EuRBPDB

Description

Ensembl ID: ENSG00000095139 (Gene tree)
Gene ID: 372
Gene Symbol: ARCN1
Alias: COPD
Full Name: archain 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 30,647 bases
Position: chr11:118,572,387-118,603,033
Accession: 649
RBP type: non-canonical RBP
Summary: This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or trafficking. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000534182	ARCN1-204	1669	-	ENSP00000431676	83 (aa)	-	E9PK34
ENST00000264028	ARCN1-201	3845	XM_005271542	ENSP00000264028	511 (aa)	XP_005271599	P48444
ENST00000614498	ARCN1-205	2238	-	ENSP00000482114	189 (aa)	-	Q6P1Q5
ENST00000359415	ARCN1-202	4038	-	ENSP00000352385	552 (aa)	-	B0YIW6
ENST00000392859	ARCN1-203	1709	-	ENSP00000376599	423 (aa)	-	P48444

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000095139	rs17122278	11	118578655	A	Total cholesterol levels	28334899	[0.013-0.034] unit decrease (EA Beta values)	0.0236	EFO_0004574
ENSG00000095139	rs17122278	11	118578655	A	Total cholesterol levels	28334899	[0.029-0.064] unit decrease	0.0465	EFO_0004574

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000095139	ARCN1	90	67.614	WBGene00015734	copd-1	100	49.811	Caenorhabditis_elegans
ENSG00000095139	ARCN1	100	99.022	ENSMUSG00000032096	Arcn1	100	99.022	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	TAS	Component
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006886	intracellular protein transport	7782067.	TAS	Process
GO:0006888	ER to Golgi vesicle-mediated transport	21873635.	IBA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	21873635.	IBA	Process
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	-	TAS	Process
GO:0008344	adult locomotory behavior	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0021691	cerebellar Purkinje cell layer maturation	-	IEA	Process
GO:0030126	COPI vesicle coat	21873635.	IBA	Component
GO:0030126	COPI vesicle coat	-	ISS	Component
GO:0030133	transport vesicle	-	TAS	Component
GO:0030137	COPI-coated vesicle	21873635.	IBA	Component
GO:0043473	pigmentation	-	IEA	Process
GO:0051645	Golgi localization	21873635.	IBA	Process