EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000092199 (Gene tree)
Gene ID: 3183
Gene Symbol: HNRNPC
Alias: hnRNPC|HNRPC
Full Name: heterogeneous nuclear ribonucleoprotein C (C1/C2)
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 60,359 bases
Position: chr14:21,209,136-21,269,494
Accession: 5035
RBP type: canonical RBP
Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000452573	RRM_1	PF00076.22	2.9e-13	1	1
ENSP00000451292	RRM_1	PF00076.22	3.2e-13	1	1
ENSP00000450467	RRM_1	PF00076.22	3.6e-13	1	1
ENSP00000452185	RRM_1	PF00076.22	7.1e-13	1	1
ENSP00000452213	RRM_1	PF00076.22	8.1e-13	1	1
ENSP00000450629	RRM_1	PF00076.22	9.7e-13	1	1
ENSP00000452021	RRM_1	PF00076.22	1e-12	1	1
ENSP00000451187	RRM_1	PF00076.22	1.1e-12	1	1
ENSP00000452214	RRM_1	PF00076.22	1.1e-12	1	1
ENSP00000404559	RRM_1	PF00076.22	1.3e-12	1	1
ENSP00000338095	RRM_1	PF00076.22	1.3e-12	1	1
ENSP00000450548	RRM_1	PF00076.22	1.3e-12	1	1
ENSP00000442816	RRM_1	PF00076.22	1.3e-12	1	1
ENSP00000450544	RRM_1	PF00076.22	1.3e-12	1	1
ENSP00000450725	RRM_1	PF00076.22	1.3e-12	1	1
ENSP00000451176	RRM_1	PF00076.22	1.3e-12	1	1
ENSP00000404848	RRM_1	PF00076.22	1.4e-12	1	1
ENSP00000451291	RRM_1	PF00076.22	1.4e-12	1	1
ENSP00000452276	RRM_1	PF00076.22	1.4e-12	1	1
ENSP00000451708	RRM_1	PF00076.22	1.5e-12	1	1
ENSP00000450790	RRM_1	PF00076.22	1.7e-12	1	1
ENSP00000451892	RRM_1	PF00076.22	2.3e-10	1	1
ENSP00000450669	RRM_1	PF00076.22	3.7e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25719671	N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions.	Nature	2015 Feb 26	Liu N	doi: 10.1038/nature14234.
25878250	Heterogeneous Nuclear Ribonucleoprotein C Proteins Interact with the Human Papillomavirus Type 16 (HPV16) Early 3'-Untranslated Region and Alleviate Suppression of HPV16 Late L1 mRNA Splicing.	J Biol Chem	2015 May 22	Dhanjal S	doi: 10.1074/jbc.M115.638098
7508381	RNA annealing activities in HeLa nuclei.	EMBO J	1994 Jan 1	Portman DS	-
28977511	Towards enhanced and interpretable clustering/classification in integrative genomics.	Nucleic Acids Res	2017 Nov 16	Lu YY	doi: 10.1093/nar/gkx767.
25890165	Role of human heterogeneous nuclear ribonucleoprotein C1/C2 in dengue virus replication.	Virol J	2015 Feb 6	Dechtawewat T	doi: 10.1186/s12985-014-0219-7.
11113151	Mutational definition of RNA-binding and protein-protein interaction domains of heterogeneous nuclear RNP C1.	J Biol Chem	2001 Mar 9	Wan L	-
24379680	hnRNP C1/C2 and Pur-beta proteins mediate induction of senescence by oligonucleotides homologous to the telomere overhang.	Onco Targets Ther	2013 Dec 18	Mulnix RE	doi: 10.2147/OTT.S54575
25506471	The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts.	Bone Res	2014	Lisse TS	-
9694897	The heterogeneous nuclear ribonucleoprotein C protein tetramer binds U1, U2, and U6 snRNAs through its high affinity RNA binding domain (the bZIP-like motif).	J Biol Chem	1998 Aug 14	Shahied-Milam L	-
8083209	The determinants of RNA-binding specificity of the heterogeneous nuclear ribonucleoprotein C proteins.	J Biol Chem	1994 Sep 16	Gorlach M	-
7593227	Characterization of adenosine-uridine-rich RNA binding factors.	J Cell Physiol	1995 Dec	Nakamaki T	-
19319956	Increased expression of cellular RNA-binding proteins in HPV-induced neoplasia and cervical cancer.	J Med Virol	2009 May	Fay J	doi: 10.1002/jmv.21406.
18494499	Posttranscriptional regulation of urokinase receptor expression by heterogeneous nuclear ribonuclear protein C.	Biochemistry	2008 Jun 17	Velusamy T	doi: 10.1021/bi702338y
20473314	hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies.	Nat Struct Mol Biol	2010 Jun	Lee EK	doi: 10.1038/nsmb.1815
23599772	Overexpression of hnRNPC2 induces multinucleation by repression of Aurora B in hepatocellular carcinoma cells.	Oncol Lett	2013 Apr	Sun DQ	-
26690054	RNA-binding proteins regulate cell respiration and coenzyme Q biosynthesis by post-transcriptional regulation of COQ7.	RNA Biol	2016 Jul 2	Cascajo MV	doi: 10.1080/15476286.2015.1119366
30158112	Function of HNRNPC in breast cancer cells by controlling the dsRNA-induced interferon response.	EMBO J	2018 Dec 3	Wu Y	doi: 10.15252/embj.201899017
30824187	LBX2-AS1 is activated by ZEB1 and promotes the development of esophageal squamous cell carcinoma by interacting with HNRNPC toenhance the stability of ZEB1 and ZEB2 mRNAs.	Biochem Biophys Res Commun	2019 Apr 9	Zhang Y	doi: 10.1016/j.bbrc.2019.02.079
12123807	Interaction of hnRNP-C1/C2 proteins with RNA: analysis using the yeast three-hybrid system.	FEBS Lett	2002 Jul 17	Koloteva-Levine N	-
25447737	Vitamin D and alternative splicing of RNA.	J Steroid Biochem Mol Biol	2015 Apr	Zhou R	doi: 10.1016/j.jsbmb.2014.09.025
9488731	Vav binding to heterogeneous nuclear ribonucleoprotein (hnRNP) C. Evidence for Vav-hnRNP interactions in an RNA-dependent manner.	J Biol Chem	1998 Mar 6	Romero F	-
22983828	HuR-hnRNP interactions and the effect of cellular stress.	Mol Cell Biochem	2013 Jan	Papadopoulou C	doi: 10.1007/s11010-012-1454-0
17321087	Proteomic analysis of cisplatin-induced cochlear damage: methods and early changes in protein expression.	Hear Res	2007 Apr	Coling DE	-
17159903	A role for hnRNP C1/C2 and Unr in internal initiation of translation during mitosis.	EMBO J	2007 Jan 10	Schepens B	-
31234696	Strand-specific affinity of host factor hnRNP C1/C2 guides positive to negative-strand ratio in Coxsackievirus B3 infection.	RNA Biol	2019 Jun 24:1-14	Dave P	doi: 10.1080/15476286.2019.1629208

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000553614	HNRNPC-207	604	-	-	- (aa)	-	-
ENST00000555127	HNRNPC-215	929	-	-	- (aa)	-	-
ENST00000556628	HNRNPC-226	1156	-	ENSP00000451652	226 (aa)	-	P07910
ENST00000430246	HNRNPC-203	4501	-	ENSP00000442816	293 (aa)	-	P07910
ENST00000557201	HNRNPC-230	1371	-	ENSP00000452276	306 (aa)	-	P07910
ENST00000336053	HNRNPC-201	3301	-	ENSP00000338095	288 (aa)	-	B4DY08
ENST00000557442	HNRNPC-232	1308	-	ENSP00000452599	147 (aa)	-	B4DSU6
ENST00000555215	HNRNPC-218	781	-	ENSP00000452213	187 (aa)	-	G3V575
ENST00000557768	HNRNPC-233	599	-	ENSP00000450669	54 (aa)	-	G3V2H6
ENST00000554969	HNRNPC-214	1924	XM_017021253	ENSP00000450725	293 (aa)	XP_016876742	P07910
ENST00000557157	HNRNPC-229	698	-	ENSP00000450601	214 (aa)	-	G3V2D6
ENST00000557033	HNRNPC-228	760	-	-	- (aa)	-	-
ENST00000556897	HNRNPC-227	1252	-	ENSP00000451176	293 (aa)	-	P07910
ENST00000555585	HNRNPC-220	682	-	-	- (aa)	-	-
ENST00000553300	HNRNPC-205	1375	XM_006720125	ENSP00000450544	293 (aa)	XP_006720188	P07910
ENST00000556226	HNRNPC-224	629	-	ENSP00000451292	121 (aa)	-	G3V3K6
ENST00000554539	HNRNPC-212	748	-	ENSP00000452545	180 (aa)	-	G3V5V7
ENST00000555137	HNRNPC-216	789	-	ENSP00000452185	175 (aa)	-	G3V555
ENST00000555176	HNRNPC-217	531	-	ENSP00000452573	117 (aa)	-	G3V5X6
ENST00000554891	HNRNPC-213	644	-	ENSP00000450467	126 (aa)	-	G3V251
ENST00000557336	HNRNPC-231	580	-	ENSP00000451892	66 (aa)	-	G3V4M8
ENST00000554383	HNRNPC-209	1039	-	ENSP00000452021	262 (aa)	-	G3V4W0
ENST00000554455	HNRNPC-211	1784	XM_011536708	ENSP00000451291	306 (aa)	XP_011535010	P07910
ENST00000555309	HNRNPC-219	1714	-	ENSP00000450790	305 (aa)	-	G3V2Q1
ENST00000554417	HNRNPC-210	691	-	-	- (aa)	-	-
ENST00000556513	HNRNPC-225	1403	-	ENSP00000452214	231 (aa)	-	G3V576
ENST00000556142	HNRNPC-223	1599	-	ENSP00000451187	231 (aa)	-	G3V576
ENST00000420743	HNRNPC-202	1559	XM_024449556	ENSP00000404848	306 (aa)	XP_024305324	P07910
ENST00000555883	HNRNPC-221	1182	-	ENSP00000450629	250 (aa)	-	P07910
ENST00000553753	HNRNPC-208	1790	-	ENSP00000450548	288 (aa)	-	B4DY08
ENST00000553444	HNRNPC-206	724	-	-	- (aa)	-	-
ENST00000555914	HNRNPC-222	1658	-	ENSP00000451708	292 (aa)	-	G3V4C1
ENST00000449098	HNRNPC-204	1599	-	ENSP00000404559	290 (aa)	-	B2R5W2

Gene Model

Click here to download ENSG00000092199's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000092199	Hemoglobin A, Glycosylated	3.7350000E-005	19875614
ENSG00000092199	Triglycerides	5.1490000E-005	-
ENSG00000092199	Bipolar Disorder	2E-6	21738484

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000092199	rs17197037	14	21257495	A	Bipolar disorder	21738484	[NR]	1.17	EFO_0000289

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000092199's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000092199	HNRNPC	62	32.500	ENSG00000213516	RBMXL1	55	32.955
ENSG00000092199	HNRNPC	76	42.000	ENSG00000100650	SRSF5	82	35.366
ENSG00000092199	HNRNPC	100	94.737	ENSG00000179172	HNRNPCL1	100	90.785
ENSG00000092199	HNRNPC	100	80.303	ENSG00000125970	RALY	88	83.784
ENSG00000092199	HNRNPC	62	34.667	ENSG00000115875	SRSF7	56	34.667
ENSG00000092199	HNRNPC	96	84.615	ENSG00000184672	RALYL	92	80.769
ENSG00000092199	HNRNPC	52	30.263	ENSG00000124193	SRSF6	56	30.263

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000092199	HNRNPC	100	100.000	ENSAMEG00000006492	HNRNPC	87	94.667	Ailuropoda_melanoleuca
ENSG00000092199	HNRNPC	100	98.485	ENSACAG00000029093	-	97	90.523	Anolis_carolinensis
ENSG00000092199	HNRNPC	100	98.473	ENSANAG00000038269	-	100	96.013	Aotus_nancymaae
ENSG00000092199	HNRNPC	100	93.939	ENSANAG00000029835	-	100	88.406	Aotus_nancymaae
ENSG00000092199	HNRNPC	93	98.000	ENSANAG00000034055	-	97	89.423	Aotus_nancymaae
ENSG00000092199	HNRNPC	100	100.000	ENSANAG00000034906	HNRNPC	100	100.000	Aotus_nancymaae
ENSG00000092199	HNRNPC	100	88.889	ENSANAG00000025823	-	84	86.312	Aotus_nancymaae
ENSG00000092199	HNRNPC	96	94.220	ENSANAG00000037534	-	98	89.952	Aotus_nancymaae
ENSG00000092199	HNRNPC	96	93.750	ENSANAG00000018389	-	100	79.452	Aotus_nancymaae
ENSG00000092199	HNRNPC	100	92.188	ENSANAG00000031628	-	100	91.186	Aotus_nancymaae
ENSG00000092199	HNRNPC	100	90.741	ENSANAG00000027016	-	97	87.739	Aotus_nancymaae
ENSG00000092199	HNRNPC	100	100.000	ENSBTAG00000011396	HNRNPC	100	98.299	Bos_taurus
ENSG00000092199	HNRNPC	100	80.303	ENSBTAG00000049420	-	95	86.735	Bos_taurus
ENSG00000092199	HNRNPC	100	98.092	ENSCJAG00000023213	-	97	96.121	Callithrix_jacchus
ENSG00000092199	HNRNPC	100	100.000	ENSCJAG00000003238	-	94	99.257	Callithrix_jacchus
ENSG00000092199	HNRNPC	100	100.000	ENSCJAG00000016319	-	99	93.728	Callithrix_jacchus
ENSG00000092199	HNRNPC	100	100.000	ENSCJAG00000009354	HNRNPC	100	100.000	Callithrix_jacchus
ENSG00000092199	HNRNPC	100	100.000	ENSCAFG00000002619	-	100	94.539	Canis_familiaris
ENSG00000092199	HNRNPC	100	98.413	ENSCAFG00000018380	-	100	96.939	Canis_familiaris
ENSG00000092199	HNRNPC	100	100.000	ENSCAFG00000005504	-	90	94.667	Canis_familiaris
ENSG00000092199	HNRNPC	100	100.000	ENSCAFG00020014469	HNRNPC	95	98.127	Canis_lupus_dingo
ENSG00000092199	HNRNPC	100	92.818	ENSCHIG00000026850	-	100	88.104	Capra_hircus
ENSG00000092199	HNRNPC	100	100.000	ENSCHIG00000022536	-	95	98.127	Capra_hircus
ENSG00000092199	HNRNPC	100	86.364	ENSCHIG00000015259	-	100	62.500	Capra_hircus
ENSG00000092199	HNRNPC	100	94.444	ENSTSYG00000034314	-	78	79.147	Carlito_syrichta
ENSG00000092199	HNRNPC	100	100.000	ENSTSYG00000003305	-	100	97.854	Carlito_syrichta
ENSG00000092199	HNRNPC	100	85.185	ENSTSYG00000026064	-	88	82.534	Carlito_syrichta
ENSG00000092199	HNRNPC	99	94.828	ENSTSYG00000027744	-	100	80.272	Carlito_syrichta
ENSG00000092199	HNRNPC	100	100.000	ENSCAPG00000008726	HNRNPC	100	95.192	Cavia_aperea
ENSG00000092199	HNRNPC	100	100.000	ENSCPOG00000001474	HNRNPC	100	97.068	Cavia_porcellus
ENSG00000092199	HNRNPC	76	89.888	ENSCCAG00000014874	-	97	79.237	Cebus_capucinus
ENSG00000092199	HNRNPC	100	100.000	ENSCCAG00000035141	-	87	100.000	Cebus_capucinus
ENSG00000092199	HNRNPC	100	98.485	ENSCCAG00000020533	-	93	96.992	Cebus_capucinus
ENSG00000092199	HNRNPC	80	87.129	ENSCCAG00000023170	-	100	71.053	Cebus_capucinus
ENSG00000092199	HNRNPC	100	97.619	ENSCCAG00000029854	-	100	93.515	Cebus_capucinus
ENSG00000092199	HNRNPC	100	100.000	ENSCCAG00000025125	-	100	100.000	Cebus_capucinus
ENSG00000092199	HNRNPC	82	100.000	ENSCATG00000030828	-	92	95.536	Cercocebus_atys
ENSG00000092199	HNRNPC	100	100.000	ENSCATG00000035936	-	93	99.624	Cercocebus_atys
ENSG00000092199	HNRNPC	100	95.556	ENSCATG00000031526	-	100	93.857	Cercocebus_atys
ENSG00000092199	HNRNPC	100	100.000	ENSCLAG00000000947	HNRNPC	100	97.720	Chinchilla_lanigera
ENSG00000092199	HNRNPC	100	100.000	ENSCSAG00000016585	HNRNPC	100	100.000	Chlorocebus_sabaeus
ENSG00000092199	HNRNPC	100	94.737	ENSCSAG00000000637	-	100	80.205	Chlorocebus_sabaeus
ENSG00000092199	HNRNPC	100	100.000	ENSCHOG00000010033	HNRNPC	100	78.495	Choloepus_hoffmanni
ENSG00000092199	HNRNPC	100	100.000	ENSCPBG00000011437	-	98	90.942	Chrysemys_picta_bellii
ENSG00000092199	HNRNPC	100	100.000	ENSCANG00000035615	HNRNPC	100	100.000	Colobus_angolensis_palliatus
ENSG00000092199	HNRNPC	100	98.485	ENSCANG00000037885	-	88	90.421	Colobus_angolensis_palliatus
ENSG00000092199	HNRNPC	99	91.188	ENSCANG00000034732	-	98	90.875	Colobus_angolensis_palliatus
ENSG00000092199	HNRNPC	100	81.481	ENSCANG00000031846	-	85	73.551	Colobus_angolensis_palliatus
ENSG00000092199	HNRNPC	100	100.000	ENSCGRG00001004415	Hnrnpc	100	95.860	Cricetulus_griseus_chok1gshd
ENSG00000092199	HNRNPC	100	94.444	ENSCGRG00001006054	-	100	68.198	Cricetulus_griseus_chok1gshd
ENSG00000092199	HNRNPC	100	92.593	ENSCGRG00001024282	-	97	81.679	Cricetulus_griseus_chok1gshd
ENSG00000092199	HNRNPC	100	100.000	ENSCGRG00000012098	Hnrnpc	100	98.046	Cricetulus_griseus_crigri
ENSG00000092199	HNRNPC	100	92.593	ENSCGRG00000009850	-	97	81.679	Cricetulus_griseus_crigri
ENSG00000092199	HNRNPC	90	75.221	ENSDNOG00000043205	-	97	64.865	Dasypus_novemcinctus
ENSG00000092199	HNRNPC	100	98.485	ENSDNOG00000040064	-	100	96.732	Dasypus_novemcinctus
ENSG00000092199	HNRNPC	100	94.872	ENSDNOG00000044551	-	100	90.411	Dasypus_novemcinctus
ENSG00000092199	HNRNPC	100	100.000	ENSDNOG00000003161	-	100	98.371	Dasypus_novemcinctus
ENSG00000092199	HNRNPC	100	100.000	ENSDORG00000012163	-	100	86.054	Dipodomys_ordii
ENSG00000092199	HNRNPC	100	100.000	ENSEASG00005010413	HNRNPC	100	98.697	Equus_asinus_asinus
ENSG00000092199	HNRNPC	100	100.000	ENSECAG00000017645	HNRNPC	100	98.697	Equus_caballus
ENSG00000092199	HNRNPC	100	98.857	ENSEEUG00000007472	HNRNPC	100	95.455	Erinaceus_europaeus
ENSG00000092199	HNRNPC	100	100.000	ENSFCAG00000014889	HNRNPC	100	98.046	Felis_catus
ENSG00000092199	HNRNPC	100	100.000	ENSFDAG00000003406	-	100	97.720	Fukomys_damarensis
ENSG00000092199	HNRNPC	100	96.970	ENSFDAG00000010728	-	99	87.500	Fukomys_damarensis
ENSG00000092199	HNRNPC	100	100.000	ENSGAGG00000011310	-	98	89.493	Gopherus_agassizii
ENSG00000092199	HNRNPC	100	100.000	ENSGGOG00000023015	HNRNPC	100	100.000	Gorilla_gorilla
ENSG00000092199	HNRNPC	100	92.593	ENSGGOG00000022340	-	94	85.433	Gorilla_gorilla
ENSG00000092199	HNRNPC	100	77.222	ENSGGOG00000028510	-	100	70.805	Gorilla_gorilla
ENSG00000092199	HNRNPC	100	84.127	ENSHGLG00000006562	-	99	78.082	Heterocephalus_glaber_female
ENSG00000092199	HNRNPC	100	92.593	ENSHGLG00000014317	-	97	78.868	Heterocephalus_glaber_female
ENSG00000092199	HNRNPC	100	92.562	ENSHGLG00000015984	-	100	69.966	Heterocephalus_glaber_female
ENSG00000092199	HNRNPC	100	100.000	ENSHGLG00000005772	HNRNPC	100	97.394	Heterocephalus_glaber_female
ENSG00000092199	HNRNPC	100	100.000	ENSHGLG00100001282	-	100	96.743	Heterocephalus_glaber_male
ENSG00000092199	HNRNPC	100	92.562	ENSHGLG00100017195	-	100	69.966	Heterocephalus_glaber_male
ENSG00000092199	HNRNPC	100	92.593	ENSHGLG00100019072	-	97	78.868	Heterocephalus_glaber_male
ENSG00000092199	HNRNPC	100	100.000	ENSSTOG00000030323	-	91	98.667	Ictidomys_tridecemlineatus
ENSG00000092199	HNRNPC	98	86.154	ENSSTOG00000021413	-	93	73.856	Ictidomys_tridecemlineatus
ENSG00000092199	HNRNPC	100	98.148	ENSJJAG00000000615	-	95	76.336	Jaculus_jaculus
ENSG00000092199	HNRNPC	100	96.970	ENSJJAG00000017581	-	100	84.642	Jaculus_jaculus
ENSG00000092199	HNRNPC	100	93.939	ENSJJAG00000019199	-	93	89.354	Jaculus_jaculus
ENSG00000092199	HNRNPC	99	100.000	ENSJJAG00000014312	-	100	94.788	Jaculus_jaculus
ENSG00000092199	HNRNPC	99	100.000	ENSJJAG00000019720	-	96	82.295	Jaculus_jaculus
ENSG00000092199	HNRNPC	100	95.455	ENSJJAG00000020950	-	100	92.708	Jaculus_jaculus
ENSG00000092199	HNRNPC	100	94.444	ENSLACG00000012197	-	97	76.846	Latimeria_chalumnae
ENSG00000092199	HNRNPC	100	100.000	ENSLAFG00000009341	HNRNPC	89	95.623	Loxodonta_africana
ENSG00000092199	HNRNPC	100	90.741	ENSMFAG00000002431	-	97	82.243	Macaca_fascicularis
ENSG00000092199	HNRNPC	100	100.000	ENSMFAG00000000371	-	95	98.876	Macaca_fascicularis
ENSG00000092199	HNRNPC	100	100.000	ENSMFAG00000002531	HNRNPC	100	100.000	Macaca_fascicularis
ENSG00000092199	HNRNPC	94	96.450	ENSMFAG00000031240	-	95	97.059	Macaca_fascicularis
ENSG00000092199	HNRNPC	100	87.037	ENSMMUG00000016162	-	89	66.667	Macaca_mulatta
ENSG00000092199	HNRNPC	100	100.000	ENSMMUG00000014809	HNRNPC	100	100.000	Macaca_mulatta
ENSG00000092199	HNRNPC	100	98.333	ENSMMUG00000018813	-	100	98.069	Macaca_mulatta
ENSG00000092199	HNRNPC	100	94.737	ENSMMUG00000046109	-	98	80.612	Macaca_mulatta
ENSG00000092199	HNRNPC	100	98.148	ENSMMUG00000001089	-	90	96.629	Macaca_mulatta
ENSG00000092199	HNRNPC	100	74.242	ENSMNEG00000041647	-	97	64.151	Macaca_nemestrina
ENSG00000092199	HNRNPC	100	99.600	ENSMNEG00000042280	-	100	99.600	Macaca_nemestrina
ENSG00000092199	HNRNPC	100	100.000	ENSMLEG00000040545	-	100	100.000	Mandrillus_leucophaeus
ENSG00000092199	HNRNPC	100	95.556	ENSMLEG00000036782	-	100	94.198	Mandrillus_leucophaeus
ENSG00000092199	HNRNPC	100	100.000	ENSMAUG00000000739	Hnrnpc	100	98.046	Mesocricetus_auratus
ENSG00000092199	HNRNPC	100	80.597	ENSMAUG00000020887	-	97	72.263	Mesocricetus_auratus
ENSG00000092199	HNRNPC	100	94.444	ENSMICG00000031852	-	99	85.902	Microcebus_murinus
ENSG00000092199	HNRNPC	100	90.741	ENSMICG00000028823	-	87	78.261	Microcebus_murinus
ENSG00000092199	HNRNPC	100	100.000	ENSMICG00000007682	HNRNPC	100	99.320	Microcebus_murinus
ENSG00000092199	HNRNPC	100	99.206	ENSMOCG00000001623	-	100	95.349	Microtus_ochrogaster
ENSG00000092199	HNRNPC	100	100.000	ENSMOCG00000020993	-	100	85.106	Microtus_ochrogaster
ENSG00000092199	HNRNPC	100	85.185	ENSMODG00000017619	-	97	77.033	Monodelphis_domestica
ENSG00000092199	HNRNPC	100	99.206	ENSMODG00000006606	HNRNPC	100	97.959	Monodelphis_domestica
ENSG00000092199	HNRNPC	100	100.000	ENSMUSG00000060373	Hnrnpc	100	100.000	Mus_musculus
ENSG00000092199	HNRNPC	100	100.000	MGP_PahariEiJ_G0030256	Hnrnpc	100	93.312	Mus_pahari
ENSG00000092199	HNRNPC	100	100.000	MGP_SPRETEiJ_G0020126	Hnrnpc	100	97.394	Mus_spretus
ENSG00000092199	HNRNPC	100	98.148	ENSMPUG00000016707	-	97	95.802	Mustela_putorius_furo
ENSG00000092199	HNRNPC	100	100.000	ENSMPUG00000000164	-	100	97.952	Mustela_putorius_furo
ENSG00000092199	HNRNPC	100	100.000	ENSMLUG00000007853	HNRNPC	100	96.939	Myotis_lucifugus
ENSG00000092199	HNRNPC	100	99.206	ENSNGAG00000020552	-	100	93.333	Nannospalax_galili
ENSG00000092199	HNRNPC	100	90.741	ENSNGAG00000017956	-	100	71.480	Nannospalax_galili
ENSG00000092199	HNRNPC	100	94.444	ENSNGAG00000017860	-	99	77.133	Nannospalax_galili
ENSG00000092199	HNRNPC	100	100.000	ENSNLEG00000014362	HNRNPC	99	100.000	Nomascus_leucogenys
ENSG00000092199	HNRNPC	100	96.296	ENSNLEG00000018726	-	98	96.198	Nomascus_leucogenys
ENSG00000092199	HNRNPC	100	96.296	ENSNLEG00000009500	-	100	75.085	Nomascus_leucogenys
ENSG00000092199	HNRNPC	100	87.037	ENSNLEG00000028034	-	85	71.377	Nomascus_leucogenys
ENSG00000092199	HNRNPC	100	98.485	ENSMEUG00000010928	-	64	98.305	Notamacropus_eugenii
ENSG00000092199	HNRNPC	100	100.000	ENSOPRG00000002800	HNRNPC	82	100.000	Ochotona_princeps
ENSG00000092199	HNRNPC	100	98.485	ENSODEG00000001160	-	98	90.345	Octodon_degus
ENSG00000092199	HNRNPC	100	85.165	ENSODEG00000017188	-	100	82.034	Octodon_degus
ENSG00000092199	HNRNPC	98	84.906	ENSODEG00000012803	-	100	79.739	Octodon_degus
ENSG00000092199	HNRNPC	100	98.485	ENSODEG00000000603	-	100	93.312	Octodon_degus
ENSG00000092199	HNRNPC	100	100.000	ENSODEG00000008102	-	100	95.578	Octodon_degus
ENSG00000092199	HNRNPC	100	98.485	ENSODEG00000020161	-	100	93.811	Octodon_degus
ENSG00000092199	HNRNPC	100	99.206	ENSOANG00000015707	HNRNPC	100	97.959	Ornithorhynchus_anatinus
ENSG00000092199	HNRNPC	100	100.000	ENSOCUG00000000339	-	100	98.046	Oryctolagus_cuniculus
ENSG00000092199	HNRNPC	100	100.000	ENSOCUG00000013026	-	97	90.909	Oryctolagus_cuniculus
ENSG00000092199	HNRNPC	100	100.000	ENSOCUG00000015029	HNRNPC	100	98.046	Oryctolagus_cuniculus
ENSG00000092199	HNRNPC	100	98.485	ENSOCUG00000008851	-	100	97.068	Oryctolagus_cuniculus
ENSG00000092199	HNRNPC	100	92.593	ENSOGAG00000029866	-	100	89.153	Otolemur_garnettii
ENSG00000092199	HNRNPC	100	100.000	ENSOGAG00000033117	-	100	96.124	Otolemur_garnettii
ENSG00000092199	HNRNPC	100	88.889	ENSOGAG00000032637	-	96	74.886	Otolemur_garnettii
ENSG00000092199	HNRNPC	100	88.889	ENSOGAG00000032179	-	100	76.144	Otolemur_garnettii
ENSG00000092199	HNRNPC	100	100.000	ENSOGAG00000028828	-	100	89.865	Otolemur_garnettii
ENSG00000092199	HNRNPC	100	100.000	ENSOGAG00000012543	-	100	97.288	Otolemur_garnettii
ENSG00000092199	HNRNPC	100	100.000	ENSOGAG00000032867	-	100	96.271	Otolemur_garnettii
ENSG00000092199	HNRNPC	100	100.000	ENSOGAG00000032454	-	100	94.576	Otolemur_garnettii
ENSG00000092199	HNRNPC	100	86.364	ENSOGAG00000034058	-	97	58.842	Otolemur_garnettii
ENSG00000092199	HNRNPC	100	92.593	ENSOARG00000010292	-	97	93.333	Ovis_aries
ENSG00000092199	HNRNPC	100	100.000	ENSOARG00000019672	-	99	94.463	Ovis_aries
ENSG00000092199	HNRNPC	100	80.000	ENSPPAG00000033436	-	100	73.154	Pan_paniscus
ENSG00000092199	HNRNPC	100	94.444	ENSPPAG00000041389	-	98	88.517	Pan_paniscus
ENSG00000092199	HNRNPC	100	92.593	ENSPPAG00000030712	-	95	81.690	Pan_paniscus
ENSG00000092199	HNRNPC	100	100.000	ENSPPAG00000034008	-	100	100.000	Pan_paniscus
ENSG00000092199	HNRNPC	100	100.000	ENSPPRG00000008763	HNRNPC	100	98.046	Panthera_pardus
ENSG00000092199	HNRNPC	100	100.000	ENSPTIG00000021061	HNRNPC	100	98.299	Panthera_tigris_altaica
ENSG00000092199	HNRNPC	100	81.111	ENSPTRG00000045559	-	100	72.819	Pan_troglodytes
ENSG00000092199	HNRNPC	88	88.608	ENSPTRG00000043617	-	87	89.542	Pan_troglodytes
ENSG00000092199	HNRNPC	100	100.000	ENSPTRG00000006118	HNRNPC	100	100.000	Pan_troglodytes
ENSG00000092199	HNRNPC	100	92.593	ENSPTRG00000043496	-	86	86.977	Pan_troglodytes
ENSG00000092199	HNRNPC	100	88.889	ENSPTRG00000039710	-	99	88.785	Pan_troglodytes
ENSG00000092199	HNRNPC	100	92.593	ENSPTRG00000043469	-	100	80.137	Pan_troglodytes
ENSG00000092199	HNRNPC	100	100.000	ENSPANG00000031574	-	86	100.000	Papio_anubis
ENSG00000092199	HNRNPC	100	100.000	ENSPANG00000020782	-	100	100.000	Papio_anubis
ENSG00000092199	HNRNPC	100	99.206	ENSPANG00000035897	-	100	94.881	Papio_anubis
ENSG00000092199	HNRNPC	92	97.576	ENSPANG00000018274	-	94	97.436	Papio_anubis
ENSG00000092199	HNRNPC	100	100.000	ENSPSIG00000012177	-	100	92.157	Pelodiscus_sinensis
ENSG00000092199	HNRNPC	100	100.000	ENSPEMG00000017899	-	100	98.046	Peromyscus_maniculatus_bairdii
ENSG00000092199	HNRNPC	100	94.444	ENSPEMG00000017675	-	100	75.503	Peromyscus_maniculatus_bairdii
ENSG00000092199	HNRNPC	100	99.206	ENSPCIG00000020021	-	100	97.952	Phascolarctos_cinereus
ENSG00000092199	HNRNPC	100	100.000	ENSPPYG00000005593	HNRNPC	100	100.000	Pongo_abelii
ENSG00000092199	HNRNPC	100	94.737	ENSPPYG00000001860	-	100	89.420	Pongo_abelii
ENSG00000092199	HNRNPC	100	96.970	ENSPCAG00000003025	HNRNPC	100	80.392	Procavia_capensis
ENSG00000092199	HNRNPC	100	100.000	ENSPCOG00000022866	HNRNPC	100	99.320	Propithecus_coquereli
ENSG00000092199	HNRNPC	100	100.000	ENSPVAG00000004499	HNRNPC	91	97.857	Pteropus_vampyrus
ENSG00000092199	HNRNPC	100	100.000	ENSRNOG00000011621	LOC100911576	100	97.619	Rattus_norvegicus
ENSG00000092199	HNRNPC	100	100.000	ENSRNOG00000050800	Hnrnpc	100	95.349	Rattus_norvegicus
ENSG00000092199	HNRNPC	100	100.000	ENSRBIG00000038355	HNRNPC	100	100.000	Rhinopithecus_bieti
ENSG00000092199	HNRNPC	100	97.368	ENSRBIG00000006622	-	98	80.887	Rhinopithecus_bieti
ENSG00000092199	HNRNPC	94	77.143	ENSRROG00000029991	-	84	69.925	Rhinopithecus_roxellana
ENSG00000092199	HNRNPC	100	98.485	ENSRROG00000036842	-	100	96.654	Rhinopithecus_roxellana
ENSG00000092199	HNRNPC	100	98.485	ENSRROG00000031669	-	100	95.257	Rhinopithecus_roxellana
ENSG00000092199	HNRNPC	100	100.000	ENSRROG00000006722	HNRNPC	100	92.675	Rhinopithecus_roxellana
ENSG00000092199	HNRNPC	100	97.521	ENSSBOG00000030368	-	82	79.012	Saimiri_boliviensis_boliviensis
ENSG00000092199	HNRNPC	88	87.446	ENSSBOG00000028896	-	97	87.295	Saimiri_boliviensis_boliviensis
ENSG00000092199	HNRNPC	99	92.105	ENSSBOG00000022725	-	99	78.082	Saimiri_boliviensis_boliviensis
ENSG00000092199	HNRNPC	100	99.237	ENSSBOG00000024757	HNRNPC	100	99.134	Saimiri_boliviensis_boliviensis
ENSG00000092199	HNRNPC	99	81.897	ENSSBOG00000032742	-	100	70.428	Saimiri_boliviensis_boliviensis
ENSG00000092199	HNRNPC	100	94.017	ENSSBOG00000028154	-	98	85.057	Saimiri_boliviensis_boliviensis
ENSG00000092199	HNRNPC	100	98.857	ENSSHAG00000006145	HNRNPC	100	96.452	Sarcophilus_harrisii
ENSG00000092199	HNRNPC	100	100.000	ENSSARG00000003711	HNRNPC	100	79.085	Sorex_araneus
ENSG00000092199	HNRNPC	100	98.485	ENSSPUG00000018728	-	100	90.523	Sphenodon_punctatus
ENSG00000092199	HNRNPC	100	100.000	ENSSSCG00000038947	HNRNPC	100	98.639	Sus_scrofa
ENSG00000092199	HNRNPC	100	100.000	ENSTBEG00000011514	-	100	89.362	Tupaia_belangeri
ENSG00000092199	HNRNPC	100	100.000	ENSTTRG00000016055	HNRNPC	100	98.371	Tursiops_truncatus
ENSG00000092199	HNRNPC	100	100.000	ENSUMAG00000003799	HNRNPC	100	98.039	Ursus_maritimus
ENSG00000092199	HNRNPC	100	100.000	ENSVPAG00000007337	HNRNPC	100	98.046	Vicugna_pacos
ENSG00000092199	HNRNPC	100	100.000	ENSVVUG00000009265	-	95	98.127	Vulpes_vulpes
ENSG00000092199	HNRNPC	100	100.000	ENSVVUG00000012230	-	90	97.826	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	9731529.11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	25719671.	IMP	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0000790	nuclear chromatin	16217013.	HDA	Component
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	16217013.	HDA	Function
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	16217013.	HDA	Function
GO:0001649	osteoblast differentiation	16210410.	HDA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	18082603.	IPI	Function
GO:0003723	RNA binding	9731529.	NAS	Function
GO:0003730	mRNA 3'-UTR binding	16010978.	IDA	Function
GO:0005515	protein binding	11546873.11687588.15034300.15161933.16189514.17289661.19447967.20467437.20618440.21516116.21988832.22365833.22446626.22720776.23602568.24965446.25416956.30021884.	IPI	Function
GO:0005576	extracellular region	27068509.	HDA	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	11687588.22720776.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	9731529.	IDA	Component
GO:0005697	telomerase holoenzyme complex	18082603.	IDA	Component
GO:0005829	cytosol	16010978.	IDA	Component
GO:0008266	poly(U) RNA binding	16010978.	IDA	Function
GO:0008380	RNA splicing	3110598.	TAS	Process
GO:0015629	actin cytoskeleton	11687588.	IDA	Component
GO:0016020	membrane	16210410.	HDA	Component
GO:0016070	RNA metabolic process	-	TAS	Process
GO:0031492	nucleosomal DNA binding	16217013.	HDA	Function
GO:0032211	negative regulation of telomere maintenance via telomerase	18082603.	IMP	Process
GO:0032991	protein-containing complex	16217013.	HDA	Component
GO:0032991	protein-containing complex	11687588.	IDA	Component
GO:0042802	identical protein binding	16189514.21516116.22365833.25416956.	IPI	Function
GO:0043044	ATP-dependent chromatin remodeling	16217013.	HDA	Process
GO:0070034	telomerase RNA binding	18082603.	IPI	Function
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0070935	3'-UTR-mediated mRNA stabilization	16010978.	IMP	Process
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component
GO:1990247	N6-methyladenosine-containing RNA binding	25719671.	IDA	Function