EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000092201 (Gene tree)
Gene ID: 11198
Gene Symbol: SUPT16H
Alias: FACT|FACTP140|SPT16/CDC68|FLJ14010|FLJ10857|CDC68
Full Name: SPT16 homolog, facilitates chromatin remodeling subunit
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 33,168 bases
Position: chr14:21,351,472-21,384,639
Accession: 11465
RBP type: non-canonical RBP
Summary: Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24707933	Histone chaperone Chz1 facilitates the disfavouring property of Spt16 to H2A.Z-containing genes in Saccharomyces cerevisiae.	Biochem J	2014 Jun 15	Liu H	doi: 10.1042/BJ20140186.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000556309	SUPT16H-206	582	-	ENSP00000452259	66 (aa)	-	G3V5A4
ENST00000216297	SUPT16H-201	4684	XM_011536381	ENSP00000216297	1047 (aa)	XP_011534683	Q9Y5B9
ENST00000552829	SUPT16H-202	669	-	-	- (aa)	-	-
ENST00000556217	SUPT16H-205	1027	-	-	- (aa)	-	-
ENST00000557394	SUPT16H-207	2324	-	-	- (aa)	-	-
ENST00000555752	SUPT16H-203	888	-	-	- (aa)	-	-
ENST00000557652	SUPT16H-208	877	-	ENSP00000451517	81 (aa)	-	G3V401
ENST00000555943	SUPT16H-204	915	-	ENSP00000450910	83 (aa)	-	G3V2X0

Gene Model

Click here to download ENSG00000092201's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000092201	rs8004294	14	21356124	A	Highest math class taken (MTAG)	30038396	[0.012-0.023] unit decrease	0.0176	EFO_0004875
ENSG00000092201	rs8004294	14	21356124	A	Educational attainment (years of education)	30038396	[0.012-0.021] unit decrease	0.0166	EFO_0004784

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000092201's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000092201	SUPT16H	96	60.255	FBgn0002183	dre4	93	60.555	Drosophila_melanogaster
ENSG00000092201	SUPT16H	100	98.758	ENSMUSG00000035726	Supt16	100	98.758	Mus_musculus
ENSG00000092201	SUPT16H	96	33.804	YGL207W	SPT16	99	34.787	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	16902406.19214185.30021884.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	-	IEA	Component
GO:0006260	DNA replication	-	IEA	Process
GO:0006281	DNA repair	-	IEA	Process
GO:0006337	nucleosome disassembly	10421373.	TAS	Process
GO:0006366	transcription by RNA polymerase II	-	TAS	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	21873635.	IBA	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	Process
GO:0031491	nucleosome binding	21873635.	IBA	Function
GO:0032786	positive regulation of DNA-templated transcription, elongation	10421373.	TAS	Process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	21873635.	IBA	Process
GO:0034724	DNA replication-independent nucleosome organization	21873635.	IBA	Process
GO:0035101	FACT complex	21873635.	IBA	Component
GO:0042393	histone binding	21873635.	IBA	Function
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process