSG00000090861AARS10092.769ENSOANG00000001157AARS10092.769Ornithorhynchus_anatinus
ENSG00000090861AARS10093.138ENSOCUG00000008872AARS10093.138Oryctolagus_cuniculus
ENSG00000090861AARS9980.000ENSORLG00000013398aars9980.000Oryzias_latipes
ENSG00000090861AARS9980.104ENSORLG00020017581aars9980.104Oryzias_latipes_hni
ENSG00000090861AARS9980.000ENSORLG00015007783aars9980.000Oryzias_latipes_hsok
ENSG00000090861AARS9980.933ENSOMEG00000014361aars9980.933Oryzias_melastigma
ENSG00000090861AARS10097.107ENSOGAG00000011601AARS10097.107Otolemur_garnettii
ENSG00000090861AARS10095.558ENSOARG00000005286AARS10095.558Ovis_aries
ENSG00000090861AARS10099.793ENSPPAG00000040404AARS100100.000Pan_paniscus
ENSG00000090861AARS10096.281ENSPPRG00000013214AARS10096.281Panthera_pardus
ENSG00000090861AARS10096.178ENSPTIG00000021477AARS10096.178Panthera_tigris_altaica
ENSG00000090861AARS10099.793ENSPTRG00000008297AARS100100.000Pan_troglodytes
ENSG00000090861AARS10098.864ENSPANG00000020452AARS10098.864Papio_anubis
ENSG00000090861AARS10081.715ENSPKIG00000002593aars10081.715Paramormyrops_kingsleyae
ENSG00000090861AARS10084.639ENSPSIG00000012820AARS10084.639Pelodiscus_sinensis
ENSG00000090861AARS9979.482ENSPMGG00000016971aars9979.482Periophthalmus_magnuspinnatus
ENSG00000090861AARS10096.074ENSPEMG00000010864Aars10096.074Peromyscus_maniculatus_bairdii
ENSG00000090861AARS9969.969ENSPMAG00000001946aars10069.969Petromyzon_marinus
ENSG00000090861AARS10089.979ENSPCIG00000010681AARS10089.979Phascolarctos_cinereus
ENSG00000090861AARS9980.518ENSPFOG00000015763aars9980.518Poecilia_formosa
ENSG00000090861AARS9980.518ENSPLAG00000014226aars9980.518Poecilia_latipinna
ENSG00000090861AARS9980.725ENSPMEG00000019736aars9980.725Poecilia_mexicana
ENSG00000090861AARS9980.104ENSPREG00000019562aars9980.104Poecilia_reticulata
ENSG00000090861AARS10076.404ENSPPYG00000007544-10076.404Pongo_abelii
ENSG00000090861AARS8994.758ENSPCAG00000012883AARS8197.959Procavia_capensis
ENSG00000090861AARS10097.626ENSPCOG00000016630AARS10097.984Propithecus_coquereli
ENSG00000090861AARS10095.558ENSPVAG00000000669AARS10095.558Pteropus_vampyrus
ENSG00000090861AARS9980.415ENSPNYG00000010796aars9980.415Pundamilia_nyererei
ENSG00000090861AARS9982.054ENSPNAG00000015269aars9282.054Pygocentrus_nattereri
ENSG00000090861AARS10095.145ENSRNOG00000018404Aars10095.145Rattus_norvegicus
ENSG00000090861AARS10098.657ENSRBIG00000032650AARS10098.657Rhinopithecus_bieti
ENSG00000090861AARS10098.967ENSRROG00000027324AARS10099.190Rhinopithecus_roxellana
ENSG00000090861AARS9551.509YOR335CALA19950.465Saccharomyces_cerevisiae
ENSG00000090861AARS10097.417ENSSBOG00000022141AARS10098.387Saimiri_boliviensis_boliviensis
ENSG00000090861AARS10091.116ENSSHAG00000007347AARS10091.116Sarcophilus_harrisii
ENSG00000090861AARS9981.516ENSSFOG00015011897AARS9981.516Scleropages_formosus
ENSG00000090861AARS9976.907ENSSFOG00015013147aars9878.835Scleropages_formosus
ENSG00000090861AARS9978.964ENSSMAG00000014488aars9978.964Scophthalmus_maximus
ENSG00000090861AARS9979.689ENSSDUG00000021127aars9979.689Seriola_dumerili
ENSG00000090861AARS9979.896ENSSLDG00000017716aars9979.896Seriola_lalandi_dorsalis
ENSG00000090861AARS5197.436ENSSARG00000006382-6997.436Sorex_araneus
ENSG00000090861AARS10085.227ENSSPUG00000001911AARS10085.227Sphenodon_punctatus
ENSG00000090861AARS9980.311ENSSPAG00000001290aars9980.311Stegastes_partitus
ENSG00000090861AARS9951.035ENSSSCG00000040225-10053.340Sus_scrofa
ENSG00000090861AARS10094.938ENSSSCG00000002723-10094.938Sus_scrofa
ENSG00000090861AARS10086.983ENSTGUG00000005683AARS10086.983Taeniopygia_guttata
ENSG00000090861AARS9080.641ENSTRUG00000000907aars9988.889Takifugu_rubripes
ENSG00000090861AARS9978.882ENSTNIG00000004016aars9978.882Tetraodon_nigroviridis
ENSG00000090861AARS9570.824ENSTBEG00000017122-9970.824Tupaia_belangeri
ENSG00000090861AARS10095.455ENSUAMG00000007008AARS10095.455Ursus_americanus
ENSG00000090861AARS10095.558ENSUMAG00000016975AARS10095.558Ursus_maritimus
ENSG00000090861AARS7697.938ENSVPAG00000003189AARS8097.938Vicugna_pacos
ENSG00000090861AARS10095.971ENSVVUG00000018036AARS10095.971Vulpes_vulpes
ENSG00000090861AARS10083.161ENSXETG00000007668aars10083.161Xenopus_tropicalis
ENSG00000090861AARS9980.518ENSXCOG00000013625aars9980.518Xiphophorus_couchianus
ENSG00000090861AARS9980.725ENSXMAG00000006282aars9980.725Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000049tRNA binding21873635.IBAFunction
GO:0002161aminoacyl-tRNA editing activity21873635.IBAFunction
GO:0002161aminoacyl-tRNA editing activity28493438.IDAFunction
GO:0002196Ser-tRNA(Ala) hydrolase activity21873635.IBAFunction
GO:0002196Ser-tRNA(Ala) hydrolase activity-ISSFunction
GO:0004813alanine-tRNA ligase activity21873635.IBAFunction
GO:0004813alanine-tRNA ligase activity27622773.28493438.IDAFunction
GO:0004813alanine-tRNA ligase activity-TASFunction
GO:0005524ATP binding21873635.IBAFunction
GO:0005737cytoplasm7654687.TASComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0006400tRNA modification21873635.IBAProcess
GO:0006400tRNA modification-ISSProcess
GO:0006418tRNA aminoacylation for protein translation-TASProcess
GO:0006419alanyl-tRNA aminoacylation21873635.IBAProcess
GO:0006419alanyl-tRNA aminoacylation27622773.28493438.IDAProcess
GO:0008033tRNA processing7654687.TASProcess
GO:0008270zinc ion binding-IEAFunction
GO:0016020membrane19946888.HDAComponent
GO:0016597amino acid binding21873635.IBAFunction
GO:0021680cerebellar Purkinje cell layer development21873635.IBAProcess
GO:0043524negative regulation of neuron apoptotic process21873635.IBAProcess
GO:0045182translation regulator activity-IEAFunction
GO:0050885neuromuscular process controlling balance21873635.IBAProcess
GO:0070062extracellular exosome20458337.HDAComponent
GO:0106074aminoacyl-tRNA metabolism involved in translational fidelity-IEAProcess
GO:0140018regulation of cytoplasmic translational fidelity21873635.IBAProcess

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