EuRBPDB

Description

Ensembl ID: ENSG00000095564 (Gene tree)
Gene ID: 9044
Gene Symbol: BTAF1
Alias: TAFII170|TAF172|MOT1|TAF-172|TAF(II)170
Full Name: B-TFIID TATA-box binding protein associated factor 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 107,230 bases
Position: chr10:91,923,769-92,030,998
Accession: 17307
RBP type: non-canonical RBP
Summary: This gene encodes a TAF (TATA box-binding protein-associated factor), which associates with TBP (TATA box-binding protein) to form the B-TFIID complex that is required for transcription initiation of genes by RNA polymerase II. This TAF has DNA-dependent ATPase activity, which drives the dissociation of TBP from DNA, freeing the TBP to associate with other TATA boxes or TATA-less promoters. [provided by RefSeq, Sep 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
7958867	Mot1, a global repressor of RNA polymerase II transcription, inhibits TBP binding to DNA by an ATP-dependent mechanism.	Genes Dev	1994 Aug 15	Auble DT	-
10887203	Purification and enzymic properties of Mot1 ATPase, a regulator of basal transcription in the yeast Saccharomyces cerevisiae.	J Biol Chem	2000 Jul 14	Adamkewicz JI	-
16179647	Mutational analysis of BTAF1-TBP interaction: BTAF1 can rescue DNA-binding defective TBP mutants.	Nucleic Acids Res	2005 Sep 22	Klejman MP	-
14557059	Roles for BTAF1 and Mot1p in dynamics of TATA-binding protein and regulation of RNA polymerase II transcription.	Gene	2003 Oct 2	Pereira LA	-
17296733	Regulation of rRNA synthesis by TATA-binding protein-associated factor Mot1.	Mol Cell Biol	2007 Apr	Dasgupta A	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000471217	BTAF1-202	2003	-	-	- (aa)	-	-
ENST00000265990	BTAF1-201	7250	XM_011540326	ENSP00000265990	1849 (aa)	XP_011538628	O14981
ENST00000476401	BTAF1-203	522	-	-	- (aa)	-	-
ENST00000544642	BTAF1-204	6938	-	ENSP00000439924	1849 (aa)	-	A0A0A0MTH9

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000095564	Schizophrenia	6.28E-5	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000095564	rs10748574	10	91953606	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000095564	rs61876492	10	92026800	C	Cigarettes smoked per day (MTAG)	30643251	[0.0085-0.0173] unit increase	0.012904	EFO_0006525

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003677	DNA binding	-	IEA	Function
GO:0003700	DNA-binding transcription factor activity	9342322.	NAS	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0035562	negative regulation of chromatin binding	23361013.	IMP	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0045892	negative regulation of transcription, DNA-templated	9488487.	NAS	Process