EuRBPDB

Description

Ensembl ID: ENSG00000094914 (Gene tree)
Gene ID: 8086
Gene Symbol: AAAS
Alias: N
Full Name: aladin WD repeat nucleoporin
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 17,409 bases
Position: chr12:53,307,456-53,324,864
Accession: 13666
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. The encoded protein is part of the nuclear pore complex and is anchored there by NDC1. Defects in this gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000549450	AAAS-213	581	-	-	- (aa)	-	-
ENST00000547761	AAAS-209	827	-	-	- (aa)	-	-
ENST00000546572	AAAS-205	582	-	-	- (aa)	-	-
ENST00000550286	AAAS-217	1652	-	ENSP00000446885	422 (aa)	-	F8VZ44
ENST00000549983	AAAS-215	860	-	-	- (aa)	-	-
ENST00000394384	AAAS-202	1703	XM_011538780	ENSP00000377908	513 (aa)	XP_011537082	Q9NRG9
ENST00000546393	AAAS-203	832	-	-	- (aa)	-	-
ENST00000547238	AAAS-206	1154	-	-	- (aa)	-	-
ENST00000546562	AAAS-204	627	-	-	- (aa)	-	-
ENST00000547520	AAAS-207	769	-	-	- (aa)	-	-
ENST00000551724	AAAS-218	552	-	-	- (aa)	-	-
ENST00000552876	AAAS-220	2016	-	-	- (aa)	-	-
ENST00000548931	AAAS-212	1075	-	ENSP00000457518	358 (aa)	-	H3BU82
ENST00000548880	AAAS-211	577	-	-	- (aa)	-	-
ENST00000548258	AAAS-210	550	-	-	- (aa)	-	-
ENST00000209873	AAAS-201	1840	XM_011538778	ENSP00000209873	546 (aa)	XP_011537080	Q9NRG9
ENST00000547757	AAAS-208	949	-	ENSP00000448020	277 (aa)	-	F8VUB6
ENST00000549821	AAAS-214	596	-	-	- (aa)	-	-
ENST00000552161	AAAS-219	585	-	-	- (aa)	-	-
ENST00000550033	AAAS-216	900	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000094914	AAAS	82	33.616	FBgn0030122	CG16892	92	31.011	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003674	molecular_function	-	ND	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005635	nuclear envelope	-	TAS	Component
GO:0005643	nuclear pore	21873635.	IBA	Component
GO:0005643	nuclear pore	12730363.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005813	centrosome	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006110	regulation of glycolytic process	-	TAS	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0006409	tRNA export from nucleus	-	TAS	Process
GO:0006913	nucleocytoplasmic transport	21873635.	IBA	Process
GO:0006913	nucleocytoplasmic transport	12730363.	IDA	Process
GO:0007612	learning	-	IEA	Process
GO:0009566	fertilization	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	TAS	Process
GO:0016925	protein sumoylation	-	TAS	Process
GO:0019083	viral transcription	-	TAS	Process
GO:0031965	nuclear membrane	-	IDA	Component
GO:0043657	host cell	-	IEA	Component
GO:0046822	regulation of nucleocytoplasmic transport	12730363.	NAS	Process
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process
GO:0075733	intracellular transport of virus	-	TAS	Process
GO:1900034	regulation of cellular response to heat	-	TAS	Process