EuRBPDB

Description

Ensembl ID: ENSG00000093000 (Gene tree)
Gene ID: 10762
Gene Symbol: NUP50
Alias: NPAP60L
Full Name: nucleoporin 50
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 24,175 bases
Position: chr22:45,163,841-45,188,015
Accession: 8065
RBP type: non-canonical RBP
Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24943837	Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics.	Mol Biol Cell	2014 Aug 15	Buchwalter AL	doi: 10.1091/mbc.E14-04-0865

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000430547	NUP50-208	537	-	ENSP00000397960	76 (aa)	-	B1AHA5
ENST00000491860	NUP50-217	493	-	-	- (aa)	-	-
ENST00000461437	NUP50-213	531	-	-	- (aa)	-	-
ENST00000419387	NUP50-205	1018	-	ENSP00000391987	30 (aa)	-	F2Z3L9
ENST00000422489	NUP50-206	543	-	ENSP00000416264	178 (aa)	-	B0QY21
ENST00000407019	NUP50-203	2059	XM_005261312	ENSP00000385555	440 (aa)	XP_005261369	Q9UKX7
ENST00000497960	NUP50-219	986	-	-	- (aa)	-	-
ENST00000434760	NUP50-210	763	-	ENSP00000388426	30 (aa)	-	F2Z3L9
ENST00000486184	NUP50-216	821	-	-	- (aa)	-	-
ENST00000461194	NUP50-212	550	-	-	- (aa)	-	-
ENST00000424634	NUP50-207	579	-	ENSP00000415062	45 (aa)	-	X6RKQ2
ENST00000469163	NUP50-214	3507	-	-	- (aa)	-	-
ENST00000445721	NUP50-211	443	-	ENSP00000398297	10 (aa)	-	A0A0G2JIF9
ENST00000396096	NUP50-202	1895	XM_006724104	ENSP00000379403	440 (aa)	XP_006724167	Q9UKX7
ENST00000432340	NUP50-209	551	-	ENSP00000400465	4 (aa)	-	UPI000014DF1F
ENST00000493456	NUP50-218	478	-	-	- (aa)	-	-
ENST00000484186	NUP50-215	431	-	-	- (aa)	-	-
ENST00000347635	NUP50-201	5233	XM_006724103	ENSP00000345895	468 (aa)	XP_006724166	Q9UKX7
ENST00000417702	NUP50-204	584	-	ENSP00000394450	8 (aa)	-	A0A0G2JI20

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000093000	Arteries	6.4090000E-006	-
ENSG00000093000	Arteries	3.0010000E-006	-
ENSG00000093000	Pulmonary Disease, Chronic Obstructive	1.1240000E-005	22837378

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000093000	rs132887	22	45174224	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000093000	NUP50	100	95.312	ENSMUSG00000016619	Nup50	100	77.447	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005096	GTPase activator activity	21873635.	IBA	Function
GO:0005515	protein binding	12802065.16648475.25416956.26496610.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005643	nuclear pore	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0006110	regulation of glycolytic process	-	TAS	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0006409	tRNA export from nucleus	-	TAS	Process
GO:0006606	protein import into nucleus	21873635.	IBA	Process
GO:0008536	Ran GTPase binding	21873635.	IBA	Function
GO:0016032	viral process	-	TAS	Process
GO:0016925	protein sumoylation	-	TAS	Process
GO:0019083	viral transcription	-	TAS	Process
GO:0031965	nuclear membrane	12802065.	IDA	Component
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0043547	positive regulation of GTPase activity	-	IEA	Process
GO:0043657	host cell	-	IEA	Component
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process
GO:0075733	intracellular transport of virus	-	TAS	Process
GO:1900034	regulation of cellular response to heat	-	TAS	Process