EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000091140 (Gene tree)
Gene ID: 1738
Gene Symbol: DLD
Alias: DLDH|E3|LAD|GCSL
Full Name: dihydrolipoamide dehydrogenase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 40,761 bases
Position: chr7:107,890,970-107,931,730
Accession: 2898
RBP type: non-canonical RBP
Summary: This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000489184	DLD-212	638	-	-	- (aa)	-	-
ENST00000460577	DLD-209	600	-	-	- (aa)	-	-
ENST00000417551	DLD-203	2041	-	ENSP00000390667	509 (aa)	-	P09622
ENST00000415325	DLD-202	1802	-	ENSP00000402593	58 (aa)	-	F8WDY5
ENST00000453354	DLD-208	537	-	-	- (aa)	-	-
ENST00000478414	DLD-210	549	-	-	- (aa)	-	-
ENST00000485066	DLD-211	483	-	-	- (aa)	-	-
ENST00000494441	DLD-213	707	-	-	- (aa)	-	-
ENST00000451081	DLD-207	930	-	ENSP00000388077	115 (aa)	-	F2Z2E3
ENST00000639772	DLD-214	421	-	ENSP00000492159	114 (aa)	-	A0A1W2PR83
ENST00000437604	DLD-204	1859	-	ENSP00000387542	461 (aa)	-	P09622
ENST00000205402	DLD-201	3755	-	ENSP00000205402	509 (aa)	-	P09622
ENST00000450038	DLD-206	682	-	ENSP00000409590	114 (aa)	-	F8WDM5
ENST00000440410	DLD-205	1993	-	ENSP00000417016	486 (aa)	-	E9PEX6

Gene Model

Click here to download ENSG00000091140's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00010	Glycolysis / Gluconeogenesis	KEGG
hsa00020	Citrate cycle (TCA cycle)	KEGG
hsa00260	Glycine, serine and threonine metabolism	KEGG
hsa00280	Valine, leucine and isoleucine degradation	KEGG
hsa00310	Lysine degradation	KEGG
hsa00380	Tryptophan metabolism	KEGG
hsa00620	Pyruvate metabolism	KEGG
hsa00630	Glyoxylate and dicarboxylate metabolism	KEGG
hsa00640	Propanoate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000091140	P-Selectin	7.8151193195575E-5	17903293
ENSG00000091140	P-Selectin	2.53119544371057E-5	17903293

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000091140's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000091140	DLD	100	94.892	ENSMUSG00000020664	Dld	100	94.892	Mus_musculus
ENSG00000091140	DLD	92	57.384	YFL018C	LPD1	94	57.384	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004148	dihydrolipoyl dehydrogenase activity	16442803.	IDA	Function
GO:0005515	protein binding	16263718.16442803.29128334.	IPI	Function
GO:0005634	nucleus	29211711.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005739	mitochondrion	29211711.	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0006090	pyruvate metabolic process	-	TAS	Process
GO:0006099	tricarboxylic acid cycle	-	TAS	Process
GO:0006103	2-oxoglutarate metabolic process	-	IEA	Process
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	-	IEA	Process
GO:0006508	proteolysis	-	IEA	Process
GO:0006554	lysine catabolic process	-	TAS	Process
GO:0007369	gastrulation	-	IEA	Process
GO:0007568	aging	-	IEA	Process
GO:0009055	electron transfer activity	-	IEA	Function
GO:0009083	branched-chain amino acid catabolic process	-	TAS	Process
GO:0009106	lipoate metabolic process	-	IEA	Process
GO:0031514	motile cilium	-	IEA	Component
GO:0034604	pyruvate dehydrogenase (NAD+) activity	9242632.	IDA	Function
GO:0042391	regulation of membrane potential	-	IEA	Process
GO:0043159	acrosomal matrix	-	IEA	Component
GO:0043544	lipoamide binding	-	IEA	Function
GO:0045252	oxoglutarate dehydrogenase complex	29211711.	IDA	Component
GO:0045254	pyruvate dehydrogenase complex	9242632.	IDA	Component
GO:0045454	cell redox homeostasis	-	IEA	Process
GO:0048240	sperm capacitation	-	IEA	Process
GO:0050660	flavin adenine dinucleotide binding	-	IEA	Function
GO:0051068	dihydrolipoamide metabolic process	-	IEA	Process
GO:0051287	NAD binding	-	IEA	Function
GO:0061732	mitochondrial acetyl-CoA biosynthetic process from pyruvate	9242632.	IC	Process
GO:0106077	histone succinylation	29211711.	IDA	Process