EuRBPDB

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  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000092208 (Gene tree)
Gene ID
8487
Gene Symbol
GEMIN2
Alias
SIP1
Full Name
gem nuclear organelle associated protein 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
22,751 bases
Position
chr14:39,114,223-39,136,973
Accession
10884
RBP type
canonical RBP
Summary
This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000308533SIP1PF04938.121.6e-7911
ENSP00000250379SIP1PF04938.129.8e-7311
ENSP00000379548SIP1PF04938.122.5e-6811
ENSP00000436065SIP1PF04938.121.3e-5412
ENSP00000436065SIP1PF04938.121.3e-5422
ENSP00000434048SIP1PF04938.124.7e-4311

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
21816274Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly.Cell2011 Aug 5Zhang Rdoi: 10.1016/j.cell.2011.06.043.
26828962A U1 snRNP-specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange.Nat Struct Mol Biol2016 MarSo BRdoi: 10.1038/nsmb.3167
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000308317GEMIN2-2021420XM_024449731ENSP00000308533280 (aa)XP_024305499O14893
ENST00000412033GEMIN2-204825-ENSP0000041682744 (aa)-O14893
ENST00000524781GEMIN2-205649-ENSP0000047497922 (aa)-S4R421
ENST00000650481GEMIN2-2131202-ENSP00000498011275 (aa)--
ENST00000525153GEMIN2-2071476-ENSP00000436854149 (aa)-G5EA29
ENST00000529365GEMIN2-210583--- (aa)--
ENST00000524980GEMIN2-206662--- (aa)--
ENST00000531684GEMIN2-211630-ENSP0000043150045 (aa)-H0YCF4
ENST00000527381GEMIN2-209592-ENSP00000434048197 (aa)-H0YDP6
ENST00000534684GEMIN2-212658-ENSP00000436065220 (aa)-H0YEL0
ENST00000525430GEMIN2-208659--- (aa)--
ENST00000396249GEMIN2-203801XM_017021709ENSP00000379548250 (aa)XP_016877198O14893
ENST00000250379GEMIN2-2011094-ENSP00000250379265 (aa)-O14893
Gene Model
Click here to download ENSG00000092208's gene model file
Pathways
Pathway IDPathway NameSource
hsa03013RNA transportKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000092208rs80099331439131008AEducational attainment (MTAG)30038396[0.0058-0.0112] unit increase0.0085EFO_0004784
ENSG00000092208rs22774581439114277GVitamin D levels28757204[0.03-0.07] nmol/L decrease0.05EFO_0004631
ENSG00000092208rs80099331439131008AEducational attainment (years of education)30038396[0.0059-0.0117] unit increase0.0088EFO_0004784
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000092208's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000092208GEMIN27967.521ENSAPOG00000008388gemin29167.521Acanthochromis_polyacanthus
ENSG00000092208GEMIN29895.652ENSAMEG00000003856GEMIN29995.652Ailuropoda_melanoleuca
ENSG00000092208GEMIN29265.759ENSACIG00000014430gemin29465.759Amphilophus_citrinellus
ENSG00000092208GEMIN29576.190ENSAOCG00000012349gemin29966.794Amphiprion_ocellaris
ENSG00000092208GEMIN29576.190ENSAPEG00000002529gemin29967.433Amphiprion_percula
ENSG00000092208GEMIN29464.394ENSATEG00000009574gemin29964.259Anabas_testudineus
ENSG00000092208GEMIN28378.355ENSAPLG00000012052GEMIN210078.355Anas_platyrhynchos
ENSG00000092208GEMIN29481.749ENSACAG00000015872GEMIN29981.749Anolis_carolinensis
ENSG00000092208GEMIN295100.000ENSANAG00000026213GEMIN210076.512Aotus_nancymaae
ENSG00000092208GEMIN29364.530ENSACLG00000024473gemin29862.857Astatotilapia_calliptera
ENSG00000092208GEMIN29267.308ENSAMXG00000033969gemin29967.308Astyanax_mexicanus
ENSG00000092208GEMIN295100.000ENSBTAG00000020930GEMIN210093.929Bos_taurus
ENSG00000092208GEMIN29998.561ENSCJAG00000016248GEMIN29998.561Callithrix_jacchus
ENSG00000092208GEMIN295100.000ENSCAFG00000013859GEMIN210095.911Canis_familiaris
ENSG00000092208GEMIN295100.000ENSCAFG00020022243GEMIN210095.911Canis_lupus_dingo
ENSG00000092208GEMIN295100.000ENSCHIG00000009881GEMIN210096.283Capra_hircus
ENSG00000092208GEMIN210094.400ENSTSYG00000003528-10094.400Carlito_syrichta
ENSG00000092208GEMIN29590.000ENSTSYG00000032612-9990.840Carlito_syrichta
ENSG00000092208GEMIN29892.386ENSCPOG00000011338GEMIN29892.593Cavia_porcellus
ENSG00000092208GEMIN295100.000ENSCCAG00000030361-9571.154Cebus_capucinus
ENSG00000092208GEMIN2100100.000ENSCCAG00000035944GEMIN29999.640Cebus_capucinus
ENSG00000092208GEMIN29899.315ENSCATG00000042473GEMIN210099.628Cercocebus_atys
ENSG00000092208GEMIN210078.947ENSCATG00000031373-10078.947Cercocebus_atys
ENSG00000092208GEMIN29893.401ENSCLAG00000008967GEMIN210094.922Chinchilla_lanigera
ENSG00000092208GEMIN29585.714ENSCSAG00000016872-9575.294Chlorocebus_sabaeus
ENSG00000092208GEMIN29590.476ENSCHOG00000011644GEMIN29972.302Choloepus_hoffmanni
ENSG00000092208GEMIN29488.172ENSCPBG00000026207GEMIN29980.608Chrysemys_picta_bellii
ENSG00000092208GEMIN28733.793ENSCING00000012240-8833.793Ciona_intestinalis
ENSG00000092208GEMIN28336.029ENSCSAVG00000009875-8436.029Ciona_savignyi
ENSG00000092208GEMIN210079.195ENSCANG00000033060-9573.585Colobus_angolensis_palliatus
ENSG00000092208GEMIN29999.642ENSCANG00000035266GEMIN210099.642Colobus_angolensis_palliatus
ENSG00000092208GEMIN29695.539ENSCGRG00001017720Gemin210095.539Cricetulus_griseus_chok1gshd
ENSG00000092208GEMIN29695.539ENSCGRG00000007060Gemin210095.539Cricetulus_griseus_crigri
ENSG00000092208GEMIN29580.952ENSCSEG00000016057gemin29962.214Cynoglossus_semilaevis
ENSG00000092208GEMIN29161.719ENSCVAG00000003125gemin29961.868Cyprinodon_variegatus
ENSG00000092208GEMIN29368.582ENSDARG00000015638gemin29968.898Danio_rerio
ENSG00000092208GEMIN29990.452ENSDNOG00000018278GEMIN29690.047Dasypus_novemcinctus
ENSG00000092208GEMIN295100.000ENSDORG00000003814Gemin210096.283Dipodomys_ordii
ENSG00000092208GEMIN29991.093ENSETEG00000006463GEMIN29990.323Echinops_telfairi
ENSG00000092208GEMIN28747.170ENSEBUG00000002198gemin27746.610Eptatretus_burgeri
ENSG00000092208GEMIN210096.071ENSEASG00005007617GEMIN210096.071Equus_asinus_asinus
ENSG00000092208GEMIN29995.968ENSECAG00000007554GEMIN29096.269Equus_caballus
ENSG00000092208GEMIN29990.955ENSEEUG00000008438GEMIN29985.455Erinaceus_europaeus
ENSG00000092208GEMIN29365.900ENSELUG00000005266gemin29965.900Esox_lucius
ENSG00000092208GEMIN295100.000ENSFCAG00000029921GEMIN210094.643Felis_catus
ENSG00000092208GEMIN29878.102ENSFALG00000006169GEMIN29878.102Ficedula_albicollis
ENSG00000092208GEMIN29891.371ENSFDAG00000001562GEMIN210093.309Fukomys_damarensis
ENSG00000092208GEMIN29367.150ENSFHEG00000020705gemin29964.773Fundulus_heteroclitus
ENSG00000092208GEMIN29162.771ENSGMOG00000009379gemin29762.771Gadus_morhua
ENSG00000092208GEMIN29479.468ENSGALG00000010154GEMIN29979.468Gallus_gallus
ENSG00000092208GEMIN29462.222ENSGAFG00000019641gemin29962.222Gambusia_affinis
ENSG00000092208GEMIN29576.190ENSGACG00000012444gemin29961.654Gasterosteus_aculeatus
ENSG00000092208GEMIN28378.970ENSGAGG00000003982GEMIN29878.970Gopherus_agassizii
ENSG00000092208GEMIN210097.351ENSGGOG00000016691GEMIN210097.351Gorilla_gorilla
ENSG00000092208GEMIN29580.952ENSGGOG00000043428-8975.839Gorilla_gorilla
ENSG00000092208GEMIN29365.019ENSHBUG00000016285gemin29965.019Haplochromis_burtoni
ENSG00000092208GEMIN29694.424ENSHGLG00000004890GEMIN210094.424Heterocephalus_glaber_female
ENSG00000092208GEMIN29694.424ENSHGLG00100009949GEMIN210094.424Heterocephalus_glaber_male
ENSG00000092208GEMIN29462.738ENSHCOG00000012786gemin29962.738Hippocampus_comes
ENSG00000092208GEMIN29571.429ENSIPUG00000012821gemin29964.961Ictalurus_punctatus
ENSG00000092208GEMIN295100.000ENSSTOG00000006357GEMIN210096.654Ictidomys_tridecemlineatus
ENSG00000092208GEMIN295100.000ENSJJAG00000022975Gemin210096.283Jaculus_jaculus
ENSG00000092208GEMIN29576.190ENSKMAG00000007880gemin29964.773Kryptolebias_marmoratus
ENSG00000092208GEMIN29154.825ENSLBEG00000022377gemin29952.569Labrus_bergylta
ENSG00000092208GEMIN29181.739ENSLACG00000004723GEMIN29880.309Latimeria_chalumnae
ENSG00000092208GEMIN29371.103ENSLOCG00000009221gemin29971.103Lepisosteus_oculatus
ENSG00000092208GEMIN29694.424ENSLAFG00000010321GEMIN210094.424Loxodonta_africana
ENSG00000092208GEMIN29999.642ENSMFAG00000014362GEMIN210099.642Macaca_fascicularis
ENSG00000092208GEMIN29978.947ENSMFAG00000003283-9378.947Macaca_fascicularis
ENSG00000092208GEMIN299100.000ENSMMUG00000021028GEMIN2100100.000Macaca_mulatta
ENSG00000092208GEMIN210081.208ENSMMUG00000001073-9281.208Macaca_mulatta
ENSG00000092208GEMIN298100.000ENSMNEG00000033286GEMIN2100100.000Macaca_nemestrina
ENSG00000092208GEMIN29976.959ENSMNEG00000033555-9873.408Macaca_nemestrina
ENSG00000092208GEMIN29979.470ENSMLEG00000008946-9872.285Mandrillus_leucophaeus
ENSG00000092208GEMIN299100.000ENSMLEG00000035575GEMIN2100100.000Mandrillus_leucophaeus
ENSG00000092208GEMIN29163.043ENSMAMG00000012985gemin29962.992Mastacembelus_armatus
ENSG00000092208GEMIN29364.259ENSMZEG00005007915gemin29964.259Maylandia_zebra
ENSG00000092208GEMIN28378.355ENSMGAG00000012566GEMIN210078.355Meleagris_gallopavo
ENSG00000092208GEMIN29894.924ENSMAUG00000017447Gemin210096.654Mesocricetus_auratus
ENSG00000092208GEMIN295100.000ENSMICG00000004811-9895.699Microcebus_murinus
ENSG00000092208GEMIN29595.238ENSMICG00000043979-10078.346Microcebus_murinus
ENSG00000092208GEMIN29695.911ENSMOCG00000023031Gemin210095.911Microtus_ochrogaster
ENSG00000092208GEMIN29559.004ENSMMOG00000004604gemin29957.812Mola_mola
ENSG00000092208GEMIN29590.476ENSMODG00000011946GEMIN29987.833Monodelphis_domestica
ENSG00000092208GEMIN29463.498ENSMALG00000021507gemin29963.498Monopterus_albus
ENSG00000092208GEMIN291100.000MGP_CAROLIEiJ_G0017777Gemin210094.796Mus_caroli
ENSG00000092208GEMIN291100.000ENSMUSG00000060121Gemin210094.424Mus_musculus
ENSG00000092208GEMIN29695.167MGP_PahariEiJ_G0029533Gemin210095.167Mus_pahari
ENSG00000092208GEMIN291100.000MGP_SPRETEiJ_G0018622Gemin210094.424Mus_spretus
ENSG00000092208GEMIN295100.000ENSMPUG00000016240GEMIN210095.539Mustela_putorius_furo
ENSG00000092208GEMIN29692.188ENSMLUG00000002619GEMIN29793.750Myotis_lucifugus
ENSG00000092208GEMIN29694.424ENSNGAG00000001053Gemin210094.424Nannospalax_galili
ENSG00000092208GEMIN29997.487ENSNLEG00000004013GEMIN210099.265Nomascus_leucogenys
ENSG00000092208GEMIN29780.992ENSMEUG00000011734-9681.609Notamacropus_eugenii
ENSG00000092208GEMIN29595.238ENSOPRG00000007714GEMIN210085.409Ochotona_princeps
ENSG00000092208GEMIN29894.924ENSODEG00000000272GEMIN210096.283Octodon_degus
ENSG00000092208GEMIN29363.878ENSONIG00000019495gemin29963.878Oreochromis_niloticus
ENSG00000092208GEMIN29590.476ENSOANG00000021148-9685.897Ornithorhynchus_anatinus
ENSG00000092208GEMIN29590.476ENSOANG00000014013-9981.362Ornithorhynchus_anatinus
ENSG00000092208GEMIN210091.459ENSOCUG00000000673GEMIN210091.459Oryctolagus_cuniculus
ENSG00000092208GEMIN29359.756ENSORLG00000017666gemin29959.756Oryzias_latipes
ENSG00000092208GEMIN29360.837ENSORLG00020016613gemin29960.837Oryzias_latipes_hni
ENSG00000092208GEMIN29361.597ENSORLG00015013224gemin29961.597Oryzias_latipes_hsok
ENSG00000092208GEMIN29362.835ENSOMEG00000011576gemin29962.835Oryzias_melastigma
ENSG00000092208GEMIN210096.071ENSOGAG00000007906GEMIN210096.071Otolemur_garnettii
ENSG00000092208GEMIN210093.950ENSOARG00000008466GEMIN210093.950Ovis_aries
ENSG00000092208GEMIN210077.852ENSPPAG00000033797-10077.852Pan_paniscus
ENSG00000092208GEMIN210099.329ENSPPAG00000043467GEMIN210099.329Pan_paniscus
ENSG00000092208GEMIN295100.000ENSPPRG00000009485GEMIN210094.643Panthera_pardus
ENSG00000092208GEMIN295100.000ENSPTIG00000018115GEMIN210095.539Panthera_tigris_altaica
ENSG00000092208GEMIN29580.952ENSPTRG00000045455-8573.208Pan_troglodytes
ENSG00000092208GEMIN2100100.000ENSPTRG00000006291GEMIN2100100.000Pan_troglodytes
ENSG00000092208GEMIN29978.146ENSPANG00000034146-9873.034Papio_anubis
ENSG00000092208GEMIN295100.000ENSPANG00000011343-10078.467Papio_anubis
ENSG00000092208GEMIN29370.270ENSPKIG00000010339gemin29870.270Paramormyrops_kingsleyae
ENSG00000092208GEMIN29480.608ENSPSIG00000013560GEMIN28880.608Pelodiscus_sinensis
ENSG00000092208GEMIN29262.934ENSPMGG00000008763gemin29962.934Periophthalmus_magnuspinnatus
ENSG00000092208GEMIN29894.416ENSPEMG00000008079Gemin210096.283Peromyscus_maniculatus_bairdii
ENSG00000092208GEMIN28350.400ENSPMAG00000009804gemin29451.394Petromyzon_marinus
ENSG00000092208GEMIN29590.476ENSPCIG00000025754GEMIN27989.354Phascolarctos_cinereus
ENSG00000092208GEMIN29463.396ENSPFOG00000014660gemin29963.396Poecilia_formosa
ENSG00000092208GEMIN29463.258ENSPLAG00000020265gemin29963.258Poecilia_latipinna
ENSG00000092208GEMIN29463.258ENSPMEG00000011134gemin29963.258Poecilia_mexicana
ENSG00000092208GEMIN29459.470ENSPREG00000007692gemin29959.533Poecilia_reticulata
ENSG00000092208GEMIN299100.000ENSPPYG00000005764GEMIN299100.000Pongo_abelii
ENSG00000092208GEMIN29590.476ENSPCAG00000005387GEMIN29981.362Procavia_capensis
ENSG00000092208GEMIN210096.000ENSPCOG00000016964GEMIN29696.000Propithecus_coquereli
ENSG00000092208GEMIN29793.004ENSPVAG00000002586GEMIN29993.511Pteropus_vampyrus
ENSG00000092208GEMIN29364.639ENSPNYG00000022626gemin29964.639Pundamilia_nyererei
ENSG00000092208GEMIN29366.794ENSPNAG00000017346gemin29866.794Pygocentrus_nattereri
ENSG00000092208GEMIN291100.000ENSRNOG00000004360Gemin210094.052Rattus_norvegicus
ENSG00000092208GEMIN298100.000ENSRBIG00000034601GEMIN2100100.000Rhinopithecus_bieti
ENSG00000092208GEMIN210080.537ENSRBIG00000038026-9280.537Rhinopithecus_bieti
ENSG00000092208GEMIN210080.537ENSRROG00000042909-9280.537Rhinopithecus_roxellana
ENSG00000092208GEMIN29999.642ENSRROG00000042627GEMIN210099.642Rhinopithecus_roxellana
ENSG00000092208GEMIN2100100.000ENSSBOG00000022280GEMIN210098.842Saimiri_boliviensis_boliviensis
ENSG00000092208GEMIN27784.211ENSSHAG00000000156-9583.871Sarcophilus_harrisii
ENSG00000092208GEMIN29368.966ENSSFOG00015012315gemin29968.966Scleropages_formosus
ENSG00000092208GEMIN29462.738ENSSMAG00000011151gemin29962.738Scophthalmus_maximus
ENSG00000092208GEMIN29464.885ENSSDUG00000017275gemin29964.885Seriola_dumerili
ENSG00000092208GEMIN29164.912ENSSLDG00000023429gemin29864.427Seriola_lalandi_dorsalis
ENSG00000092208GEMIN29991.532ENSSARG00000010294GEMIN210092.135Sorex_araneus
ENSG00000092208GEMIN29480.193ENSSPUG00000017222GEMIN29973.004Sphenodon_punctatus
ENSG00000092208GEMIN29576.190ENSSPAG00000001354gemin29965.267Stegastes_partitus
ENSG00000092208GEMIN210095.374ENSSSCG00000004985GEMIN210095.374Sus_scrofa
ENSG00000092208GEMIN29480.608ENSTGUG00000012039GEMIN29980.608Taeniopygia_guttata
ENSG00000092208GEMIN29461.217ENSTRUG00000021760gemin29761.217Takifugu_rubripes
ENSG00000092208GEMIN29461.597ENSTNIG00000016875gemin29961.597Tetraodon_nigroviridis
ENSG00000092208GEMIN295100.000ENSTBEG00000002654GEMIN29994.604Tupaia_belangeri
ENSG00000092208GEMIN295100.000ENSTTRG00000017126GEMIN210083.214Tursiops_truncatus
ENSG00000092208GEMIN29695.167ENSUAMG00000021811GEMIN210095.167Ursus_americanus
ENSG00000092208GEMIN29695.539ENSUMAG00000008366GEMIN210095.539Ursus_maritimus
ENSG00000092208GEMIN295100.000ENSVPAG00000006856GEMIN29995.699Vicugna_pacos
ENSG00000092208GEMIN210095.000ENSVVUG00000020954GEMIN210095.000Vulpes_vulpes
ENSG00000092208GEMIN29378.927ENSXETG00000000298gemin29678.927Xenopus_tropicalis
ENSG00000092208GEMIN29361.966ENSXCOG00000014021gemin29959.623Xiphophorus_couchianus
ENSG00000092208GEMIN29361.538ENSXMAG00000009532gemin29959.091Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000245spliceosomal complex assembly-IEAProcess
GO:0000375RNA splicing, via transesterification reactions9323129.TASProcess
GO:0000387spliceosomal snRNP assembly21873635.IBAProcess
GO:0000387spliceosomal snRNP assembly18984161.IDAProcess
GO:0000387spliceosomal snRNP assembly-TASProcess
GO:0005515protein binding11714716.18984161.19928837.21816274.21900206.23022347.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005681spliceosomal complex-IEAComponent
GO:0005730nucleolus-IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005829cytosol18984161.IDAComponent
GO:0005829cytosol-TASComponent
GO:0006397mRNA processing9323130.TASProcess
GO:0008380RNA splicing9323129.TASProcess
GO:0016604nuclear body-IDAComponent
GO:0032797SMN complex21873635.IBAComponent
GO:0032797SMN complex18984161.IDAComponent
GO:0034719SMN-Sm protein complex18984161.IDAComponent
GO:0051170import into nucleus-TASProcess
GO:0097504Gemini of coiled bodies20513430.IDAComponent

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