EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000092847 (Gene tree)
Gene ID: 26523
Gene Symbol: AGO1
Alias: hAGO1|EIF2C1
Full Name: argonaute RISC component 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 60,738 bases
Position: chr1:35,869,791-35,930,528
Accession: 3262
RBP type: canonical RBP
Summary: This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000362300	PAZ	PF02170.22	3.6e-28	1	1
ENSP00000362302	PAZ	PF02170.22	4.2e-28	1	1
ENSP00000362302	Piwi	PF02171.17	3.7e-110	1	1
ENSP00000362300	Piwi	PF02171.17	4.6e-110	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18635957	The XS domain of a plant specific SGS3 protein adopts a unique RNA recognition motif (RRM) fold.	Cell Cycle	2008 Jul 15	Zhang D	-
16936726	Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells.	Nat Struct Mol Biol	2006 Sep	Kim DH	-
26641460	Formation of Potato Virus A-Induced RNA Granules and Viral Translation Are Interrelated Processes Required for Optimal Virus Accumulation.	PLoS Pathog	2015 Dec 7	Hafren A	doi: 10.1371/journal.ppat.1005314
28499009	A viral suppressor of RNA silencing inhibits ARGONAUTE 1 function by precluding target RNA binding to pre-assembled RISC.	Nucleic Acids Res	2017 Jul 27	Kenesi E	doi: 10.1093/nar/gkx379.
19861421	The Arabidopsis thaliana double-stranded RNA binding protein DRB1 directs guide strand selection from microRNA duplexes.	RNA	2009 Dec	Eamens AL	doi: 10.1261/rna.1646909
19763164	Redundant and specific roles of the ARGONAUTE proteins AGO1 and ZLL in development and small RNA-directed gene silencing.	PLoS Genet	2009 Sep	Mallory AC	doi: 10.1371/journal.pgen.1000646
21878547	Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing.	RNA	2011 Oct	Broderick JA	doi: 10.1261/rna.2778911
22025453	Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer.	Mol Carcinog	2012 Nov	Sand M	doi: 10.1002/mc.20861
23184089	microRNA-independent recruitment of Argonaute 1 to nanos mRNA through the Smaug RNA-binding protein.	EMBO Rep	2013 Jan	Pinder BD	doi: 10.1038/embor.2012.192
25480915	Coordinate control of terminal dendrite patterning and dynamics by the membrane protein Raw.	Development	2015 Jan 1	Lee J	doi: 10.1242/dev.113423
28634830	The microRNA effector RNA-induced silencing complex in hidradenitis suppurativa: a significant dysregulation within active inflammatory lesions.	Arch Dermatol Res	2017 Sep	Hessam S	doi: 10.1007/s00403-017-1752-1
29396181	Argonaute 2 Is Required for Extra-embryonic Endoderm Differentiation of Mouse Embryonic Stem Cells.	Stem Cell Reports	2018 Feb 13	Ngondo RP	doi: 10.1016/j.stemcr.2017.12.023
16287716	Slicer function of Drosophila Argonautes and its involvement in RISC formation.	Genes Dev	2005 Dec 1	Miyoshi K	-
19394293	An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing.	Mol Cell	2009 Apr 24	Li H	doi: 10.1016/j.molcel.2009.02.032.
22363633	Small RNAs targeting transcription start site induce heparanase silencing through interference with transcription initiation in human cancer cells.	PLoS One	2012	Jiang G	doi: 10.1371/journal.pone.0031379
22045333	Cyclophilin 40 facilitates HSP90-mediated RISC assembly in plants.	EMBO J	2012 Jan 18	Iki T	doi: 10.1038/emboj.2011.395
21646546	Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein.	Proc Natl Acad Sci U S A	2011 Jun 28	Boland A	doi: 10.1073/pnas.1103946108
24092744	Fungal small RNAs suppress plant immunity by hijacking host RNA interference pathways.	Science	2013 Oct 4	Weiberg A	doi: 10.1126/science.1239705.
24062160	Independent parallel functions of p19 plant viral suppressor of RNA silencing required for effective suppressor activity.	Nucleic Acids Res	2014 Jan	Varallyay e	doi: 10.1093/nar/gkt846
28325872	Small RNA-mediated repair of UV-induced DNA lesions by the DNA DAMAGE-BINDING PROTEIN 2 and ARGONAUTE 1.	Proc Natl Acad Sci U S A	2017 Apr 4	Schalk C	doi: 10.1073/pnas.1618834114
27543392	Alfalfa dwarf cytorhabdovirus P protein is a local and systemic RNA silencing supressor which inhibits programmed RISC activity and prevents transitive amplification of RNA silencing.	Virus Res	2016 Sep 15	Bejerman N	doi: 10.1016/j.virusres.2016.08.008
26355083	Requirement for Host RNA-Silencing Components and the Virus-Silencing Suppressor when Second-Site Mutations Compensate for Structural Defects in the 3' Untranslated Region.	J Virol	2015 Nov	Chattopadhyay M	doi: 10.1128/JVI.01566-15

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000373206	AGO1-202	3996	XM_017001018	ENSP00000362302	782 (aa)	XP_016856507	Q5TA58
ENST00000635259	AGO1-203	2836	-	ENSP00000489254	133 (aa)	-	A0A0U1RQZ8
ENST00000373204	AGO1-201	13708	XM_011541236	ENSP00000362300	857 (aa)	XP_011539538	Q9UL18

Gene Model

Click here to download ENSG00000092847's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000092847's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000092847	AGO1	100	84.802	ENSG00000123908	AGO2	100	83.333
ENSG00000092847	AGO1	100	84.131	ENSG00000134698	AGO4	99	83.489
ENSG00000092847	AGO1	100	85.461	ENSG00000126070	AGO3	100	89.617

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000092847	AGO1	100	97.187	ENSAPOG00000024299	ago1	98	96.916	Acanthochromis_polyacanthus
ENSG00000092847	AGO1	100	100.000	ENSAMEG00000000504	AGO1	100	100.000	Ailuropoda_melanoleuca
ENSG00000092847	AGO1	90	92.023	ENSACIG00000005298	ago1	98	92.023	Amphilophus_citrinellus
ENSG00000092847	AGO1	100	97.187	ENSAOCG00000017727	ago1	98	96.916	Amphiprion_ocellaris
ENSG00000092847	AGO1	100	97.187	ENSAPEG00000004458	ago1	99	96.576	Amphiprion_percula
ENSG00000092847	AGO1	100	97.187	ENSATEG00000008523	ago1	98	96.916	Anabas_testudineus
ENSG00000092847	AGO1	100	93.257	ENSAPLG00000010440	AGO1	98	93.794	Anas_platyrhynchos
ENSG00000092847	AGO1	100	99.872	ENSACAG00000029174	AGO1	100	99.872	Anolis_carolinensis
ENSG00000092847	AGO1	100	100.000	ENSANAG00000037711	AGO1	100	100.000	Aotus_nancymaae
ENSG00000092847	AGO1	100	97.059	ENSACLG00000000890	ago1	98	96.679	Astatotilapia_calliptera
ENSG00000092847	AGO1	88	98.542	ENSAMXG00000001917	ago1	98	98.542	Astyanax_mexicanus
ENSG00000092847	AGO1	100	99.883	ENSBTAG00000012253	AGO1	100	99.883	Bos_taurus
ENSG00000092847	AGO1	100	100.000	ENSCJAG00000032023	AGO1	100	100.000	Callithrix_jacchus
ENSG00000092847	AGO1	100	100.000	ENSCAFG00000003443	AGO1	100	100.000	Canis_familiaris
ENSG00000092847	AGO1	100	100.000	ENSCAFG00020009251	AGO1	99	99.683	Canis_lupus_dingo
ENSG00000092847	AGO1	100	99.488	ENSCHIG00000011848	-	100	99.072	Capra_hircus
ENSG00000092847	AGO1	100	100.000	ENSTSYG00000009767	-	100	100.000	Carlito_syrichta
ENSG00000092847	AGO1	100	78.772	ENSTSYG00000032426	-	99	79.499	Carlito_syrichta
ENSG00000092847	AGO1	89	93.983	ENSCAPG00000010228	AGO1	99	93.111	Cavia_aperea
ENSG00000092847	AGO1	100	100.000	ENSCPOG00000011568	AGO1	100	100.000	Cavia_porcellus
ENSG00000092847	AGO1	100	100.000	ENSCCAG00000011823	AGO1	100	100.000	Cebus_capucinus
ENSG00000092847	AGO1	100	100.000	ENSCATG00000031521	AGO1	100	100.000	Cercocebus_atys
ENSG00000092847	AGO1	100	100.000	ENSCLAG00000011507	AGO1	100	100.000	Chinchilla_lanigera
ENSG00000092847	AGO1	100	100.000	ENSCSAG00000001091	AGO1	100	100.000	Chlorocebus_sabaeus
ENSG00000092847	AGO1	85	94.574	ENSCHOG00000011591	AGO1	86	94.574	Choloepus_hoffmanni
ENSG00000092847	AGO1	100	99.872	ENSCPBG00000018594	AGO1	100	99.767	Chrysemys_picta_bellii
ENSG00000092847	AGO1	100	100.000	ENSCANG00000039798	AGO1	100	100.000	Colobus_angolensis_palliatus
ENSG00000092847	AGO1	100	100.000	ENSCGRG00001022708	Ago1	100	100.000	Cricetulus_griseus_chok1gshd
ENSG00000092847	AGO1	100	100.000	ENSCGRG00000010386	Ago1	100	100.000	Cricetulus_griseus_crigri
ENSG00000092847	AGO1	100	95.358	ENSCSEG00000001051	ago1	99	94.780	Cynoglossus_semilaevis
ENSG00000092847	AGO1	100	97.187	ENSCVAG00000018173	ago1	98	96.916	Cyprinodon_variegatus
ENSG00000092847	AGO1	100	97.315	ENSDARG00000092644	ago1	98	96.923	Danio_rerio
ENSG00000092847	AGO1	100	100.000	ENSDNOG00000008077	AGO1	100	100.000	Dasypus_novemcinctus
ENSG00000092847	AGO1	93	98.820	ENSDORG00000008494	Ago1	100	100.000	Dipodomys_ordii
ENSG00000092847	AGO1	84	93.204	ENSETEG00000007626	AGO1	100	93.204	Echinops_telfairi
ENSG00000092847	AGO1	100	100.000	ENSEASG00005012086	AGO1	100	100.000	Equus_asinus_asinus
ENSG00000092847	AGO1	100	100.000	ENSECAG00000024353	AGO1	100	100.000	Equus_caballus
ENSG00000092847	AGO1	100	91.560	ENSEEUG00000005349	AGO1	92	91.614	Erinaceus_europaeus
ENSG00000092847	AGO1	100	97.059	ENSELUG00000016803	ago1	100	97.059	Esox_lucius
ENSG00000092847	AGO1	100	100.000	ENSFCAG00000000746	AGO1	100	100.000	Felis_catus
ENSG00000092847	AGO1	100	92.219	ENSFALG00000000790	AGO1	100	92.219	Ficedula_albicollis
ENSG00000092847	AGO1	100	100.000	ENSFDAG00000017210	AGO1	100	99.883	Fukomys_damarensis
ENSG00000092847	AGO1	96	97.460	ENSFHEG00000017927	ago1	99	93.001	Fundulus_heteroclitus
ENSG00000092847	AGO1	96	84.646	ENSGMOG00000019413	ago1	100	84.646	Gadus_morhua
ENSG00000092847	AGO1	100	99.883	ENSGALG00000002249	AGO1	100	99.883	Gallus_gallus
ENSG00000092847	AGO1	100	97.187	ENSGAFG00000009775	ago1	98	96.916	Gambusia_affinis
ENSG00000092847	AGO1	96	97.204	ENSGACG00000012443	ago1	100	97.204	Gasterosteus_aculeatus
ENSG00000092847	AGO1	100	99.872	ENSGAGG00000012893	-	100	99.872	Gopherus_agassizii
ENSG00000092847	AGO1	100	100.000	ENSGGOG00000003316	AGO1	100	100.000	Gorilla_gorilla
ENSG00000092847	AGO1	100	97.059	ENSHBUG00000010459	ago1	98	96.679	Haplochromis_burtoni
ENSG00000092847	AGO1	100	100.000	ENSHGLG00000011540	AGO1	100	100.000	Heterocephalus_glaber_female
ENSG00000092847	AGO1	100	100.000	ENSHGLG00100005568	AGO1	100	100.000	Heterocephalus_glaber_male
ENSG00000092847	AGO1	100	97.187	ENSHCOG00000005708	ago1	99	96.576	Hippocampus_comes
ENSG00000092847	AGO1	100	96.931	ENSIPUG00000023216	ago1	98	96.686	Ictalurus_punctatus
ENSG00000092847	AGO1	100	100.000	ENSSTOG00000010857	AGO1	100	100.000	Ictidomys_tridecemlineatus
ENSG00000092847	AGO1	100	100.000	ENSJJAG00000019449	Ago1	100	99.883	Jaculus_jaculus
ENSG00000092847	AGO1	100	97.187	ENSKMAG00000019464	ago1	98	96.916	Kryptolebias_marmoratus
ENSG00000092847	AGO1	100	97.187	ENSLBEG00000007694	ago1	98	96.916	Labrus_bergylta
ENSG00000092847	AGO1	100	93.240	ENSLACG00000017009	AGO1	99	93.625	Latimeria_chalumnae
ENSG00000092847	AGO1	100	94.501	ENSLOCG00000000504	AGO1	98	94.662	Lepisosteus_oculatus
ENSG00000092847	AGO1	100	100.000	ENSLAFG00000010835	AGO1	99	100.000	Loxodonta_africana
ENSG00000092847	AGO1	100	100.000	ENSMFAG00000002846	AGO1	100	100.000	Macaca_fascicularis
ENSG00000092847	AGO1	100	95.013	ENSMMUG00000006251	AGO1	100	95.255	Macaca_mulatta
ENSG00000092847	AGO1	100	100.000	ENSMNEG00000028881	AGO1	100	100.000	Macaca_nemestrina
ENSG00000092847	AGO1	100	100.000	ENSMLEG00000038388	AGO1	100	100.000	Mandrillus_leucophaeus
ENSG00000092847	AGO1	100	97.187	ENSMAMG00000008381	ago1	98	96.916	Mastacembelus_armatus
ENSG00000092847	AGO1	100	97.059	ENSMZEG00005007996	ago1	98	96.679	Maylandia_zebra
ENSG00000092847	AGO1	100	94.043	ENSMGAG00000003822	AGO1	99	94.484	Meleagris_gallopavo
ENSG00000092847	AGO1	100	100.000	ENSMAUG00000015189	Ago1	100	100.000	Mesocricetus_auratus
ENSG00000092847	AGO1	100	100.000	ENSMICG00000016147	AGO1	100	100.000	Microcebus_murinus
ENSG00000092847	AGO1	100	99.883	ENSMOCG00000000537	Ago1	100	99.883	Microtus_ochrogaster
ENSG00000092847	AGO1	86	98.657	ENSMMOG00000018459	ago1	93	98.657	Mola_mola
ENSG00000092847	AGO1	100	99.744	ENSMODG00000023335	AGO1	100	99.650	Monodelphis_domestica
ENSG00000092847	AGO1	100	97.059	ENSMALG00000011057	ago1	99	96.797	Monopterus_albus
ENSG00000092847	AGO1	100	100.000	MGP_CAROLIEiJ_G0026478	Ago1	100	100.000	Mus_caroli
ENSG00000092847	AGO1	100	100.000	ENSMUSG00000041530	Ago1	100	100.000	Mus_musculus
ENSG00000092847	AGO1	100	100.000	MGP_PahariEiJ_G0028809	Ago1	100	100.000	Mus_pahari
ENSG00000092847	AGO1	100	100.000	MGP_SPRETEiJ_G0027457	Ago1	100	100.000	Mus_spretus
ENSG00000092847	AGO1	92	100.000	ENSMPUG00000014872	AGO1	100	100.000	Mustela_putorius_furo
ENSG00000092847	AGO1	70	100.000	ENSMLUG00000009628	AGO1	99	99.617	Myotis_lucifugus
ENSG00000092847	AGO1	100	100.000	ENSNGAG00000017448	Ago1	100	99.767	Nannospalax_galili
ENSG00000092847	AGO1	100	97.059	ENSNBRG00000010867	ago1	100	97.059	Neolamprologus_brichardi
ENSG00000092847	AGO1	100	100.000	ENSNLEG00000011181	AGO1	100	99.883	Nomascus_leucogenys
ENSG00000092847	AGO1	91	100.000	ENSMEUG00000013429	AGO1	91	100.000	Notamacropus_eugenii
ENSG00000092847	AGO1	93	100.000	ENSOPRG00000012325	AGO1	93	100.000	Ochotona_princeps
ENSG00000092847	AGO1	100	100.000	ENSODEG00000005321	AGO1	100	100.000	Octodon_degus
ENSG00000092847	AGO1	100	97.059	ENSONIG00000016345	ago1	99	96.679	Oreochromis_niloticus
ENSG00000092847	AGO1	100	91.003	ENSOANG00000002080	AGO1	100	91.977	Ornithorhynchus_anatinus
ENSG00000092847	AGO1	100	99.883	ENSOCUG00000023116	AGO1	100	99.883	Oryctolagus_cuniculus
ENSG00000092847	AGO1	100	97.187	ENSORLG00000014965	ago1	98	96.916	Oryzias_latipes
ENSG00000092847	AGO1	100	97.187	ENSORLG00020018253	ago1	98	96.916	Oryzias_latipes_hni
ENSG00000092847	AGO1	100	97.187	ENSORLG00015003287	ago1	98	96.916	Oryzias_latipes_hsok
ENSG00000092847	AGO1	100	97.187	ENSOMEG00000020528	ago1	98	96.916	Oryzias_melastigma
ENSG00000092847	AGO1	100	100.000	ENSOGAG00000010279	AGO1	99	100.000	Otolemur_garnettii
ENSG00000092847	AGO1	100	99.883	ENSOARG00000019591	AGO1	100	99.883	Ovis_aries
ENSG00000092847	AGO1	100	100.000	ENSPPAG00000034838	AGO1	100	100.000	Pan_paniscus
ENSG00000092847	AGO1	100	100.000	ENSPPRG00000006475	AGO1	100	100.000	Panthera_pardus
ENSG00000092847	AGO1	100	99.767	ENSPTIG00000020991	AGO1	100	99.767	Panthera_tigris_altaica
ENSG00000092847	AGO1	100	100.000	ENSPTRG00000000528	AGO1	100	100.000	Pan_troglodytes
ENSG00000092847	AGO1	100	100.000	ENSPANG00000009060	AGO1	100	100.000	Papio_anubis
ENSG00000092847	AGO1	100	98.980	ENSPSIG00000017482	AGO1	100	99.050	Pelodiscus_sinensis
ENSG00000092847	AGO1	88	97.384	ENSPMGG00000024099	ago1	98	97.384	Periophthalmus_magnuspinnatus
ENSG00000092847	AGO1	100	100.000	ENSPEMG00000023313	Ago1	100	100.000	Peromyscus_maniculatus_bairdii
ENSG00000092847	AGO1	100	99.744	ENSPCIG00000000172	AGO1	100	99.650	Phascolarctos_cinereus
ENSG00000092847	AGO1	100	97.187	ENSPFOG00000005867	ago1	98	96.916	Poecilia_formosa
ENSG00000092847	AGO1	100	97.187	ENSPLAG00000002824	ago1	99	98.119	Poecilia_latipinna
ENSG00000092847	AGO1	100	97.187	ENSPMEG00000001787	ago1	99	98.119	Poecilia_mexicana
ENSG00000092847	AGO1	100	97.187	ENSPREG00000006534	ago1	98	96.916	Poecilia_reticulata
ENSG00000092847	AGO1	100	100.000	ENSPPYG00000001551	AGO1	100	100.000	Pongo_abelii
ENSG00000092847	AGO1	58	100.000	ENSPCAG00000005604	AGO1	66	100.000	Procavia_capensis
ENSG00000092847	AGO1	100	100.000	ENSPCOG00000022061	AGO1	100	100.000	Propithecus_coquereli
ENSG00000092847	AGO1	100	100.000	ENSPVAG00000005082	AGO1	100	100.000	Pteropus_vampyrus
ENSG00000092847	AGO1	100	92.219	ENSPNYG00000012586	ago1	100	92.219	Pundamilia_nyererei
ENSG00000092847	AGO1	95	92.246	ENSPNAG00000000597	ago1	99	92.356	Pygocentrus_nattereri
ENSG00000092847	AGO1	100	99.883	ENSRNOG00000055915	Ago1	100	99.883	Rattus_norvegicus
ENSG00000092847	AGO1	100	100.000	ENSRBIG00000032611	AGO1	100	100.000	Rhinopithecus_bieti
ENSG00000092847	AGO1	100	100.000	ENSRROG00000044469	AGO1	100	100.000	Rhinopithecus_roxellana
ENSG00000092847	AGO1	100	100.000	ENSSBOG00000020867	AGO1	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000092847	AGO1	100	98.726	ENSSHAG00000017468	AGO1	100	98.480	Sarcophilus_harrisii
ENSG00000092847	AGO1	100	97.059	ENSSFOG00015020982	ago1	97	98.121	Scleropages_formosus
ENSG00000092847	AGO1	100	97.187	ENSSMAG00000002841	ago1	98	96.797	Scophthalmus_maximus
ENSG00000092847	AGO1	100	97.187	ENSSDUG00000010864	ago1	98	96.916	Seriola_dumerili
ENSG00000092847	AGO1	100	97.187	ENSSLDG00000000386	ago1	98	96.916	Seriola_lalandi_dorsalis
ENSG00000092847	AGO1	74	100.000	ENSSARG00000011520	AGO1	74	100.000	Sorex_araneus
ENSG00000092847	AGO1	100	99.744	ENSSPUG00000000836	AGO1	100	99.646	Sphenodon_punctatus
ENSG00000092847	AGO1	100	97.187	ENSSPAG00000019154	ago1	98	96.916	Stegastes_partitus
ENSG00000092847	AGO1	100	96.442	ENSTRUG00000024431	ago1	100	96.442	Takifugu_rubripes
ENSG00000092847	AGO1	100	96.935	ENSTNIG00000012102	ago1	98	96.454	Tetraodon_nigroviridis
ENSG00000092847	AGO1	89	99.423	ENSTBEG00000016514	AGO1	100	99.445	Tupaia_belangeri
ENSG00000092847	AGO1	100	98.338	ENSTTRG00000015088	AGO1	100	98.250	Tursiops_truncatus
ENSG00000092847	AGO1	100	100.000	ENSUAMG00000027154	AGO1	100	100.000	Ursus_americanus
ENSG00000092847	AGO1	100	96.292	ENSUMAG00000002480	AGO1	99	96.226	Ursus_maritimus
ENSG00000092847	AGO1	91	98.743	ENSVPAG00000006663	AGO1	100	92.289	Vicugna_pacos
ENSG00000092847	AGO1	100	100.000	ENSVVUG00000000405	AGO1	100	100.000	Vulpes_vulpes
ENSG00000092847	AGO1	100	98.469	ENSXETG00000004364	ago1	100	98.021	Xenopus_tropicalis
ENSG00000092847	AGO1	100	96.419	ENSXCOG00000007669	ago1	100	96.419	Xiphophorus_couchianus
ENSG00000092847	AGO1	100	97.187	ENSXMAG00000021899	ago1	98	96.916	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000932	P-body	-	IEA	Component
GO:0000956	nuclear-transcribed mRNA catabolic process	18771919.	IDA	Process
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	Function
GO:0000993	RNA polymerase II complex binding	25336585.	IDA	Function
GO:0001047	core promoter binding	25336585.	IMP	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003723	RNA binding	23809764.	IDA	Function
GO:0003725	double-stranded RNA binding	19966796.	IDA	Function
GO:0003727	single-stranded RNA binding	19966796.	IDA	Function
GO:0004521	endoribonuclease activity	23809764.	IDA	Function
GO:0005515	protein binding	12526743.16289642.16756390.17891150.17932509.18482256.19167051.19324964.19383768.19716330.20616046.22484317.22915799.25036637.25336585.28330616.	IPI	Function
GO:0005634	nucleus	25336585.	IC	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	15260970.20014101.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005844	polysome	17932509.	IDA	Component
GO:0007223	Wnt signaling pathway, calcium modulating pathway	-	TAS	Process
GO:0010501	RNA secondary structure unwinding	19966796.	IDA	Process
GO:0010501	RNA secondary structure unwinding	22795694.	IMP	Process
GO:0010586	miRNA metabolic process	-	IEA	Process
GO:0010628	positive regulation of gene expression	-	TAS	Process
GO:0010629	negative regulation of gene expression	-	TAS	Process
GO:0016442	RISC complex	15260970.19966796.	IDA	Component
GO:0016525	negative regulation of angiogenesis	23426184.	IMP	Process
GO:0031054	pre-miRNA processing	19966796.	IDA	Process
GO:0035068	micro-ribonucleoprotein complex	17932509.	IDA	Component
GO:0035194	posttranscriptional gene silencing by RNA	-	TAS	Process
GO:0035196	production of miRNAs involved in gene silencing by miRNA	22795694.	IMP	Process
GO:0035198	miRNA binding	15260970.	IDA	Function
GO:0035278	miRNA mediated inhibition of translation	18771919.	IDA	Process
GO:0035279	mRNA cleavage involved in gene silencing by miRNA	15260970.	IDA	Process
GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA	19966796.	IDA	Process
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	25336585.	IMP	Process
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process
GO:0070578	RISC-loading complex	19966796.	IDA	Component
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process
GO:0090625	mRNA cleavage involved in gene silencing by siRNA	15260970.	IDA	Process
GO:1901224	positive regulation of NIK/NF-kappaB signaling	-	IEA	Process
GO:1990904	ribonucleoprotein complex	17932509.	IDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23426184	Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis.	J Clin Invest	2013 Mar	Chen Z	doi: 10.1172/JCI65344
20721975	Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.	Mol Carcinog	2010 Oct	Kim JS	doi: 10.1002/mc.20672.
27669275	Polymorphisms in GEMIN4 and AGO1 Genes Are Associated with the Risk of Lung Cancer: A Case-Control Study in Chinese Female Non-Smokers.	Int J Environ Res Public Health	2016 Sep 23	Fang X	doi: 10.3390/ijerph13100939.
30858133	Targeting high transcriptional control activity of long mononucleotide A-T repeats in cancer by Argonaute 1.	Gene	2019 May 30	Pin-On P	doi: 10.1016/j.gene.2019.03.010
22025453	Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer.	Mol Carcinog	2012 Nov	Sand M	doi: 10.1002/mc.20861
25656609	EIF2C, Dicer, and Drosha are up-regulated along tumor progression and associated with poor prognosis in bladder carcinoma.	Tumour Biol	2015 Jul	Zhang Z	doi: 10.1007/s13277-015-3158-z
19723326	mRNA expression profiles show differential regulatory effects of microRNAs between estrogen receptor-positive and estrogen receptor-negative breast cancer.	Genome Biol	2009	Cheng C	doi: 10.1186/gb-2009-10-9-r90

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr1	35914197	Missense_Mutation	NA	Q586E	0.74	PAZ
BLCA	chr1	35907058	Missense_Mutation	novel	K507N	0.18
BLCA	chr1	35919157	Nonsense_Mutation	novel	R790*	0.08	PAZ
BLCA	chr1	35895179	Silent	novel	F310F	0.58
BLCA	chr1	35906984	Missense_Mutation	novel	I483L	0.44
BLCA	chr1	35915525	Missense_Mutation	novel	E671K	0.48	PAZ
BLCA	chr1	35893711	Missense_Mutation	novel	E184Q	0.53
BLCA	chr1	35901539	Missense_Mutation	novel	M362I	0.13
BLCA	chr1	35906935	Splice_Region	novel	K466K	0.42
BLCA	chr1	35888436	Frame_Shift_Ins	novel	*F21Lfs32**	0.16
BLCA	chr1	35901998	Silent	NA	I397I	0.37
BRCA	chr1	35907026	Missense_Mutation	NA	D497H	0.23
BRCA	chr1	35902003	Missense_Mutation	NA	V399A	0.22
BRCA	chr1	35906981	Missense_Mutation	novel	P482S	0.05
BRCA	chr1	35892635	Silent	NA	K96K	0.51
BRCA	chr1	35915439	Missense_Mutation	NA	Y642C	0.38	PAZ
BRCA	chr1	35901983	Silent	novel	I392I	0.05
BRCA	chr1	35923457	3'UTR	novel		0.21
BRCA	chr1	35892610	Missense_Mutation	rs745615692	R88H	0.14
BRCA	chr1	35907055	Silent	NA	L506L	0.25
BRCA	chr1	35914197	Missense_Mutation	NA	Q586E	0.16	PAZ
BRCA	chr1	35894381	Missense_Mutation	NA	R284H	0.49
BRCA	chr1	35919496	Splice_Region	novel		0.13
BRCA	chr1	35918398	Missense_Mutation	novel	Y747S	0.07	PAZ
CESC	chr1	35920981	3'UTR	novel		0.11
CESC	chr1	35893213	Silent	novel	Q149Q	0.51
CESC	chr1	35920415	3'UTR	novel		0.44
CESC	chr1	35907032	Missense_Mutation	NA	V499M	0.35
CESC	chr1	35921822	3'UTR	novel		0.48
CESC	chr1	35893706	Missense_Mutation	novel	P182L	0.23
CESC	chr1	35921743	3'UTR	novel		0.29
CESC	chr1	35919542	Missense_Mutation	novel	P837S	0.4
COAD	chr1	35919537	Missense_Mutation	novel	R835Q	0.23
COAD	chr1	35893182	Missense_Mutation	rs748561732	R139Q	0.42
COAD	chr1	35914221	Missense_Mutation	NA	A594T	0.28	PAZ
COAD	chr1	35893182	Missense_Mutation	rs748561732	R139Q	0.26
COAD	chr1	35892675	Missense_Mutation	novel	R110W	0.09
COAD	chr1	35907018	Missense_Mutation	novel	Q494R	0.12
COAD	chr1	35893741	Missense_Mutation	NA	R194C	0.28
COAD	chr1	35919588	Missense_Mutation	novel	R852H	0.38
COAD	chr1	35915510	Nonsense_Mutation	novel	R666*	0.43	PAZ
COAD	chr1	35895222	Missense_Mutation	novel	C325R	0.15
COAD	chr1	35894362	Missense_Mutation	NA	R278C	0.34
COAD	chr1	35892672	Missense_Mutation	rs371043471	E109K	0.25
COAD	chr1	35901533	Silent	rs199616208	S360S	0.37
COAD	chr1	35915413	Silent	NA	R633R	0.33
COAD	chr1	35919588	Missense_Mutation	novel	R852H	0.23
ESCA	chr1	35920516	3'UTR	rs559288688		0.23
ESCA	chr1	35913841	Splice_Site	novel	X528_splice	0.29
ESCA	chr1	35922113	3'UTR	rs536462158		0.28
ESCA	chr1	35917682	Silent	novel	Q706Q	0.27
GBM	chr1	35915516	Missense_Mutation	novel	G668R	0.18	PAZ
GBM	chr1	35883407	5'UTR	novel		0.21
GBM	chr1	35893182	Missense_Mutation	rs748561732	R139Q	0.2
GBM	chr1	35883350	5'UTR	novel		0.5
GBM	chr1	35917718	Missense_Mutation	novel	K718N	0.07	PAZ
GBM	chr1	35915519	Missense_Mutation	novel	V669M	0.09	PAZ
GBM	chr1	35892606	Missense_Mutation	novel	D87Y	0.07
HNSC	chr1	35913862	Missense_Mutation	novel	D535N	0.14	PAZ
HNSC	chr1	35907004	Silent	NA	F489F	0.36
HNSC	chr1	35907011	Missense_Mutation	NA	Y492D	0.42
HNSC	chr1	35917620	Missense_Mutation	NA	R686C	0.13	PAZ
HNSC	chr1	35902307	Missense_Mutation	novel	P456L	0.26
HNSC	chr1	35902308	Silent	novel	P456P	0.26
HNSC	chr1	35894139	Missense_Mutation	novel	S251F	0.28
HNSC	chr1	35919158	Missense_Mutation	novel	R790L	0.32	PAZ
HNSC	chr1	35913946	Missense_Mutation	novel	L563F	0.35	PAZ
KIRC	chr1	35907082	Silent	NA	L515L	0.26
KIRP	chr1	35888461	Silent	NA	V20V	0.29
KIRP	chr1	35894387	Missense_Mutation	NA	P286L	0.35
LAML	chr1	35892600	Missense_Mutation	novel	F85I	0.09
LGG	chr1	35914253	Frame_Shift_Ins	novel	*P607Tfs32**	0.27	PAZ
LGG	chr1	35888430	Missense_Mutation	novel	A10V	0.48
LGG	chr1	35892554	Splice_Region	novel		0.54
LGG	chr1	35902271	Missense_Mutation	novel	I444T	0.39
LIHC	chr1	35918340	Missense_Mutation	NA	I728V	0.43	PAZ
LIHC	chr1	35893732	Missense_Mutation	novel	G191W	0.38
LUAD	chr1	35893279	Splice_Site	NA	X171_splice	0.13
LUAD	chr1	35883433	Silent	NA	G4G	0.17
LUAD	chr1	35893257	Missense_Mutation	NA	M164T	0.1
LUAD	chr1	35915398	Silent	novel	R628R	0.58
LUAD	chr1	35918323	Missense_Mutation	NA	I722T	0.17	PAZ
LUAD	chr1	35888444	Frame_Shift_Del	NA	*L17Cfs99**	0.36
LUAD	chr1	35901527	Missense_Mutation	novel	Q358H	0.51
LUAD	chr1	35915395	Frame_Shift_Del	novel	*R628Gfs153**	0.19	PAZ
LUAD	chr1	35915396	Missense_Mutation	novel	R628W	0.19	PAZ
LUAD	chr1	35919220	Missense_Mutation	novel	A811S	0.45	PAZ
LUAD	chr1	35902230	Missense_Mutation	rs773266381	Q430H	0.23
LUAD	chr1	35915462	Nonsense_Mutation	NA	Q650*	0.32	PAZ
LUSC	chr1	35917697	Silent	novel	T711T	0.25
LUSC	chr1	35893108	Missense_Mutation	NA	E114D	0.38
LUSC	chr1	35895179	Missense_Mutation	novel	F310L	0.29
LUSC	chr1	35901994	Missense_Mutation	novel	G396V	0.16
LUSC	chr1	35895244	Frame_Shift_Del	novel	*K333Sfs7**	0.25
LUSC	chr1	35906954	Missense_Mutation	novel	R473W	0.1
LUSC	chr1	35902046	Silent	novel	A413A	0.31
LUSC	chr1	35895240	Missense_Mutation	rs759454083	E331K	0.19
MESO	chr1	35913902	Missense_Mutation	novel	K548T	0.3	PAZ
OV	chr1	35919076	Missense_Mutation	novel	Y763H	0.07	PAZ
OV	chr1	35901976	Missense_Mutation	rs758951181	P390L	0.35
OV	chr1	35918381	Frame_Shift_Ins	novel	*F742Lfs2**	0.08	PAZ
OV	chr1	35902059	Missense_Mutation	NA	Y418H	0.12
OV	chr1	35902268	Missense_Mutation	NA	G443V	0.16
OV	chr1	35918372	Silent	novel	I738I	0.04
OV	chr1	35919709	3'UTR	novel		0.23
PAAD	chr1	35893758	Silent	novel	G199G	0.09
PRAD	chr1	35892638	Silent	novel	N97N	0.32
PRAD	chr1	35902217	Missense_Mutation	novel	A426V	0.37
READ	chr1	35888551	Silent	rs200988923	I50I	0.2
READ	chr1	35893137	Missense_Mutation	novel	R124L	0.48
READ	chr1	35919601	Silent	rs764523718	F856F	0.42
SARC	chr1	35924056	3'UTR	novel		0.29
SARC	chr1	35923686	3'UTR	novel		0.28
SARC	chr1	35906955	Missense_Mutation	rs761121371	R473Q	0.81
SARC	chr1	35920182	3'UTR	novel		0.45
SKCM	chr1	35919207	Silent	NA	L806L	0.34
SKCM	chr1	35893217	Missense_Mutation	rs746713624	P151S	0.21
SKCM	chr1	35902309	Nonsense_Mutation	NA	Q457*	0.31
SKCM	chr1	35901532	Missense_Mutation	NA	S360L	0.3
SKCM	chr1	35919064	Nonsense_Mutation	NA	R759*	0.53	PAZ
SKCM	chr1	35919561	Missense_Mutation	novel	A843V	0.11
SKCM	chr1	35914190	Silent	rs770625415	A583A	0.34
SKCM	chr1	35913899	Missense_Mutation	novel	V547G	0.11	PAZ
SKCM	chr1	35915436	Missense_Mutation	NA	S641F	0.24	PAZ
SKCM	chr1	35919671	3'UTR	novel		0.38
SKCM	chr1	35919672	3'UTR	novel		0.27
SKCM	chr1	35914261	Missense_Mutation	NA	P607H	0.35	PAZ
SKCM	chr1	35919544	Silent	NA	P837P	0.68
SKCM	chr1	35913960	Silent	NA	V567V	0.18
SKCM	chr1	35893167	Missense_Mutation	NA	A134V	0.54
SKCM	chr1	35895210	Missense_Mutation	NA	P321S	0.19
SKCM	chr1	35893746	Silent	novel	E195E	0.39
SKCM	chr1	35917598	Silent	rs756047129	L678L	0.25
SKCM	chr1	35907098	Missense_Mutation	novel	P521S	0.52	PAZ
SKCM	chr1	35907099	Missense_Mutation	novel	P521L	0.51	PAZ
SKCM	chr1	35883366	5'UTR	novel		0.33
SKCM	chr1	35888542	Silent	NA	I47I	0.14
SKCM	chr1	35895261	Missense_Mutation	NA	P338S	0.53
SKCM	chr1	35915372	Missense_Mutation	NA	P620S	0.25	PAZ
SKCM	chr1	35895194	Silent	novel	N315N	0.27
SKCM	chr1	35895195	Missense_Mutation	novel	L316F	0.26
SKCM	chr1	35894080	Silent	NA	F231F	0.4
STAD	chr1	35919065	Missense_Mutation	NA	R759Q	0.45	PAZ
STAD	chr1	35893755	Silent	NA	F198F	0.06
STAD	chr1	35915480	Missense_Mutation	novel	R656S	0.21	PAZ
STAD	chr1	35893257	Missense_Mutation	NA	M164T	0.27
STAD	chr1	35893741	Missense_Mutation	NA	R194C	0.28
STAD	chr1	35902068	Missense_Mutation	NA	R421W	0.19
STAD	chr1	35893741	Missense_Mutation	NA	R194C	0.09
STAD	chr1	35888581	Missense_Mutation	NA	K60N	0.21
STAD	chr1	35892609	Missense_Mutation	rs774432228	R88C	0.23
STAD	chr1	35917594	Missense_Mutation	novel	I677K	0.09	PAZ
STAD	chr1	35914235	Frame_Shift_Del	novel	*P600Qfs14**	0.09	PAZ
STAD	chr1	35913853	Missense_Mutation	NA	R532C	0.27	PAZ
STAD	chr1	35902322	Missense_Mutation	novel	R461Q	0.43
STAD	chr1	35914272	Missense_Mutation	rs756692838	A611T	0.27	PAZ
STAD	chr1	35917699	Missense_Mutation	NA	R712H	0.19	PAZ
STAD	chr1	35915447	Missense_Mutation	NA	R645C	0.23	PAZ
STAD	chr1	35919101	Missense_Mutation	rs371456175	R771H	0.3	PAZ
STAD	chr1	35892670	Missense_Mutation	NA	N108S	0.21
STAD	chr1	35902335	Splice_Region	NA	L465L	0.25
STAD	chr1	35902303	Missense_Mutation	NA	A455T	0.22
THCA	chr1	35915431	Silent	NA	D639D	0.11
THYM	chr1	35919616	3'UTR	rs750483408		0.19
THYM	chr1	35923576	3'UTR	novel		0.29
UCEC	chr1	35888444	Frame_Shift_Del	NA	*L17Cfs99**	0.46
UCEC	chr1	35920058	3'UTR	novel		0.25
UCEC	chr1	35888551	Silent	rs200988923	I50I	0.3
UCEC	chr1	35892610	Missense_Mutation	rs745615692	R88H	0.35
UCEC	chr1	35893137	Missense_Mutation	novel	R124Q	0.39
UCEC	chr1	35901589	Missense_Mutation	novel	R379H	0.38
UCEC	chr1	35902018	Missense_Mutation	novel	T404M	0.41
UCEC	chr1	35892672	Missense_Mutation	rs371043471	E109K	0.32
UCEC	chr1	35902305	Silent	NA	A455A	0.29
UCEC	chr1	35921118	3'UTR	novel		0.35
UCEC	chr1	35921528	3'UTR	novel		0.63
UCEC	chr1	35893730	Frame_Shift_Ins	novel	*G193Wfs24**	0.44
UCEC	chr1	35923824	3'UTR	novel		0.42
UCEC	chr1	35920204	3'UTR	novel		0.35
UCEC	chr1	35919131	Missense_Mutation	NA	T781M	0.06	PAZ
UCEC	chr1	35913860	Missense_Mutation	novel	G534E	0.43	PAZ
UCEC	chr1	35919601	Silent	rs764523718	F856F	0.44
UCEC	chr1	35920220	3'UTR	novel		0.69
UCEC	chr1	35920848	3'UTR	novel		0.29
UCEC	chr1	35919064	Nonsense_Mutation	NA	R759*	0.48	PAZ
UCEC	chr1	35888552	Missense_Mutation	rs773153331	D51N	0.25
UCEC	chr1	35907058	Missense_Mutation	novel	K507N	0.05
UCEC	chr1	35915429	Missense_Mutation	novel	D639Y	0.1	PAZ
UCEC	chr1	35917620	Missense_Mutation	NA	R686C	0.3	PAZ
UCEC	chr1	35920896	3'UTR	novel		0.63
UCEC	chr1	35920059	3'UTR	novel		0.42
UCEC	chr1	35923508	3'UTR	novel		0.35
UCEC	chr1	35919203	Missense_Mutation	novel	R805H	0.21	PAZ
UCEC	chr1	35919554	Missense_Mutation	novel	A841T	0.14
UCEC	chr1	35922123	3'UTR	novel		0.06
UCEC	chr1	35888430	Missense_Mutation	novel	A10V	0.42
UCEC	chr1	35919963	3'UTR	novel		0.25
UCEC	chr1	35920343	3'UTR	novel		0.41
UCEC	chr1	35920220	3'UTR	novel		0.33
UCEC	chr1	35893099	Splice_Region	novel	V111V	0.07
UCEC	chr1	35921952	3'UTR	rs774314069		0.39
UCEC	chr1	35922143	3'UTR	novel		0.37
UCEC	chr1	35920711	3'UTR	novel		0.13
UCEC	chr1	35921390	3'UTR	novel		0.32
UCEC	chr1	35894337	Silent	NA	H269H	0.51
UCEC	chr1	35893136	Nonsense_Mutation	novel	R124*	0.38
UCEC	chr1	35888455	Silent	novel	Q18Q	0.64
UCEC	chr1	35888566	Silent	rs143228790	Y55Y	0.36
UCEC	chr1	35920431	3'UTR	novel		0.19
UCEC	chr1	35920867	3'UTR	novel		0.44
UCEC	chr1	35922250	3'UTR	novel		0.21
UCEC	chr1	35893731	Frame_Shift_Del	novel	*G192Vfs20**	0.33
UCEC	chr1	35894333	Missense_Mutation	novel	T268I	0.38
UCEC	chr1	35917627	Missense_Mutation	novel	A688V	0.39	PAZ
UCEC	chr1	35924204	3'UTR	novel		0.18
UCEC	chr1	35888527	Nonsense_Mutation	novel	Y42*	0.35
UCEC	chr1	35893798	Missense_Mutation	novel	L213F	0.15
UCEC	chr1	35919601	Silent	rs764523718	F856F	0.18
UCEC	chr1	35892610	Missense_Mutation	rs745615692	R88H	0.41
UCEC	chr1	35893731	Frame_Shift_Del	novel	*G192Vfs20**	0.5
UCEC	chr1	35921419	3'UTR	novel		0.4
UCEC	chr1	35888435	Missense_Mutation	novel	A12T	0.5
UCEC	chr1	35917620	Missense_Mutation	NA	R686C	0.39	PAZ
UCEC	chr1	35921448	3'UTR	novel		0.31
UCEC	chr1	35920050	3'UTR	novel		0.45
UCEC	chr1	35922090	3'UTR	novel		0.31
UCEC	chr1	35921906	3'UTR	novel		0.32
UCEC	chr1	35923559	3'UTR	novel		0.47
UCEC	chr1	35923828	3'UTR	novel		0.35
UCEC	chr1	35906973	Missense_Mutation	NA	A479V	0.42
UCEC	chr1	35892599	Silent	NA	I84I	0.24
UCEC	chr1	35921952	3'UTR	rs774314069		0.18
UCEC	chr1	35888609	Missense_Mutation	novel	R70W	0.35
UCEC	chr1	35901533	Silent	rs199616208	S360S	0.38
UCEC	chr1	35921944	3'UTR	novel		0.09
UCEC	chr1	35893731	Frame_Shift_Del	novel	*G192Vfs20**	0.22
UCEC	chr1	35917620	Missense_Mutation	NA	R686C	0.48	PAZ
UCEC	chr1	35888598	Missense_Mutation	novel	R66L	0.11
UCEC	chr1	35901493	In_Frame_Ins	novel	Q348dup	0.2
UCEC	chr1	35902032	Nonsense_Mutation	novel	R409*	0.28
UCEC	chr1	35915383	Silent	novel	Y623Y	0.16
UCEC	chr1	35888444	Frame_Shift_Del	NA	*L17Cfs99**	0.46
UCEC	chr1	35902019	Silent	rs747545727	T404T	0.26
UCEC	chr1	35913870	Silent	novel	L537L	0.29
UCEC	chr1	35919851	3'UTR	novel		0.42
UCEC	chr1	35920839	3'UTR	novel		0.38
UCEC	chr1	35920945	3'UTR	novel		0.37
UCEC	chr1	35921739	3'UTR	novel		0.24
UCEC	chr1	35902013	Silent	novel	D402D	0.39
UCEC	chr1	35920937	3'UTR	novel		0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0833	0.011841
TGCT	DEL	0.14	0.00046313

Survival Analysis

Cancer	P-value	Q-value
ACC	0.00011	Kaplan-Meier Survival Analysis
ESCA	0.027	Kaplan-Meier Survival Analysis
READ	0.0035	Kaplan-Meier Survival Analysis
KICH	0.00061	Kaplan-Meier Survival Analysis
UCEC	0.016	Kaplan-Meier Survival Analysis
LIHC	0.0029	Kaplan-Meier Survival Analysis
LGG	0.015	Kaplan-Meier Survival Analysis
LUAD	0.0089	Kaplan-Meier Survival Analysis
UVM	0.011	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742