EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000092964 (Gene tree)
Gene ID: 1808
Gene Symbol: DPYSL2
Alias: DRP-2|DHPRP2|CRMP2|DRP2
Full Name: dihydropyrimidinase like 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 144,157 bases
Position: chr8:26,514,022-26,658,178
Accession: 3014
RBP type: non-canonical RBP
Summary: This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000474808	DPYSL2-202	566	-	-	- (aa)	-	-
ENST00000523093	DPYSL2-207	728	-	-	- (aa)	-	-
ENST00000311151	DPYSL2-201	4603	-	ENSP00000309539	572 (aa)	-	Q16555
ENST00000523690	DPYSL2-208	544	-	-	- (aa)	-	-
ENST00000521983	DPYSL2-205	591	-	-	- (aa)	-	-
ENST00000521913	DPYSL2-204	4805	-	ENSP00000427985	677 (aa)	-	A0A1C7CYX9
ENST00000493789	DPYSL2-203	562	-	ENSP00000427954	170 (aa)	-	E5RFU4
ENST00000523027	DPYSL2-206	2130	-	ENSP00000431117	536 (aa)	-	Q16555

Gene Model

Click here to download ENSG00000092964's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04360	Axon guidance	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000092964	Cholesterol, LDL	8.5860000E-005	-
ENSG00000092964	Erythrocyte Indices	7.2870000E-005	-
ENSG00000092964	Erythrocyte Count	3.0240000E-005	-
ENSG00000092964	Leukoaraiosis	3.6818886E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000092964	rs562044044	8	26604499	G	Plasma trimethyllysine levels	29563342	[0.19-0.41] unit increase	0.301	EFO_0009134
ENSG00000092964	rs10107066	8	26542619	?	Cardiovascular disease	30595370			EFO_0000319
ENSG00000092964	rs17321041	8	26587678	C	Diastolic blood pressure	30224653	[0.16-0.3] mmHg decrease	0.2313	EFO_0006336

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000092964's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000092964	DPYSL2	99	76.708	ENSG00000113657	DPYSL3	100	89.130	Homo_sapiens
ENSG00000092964	DPYSL2	100	98.776	ENSMUSG00000022048	Dpysl2	100	98.776	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004157	dihydropyrimidinase activity	8973361.	TAS	Function
GO:0005515	protein binding	16260607.19235893.21900206.25416956.	IPI	Function
GO:0005829	cytosol	20801876.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005874	microtubule	20801876.	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006139	nucleobase-containing compound metabolic process	8973361.	TAS	Process
GO:0006897	endocytosis	20801876.	IMP	Process
GO:0007010	cytoskeleton organization	-	ISS	Process
GO:0007165	signal transduction	8973361.	TAS	Process
GO:0007399	nervous system development	8973361.	TAS	Process
GO:0007411	axon guidance	-	IEA	Process
GO:0007420	brain development	-	IEA	Process
GO:0008017	microtubule binding	-	IEA	Function
GO:0016020	membrane	20801876.	IDA	Component
GO:0030516	regulation of axon extension	-	IEA	Process
GO:0042802	identical protein binding	21516116.25416956.	IPI	Function
GO:0070062	extracellular exosome	20458337.	HDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24518087	Discovery of new membrane-associated proteins overexpressed in small-cell lung cancer.	J Thorac Oncol	2014 Mar	Ocak S	doi: 10.1097/JTO.0000000000000090.
23381229	Collapsin response mediator protein 2 is involved in regulating breast cancer progression.	Breast Cancer	2014 Nov	Shimada K	doi: 10.1007/s12282-013-0447-5
23023514	Phosphorylated tubulin adaptor protein CRMP-2 as prognostic marker and candidate therapeutic target for NSCLC.	Int J Cancer	2013 May 1	Oliemuller E	doi: 10.1002/ijc.27881
18203259	Identification of collapsin response mediator protein-2 as a potential marker of colorectal carcinoma by comparative analysis of cancer cell secretomes.	Proteomics	2008 Jan	Wu CC	doi: 10.1002/pmic.200700819.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr8	26647627	Splice_Region	novel		0.38
BLCA	chr8	26647708	Missense_Mutation	novel	R397W	0.23
BLCA	chr8	26627293	Nonsense_Mutation	novel	E207*	0.05
BLCA	chr8	26643486	Missense_Mutation	NA	G287S	0.32
BLCA	chr8	26652374	Missense_Mutation	rs773717246	R467C	0.3
BRCA	chr8	26658129	3'UTR	novel		0.25
BRCA	chr8	26658005	3'UTR	novel		0.17
BRCA	chr8	26647704	Frame_Shift_Del	novel	*R397Gfs95**	0.13
BRCA	chr8	26583868	Missense_Mutation	NA	I66M	0.16
BRCA	chr8	26627251	Missense_Mutation	rs143980725	A193T	0.15
BRCA	chr8	26578107	5'UTR	novel		0.5
BRCA	chr8	26643485	Silent	rs138088405	D286D	0.1
BRCA	chr8	26626674	Missense_Mutation	NA	C179Y	0.25
CESC	chr8	26647704	Silent	novel	Y395Y	0.15
CESC	chr8	26652293	Missense_Mutation	rs779134278	R440C	0.43
CESC	chr8	26583893	Missense_Mutation	rs774132967	R75C	0.53
CESC	chr8	26647750	Missense_Mutation	novel	I411L	0.33
CESC	chr8	26578125	5'UTR	novel		0.47
CESC	chr8	26634893	Silent	novel	R268R	0.29
CESC	chr8	26652282	Missense_Mutation	novel	G436D	0.57
CESC	chr8	26657264	3'UTR	rs535805174		0.11
CESC	chr8	26657306	3'UTR	novel		0.25
COAD	chr8	26578176	5'UTR	novel		0.27
COAD	chr8	26624244	Missense_Mutation	NA	V139M	0.29
COAD	chr8	26578254	5'UTR	novel		0.34
COAD	chr8	26634882	Missense_Mutation	rs751569597	A265T	0.29
COAD	chr8	26655668	Frame_Shift_Del	NA	*G563Vfs121**	0.62
COAD	chr8	26634891	Missense_Mutation	novel	R268W	0.33
COAD	chr8	26624267	Silent	rs760000083	K146K	0.1
COAD	chr8	26627280	Silent	rs773335767	G202G	0.36
COAD	chr8	26643486	Missense_Mutation	NA	G287S	0.31
COAD	chr8	26583872	Missense_Mutation	novel	G68R	0.4
COAD	chr8	26653296	Missense_Mutation	rs374825617	T509M	0.28
COAD	chr8	26653307	Missense_Mutation	NA	V513I	0.17
COAD	chr8	26581976	Missense_Mutation	rs765937076	R16H	0.37
COAD	chr8	26634892	Missense_Mutation	NA	R268Q	0.23
GBM	chr8	26643982	Missense_Mutation	novel	C334S	0.06
GBM	chr8	26653249	Silent	NA	G493G	0.23
GBM	chr8	26583905	Missense_Mutation	novel	P79S	0.49
GBM	chr8	26652413	Frame_Shift_Ins	novel	*K480Tfs11**	0.06
GBM	chr8	26634832	Missense_Mutation	novel	C248Y	0.1
GBM	chr8	26653240	Silent	novel	E490E	0.47
GBM	chr8	26624300	Frame_Shift_Del	novel	*D158Ifs4**	0.2
GBM	chr8	26643526	Missense_Mutation	novel	A300D	0.06
HNSC	chr8	26624239	Missense_Mutation	novel	L137Q	0.23
HNSC	chr8	26634788	Silent	rs529587582	A233A	0.33
HNSC	chr8	26578412	Intron	novel		0.12
HNSC	chr8	26634801	Missense_Mutation	NA	R238C	0.04
HNSC	chr8	26626648	Missense_Mutation	novel	F170L	0.22
HNSC	chr8	26644047	Missense_Mutation	novel	N356Y	0.42
KICH	chr8	26655673	Silent	rs747715290	P562P	0.15
KIRP	chr8	26647680	Missense_Mutation	novel	N387K	0.61
LIHC	chr8	26627920	Missense_Mutation	NA	V224L	0.21
LUAD	chr8	26634791	Missense_Mutation	NA	E234D	0.15
LUAD	chr8	26583858	Missense_Mutation	novel	R63L	0.1
LUAD	chr8	26644073	Silent	NA	V364V	0.12
LUAD	chr8	26655701	Missense_Mutation	NA	G572C	0.12
LUAD	chr8	26583942	Missense_Mutation	rs113269672	Q91R	0.19
LUAD	chr8	26627280	Silent	novel	G202G	0.22
LUSC	chr8	26634884	Silent	novel	A265A	0.67
LUSC	chr8	26643513	Missense_Mutation	novel	A296S	0.47
LUSC	chr8	26643458	Missense_Mutation	novel	E277D	0.53
LUSC	chr8	26653242	Missense_Mutation	NA	L491Q	0.09
LUSC	chr8	26655701	Missense_Mutation	novel	G572R	0.2
MESO	chr8	26653232	Missense_Mutation	novel	L488V	0.29
OV	chr8	26583858	Missense_Mutation	novel	R63L	0.07
OV	chr8	26627215	Missense_Mutation	NA	I181V	0.37
PAAD	chr8	26634816	Missense_Mutation	NA	A243T	0.18
PRAD	chr8	26627221	Missense_Mutation	NA	E183K	0.18
PRAD	chr8	26624307	Missense_Mutation	novel	G160R	0.34
READ	chr8	26583888	In_Frame_Del	novel	T74_D80del	0.11
READ	chr8	26647768	Missense_Mutation	rs771160273	V417I	0.4
READ	chr8	26578254	5'UTR	novel		0.1
READ	chr8	26647735	Missense_Mutation	NA	D406N	0.44
READ	chr8	26655771	3'UTR	novel		0.4
SKCM	chr8	26653379	Missense_Mutation	novel	S537P	0.25
SKCM	chr8	26655668	Missense_Mutation	novel	P561S	0.63
SKCM	chr8	26583844	Silent	rs374040535	I58I	0.32
SKCM	chr8	26578272	Silent	NA	K6K	0.19
SKCM	chr8	26583869	Missense_Mutation	novel	P67S	0.24
SKCM	chr8	26578242	5'UTR	novel		0.24
SKCM	chr8	26643527	Silent	rs764265785	A300A	0.32
SKCM	chr8	26647749	Silent	NA	V410V	0.1
SKCM	chr8	26655661	Silent	rs780843208	I558I	0.28
SKCM	chr8	26647749	Silent	NA	V410V	0.37
SKCM	chr8	26626655	Missense_Mutation	rs781052884	R173C	0.14
SKCM	chr8	26643584	Silent	NA	S319S	0.17
SKCM	chr8	26647734	Silent	rs757945823	S405S	0.16
SKCM	chr8	26624209	Missense_Mutation	NA	A127V	0.38
SKCM	chr8	26583893	Missense_Mutation	rs774132967	R75C	0.41
SKCM	chr8	26653313	Missense_Mutation	NA	P515S	0.17
STAD	chr8	26643528	Missense_Mutation	novel	F301V	0.14
STAD	chr8	26655737	3'UTR	novel		0.29
STAD	chr8	26578254	5'UTR	novel		0.23
STAD	chr8	26647717	Missense_Mutation	rs765277758	R400C	0.1
STAD	chr8	26624243	Silent	NA	H138H	0.22
STAD	chr8	26647731	Silent	NA	G404G	0.07
STAD	chr8	26578237	5'UTR	novel		0.26
STAD	chr8	26583894	Missense_Mutation	rs759388658	R75H	0.45
STAD	chr8	26634859	Missense_Mutation	novel	S257N	0.12
STAD	chr8	26624151	Missense_Mutation	rs752044385	V108I	0.44
UCEC	chr8	26652361	Silent	rs139997920	T462T	0.47
UCEC	chr8	26627269	Missense_Mutation	rs765160936	A199T	0.33
UCEC	chr8	26624276	Missense_Mutation	NA	Q149H	0.28
UCEC	chr8	26624203	Missense_Mutation	novel	E125G	0.06
UCEC	chr8	26656520	3'UTR	novel		0.27
UCEC	chr8	26643952	Missense_Mutation	novel	G324V	0.2
UCEC	chr8	26634801	Missense_Mutation	NA	R238C	0.45
UCEC	chr8	26583845	Missense_Mutation	NA	E59K	0.41
UCEC	chr8	26578175	5'UTR	novel		0.52
UCEC	chr8	26657264	3'UTR	rs535805174		0.35
UCEC	chr8	26578157	5'UTR	novel		0.35
UCEC	chr8	26657143	3'UTR	novel		0.4
UCEC	chr8	26583812	Missense_Mutation	novel	N48H	0.43
UCEC	chr8	26644062	Missense_Mutation	novel	R361W	0.45
UCEC	chr8	26643954	Missense_Mutation	novel	D325Y	0.3
UCEC	chr8	26581997	Missense_Mutation	novel	K23T	0.28
UCEC	chr8	26643570	Missense_Mutation	novel	D315Y	0.07
UCEC	chr8	26656728	3'UTR	novel		0.24
UCEC	chr8	26627281	Missense_Mutation	rs762997682	D203N	0.42
UCEC	chr8	26627910	Silent	rs145417759	P220P	0.09
UCEC	chr8	26624156	Silent	novel	V109V	0.07
UCEC	chr8	26581976	Missense_Mutation	rs765937076	R16H	0.48
UCEC	chr8	26657655	3'UTR	novel		0.14
UCEC	chr8	26583954	Missense_Mutation	NA	A95V	0.25
UCEC	chr8	26653236	Missense_Mutation	NA	A489V	0.51
UCEC	chr8	26643949	Splice_Site	novel	X323_splice	0.05
UCEC	chr8	26657655	3'UTR	novel		0.27
UCEC	chr8	26578176	5'UTR	novel		0.49
UCEC	chr8	26657372	3'UTR	novel		0.34
UCEC	chr8	26647706	Missense_Mutation	novel	P396H	0.21
UCEC	chr8	26657826	3'UTR	novel		0.36
UCEC	chr8	26624180	Silent	rs779830687	L117L	0.22
UCEC	chr8	26578086	5'UTR	novel		0.36
UCEC	chr8	26582019	Silent	rs199994960	S30S	0.22
UCEC	chr8	26578176	5'UTR	novel		0.4
UCEC	chr8	26644063	Missense_Mutation	NA	R361Q	0.38
UCEC	chr8	26657885	3'UTR	novel		0.32
UCEC	chr8	26581976	Missense_Mutation	rs765937076	R16H	0.47
UCEC	chr8	26626619	Missense_Mutation	novel	V161I	0.38
UCEC	chr8	26657576	3'UTR	novel		0.45
UCEC	chr8	26634802	Missense_Mutation	novel	R238H	0.77
UCEC	chr8	26657306	3'UTR	novel		0.48
UCEC	chr8	26578176	5'UTR	novel		0.43
UCEC	chr8	26634888	Missense_Mutation	NA	A267T	0.11
UCEC	chr8	26643439	Missense_Mutation	novel	G271E	0.59
UCEC	chr8	26653333	Silent	rs768396730	T521T	0.61
UCEC	chr8	26658163	3'UTR	novel		0.67
UCEC	chr8	26644018	Missense_Mutation	novel	D346G	0.13
UCEC	chr8	26655784	3'UTR	novel		0.64
UCEC	chr8	26658044	3'UTR	rs35258691		0.67
UCEC	chr8	26655622	Missense_Mutation	novel	Q545H	0.22
UCEC	chr8	26658143	3'UTR	novel		0.29
UCEC	chr8	26583812	Missense_Mutation	novel	N48H	0.3
UCEC	chr8	26647767	Silent	rs151050891	S416S	0.43
UCEC	chr8	26655645	Missense_Mutation	novel	R553H	0.41
UCEC	chr8	26656346	3'UTR	novel		0.29
UCEC	chr8	26652295	Silent	rs144002094	R440R	0.29
UCEC	chr8	26647699	Missense_Mutation	novel	L394I	0.35
UCEC	chr8	26652432	Missense_Mutation	rs764560894	S486N	0.32
UCEC	chr8	26653332	Missense_Mutation	novel	T521M	0.26
UCEC	chr8	26657531	3'UTR	novel		0.35
UCEC	chr8	26658137	3'UTR	novel		0.3
UCEC	chr8	26656306	3'UTR	novel		0.07
UCEC	chr8	26583845	Missense_Mutation	NA	E59K	0.58
UCEC	chr8	26634860	Silent	NA	S257S	0.39
UCEC	chr8	26656284	3'UTR	novel		0.15
UCEC	chr8	26647801	Splice_Site	novel	X427_splice	0.61
UCEC	chr8	26627280	Silent	rs773335767	G202G	0.18
UCEC	chr8	26656471	3'UTR	novel		0.38
UCEC	chr8	26657919	3'UTR	novel		0.5
UCEC	chr8	26657244	3'UTR	novel		0.21
UCEC	chr8	26655784	3'UTR	novel		0.41
UCEC	chr8	26643457	Missense_Mutation	NA	E277G	0.47
UCEC	chr8	26578175	5'UTR	novel		0.42
UCEC	chr8	26627921	Missense_Mutation	novel	V224A	0.33
UCEC	chr8	26655829	3'UTR	novel		0.17
UCEC	chr8	26656539	3'UTR	novel		0.35
UCEC	chr8	26657530	3'UTR	novel		0.36
UCEC	chr8	26658044	3'UTR	rs35258691		0.44
UCEC	chr8	26643486	Missense_Mutation	NA	G287S	0.32
UCEC	chr8	26644036	Missense_Mutation	NA	P352L	0.34
UCEC	chr8	26578175	5'UTR	novel		0.35
UCEC	chr8	26656536	3'UTR	novel		0.35
UCEC	chr8	26578175	5'UTR	novel		0.24
UCEC	chr8	26644091	Splice_Region	novel	V370V	0.05
UCS	chr8	26578175	5'UTR	novel		0.2
UCS	chr8	26624150	Silent	rs113199330	H107H	0.13

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.5515	4.5185e-08
DLBC	DEL	0.2083	0.15679
ESCA	DEL	0.4185	0.060925
KIRC	AMP	0.0284	0.12739
PAAD	DEL	0.2283	0.050455
READ	DEL	0.5758	0.20625
THCA	DEL	0.008	0.21991
UCEC	DEL	0.2041	1.6228e-10
UCS	DEL	0.5179	0.0031922

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.03	Kaplan-Meier Survival Analysis
ACC	0.0013	Kaplan-Meier Survival Analysis
HNSC	0.032	Kaplan-Meier Survival Analysis
SKCM	0.035	Kaplan-Meier Survival Analysis
LUSC	0.007	Kaplan-Meier Survival Analysis
KIRP	0.037	Kaplan-Meier Survival Analysis
PAAD	0.0056	Kaplan-Meier Survival Analysis
BLCA	0.00045	Kaplan-Meier Survival Analysis
CESC	0.017	Kaplan-Meier Survival Analysis
LAML	0.00074	Kaplan-Meier Survival Analysis
UCEC	0.016	Kaplan-Meier Survival Analysis
LGG	0.00046	Kaplan-Meier Survival Analysis
CHOL	0.043	Kaplan-Meier Survival Analysis
THCA	0.046	Kaplan-Meier Survival Analysis
LUAD	0.00011	Kaplan-Meier Survival Analysis
UVM	0.011	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742