EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000099246 (Gene tree)
Gene ID: 22931
Gene Symbol: RAB18
Alias: -
Full Name: RAB18, member RAS oncogene family
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 38,064 bases
Position: chr10:27,504,174-27,542,237
Accession: 14244
RBP type: canonical RBP
Summary: The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000349415	MMR_HSR1	PF01926.23	5.1e-07	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000484281	RAB18-205	355	-	-	- (aa)	-	-
ENST00000535776	RAB18-207	4811	-	ENSP00000439321	142 (aa)	-	Q9NP72
ENST00000611151	RAB18-208	4931	-	ENSP00000483927	182 (aa)	-	A0A087X163
ENST00000423465	RAB18-203	873	-	ENSP00000407872	291 (aa)	-	H0Y6T8
ENST00000356940	RAB18-201	4886	-	ENSP00000349415	206 (aa)	-	Q9NP72
ENST00000490236	RAB18-206	730	-	-	- (aa)	-	-
ENST00000375802	RAB18-202	617	-	ENSP00000364960	161 (aa)	-	Q5W0J0
ENST00000621805	RAB18-209	4894	-	ENSP00000478479	235 (aa)	-	Q9NP72
ENST00000465772	RAB18-204	985	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000099246's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000099246	Intelligence Tests	3.0461000E-005	-
ENSG00000099246	Child Development Disorders, Pervasive	1.7464400E-005	-
ENSG00000099246	Child Development Disorders, Pervasive	2.3762500E-005	-
ENSG00000099246	Otitis	5E-16	27182965

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000099246's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000099246	RAB18	99	85.938	ENSAPOG00000019881	rab18b	99	84.390	Acanthochromis_polyacanthus
ENSG00000099246	RAB18	100	100.000	ENSAMEG00000015990	RAB18	100	92.373	Ailuropoda_melanoleuca
ENSG00000099246	RAB18	99	88.889	ENSACIG00000008102	rab18b	99	86.341	Amphilophus_citrinellus
ENSG00000099246	RAB18	99	85.938	ENSAOCG00000013479	rab18b	99	84.390	Amphiprion_ocellaris
ENSG00000099246	RAB18	99	84.375	ENSAPEG00000022923	rab18b	99	83.902	Amphiprion_percula
ENSG00000099246	RAB18	99	85.938	ENSATEG00000002952	rab18b	99	83.415	Anabas_testudineus
ENSG00000099246	RAB18	100	100.000	ENSANAG00000035856	RAB18	100	100.000	Aotus_nancymaae
ENSG00000099246	RAB18	99	85.714	ENSACLG00000015289	rab18b	99	85.366	Astatotilapia_calliptera
ENSG00000099246	RAB18	100	92.063	ENSAMXG00000042073	rab18b	100	87.379	Astyanax_mexicanus
ENSG00000099246	RAB18	100	97.087	ENSBTAG00000050873	-	100	97.087	Bos_taurus
ENSG00000099246	RAB18	100	99.515	ENSBTAG00000009871	RAB18	88	99.515	Bos_taurus
ENSG00000099246	RAB18	100	100.000	ENSCJAG00000045749	RAB18	100	100.000	Callithrix_jacchus
ENSG00000099246	RAB18	100	98.544	ENSCAFG00020003253	RAB18	100	98.544	Canis_lupus_dingo
ENSG00000099246	RAB18	100	99.515	ENSCHIG00000008749	RAB18	100	99.515	Capra_hircus
ENSG00000099246	RAB18	100	99.029	ENSTSYG00000013092	RAB18	100	99.029	Carlito_syrichta
ENSG00000099246	RAB18	100	98.544	ENSCPOG00000032827	RAB18	100	98.544	Cavia_porcellus
ENSG00000099246	RAB18	100	100.000	ENSCCAG00000006762	RAB18	100	100.000	Cebus_capucinus
ENSG00000099246	RAB18	100	100.000	ENSCATG00000009672	RAB18	100	100.000	Cercocebus_atys
ENSG00000099246	RAB18	100	100.000	ENSCSAG00000011749	RAB18	100	100.000	Chlorocebus_sabaeus
ENSG00000099246	RAB18	100	100.000	ENSCANG00000035397	RAB18	100	100.000	Colobus_angolensis_palliatus
ENSG00000099246	RAB18	100	99.029	ENSCGRG00001017519	Rab18	100	99.029	Cricetulus_griseus_chok1gshd
ENSG00000099246	RAB18	100	99.029	ENSCGRG00000017201	Rab18	100	99.029	Cricetulus_griseus_crigri
ENSG00000099246	RAB18	95	84.615	ENSCSEG00000016803	rab18b	98	85.417	Cynoglossus_semilaevis
ENSG00000099246	RAB18	100	92.063	ENSDARG00000098344	rab18b	100	88.350	Danio_rerio
ENSG00000099246	RAB18	62	88.372	ENSDNOG00000038845	-	85	88.372	Dasypus_novemcinctus
ENSG00000099246	RAB18	100	100.000	ENSDNOG00000047713	RAB18	100	100.000	Dasypus_novemcinctus
ENSG00000099246	RAB18	100	98.544	ENSDORG00000028596	-	100	98.544	Dipodomys_ordii
ENSG00000099246	RAB18	84	91.379	ENSDORG00000029360	-	83	91.379	Dipodomys_ordii
ENSG00000099246	RAB18	100	99.515	ENSEASG00005007164	RAB18	100	99.515	Equus_asinus_asinus
ENSG00000099246	RAB18	100	99.515	ENSECAG00000017521	RAB18	88	99.515	Equus_caballus
ENSG00000099246	RAB18	99	93.651	ENSELUG00000016450	rab18b	99	86.408	Esox_lucius
ENSG00000099246	RAB18	100	98.544	ENSFCAG00000027161	RAB18	100	98.544	Felis_catus
ENSG00000099246	RAB18	100	96.135	ENSFALG00000007160	RAB18	100	96.135	Ficedula_albicollis
ENSG00000099246	RAB18	99	84.878	ENSFHEG00000020035	rab18b	99	84.390	Fundulus_heteroclitus
ENSG00000099246	RAB18	99	79.512	ENSGMOG00000016608	rab18b	99	79.024	Gadus_morhua
ENSG00000099246	RAB18	100	98.413	ENSGALG00000007435	RAB18	100	97.087	Gallus_gallus
ENSG00000099246	RAB18	99	84.878	ENSGAFG00000008560	rab18b	99	84.390	Gambusia_affinis
ENSG00000099246	RAB18	99	85.938	ENSGACG00000016395	rab18b	99	83.415	Gasterosteus_aculeatus
ENSG00000099246	RAB18	100	100.000	ENSGGOG00000008086	RAB18	100	100.000	Gorilla_gorilla
ENSG00000099246	RAB18	99	85.714	ENSHBUG00000003696	rab18b	99	85.366	Haplochromis_burtoni
ENSG00000099246	RAB18	99	81.463	ENSHGLG00000007301	-	88	85.714	Heterocephalus_glaber_female
ENSG00000099246	RAB18	100	98.413	ENSHGLG00000004365	RAB18	100	97.087	Heterocephalus_glaber_female
ENSG00000099246	RAB18	100	98.413	ENSHGLG00100013089	-	100	97.087	Heterocephalus_glaber_male
ENSG00000099246	RAB18	99	81.463	ENSHGLG00100009117	-	88	85.714	Heterocephalus_glaber_male
ENSG00000099246	RAB18	99	84.390	ENSHCOG00000002217	rab18b	99	83.902	Hippocampus_comes
ENSG00000099246	RAB18	100	92.188	ENSIPUG00000010859	rab18b	100	84.466	Ictalurus_punctatus
ENSG00000099246	RAB18	100	98.544	ENSSTOG00000014560	-	100	98.544	Ictidomys_tridecemlineatus
ENSG00000099246	RAB18	99	85.366	ENSKMAG00000007364	rab18b	99	84.878	Kryptolebias_marmoratus
ENSG00000099246	RAB18	99	88.889	ENSLBEG00000019428	rab18b	99	85.854	Labrus_bergylta
ENSG00000099246	RAB18	100	80.193	ENSLACG00000011256	rab18b	100	79.612	Latimeria_chalumnae
ENSG00000099246	RAB18	100	99.029	ENSLAFG00000015582	RAB18	100	99.029	Loxodonta_africana
ENSG00000099246	RAB18	100	100.000	ENSMFAG00000006430	RAB18	100	100.000	Macaca_fascicularis
ENSG00000099246	RAB18	100	98.413	ENSMMUG00000046971	RAB18	74	98.058	Macaca_mulatta
ENSG00000099246	RAB18	100	100.000	ENSMNEG00000038180	RAB18	100	100.000	Macaca_nemestrina
ENSG00000099246	RAB18	100	100.000	ENSMLEG00000033595	RAB18	100	100.000	Mandrillus_leucophaeus
ENSG00000099246	RAB18	100	85.938	ENSMAMG00000018445	rab18b	100	82.524	Mastacembelus_armatus
ENSG00000099246	RAB18	99	85.714	ENSMZEG00005008244	rab18b	99	85.366	Maylandia_zebra
ENSG00000099246	RAB18	95	93.651	ENSMAUG00000020698	-	94	91.525	Mesocricetus_auratus
ENSG00000099246	RAB18	100	99.515	ENSMICG00000017280	RAB18	100	99.515	Microcebus_murinus
ENSG00000099246	RAB18	100	99.029	ENSMOCG00000013044	Rab18	100	99.029	Microtus_ochrogaster
ENSG00000099246	RAB18	99	87.500	ENSMMOG00000017849	rab18b	99	72.222	Mola_mola
ENSG00000099246	RAB18	100	98.413	ENSMODG00000008253	RAB18	100	96.602	Monodelphis_domestica
ENSG00000099246	RAB18	100	88.889	ENSMODG00000024936	-	94	86.979	Monodelphis_domestica
ENSG00000099246	RAB18	99	87.500	ENSMALG00000005069	rab18b	99	84.878	Monopterus_albus
ENSG00000099246	RAB18	100	99.029	MGP_CAROLIEiJ_G0021978	Rab18	100	99.029	Mus_caroli
ENSG00000099246	RAB18	100	99.029	ENSMUSG00000073639	Rab18	100	99.029	Mus_musculus
ENSG00000099246	RAB18	100	99.029	MGP_PahariEiJ_G0018716	Rab18	100	99.029	Mus_pahari
ENSG00000099246	RAB18	100	99.029	MGP_SPRETEiJ_G0022894	Rab18	100	99.029	Mus_spretus
ENSG00000099246	RAB18	100	98.544	ENSMPUG00000010592	RAB18	100	98.544	Mustela_putorius_furo
ENSG00000099246	RAB18	100	100.000	ENSMLUG00000027295	RAB18	100	90.678	Myotis_lucifugus
ENSG00000099246	RAB18	100	98.544	ENSNGAG00000001465	Rab18	100	98.544	Nannospalax_galili
ENSG00000099246	RAB18	99	85.714	ENSNBRG00000008137	rab18b	99	84.878	Neolamprologus_brichardi
ENSG00000099246	RAB18	100	100.000	ENSNLEG00000016970	RAB18	100	100.000	Nomascus_leucogenys
ENSG00000099246	RAB18	100	98.544	ENSODEG00000004150	-	100	98.544	Octodon_degus
ENSG00000099246	RAB18	99	85.714	ENSONIG00000018673	rab18b	99	84.878	Oreochromis_niloticus
ENSG00000099246	RAB18	100	98.413	ENSOANG00000021391	RAB18	100	97.087	Ornithorhynchus_anatinus
ENSG00000099246	RAB18	100	98.413	ENSOCUG00000022307	RAB18	100	98.058	Oryctolagus_cuniculus
ENSG00000099246	RAB18	99	84.375	ENSORLG00000009609	rab18b	99	83.902	Oryzias_latipes
ENSG00000099246	RAB18	99	84.375	ENSORLG00020011590	rab18b	99	83.902	Oryzias_latipes_hni
ENSG00000099246	RAB18	99	84.375	ENSORLG00015007182	rab18b	99	83.902	Oryzias_latipes_hsok
ENSG00000099246	RAB18	99	85.714	ENSOMEG00000007546	rab18b	99	83.902	Oryzias_melastigma
ENSG00000099246	RAB18	100	99.029	ENSOGAG00000028015	RAB18	100	99.029	Otolemur_garnettii
ENSG00000099246	RAB18	100	99.515	ENSOARG00000016208	RAB18	100	99.515	Ovis_aries
ENSG00000099246	RAB18	100	100.000	ENSPPAG00000041625	RAB18	100	100.000	Pan_paniscus
ENSG00000099246	RAB18	100	98.544	ENSPPRG00000010314	RAB18	100	98.544	Panthera_pardus
ENSG00000099246	RAB18	100	98.544	ENSPTIG00000011667	RAB18	100	98.544	Panthera_tigris_altaica
ENSG00000099246	RAB18	100	100.000	ENSPTRG00000002384	RAB18	100	100.000	Pan_troglodytes
ENSG00000099246	RAB18	100	100.000	ENSPANG00000023005	RAB18	100	100.000	Papio_anubis
ENSG00000099246	RAB18	98	85.294	ENSPMAG00000005322	rab18b	98	85.294	Petromyzon_marinus
ENSG00000099246	RAB18	100	96.875	ENSPCIG00000028705	-	88	96.602	Phascolarctos_cinereus
ENSG00000099246	RAB18	99	87.097	ENSPFOG00000013491	rab18b	99	84.878	Poecilia_formosa
ENSG00000099246	RAB18	99	85.714	ENSPLAG00000019136	rab18b	99	84.878	Poecilia_latipinna
ENSG00000099246	RAB18	99	85.714	ENSPMEG00000008223	rab18b	99	84.878	Poecilia_mexicana
ENSG00000099246	RAB18	100	100.000	ENSPPYG00000002172	RAB18	100	100.000	Pongo_abelii
ENSG00000099246	RAB18	100	99.515	ENSPCOG00000018906	RAB18	100	99.515	Propithecus_coquereli
ENSG00000099246	RAB18	99	85.714	ENSPNYG00000001751	rab18b	99	85.366	Pundamilia_nyererei
ENSG00000099246	RAB18	100	87.379	ENSPNAG00000002404	rab18b	100	87.379	Pygocentrus_nattereri
ENSG00000099246	RAB18	100	98.544	ENSRNOG00000018972	Rab18	100	98.544	Rattus_norvegicus
ENSG00000099246	RAB18	100	99.515	ENSRBIG00000035948	RAB18	100	99.515	Rhinopithecus_bieti
ENSG00000099246	RAB18	100	100.000	ENSRROG00000040563	RAB18	100	100.000	Rhinopithecus_roxellana
ENSG00000099246	RAB18	100	100.000	ENSSHAG00000007613	RAB18	100	97.087	Sarcophilus_harrisii
ENSG00000099246	RAB18	99	85.938	ENSSMAG00000011814	rab18b	99	83.415	Scophthalmus_maximus
ENSG00000099246	RAB18	99	84.878	ENSSDUG00000005960	rab18b	99	84.878	Seriola_dumerili
ENSG00000099246	RAB18	99	84.878	ENSSLDG00000006014	rab18b	99	84.878	Seriola_lalandi_dorsalis
ENSG00000099246	RAB18	99	84.390	ENSSPAG00000020875	rab18b	99	84.390	Stegastes_partitus
ENSG00000099246	RAB18	100	99.515	ENSSSCG00000028655	RAB18	100	99.515	Sus_scrofa
ENSG00000099246	RAB18	91	95.455	ENSTGUG00000001105	-	100	85.356	Taeniopygia_guttata
ENSG00000099246	RAB18	99	89.062	ENSTRUG00000004283	rab18b	99	84.878	Takifugu_rubripes
ENSG00000099246	RAB18	99	82.439	ENSTNIG00000007882	rab18b	99	82.439	Tetraodon_nigroviridis
ENSG00000099246	RAB18	100	98.544	ENSVVUG00000001705	RAB18	100	98.544	Vulpes_vulpes
ENSG00000099246	RAB18	99	85.714	ENSXMAG00000006945	rab18b	99	85.366	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001654	eye development	-	ISS	Process
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0003924	GTPase activity	10648831.	NAS	Function
GO:0005515	protein binding	23935497.24891604.25416956.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005794	Golgi apparatus	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0007264	small GTPase mediated signal transduction	10648831.	NAS	Process
GO:0007420	brain development	-	ISS	Process
GO:0019003	GDP binding	20937701.	IDA	Function
GO:0030667	secretory granule membrane	-	TAS	Component
GO:0032482	Rab protein signal transduction	21873635.	IBA	Process
GO:0034389	lipid droplet organization	21873635.	IBA	Process
GO:0034389	lipid droplet organization	24239381.	IMP	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045202	synapse	-	IEA	Component
GO:0071782	endoplasmic reticulum tubular network	24891604.	IDA	Component
GO:0071786	endoplasmic reticulum tubular network organization	24891604.	IMP	Process