EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000095261 (Gene tree)
Gene ID: 5711
Gene Symbol: PSMD5
Alias: S5B|KIAA0072
Full Name: proteasome 26S subunit, non-ATPase 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 28,243 bases
Position: chr9:120,814,779-120,843,021
Accession: 9563
RBP type: non-canonical RBP
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S proteasome assembly. [provided by RefSeq, Jul 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000496688	PSMD5-207	384	-	-	- (aa)	-	-
ENST00000476949	PSMD5-206	382	-	ENSP00000435773	72 (aa)	-	F2Z3J2
ENST00000471789	PSMD5-205	567	-	-	- (aa)	-	-
ENST00000625444	PSMD5-208	219	-	ENSP00000487480	72 (aa)	-	F2Z3J2
ENST00000210313	PSMD5-201	3443	-	ENSP00000210313	504 (aa)	-	Q16401
ENST00000373903	PSMD5-202	686	-	-	- (aa)	-	-
ENST00000373904	PSMD5-203	1538	-	ENSP00000363011	461 (aa)	-	Q16401
ENST00000373920	PSMD5-204	569	-	ENSP00000363030	113 (aa)	-	Q4VXH0

Gene Model

Click here to download ENSG00000095261's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000095261	rs10760117	9	120824459	T	Systolic blood pressure	27618452	[0.19-0.37] mm Hg increase	0.283	EFO_0006335
ENSG00000095261	rs13299616	9	120832525	?	Autoimmune traits	30595370			EFO_0005140

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000095261's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0000502	proteasome complex	8811196.	TAS	Component
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	-	TAS	Process
GO:0005515	protein binding	16189514.19490896.21516116.22901813.25416956.26496610.27107012.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006521	regulation of cellular amino acid metabolic process	-	TAS	Process
GO:0008540	proteasome regulatory particle, base subcomplex	21873635.	IBA	Component
GO:0008540	proteasome regulatory particle, base subcomplex	19412159.19490896.	IDA	Component
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0022624	proteasome accessory complex	-	ISS	Component
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	TAS	Process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	Process
GO:0038061	NIK/NF-kappaB signaling	-	TAS	Process
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	Process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	TAS	Process
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	Process
GO:0070682	proteasome regulatory particle assembly	19490896.	IDA	Process
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:1901990	regulation of mitotic cell cycle phase transition	-	TAS	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	-	TAS	Process