EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000091542 (Gene tree)
Gene ID: 54890
Gene Symbol: ALKBH5
Alias: FLJ20308|OFOXD1
Full Name: alkB homolog 5, RNA demethylase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 26,877 bases
Position: chr17:18,183,078-18,209,954
Accession: 25996
RBP type: canonical RBP
Summary: (AlkB Homolog 5, RNA Demethylase) is a Protein Coding gene. Diseases associated with ALKBH5 include Retinitis Pigmentosa 71 and Retinitis Pigmentosa 43. Among its related pathways are DNA Damage Reversal and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include oxidative RNA demethylase activity.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000382091	2OG-FeII_Oxy_2	PF13532.6	6e-10	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30306128	Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression.	Sci Adv	2018 Oct 3	Panneerdoss S	doi: 10.1126/sciadv.aar8263
30894375	The Critical Role of RNA m6A Methylation in Cancer.	Cancer Res	2019 Apr 1	Lan Q	doi: 10.1158/0008-5472.CAN-18-2965
24778178	Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.	J Biol Chem	2014 Jun 20	Xu C	doi: 10.1074/jbc.M114.550350
24616105	Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition.	J Biol Chem	2014 Apr 25	Feng C	doi: 10.1074/jbc.M113.546168
27072590	Increased N6-methyladenosine in Human Sperm RNA as a Risk Factor for Asthenozoospermia.	Sci Rep	2016 Apr 13	Yang Y	doi: 10.1038/srep24345.
27179969	N (6)-Methyladenosine (m(6)A) Methylation in mRNA with A Dynamic and Reversible Epigenetic Modification.	Mol Biotechnol	2016 Jul	Wu R	doi: 10.1007/s12033-016-9947-9.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000399138	ALKBH5-201	2748	-	ENSP00000382091	394 (aa)	-	Q6P6C2
ENST00000541285	ALKBH5-203	1605	-	ENSP00000468116	53 (aa)	-	K7ER58
ENST00000490106	ALKBH5-202	2146	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000091542's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000091542	Alanine Transaminase	7.996e-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000091542's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000091542	ALKBH5	99	64.631	ENSAPOG00000009959	alkbh5	99	64.631	Acanthochromis_polyacanthus
ENSG00000091542	ALKBH5	100	96.226	ENSAMEG00000004956	ALKBH5	97	98.857	Ailuropoda_melanoleuca
ENSG00000091542	ALKBH5	99	64.631	ENSACIG00000017828	alkbh5	99	64.377	Amphilophus_citrinellus
ENSG00000091542	ALKBH5	99	64.885	ENSAOCG00000022195	alkbh5	99	65.140	Amphiprion_ocellaris
ENSG00000091542	ALKBH5	99	64.377	ENSAPEG00000022697	alkbh5	99	64.377	Amphiprion_percula
ENSG00000091542	ALKBH5	99	64.122	ENSATEG00000007186	alkbh5	99	63.613	Anabas_testudineus
ENSG00000091542	ALKBH5	99	78.055	ENSACAG00000009646	ALKBH5	99	78.195	Anolis_carolinensis
ENSG00000091542	ALKBH5	100	100.000	ENSANAG00000032817	ALKBH5	100	99.746	Aotus_nancymaae
ENSG00000091542	ALKBH5	99	63.868	ENSACLG00000002713	alkbh5	99	63.613	Astatotilapia_calliptera
ENSG00000091542	ALKBH5	99	62.907	ENSAMXG00000037092	alkbh5	99	63.910	Astyanax_mexicanus
ENSG00000091542	ALKBH5	100	97.208	ENSBTAG00000025046	ALKBH5	100	97.208	Bos_taurus
ENSG00000091542	ALKBH5	100	100.000	ENSCJAG00000000974	-	100	99.239	Callithrix_jacchus
ENSG00000091542	ALKBH5	100	100.000	ENSCJAG00000046984	-	100	95.939	Callithrix_jacchus
ENSG00000091542	ALKBH5	100	97.970	ENSCAFG00000018315	ALKBH5	91	97.970	Canis_familiaris
ENSG00000091542	ALKBH5	100	99.492	ENSCAFG00020021061	ALKBH5	100	99.492	Canis_lupus_dingo
ENSG00000091542	ALKBH5	100	97.462	ENSCHIG00000027248	ALKBH5	100	97.462	Capra_hircus
ENSG00000091542	ALKBH5	59	100.000	ENSTSYG00000012134	ALKBH5	91	100.000	Carlito_syrichta
ENSG00000091542	ALKBH5	100	98.223	ENSCPOG00000037709	ALKBH5	100	98.223	Cavia_porcellus
ENSG00000091542	ALKBH5	100	100.000	ENSCCAG00000020369	ALKBH5	100	99.239	Cebus_capucinus
ENSG00000091542	ALKBH5	100	100.000	ENSCATG00000041372	ALKBH5	100	94.162	Cercocebus_atys
ENSG00000091542	ALKBH5	100	98.113	ENSCLAG00000003812	ALKBH5	100	95.178	Chinchilla_lanigera
ENSG00000091542	ALKBH5	100	100.000	ENSCSAG00000008183	ALKBH5	100	100.000	Chlorocebus_sabaeus
ENSG00000091542	ALKBH5	99	81.454	ENSCPBG00000020984	ALKBH5	99	80.397	Chrysemys_picta_bellii
ENSG00000091542	ALKBH5	100	100.000	ENSCANG00000033849	ALKBH5	100	96.447	Colobus_angolensis_palliatus
ENSG00000091542	ALKBH5	100	97.215	ENSCGRG00001004268	Alkbh5	100	97.215	Cricetulus_griseus_chok1gshd
ENSG00000091542	ALKBH5	99	65.228	ENSCSEG00000002327	alkbh5	99	64.631	Cynoglossus_semilaevis
ENSG00000091542	ALKBH5	99	64.912	ENSCVAG00000022772	alkbh5	99	64.885	Cyprinodon_variegatus
ENSG00000091542	ALKBH5	99	65.909	ENSDARG00000063003	alkbh5	99	65.404	Danio_rerio
ENSG00000091542	ALKBH5	85	98.512	ENSDNOG00000007935	ALKBH5	100	98.512	Dasypus_novemcinctus
ENSG00000091542	ALKBH5	100	99.239	ENSEASG00005017626	ALKBH5	100	99.239	Equus_asinus_asinus
ENSG00000091542	ALKBH5	100	99.492	ENSECAG00000018358	ALKBH5	100	99.492	Equus_caballus
ENSG00000091542	ALKBH5	98	93.041	ENSEEUG00000010618	ALKBH5	87	92.802	Erinaceus_europaeus
ENSG00000091542	ALKBH5	99	64.885	ENSELUG00000016444	alkbh5	99	65.903	Esox_lucius
ENSG00000091542	ALKBH5	100	99.239	ENSFCAG00000033826	ALKBH5	100	99.239	Felis_catus
ENSG00000091542	ALKBH5	100	76.364	ENSFALG00000013746	ALKBH5	97	86.167	Ficedula_albicollis
ENSG00000091542	ALKBH5	100	98.113	ENSFDAG00000011356	ALKBH5	100	88.832	Fukomys_damarensis
ENSG00000091542	ALKBH5	85	66.866	ENSFHEG00000017211	alkbh5	88	65.269	Fundulus_heteroclitus
ENSG00000091542	ALKBH5	99	62.217	ENSGMOG00000007690	alkbh5	99	60.448	Gadus_morhua
ENSG00000091542	ALKBH5	99	80.203	ENSGALG00000043693	ALKBH5	99	80.711	Gallus_gallus
ENSG00000091542	ALKBH5	99	63.317	ENSGAFG00000013091	alkbh5	94	62.814	Gambusia_affinis
ENSG00000091542	ALKBH5	99	61.168	ENSGACG00000016621	alkbh5	99	61.168	Gasterosteus_aculeatus
ENSG00000091542	ALKBH5	99	82.532	ENSGAGG00000007453	ALKBH5	99	81.343	Gopherus_agassizii
ENSG00000091542	ALKBH5	100	100.000	ENSGGOG00000016223	ALKBH5	100	100.000	Gorilla_gorilla
ENSG00000091542	ALKBH5	99	64.122	ENSHBUG00000018324	alkbh5	99	63.868	Haplochromis_burtoni
ENSG00000091542	ALKBH5	83	98.773	ENSHGLG00000013317	-	100	98.773	Heterocephalus_glaber_female
ENSG00000091542	ALKBH5	100	98.113	ENSHGLG00100008720	-	100	90.863	Heterocephalus_glaber_male
ENSG00000091542	ALKBH5	99	60.152	ENSHCOG00000010816	alkbh5	99	61.323	Hippocampus_comes
ENSG00000091542	ALKBH5	100	98.477	ENSSTOG00000024574	ALKBH5	100	98.477	Ictidomys_tridecemlineatus
ENSG00000091542	ALKBH5	99	63.959	ENSKMAG00000008615	alkbh5	99	63.452	Kryptolebias_marmoratus
ENSG00000091542	ALKBH5	99	62.755	ENSLBEG00000007886	alkbh5	99	61.713	Labrus_bergylta
ENSG00000091542	ALKBH5	100	67.273	ENSLOCG00000005006	alkbh5	82	76.968	Lepisosteus_oculatus
ENSG00000091542	ALKBH5	100	98.223	ENSLAFG00000015521	ALKBH5	100	98.223	Loxodonta_africana
ENSG00000091542	ALKBH5	100	100.000	ENSMFAG00000001517	ALKBH5	100	100.000	Macaca_fascicularis
ENSG00000091542	ALKBH5	100	100.000	ENSMNEG00000037007	ALKBH5	100	100.000	Macaca_nemestrina
ENSG00000091542	ALKBH5	100	100.000	ENSMLEG00000036607	ALKBH5	100	100.000	Mandrillus_leucophaeus
ENSG00000091542	ALKBH5	99	63.797	ENSMAMG00000007695	alkbh5	99	63.452	Mastacembelus_armatus
ENSG00000091542	ALKBH5	99	63.868	ENSMZEG00005012673	alkbh5	99	63.613	Maylandia_zebra
ENSG00000091542	ALKBH5	100	96.709	ENSMAUG00000012991	Alkbh5	100	96.709	Mesocricetus_auratus
ENSG00000091542	ALKBH5	100	99.746	ENSMICG00000044316	ALKBH5	100	99.746	Microcebus_murinus
ENSG00000091542	ALKBH5	100	97.975	ENSMOCG00000002615	Alkbh5	100	97.975	Microtus_ochrogaster
ENSG00000091542	ALKBH5	99	62.217	ENSMMOG00000020265	alkbh5	99	62.406	Mola_mola
ENSG00000091542	ALKBH5	100	89.594	ENSMODG00000013731	ALKBH5	100	88.325	Monodelphis_domestica
ENSG00000091542	ALKBH5	99	64.631	ENSMALG00000018344	alkbh5	99	64.090	Monopterus_albus
ENSG00000091542	ALKBH5	100	96.962	MGP_CAROLIEiJ_G0016458	Alkbh5	100	96.962	Mus_caroli
ENSG00000091542	ALKBH5	100	96.962	ENSMUSG00000042650	Alkbh5	100	96.962	Mus_musculus
ENSG00000091542	ALKBH5	100	97.215	MGP_PahariEiJ_G0017588	Alkbh5	100	97.215	Mus_pahari
ENSG00000091542	ALKBH5	100	96.962	MGP_SPRETEiJ_G0017293	Alkbh5	100	96.962	Mus_spretus
ENSG00000091542	ALKBH5	100	99.492	ENSMPUG00000000032	ALKBH5	100	99.492	Mustela_putorius_furo
ENSG00000091542	ALKBH5	100	98.985	ENSMLUG00000001337	ALKBH5	100	98.985	Myotis_lucifugus
ENSG00000091542	ALKBH5	100	97.716	ENSNGAG00000011033	Alkbh5	100	97.716	Nannospalax_galili
ENSG00000091542	ALKBH5	99	64.377	ENSNBRG00000009936	alkbh5	99	63.868	Neolamprologus_brichardi
ENSG00000091542	ALKBH5	100	100.000	ENSNLEG00000035985	ALKBH5	100	93.401	Nomascus_leucogenys
ENSG00000091542	ALKBH5	100	87.817	ENSMEUG00000010609	ALKBH5	88	86.802	Notamacropus_eugenii
ENSG00000091542	ALKBH5	100	98.731	ENSODEG00000005760	ALKBH5	100	98.731	Octodon_degus
ENSG00000091542	ALKBH5	99	64.631	ENSONIG00000003181	alkbh5	99	64.377	Oreochromis_niloticus
ENSG00000091542	ALKBH5	99	92.839	ENSOCUG00000009240	ALKBH5	87	92.839	Oryctolagus_cuniculus
ENSG00000091542	ALKBH5	100	64.051	ENSORLG00000009235	alkbh5	100	63.772	Oryzias_latipes
ENSG00000091542	ALKBH5	100	63.797	ENSORLG00020011448	alkbh5	94	69.527	Oryzias_latipes_hni
ENSG00000091542	ALKBH5	100	63.797	ENSORLG00015010675	alkbh5	100	63.524	Oryzias_latipes_hsok
ENSG00000091542	ALKBH5	99	65.140	ENSOMEG00000020820	alkbh5	99	64.589	Oryzias_melastigma
ENSG00000091542	ALKBH5	100	100.000	ENSPPAG00000030479	ALKBH5	100	100.000	Pan_paniscus
ENSG00000091542	ALKBH5	100	99.239	ENSPPRG00000017981	ALKBH5	100	99.239	Panthera_pardus
ENSG00000091542	ALKBH5	100	100.000	ENSPTRG00000024216	ALKBH5	100	100.000	Pan_troglodytes
ENSG00000091542	ALKBH5	100	100.000	ENSPANG00000023682	ALKBH5	100	100.000	Papio_anubis
ENSG00000091542	ALKBH5	99	66.667	ENSPKIG00000013829	ALKBH5	99	66.919	Paramormyrops_kingsleyae
ENSG00000091542	ALKBH5	93	66.033	ENSPKIG00000017327	alkbh5	96	65.229	Paramormyrops_kingsleyae
ENSG00000091542	ALKBH5	99	82.576	ENSPSIG00000009583	ALKBH5	99	81.047	Pelodiscus_sinensis
ENSG00000091542	ALKBH5	99	62.341	ENSPMGG00000009517	alkbh5	99	64.213	Periophthalmus_magnuspinnatus
ENSG00000091542	ALKBH5	100	90.609	ENSPCIG00000001861	ALKBH5	100	89.340	Phascolarctos_cinereus
ENSG00000091542	ALKBH5	99	64.051	ENSPFOG00000004159	alkbh5	99	64.051	Poecilia_formosa
ENSG00000091542	ALKBH5	99	64.377	ENSPLAG00000010799	alkbh5	99	64.377	Poecilia_latipinna
ENSG00000091542	ALKBH5	99	64.377	ENSPMEG00000020572	alkbh5	99	64.377	Poecilia_mexicana
ENSG00000091542	ALKBH5	99	64.631	ENSPREG00000000055	alkbh5	99	64.631	Poecilia_reticulata
ENSG00000091542	ALKBH5	99	77.608	ENSPCAG00000011113	ALKBH5	88	77.608	Procavia_capensis
ENSG00000091542	ALKBH5	100	99.746	ENSPCOG00000000705	ALKBH5	100	99.746	Propithecus_coquereli
ENSG00000091542	ALKBH5	98	98.705	ENSPVAG00000005776	ALKBH5	88	98.705	Pteropus_vampyrus
ENSG00000091542	ALKBH5	99	64.122	ENSPNYG00000020156	alkbh5	99	63.868	Pundamilia_nyererei
ENSG00000091542	ALKBH5	99	63.819	ENSPNAG00000014968	alkbh5	99	63.384	Pygocentrus_nattereri
ENSG00000091542	ALKBH5	100	97.468	ENSRNOG00000028341	Alkbh5	100	97.468	Rattus_norvegicus
ENSG00000091542	ALKBH5	100	100.000	ENSRBIG00000029698	ALKBH5	100	100.000	Rhinopithecus_bieti
ENSG00000091542	ALKBH5	100	100.000	ENSRROG00000033654	ALKBH5	100	100.000	Rhinopithecus_roxellana
ENSG00000091542	ALKBH5	100	98.113	ENSSBOG00000023339	ALKBH5	100	92.982	Saimiri_boliviensis_boliviensis
ENSG00000091542	ALKBH5	98	90.464	ENSSHAG00000005278	ALKBH5	93	89.175	Sarcophilus_harrisii
ENSG00000091542	ALKBH5	98	51.667	ENSSFOG00015023592	ALKBH5	90	69.350	Scleropages_formosus
ENSG00000091542	ALKBH5	99	67.513	ENSSFOG00015008148	alkbh5	99	66.332	Scleropages_formosus
ENSG00000091542	ALKBH5	99	64.631	ENSSMAG00000000195	alkbh5	99	63.613	Scophthalmus_maximus
ENSG00000091542	ALKBH5	99	64.631	ENSSDUG00000015880	alkbh5	99	64.885	Seriola_dumerili
ENSG00000091542	ALKBH5	99	64.631	ENSSLDG00000022333	alkbh5	99	64.885	Seriola_lalandi_dorsalis
ENSG00000091542	ALKBH5	98	81.186	ENSSARG00000009722	ALKBH5	83	81.491	Sorex_araneus
ENSG00000091542	ALKBH5	99	81.704	ENSSPUG00000004432	ALKBH5	99	81.658	Sphenodon_punctatus
ENSG00000091542	ALKBH5	99	64.885	ENSSPAG00000011009	alkbh5	99	65.140	Stegastes_partitus
ENSG00000091542	ALKBH5	100	96.193	ENSSSCG00000035120	ALKBH5	100	96.193	Sus_scrofa
ENSG00000091542	ALKBH5	99	79.442	ENSTGUG00000007229	ALKBH5	99	80.506	Taeniopygia_guttata
ENSG00000091542	ALKBH5	99	61.266	ENSTRUG00000013324	alkbh5	99	61.168	Takifugu_rubripes
ENSG00000091542	ALKBH5	99	62.532	ENSTNIG00000008275	alkbh5	99	63.131	Tetraodon_nigroviridis
ENSG00000091542	ALKBH5	98	97.409	ENSTTRG00000008156	ALKBH5	87	97.409	Tursiops_truncatus
ENSG00000091542	ALKBH5	100	99.239	ENSUAMG00000010729	ALKBH5	100	99.239	Ursus_americanus
ENSG00000091542	ALKBH5	92	83.425	ENSVPAG00000008327	ALKBH5	87	83.425	Vicugna_pacos
ENSG00000091542	ALKBH5	100	96.226	ENSVVUG00000030107	ALKBH5	100	94.670	Vulpes_vulpes
ENSG00000091542	ALKBH5	100	66.071	ENSXETG00000005769	alkbh5	99	63.706	Xenopus_tropicalis
ENSG00000091542	ALKBH5	99	63.291	ENSXCOG00000005331	alkbh5	99	64.122	Xiphophorus_couchianus
ENSG00000091542	ALKBH5	99	63.038	ENSXMAG00000015514	alkbh5	95	62.563	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001666	response to hypoxia	21264265.	IDA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	21264265.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006307	DNA dealkylation involved in DNA repair	-	TAS	Process
GO:0006397	mRNA processing	21873635.	IBA	Process
GO:0006397	mRNA processing	23177736.	IMP	Process
GO:0006406	mRNA export from nucleus	21873635.	IBA	Process
GO:0006406	mRNA export from nucleus	23177736.	IMP	Process
GO:0007283	spermatogenesis	-	ISS	Process
GO:0016607	nuclear speck	23177736.	IDA	Component
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	21264265.	IDA	Function
GO:0030154	cell differentiation	-	IEA	Process
GO:0035553	oxidative single-stranded RNA demethylation	21873635.	IBA	Process
GO:0035553	oxidative single-stranded RNA demethylation	23177736.24616105.	IDA	Process
GO:0043488	regulation of mRNA stability	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:1990931	RNA N6-methyladenosine dioxygenase activity	23177736.24616105.	IDA	Function