EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000096384 (Gene tree)
Gene ID: 3326
Gene Symbol: HSP90AB1
Alias: HSPC2|HSPCB
Full Name: heat shock protein 90 alpha family class B member 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 7,723 bases
Position: chr6:44,246,166-44,253,888
Accession: 5258
RBP type: non-canonical RBP
Summary: This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19940440	Potential contributions of heat shock proteins to temperature-dependent sex determination in the American alligator.	Sex Dev	2010	Kohno S	doi: 10.1159/000260374

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000371554	HSP90AB1-202	2674	XM_024446421	ENSP00000360609	724 (aa)	XP_024302189	P08238
ENST00000620073	HSP90AB1-204	2644	-	ENSP00000481908	724 (aa)	-	P08238
ENST00000371646	HSP90AB1-203	2572	-	ENSP00000360709	724 (aa)	-	P08238
ENST00000353801	HSP90AB1-201	2582	-	ENSP00000325875	724 (aa)	-	P08238

Gene Model

Click here to download ENSG00000096384's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04217	Necroptosis	KEGG
hsa04612	Antigen processing and presentation	KEGG
hsa04621	NOD-like receptor signaling pathway	KEGG
hsa04657	IL-17 signaling pathway	KEGG
hsa04659	Th17 cell differentiation	KEGG
hsa04914	Progesterone-mediated oocyte maturation	KEGG
hsa04915	Estrogen signaling pathway	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05215	Prostate cancer	KEGG
hsa05418	Fluid shear stress and atherosclerosis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000096384's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000096384	HSP90AB1	99	75.522	WBGene00000915	daf-21	99	75.664	Caenorhabditis_elegans
ENSG00000096384	HSP90AB1	99	78.462	FBgn0001233	Hsp83	99	78.481	Drosophila_melanogaster
ENSG00000096384	HSP90AB1	83	45.540	FBgn0026761	Trap1	88	46.154	Drosophila_melanogaster
ENSG00000096384	HSP90AB1	100	85.246	ENSG00000080824	HSP90AA1	98	86.134	Homo_sapiens
ENSG00000096384	HSP90AB1	57	48.815	ENSG00000166598	HSP90B1	100	70.833	Homo_sapiens
ENSG00000096384	HSP90AB1	85	46.411	ENSG00000126602	TRAP1	93	46.411	Homo_sapiens
ENSG00000096384	HSP90AB1	100	99.586	ENSMUSG00000023944	Hsp90ab1	100	100.000	Mus_musculus
ENSG00000096384	HSP90AB1	100	84.311	ENSMUSG00000021270	Hsp90aa1	91	93.443	Mus_musculus
ENSG00000096384	HSP90AB1	95	47.286	ENSMUSG00000020048	Hsp90b1	89	49.699	Mus_musculus
ENSG00000096384	HSP90AB1	84	46.411	ENSMUSG00000005981	Trap1	86	46.411	Mus_musculus
ENSG00000096384	HSP90AB1	98	61.646	YPL240C	HSP82	99	61.259	Saccharomyces_cerevisiae
ENSG00000096384	HSP90AB1	61	60.762	YMR186W	HSC82	99	61.150	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001890	placenta development	-	IEA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003725	double-stranded RNA binding	21266579.	IDA	Function
GO:0005515	protein binding	21873635.	IBA	Function
GO:0005515	protein binding	11036079.14743216.15358771.15581363.15657067.15870294.16293251.16314389.16330544.16531226.16580629.16698020.17932509.17979178.18239673.18320024.18818696.19375531.20029029.20374249.20618441.21170051.21183720.21360678.21730179.21988832.22022502.22843495.22939624.23349634.23414517.23428871.23431407.23455922.23585225.24189400.24581495.24613385.24618592.24658140.24880080.25036637.25241761.25416956.25486457.25609649.25910212.26496610.26517842.27339980.28330616.29127155.29568061.	IPI	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005524	ATP binding	10811660.	IDA	Function
GO:0005524	ATP binding	10543959.	IMP	Function
GO:0005576	extracellular region	20599762.	IDA	Component
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	18239673.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	10791971.11785981.16580629.18239673.24880080.	IDA	Component
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0006457	protein folding	-	IEA	Process
GO:0006805	xenobiotic metabolic process	-	TAS	Process
GO:0006986	response to unfolded protein	2768249.	NAS	Process
GO:0007004	telomere maintenance via telomerase	10197982.	IDA	Process
GO:0008180	COP9 signalosome	18850735.	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0019062	virion attachment to host cell	24098578.	IMP	Process
GO:0019887	protein kinase regulator activity	-	IEA	Function
GO:0019900	kinase binding	20353823.21855797.	IPI	Function
GO:0019901	protein kinase binding	21873635.	IBA	Function
GO:0021955	central nervous system neuron axonogenesis	-	ISS	Process
GO:0023026	MHC class II protein complex binding	20458337.	HDA	Function
GO:0030010	establishment of cell polarity	-	ISS	Process
GO:0030235	nitric-oxide synthase regulator activity	-	ISS	Function
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	24613385.	IDA	Process
GO:0030911	TPR domain binding	-	ISS	Function
GO:0031072	heat shock protein binding	20353823.	IPI	Function
GO:0031396	regulation of protein ubiquitination	16809764.	IDA	Process
GO:0031625	ubiquitin protein ligase binding	16207813.	IPI	Function
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	24613385.	IDA	Process
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	16280321.	IMP	Process
GO:0032516	positive regulation of phosphoprotein phosphatase activity	26593036.	IDA	Process
GO:0032991	protein-containing complex	10811660.23349634.	IDA	Component
GO:0032991	protein-containing complex	10543959.	IMP	Component
GO:0033138	positive regulation of peptidyl-serine phosphorylation	-	ISS	Process
GO:0034751	aryl hydrocarbon receptor complex	15581363.	IDA	Component
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	-	TAS	Process
GO:0042277	peptide binding	20599762.	IPI	Function
GO:0042470	melanosome	-	IEA	Component
GO:0042623	ATPase activity, coupled	-	TAS	Function
GO:0042802	identical protein binding	21183720.22939624.	IPI	Function
GO:0042803	protein homodimerization activity	10811660.	IDA	Function
GO:0042826	histone deacetylase binding	16809764.	IPI	Function
GO:0043008	ATP-dependent protein binding	10543959.10811660.	IPI	Function
GO:0043025	neuronal cell body	-	ISS	Component
GO:0043066	negative regulation of apoptotic process	-	IEA	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0044294	dendritic growth cone	-	ISS	Component
GO:0044295	axonal growth cone	-	ISS	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045429	positive regulation of nitric oxide biosynthetic process	-	ISS	Process
GO:0045597	positive regulation of cell differentiation	18239673.	IMP	Process
GO:0046983	protein dimerization activity	7588731.	IDA	Function
GO:0048156	tau protein binding	28386764.	NAS	Function
GO:0048471	perinuclear region of cytoplasm	-	ISS	Component
GO:0048675	axon extension	-	ISS	Process
GO:0050821	protein stabilization	-	TAS	Process
GO:0051082	unfolded protein binding	-	IEA	Function
GO:0051131	chaperone-mediated protein complex assembly	10811660.	IDA	Process
GO:0051248	negative regulation of protein metabolic process	17517623.	ISS	Process
GO:0051897	positive regulation of protein kinase B signaling	-	ISS	Process
GO:0051973	positive regulation of telomerase activity	10197982.	IDA	Process
GO:0060334	regulation of interferon-gamma-mediated signaling pathway	16280321.	IMP	Process
GO:0060338	regulation of type I interferon-mediated signaling pathway	16280321.	IMP	Process
GO:0070062	extracellular exosome	20458337.23533145.	HDA	Component
GO:0070182	DNA polymerase binding	10197982.19751963.	IPI	Function
GO:0071157	negative regulation of cell cycle arrest	22843495.	IMP	Process
GO:0071353	cellular response to interleukin-4	-	IEA	Process
GO:0097435	supramolecular fiber organization	24466266.	IMP	Process
GO:0097718	disordered domain specific binding	11785981.15713458.	IPI	Function
GO:1900034	regulation of cellular response to heat	-	TAS	Process
GO:1901389	negative regulation of transforming growth factor beta activation	20599762.	IDA	Process
GO:1901799	negative regulation of proteasomal protein catabolic process	21873635.	IBA	Process
GO:1901799	negative regulation of proteasomal protein catabolic process	17517623.	ISS	Process
GO:1902949	positive regulation of tau-protein kinase activity	-	IC	Process
GO:1903827	regulation of cellular protein localization	21873635.	IBA	Process
GO:1903827	regulation of cellular protein localization	-	ISS	Process
GO:1904031	positive regulation of cyclin-dependent protein kinase activity	17517623.	ISS	Process
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component
GO:1905323	telomerase holoenzyme complex assembly	10197982.	IDA	Process
GO:1990226	histone methyltransferase binding	24880080.	IPI	Function
GO:1990565	HSP90-CDC37 chaperone complex	21855797.	IDA	Component
GO:2000010	positive regulation of protein localization to cell surface	23431407.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28359326	Hsp90β promoted endothelial cell-dependent tumor angiogenesis in hepatocellular carcinoma.	Mol Cancer	2017 Mar 31	Meng J	doi: 10.1186/s12943-017-0640-9.
26903158	[Hsp90AB1 Protein is Overexpressed in Non-small Cell Lung Cancer Tissues and Associated with Poor Prognosis in Lung Adenocarcinoma Patients].	Zhongguo Fei Ai Za Zhi	2016 Feb	Wang M	doi: 10.3779/j.issn.1009-3419.2016.02.02.
24466266	Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells.	PLoS One	2014 Jan 22	Hunter MC	doi: 10.1371/journal.pone.0086842
25300907	Co-overexpression of Hsp90-β and annexin A1 with a significantly positive correlation contributes to the diagnosis of lung cancer.	Expert Rev Mol Diagn	2014 Nov	Biaoxue R	doi: 10.1586/14737159.2014.960517
19576239	Expression of Hsp90 chaperone [corrected] proteins in human tumor tissue.	Int J Biol Macromol	2009 Oct 1	McDowell CL	doi: 10.1016/j.ijbiomac.2009.06.012
22849407	Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells.	Biochem J	2012 Oct 15	Kang SA	-
22929401	Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients.	J Exp Clin Cancer Res	2012 Aug 28	Biaoxue R	-
30305727	Hsp90ab1 stabilizes LRP5 to promote epithelial-mesenchymal transition via activating of AKT and Wnt/β-catenin signaling pathways in gastric cancer progression.	Oncogene	2019 Feb	Wang H	doi: 10.1038/s41388-018-0532-5

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr6	44253820	3'UTR	novel		0.83
ACC	chr6	44249476	Missense_Mutation	novel	T83A	0.09
BLCA	chr6	44253737	3'UTR	novel		0.12
BLCA	chr6	44253635	3'UTR	novel		0.36
BLCA	chr6	44253348	Missense_Mutation	novel	R679G	0.42
BLCA	chr6	44248681	Nonsense_Mutation	rs765906022	Q18*	0.26
BLCA	chr6	44252121	Missense_Mutation	novel	D529N	0.4
BLCA	chr6	44249417	Nonsense_Mutation	novel	S63*	0.46
BLCA	chr6	44252140	Nonsense_Mutation	NA	S535*	0.16
BLCA	chr6	44251471	Nonsense_Mutation	novel	E393*	0.62
BLCA	chr6	44251045	Splice_Region	novel		0.29
BLCA	chr6	44250437	Silent	novel	K265K	0.21
BLCA	chr6	44250393	Missense_Mutation	rs772738556	E251K	0.12
BLCA	chr6	44249487	Silent	novel	L86L	0.49
BLCA	chr6	44252140	Missense_Mutation	novel	S535L	0.31
BLCA	chr6	44253365	Missense_Mutation	NA	I684M	0.24
BLCA	chr6	44248681	Nonsense_Mutation	rs765906022	Q18*	0.3
BRCA	chr6	44253337	Missense_Mutation	novel	T675S	0.06
BRCA	chr6	44251789	Missense_Mutation	NA	R456L	0.17
BRCA	chr6	44251790	Silent	NA	R456R	0.16
BRCA	chr6	44249444	Frame_Shift_Del	novel	*I73Pfs19**	0.36
BRCA	chr6	44253260	Silent	NA	K649K	0.13
BRCA	chr6	44250390	Missense_Mutation	novel	I250V	0.35
BRCA	chr6	44252191	Missense_Mutation	rs756933263	K552M	0.38
BRCA	chr6	44250308	Silent	NA	E222E	0.37
BRCA	chr6	44253690	3'UTR	novel		0.06
BRCA	chr6	44253307	Missense_Mutation	NA	S665C	0.27
BRCA	chr6	44249733	Nonsense_Mutation	novel	L138*	0.06
BRCA	chr6	44253723	3'UTR	novel		0.06
BRCA	chr6	44251817	Silent	rs755443850	E465E	0.55
CESC	chr6	44248681	Missense_Mutation	novel	Q18E	0.22
CESC	chr6	44248716	Missense_Mutation	NA	I29M	0.28
CESC	chr6	44251768	Missense_Mutation	rs770945397	R449H	0.35
CESC	chr6	44250596	Silent	NA	V318V	0.19
CESC	chr6	44248681	Missense_Mutation	novel	Q18E	0.12
CESC	chr6	44253542	Nonsense_Mutation	novel	E707*	0.07
COAD	chr6	44253495	Missense_Mutation	rs748973555	D691G	0.52
COAD	chr6	44252091	Missense_Mutation	NA	E519K	0.26
COAD	chr6	44249418	Silent	rs778973317	S63S	0.22
COAD	chr6	44253710	3'UTR	NA		0.27
COAD	chr6	44249822	Missense_Mutation	rs370988754	R168C	0.08
COAD	chr6	44253625	3'UTR	novel		0.43
COAD	chr6	44251177	Missense_Mutation	novel	M363V	0.15
COAD	chr6	44251151	Missense_Mutation	novel	K354T	0.26
COAD	chr6	44248740	Silent	NA	E37E	0.3
COAD	chr6	44253710	3'UTR	NA		0.33
COAD	chr6	44249498	Missense_Mutation	novel	G90D	0.36
COAD	chr6	44253710	3'UTR	NA		0.3
COAD	chr6	44252156	Nonsense_Mutation	novel	G540_L541insN*	0.07
COAD	chr6	44252157	Missense_Mutation	novel	L541M	0.05
DLBC	chr6	44250407	Silent	novel	S255S	0.14
ESCA	chr6	44253349	Missense_Mutation	rs199811663	R679H	0.2
GBM	chr6	44251854	Nonsense_Mutation	novel	E478*	0.08
GBM	chr6	44250091	Missense_Mutation	NA	E195D	0.3
GBM	chr6	44249584	Splice_Site	NA	X118_splice	0.38
GBM	chr6	44252211	Missense_Mutation	novel	K559E	0.06
GBM	chr6	44253135	Frame_Shift_Ins	novel	*A608Vfs15**	0.12
HNSC	chr6	44252253	Nonsense_Mutation	novel	K573*	0.35
HNSC	chr6	44248681	Missense_Mutation	novel	Q18E	0.12
HNSC	chr6	44249467	Nonsense_Mutation	novel	Q80*	0.13
HNSC	chr6	44253346	Missense_Mutation	novel	N678I	0.1
HNSC	chr6	44253515	Missense_Mutation	novel	E698Q	0.16
HNSC	chr6	44251765	Missense_Mutation	NA	R448H	0.1
HNSC	chr6	44251079	Missense_Mutation	novel	R330K	0.4
HNSC	chr6	44249552	Missense_Mutation	novel	S108F	0.13
HNSC	chr6	44253147	Silent	rs373017568	R612R	0.1
KICH	chr6	44251054	Missense_Mutation	novel	S322A	0.42
KIRC	chr6	44250483	Missense_Mutation	novel	E281K	0.35
KIRC	chr6	44251866	Frame_Shift_Ins	novel	*I483Hfs7**	0.32
KIRC	chr6	44253647	3'UTR	rs758072964		0.31
KIRC	chr6	44251765	Frame_Shift_Ins	novel	*R449Pfs5**	0.33
LGG	chr6	44251529	Missense_Mutation	novel	C412Y	0.5
LIHC	chr6	44251867	Frame_Shift_Del	novel	*I483Sfs31**	0.64
LIHC	chr6	44253716	3'UTR	rs567895542		0.48
LIHC	chr6	44253777	3'UTR	novel		0.11
LIHC	chr6	44253564	Frame_Shift_Ins	novel	*E715Dfs2**	0.03
LIHC	chr6	44248725	Missense_Mutation	novel	F32L	0.21
LIHC	chr6	44250429	Missense_Mutation	novel	K263E	0.32
LIHC	chr6	44251089	Silent	rs2070694	L333L	0.55
LUAD	chr6	44248766	Missense_Mutation	novel	N46T	0.07
LUAD	chr6	44253611	3'UTR	novel		0.24
LUAD	chr6	44253339	Missense_Mutation	NA	H676Y	0.14
LUAD	chr6	44252111	Silent	NA	L525L	0.13
LUAD	chr6	44251114	Missense_Mutation	NA	D342H	0.13
LUAD	chr6	44249535	Missense_Mutation	NA	L102F	0.1
LUAD	chr6	44252184	Missense_Mutation	rs139414975	K550E	0.26
LUAD	chr6	44253557	Nonsense_Mutation	novel	E712*	0.4
LUAD	chr6	44250409	Missense_Mutation	NA	D256V	0.55
LUSC	chr6	44249473	Missense_Mutation	rs61753592	R82C	0.25
LUSC	chr6	44253542	Missense_Mutation	novel	E707K	0.35
LUSC	chr6	44253593	Missense_Mutation	NA	D724N	0.39
LUSC	chr6	44253721	3'UTR	novel		0.25
LUSC	chr6	44250140	Missense_Mutation	novel	P212A	0.13
LUSC	chr6	44250495	Missense_Mutation	NA	T285S	0.28
LUSC	chr6	44249406	Silent	NA	L59L	0.1
LUSC	chr6	44251192	Nonsense_Mutation	novel	E368*	0.47
OV	chr6	44251100	Missense_Mutation	novel	R337L	0.25
OV	chr6	44249759	Missense_Mutation	novel	T147S	0.04
OV	chr6	44251820	Missense_Mutation	novel	M466I	0.08
PAAD	chr6	44253850	3'UTR	novel		0.06
PRAD	chr6	44248671	Frame_Shift_Del	novel	*F15Cfs31**	0.11
PRAD	chr6	44250324	Missense_Mutation	NA	D228N	0.11
READ	chr6	44251799	Silent	NA	T459T	0.3
READ	chr6	44250539	Missense_Mutation	novel	E299D	0.36
READ	chr6	44253587	Nonsense_Mutation	NA	E722*	0.46
READ	chr6	44251575	Missense_Mutation	NA	K427N	0.45
SARC	chr6	44253705	3'UTR	novel		0.23
SARC	chr6	44250573	Missense_Mutation	novel	D311Y	0.23
SARC	chr6	44253536	Missense_Mutation	novel	P705A	0.18
SARC	chr6	44249723	Missense_Mutation	novel	S135A	0.07
SKCM	chr6	44253195	Frame_Shift_Del	novel	*I628Sfs56**	0.12
SKCM	chr6	44248648	Missense_Mutation	novel	H7Y	0.18
SKCM	chr6	44250465	Missense_Mutation	NA	K275E	0.19
SKCM	chr6	44251467	Silent	novel	S391S	0.4
SKCM	chr6	44251468	Nonsense_Mutation	NA	R392*	0.42
SKCM	chr6	44251425	Silent	novel	I377I	0.26
SKCM	chr6	44250062	Missense_Mutation	NA	K186E	0.31
SKCM	chr6	44253770	3'UTR	rs763924937		0.64
SKCM	chr6	44250053	Missense_Mutation	NA	L183I	0.14
SKCM	chr6	44250095	Missense_Mutation	NA	R197W	0.38
SKCM	chr6	44251078	Missense_Mutation	NA	R330W	0.17
SKCM	chr6	44250315	Missense_Mutation	rs765842603	I225V	0.21
STAD	chr6	44251469	Missense_Mutation	novel	R392Q	0.15
STAD	chr6	44251182	Silent	novel	D364D	0.37
STAD	chr6	44248719	Silent	NA	N30N	0.13
STAD	chr6	44253710	3'UTR	NA		0.32
STAD	chr6	44253710	3'UTR	NA		0.27
STAD	chr6	44249810	Missense_Mutation	NA	S164A	0.28
STAD	chr6	44251100	Missense_Mutation	NA	R337H	0.4
STAD	chr6	44253199	Missense_Mutation	novel	N629I	0.32
STAD	chr6	44253710	3'UTR	NA		0.25
STAD	chr6	44251102	Missense_Mutation	NA	R338W	0.33
STAD	chr6	44251507	Missense_Mutation	novel	R405C	0.21
STAD	chr6	44253710	3'UTR	NA		0.25
STAD	chr6	44252068	Missense_Mutation	NA	V511A	0.34
STAD	chr6	44251509	Frame_Shift_Ins	novel	*N407Kfs4**	0.23
TGCT	chr6	44251059	In_Frame_Del	novel	E324del	0.42
THCA	chr6	44250375	Nonsense_Mutation	novel	E245delinsGIA*	0.08
THCA	chr6	44250387	Frame_Shift_Ins	novel	*K249Ifs11**	0.1
THYM	chr6	44253710	3'UTR	NA		0.26
UCEC	chr6	44252094	Missense_Mutation	novel	Y520D	0.33
UCEC	chr6	44250409	Missense_Mutation	novel	D256A	0.32
UCEC	chr6	44249460	Silent	NA	P77P	0.2
UCEC	chr6	44249445	Missense_Mutation	NA	K72N	0.3
UCEC	chr6	44253297	Missense_Mutation	rs141615003	A662T	0.3
UCEC	chr6	44250375	Nonsense_Mutation	novel	E245*	0.28
UCEC	chr6	44249563	Missense_Mutation	NA	A112S	0.31
UCEC	chr6	44253117	Missense_Mutation	NA	M602V	0.41
UCEC	chr6	44249396	Missense_Mutation	rs771117200	Y56C	0.3
UCEC	chr6	44253148	Missense_Mutation	NA	R612Q	0.5
UCEC	chr6	44253563	Missense_Mutation	rs374209904	D714N	0.38
UCEC	chr6	44249782	Silent	novel	Q154Q	0.4
UCEC	chr6	44251114	Missense_Mutation	novel	D342N	0.4
UCEC	chr6	44253167	Silent	novel	G618G	0.45
UCEC	chr6	44251749	Missense_Mutation	NA	E443K	0.09
UCEC	chr6	44251508	Missense_Mutation	rs749530631	R405H	0.26
UCEC	chr6	44249700	Missense_Mutation	novel	G127V	0.06
UCEC	chr6	44249831	Missense_Mutation	NA	H171Y	0.24
UCEC	chr6	44250104	Nonsense_Mutation	NA	E200*	0.2
UCEC	chr6	44250455	Silent	novel	K271K	0.04
UCEC	chr6	44253297	Missense_Mutation	rs141615003	A662T	0.21
UCEC	chr6	44252061	Missense_Mutation	rs777481314	E509K	0.22
UCEC	chr6	44251072	Missense_Mutation	novel	E328K	0.19
UCEC	chr6	44251748	Silent	rs531868996	H442H	0.21
UCEC	chr6	44249383	Missense_Mutation	NA	D52N	0.43
UCEC	chr6	44252140	Nonsense_Mutation	NA	S535*	0.25
UCEC	chr6	44251161	Silent	NA	V357V	0.23
UCEC	chr6	44251166	Missense_Mutation	novel	R359H	0.33
UCEC	chr6	44251452	Silent	novel	L386L	0.36
UCEC	chr6	44253237	Missense_Mutation	novel	A642T	0.35
UCEC	chr6	44253357	Missense_Mutation	novel	R682C	0.46
UCEC	chr6	44250048	Missense_Mutation	novel	V181A	0.42
UCEC	chr6	44253710	3'UTR	NA		0.29
UCEC	chr6	44248740	Missense_Mutation	novel	E37D	0.41
UCEC	chr6	44249418	Silent	rs778973317	S63S	0.4
UCEC	chr6	44252014	Missense_Mutation	NA	Q493P	0.35
UCEC	chr6	44249504	Missense_Mutation	NA	G92D	0.36
UCEC	chr6	44252096	Silent	rs773495096	Y520Y	0.4
UCEC	chr6	44249418	Silent	rs778973317	S63S	0.4
UCEC	chr6	44250104	Nonsense_Mutation	NA	E200*	0.13
UCEC	chr6	44252254	Missense_Mutation	novel	K573T	0.19
UCEC	chr6	44250104	Nonsense_Mutation	NA	E200*	0.39
UCEC	chr6	44248740	Missense_Mutation	novel	E37D	0.3
UCEC	chr6	44249510	Missense_Mutation	novel	T94S	0.34
UCEC	chr6	44250308	Missense_Mutation	novel	E222D	0.37
UCEC	chr6	44253224	Silent	novel	T637T	0.3
UCEC	chr6	44251581	Missense_Mutation	novel	F429L	0.04
UCEC	chr6	44249418	Silent	rs778973317	S63S	0.08
UCEC	chr6	44252115	Missense_Mutation	novel	E527K	0.1
UCEC	chr6	44253877	3'UTR	novel		0.19
UCEC	chr6	44253223	Missense_Mutation	rs149806037	T637M	0.06
UCEC	chr6	44250369	Missense_Mutation	novel	D243Y	0.15
UCEC	chr6	44253116	Silent	rs781563737	N601N	0.31
UCEC	chr6	44253224	Silent	novel	T637T	0.06
UCEC	chr6	44250369	Frame_Shift_Del	novel	*D243Mfs40**	0.33
UCEC	chr6	44251109	Missense_Mutation	novel	P340H	0.34
UCEC	chr6	44250138	Missense_Mutation	novel	Y211F	0.07
UCEC	chr6	44250464	Missense_Mutation	NA	E274D	0.42
UCEC	chr6	44250437	Missense_Mutation	NA	K265N	0.3
UCEC	chr6	44250443	Missense_Mutation	novel	K267N	0.42
UCEC	chr6	44251163	Missense_Mutation	NA	R358H	0.31
UCEC	chr6	44251577	Missense_Mutation	novel	K428T	0.23
UCEC	chr6	44253593	Missense_Mutation	NA	D724N	0.18
UCEC	chr6	44249541	Silent	novel	T104T	0.47
UCEC	chr6	44250552	Missense_Mutation	novel	F304L	0.34
UCEC	chr6	44253710	3'UTR	NA		0.33
UCEC	chr6	44253123	Missense_Mutation	rs184003361	R604W	0.24
UCEC	chr6	44249429	Missense_Mutation	novel	S67I	0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
COAD	AMP	0.1729	0.005341
READ	AMP	0.2848	0.02906

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0014	Kaplan-Meier Survival Analysis
SARC	0.00093	Kaplan-Meier Survival Analysis
MESO	0.029	Kaplan-Meier Survival Analysis
ACC	0.0088	Kaplan-Meier Survival Analysis
HNSC	0.001	Kaplan-Meier Survival Analysis
SKCM	0.022	Kaplan-Meier Survival Analysis
BRCA	0.022	Kaplan-Meier Survival Analysis
ESCA	0.0031	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
BLCA	0.047	Kaplan-Meier Survival Analysis
CESC	0.0018	Kaplan-Meier Survival Analysis
READ	0.03	Kaplan-Meier Survival Analysis
UCEC	0.027	Kaplan-Meier Survival Analysis
LIHC	0.00053	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
UVM	0.0039	Kaplan-Meier Survival Analysis
OV	0.002	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

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Input Drug :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742