EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000099783 (Gene tree)
Gene ID: 4670
Gene Symbol: HNRNPM
Alias: HTGR1|HNRNPM4|HNRPM4|CEAR|NAGR1|HNRPM
Full Name: heterogeneous nuclear ribonucleoprotein M
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 44,544 bases
Position: chr19:8,444,575-8,489,118
Accession: 5046
RBP type: canonical RBP
Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000470017	HnRNP_M	PF11532.8	4.2e-18	1	1
ENSP00000471339	HnRNP_M	PF11532.8	7.1e-18	1	1
ENSP00000470932	HnRNP_M	PF11532.8	8.9e-18	1	1
ENSP00000472789	HnRNP_M	PF11532.8	9.1e-18	1	1
ENSP00000325732	HnRNP_M	PF11532.8	2.3e-17	1	1
ENSP00000325376	HnRNP_M	PF11532.8	2.5e-17	1	1
ENSP00000483715	HnRNP_M	PF11532.8	2.5e-17	1	1
ENSP00000325732	RRM_1	PF00076.22	3.1e-52	1	3
ENSP00000325732	RRM_1	PF00076.22	3.1e-52	2	3
ENSP00000325732	RRM_1	PF00076.22	3.1e-52	3	3
ENSP00000325376	RRM_1	PF00076.22	3.9e-52	1	3
ENSP00000325376	RRM_1	PF00076.22	3.9e-52	2	3
ENSP00000325376	RRM_1	PF00076.22	3.9e-52	3	3
ENSP00000483715	RRM_1	PF00076.22	2.5e-49	1	3
ENSP00000483715	RRM_1	PF00076.22	2.5e-49	2	3
ENSP00000483715	RRM_1	PF00076.22	2.5e-49	3	3
ENSP00000470932	RRM_1	PF00076.22	1.5e-31	1	2
ENSP00000470932	RRM_1	PF00076.22	1.5e-31	2	2
ENSP00000472789	RRM_1	PF00076.22	1.6e-31	1	2
ENSP00000472789	RRM_1	PF00076.22	1.6e-31	2	2
ENSP00000471339	RRM_1	PF00076.22	2.9e-29	1	2
ENSP00000471339	RRM_1	PF00076.22	2.9e-29	2	2
ENSP00000470017	RRM_1	PF00076.22	8.6e-23	1	1
ENSP00000470635	RRM_1	PF00076.22	1.1e-09	1	1
ENSP00000469681	RRM_1	PF00076.22	0.00035	1	1
ENSP00000472599	RRM_1	PF00076.22	0.00078	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19317654	Affinity chromatography using 2' fluoro-substituted RNAs for detection of RNA-protein interactions in RNase-rich or RNase-treated extracts.	Biotechniques	2009 Feb	Hovhannisyan R	doi: 10.2144/000113067.
8413212	PUB1 is a major nuclear and cytoplasmic polyadenylated RNA-binding protein in Saccharomyces cerevisiae.	Mol Cell Biol	1993 Oct	Anderson JT	-
17959601	Heterogeneous ribonucleoprotein m is a splicing regulatory protein that can enhance or silence splicing of alternatively spliced exons.	J Biol Chem	2007 Dec 14	Hovhannisyan RH	-
21901530	Carcinoembryonic antigen (CEA) and its receptor hnRNP M are mediators of metastasis and the inflammatory response in the liver.	Clin Exp Metastasis	2011 Dec	Thomas P	doi: 10.1007/s10585-011-9419-3
21846828	Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins.	MBio	2011 Aug 16	Bortz E	doi: 10.1128/mBio.00151-11
24840202	Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing.	Genes Dev	2014 Jun 1	Xu Y	doi: 10.1101/gad.241968.114
23938467	Linking spermatid ribonucleic acid (RNA) binding protein and retrogene diversity to reproductive success.	Mol Cell Proteomics	2013 Nov	Chapman KM	doi: 10.1074/mcp.M113.030585
23864636	Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication complexes of Semliki Forest virus.	J Virol	2013 Sep	Varjak M	doi: 10.1128/JVI.01105-13
28716093	C. elegans SUP-46, an HNRNPM family RNA-binding protein that prevents paternally-mediated epigenetic sterility.	BMC Biol	2017 Jul 17	Johnston WL	doi: 10.1186/s12915-017-0398-y.
27871485	Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins.	Mol Cell	2016 Nov 3	Wu H	doi: 10.1016/j.molcel.2016.10.007
19874820	hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures.	Exp Cell Res	2010 Feb 1	Marko M	doi: 10.1016/j.yexcr.2009.10.021
19673543	Analysis of Ewing sarcoma (EWS)-binding proteins: interaction with hnRNP M, U, and RNA-helicases p68/72 within protein-RNA complexes.	J Proteome Res	2009 Oct	Pahlich S	doi: 10.1021/pr900235t.
22317749	Engagement of heterogeneous nuclear ribonucleoprotein M with listeriolysin O induces type I interferon expression and restricts Listeria monocytogenes growth in host cells.	Immunobiology	2012 Oct	Luo Z	doi: 10.1016/j.imbio.2012.01.009
21622564	Regulatory roles of heterogeneous nuclear ribonucleoprotein M and Nova-1 protein in alternative splicing of dopamine D2 receptor pre-mRNA.	J Biol Chem	2011 Jul 15	Park E	doi: 10.1074/jbc.M110.206540
29321325	Identification and Characterization of Sindbis Virus RNA-Host Protein Interactions.	J Virol	2018 Mar 14	LaPointe AT	doi: 10.1128/JVI.02171-17

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000597270	HNRNPM-208	1147	-	ENSP00000470635	383 (aa)	-	M0QZM1
ENST00000597813	HNRNPM-209	630	-	-	- (aa)	-	-
ENST00000597081	HNRNPM-207	1004	-	-	- (aa)	-	-
ENST00000594907	HNRNPM-204	1078	-	ENSP00000472789	357 (aa)	-	M0R2T0
ENST00000598367	HNRNPM-210	298	-	ENSP00000469906	99 (aa)	-	M0QYL3
ENST00000598999	HNRNPM-212	409	-	ENSP00000469681	116 (aa)	-	M0QY96
ENST00000601645	HNRNPM-215	832	-	ENSP00000471339	275 (aa)	-	M0R0N3
ENST00000593293	HNRNPM-203	764	-	-	- (aa)	-	-
ENST00000602219	HNRNPM-216	1809	-	-	- (aa)	-	-
ENST00000598603	HNRNPM-211	784	-	-	- (aa)	-	-
ENST00000325495	HNRNPM-201	2494	XM_005272478	ENSP00000325376	730 (aa)	XP_005272535	P52272
ENST00000600806	HNRNPM-214	2373	-	ENSP00000471530	99 (aa)	-	M0R0Y6
ENST00000348943	HNRNPM-202	2568	XM_005272480	ENSP00000325732	691 (aa)	XP_005272537	P52272
ENST00000596984	HNRNPM-206	664	-	ENSP00000470017	219 (aa)	-	M0QYQ7
ENST00000600092	HNRNPM-213	1086	-	ENSP00000470932	352 (aa)	-	M0R019
ENST00000620401	HNRNPM-217	2458	XM_005272481	ENSP00000483715	730 (aa)	XP_005272538	A0A087X0X3
ENST00000596295	HNRNPM-205	910	-	ENSP00000472599	214 (aa)	-	M0R2I7

Gene Model

Click here to download ENSG00000099783's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000099783	Tunica Media	8.9730861E-005	-
ENSG00000099783	Interleukin 1 Receptor Antagonist Protein	5.8410000E-005	-
ENSG00000099783	Interleukin 1 Receptor Antagonist Protein	4.8500000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000099783	rs59372292	19	8481254	T	Coronary artery disease	29212778	[0.023-0.055] unit increase	0.039	EFO_0000378

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000099783's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000099783	HNRNPM	52	30.201	ENSG00000107105	ELAVL2	78	30.201
ENSG00000099783	HNRNPM	61	30.000	ENSG00000151846	PABPC3	51	42.857
ENSG00000099783	HNRNPM	65	38.028	ENSG00000070756	PABPC1	61	41.429
ENSG00000099783	HNRNPM	66	31.452	ENSG00000101104	PABPC1L	84	38.356
ENSG00000099783	HNRNPM	87	54.125	ENSG00000104177	MYEF2	99	55.556
ENSG00000099783	HNRNPM	56	32.258	ENSG00000143368	SF3B4	71	30.986

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000099783	HNRNPM	91	68.000	ENSAPOG00000001463	hnrnpm	84	66.667	Acanthochromis_polyacanthus
ENSG00000099783	HNRNPM	100	98.219	ENSAMEG00000004979	HNRNPM	100	98.219	Ailuropoda_melanoleuca
ENSG00000099783	HNRNPM	79	87.500	ENSACIG00000011870	hnrnpm	88	66.667	Amphilophus_citrinellus
ENSG00000099783	HNRNPM	79	85.000	ENSAOCG00000008519	hnrnpm	91	69.231	Amphiprion_ocellaris
ENSG00000099783	HNRNPM	79	85.000	ENSAPEG00000004257	hnrnpm	88	70.085	Amphiprion_percula
ENSG00000099783	HNRNPM	79	87.500	ENSATEG00000008976	hnrnpm	88	66.379	Anabas_testudineus
ENSG00000099783	HNRNPM	95	73.061	ENSAPLG00000010149	HNRNPM	99	72.920	Anas_platyrhynchos
ENSG00000099783	HNRNPM	99	91.837	ENSANAG00000019489	-	95	85.931	Aotus_nancymaae
ENSG00000099783	HNRNPM	100	99.726	ENSANAG00000025358	HNRNPM	100	99.726	Aotus_nancymaae
ENSG00000099783	HNRNPM	83	88.750	ENSACLG00000020495	hnrnpm	91	64.800	Astatotilapia_calliptera
ENSG00000099783	HNRNPM	80	86.250	ENSAMXG00000016073	hnrnpm	87	67.480	Astyanax_mexicanus
ENSG00000099783	HNRNPM	100	99.315	ENSBTAG00000021039	HNRNPM	100	99.315	Bos_taurus
ENSG00000099783	HNRNPM	88	61.765	ENSBTAG00000048355	-	100	56.680	Bos_taurus
ENSG00000099783	HNRNPM	100	99.452	ENSCJAG00000010802	HNRNPM	100	99.452	Callithrix_jacchus
ENSG00000099783	HNRNPM	100	98.987	ENSCAFG00000018524	HNRNPM	93	98.987	Canis_familiaris
ENSG00000099783	HNRNPM	100	95.729	ENSCAFG00020022128	HNRNPM	99	95.729	Canis_lupus_dingo
ENSG00000099783	HNRNPM	100	98.987	ENSCHIG00000026313	HNRNPM	100	98.987	Capra_hircus
ENSG00000099783	HNRNPM	100	88.183	ENSTSYG00000037074	-	96	88.253	Carlito_syrichta
ENSG00000099783	HNRNPM	90	81.298	ENSTSYG00000030502	-	99	74.858	Carlito_syrichta
ENSG00000099783	HNRNPM	99	99.738	ENSTSYG00000011487	-	100	99.649	Carlito_syrichta
ENSG00000099783	HNRNPM	93	99.495	ENSCAPG00000011505	HNRNPM	100	90.718	Cavia_aperea
ENSG00000099783	HNRNPM	100	98.553	ENSCPOG00000015182	HNRNPM	100	98.553	Cavia_porcellus
ENSG00000099783	HNRNPM	99	91.361	ENSCCAG00000018580	-	100	88.713	Cebus_capucinus
ENSG00000099783	HNRNPM	100	93.000	ENSCCAG00000029331	-	85	93.103	Cebus_capucinus
ENSG00000099783	HNRNPM	100	98.906	ENSCCAG00000018782	HNRNPM	100	98.906	Cebus_capucinus
ENSG00000099783	HNRNPM	100	100.000	ENSCATG00000035478	HNRNPM	100	100.000	Cercocebus_atys
ENSG00000099783	HNRNPM	95	87.234	ENSCLAG00000003049	-	98	72.820	Chinchilla_lanigera
ENSG00000099783	HNRNPM	100	98.842	ENSCLAG00000011194	-	100	98.842	Chinchilla_lanigera
ENSG00000099783	HNRNPM	100	95.470	ENSCSAG00000008009	HNRNPM	98	95.147	Chlorocebus_sabaeus
ENSG00000099783	HNRNPM	100	98.493	ENSCHOG00000013627	HNRNPM	100	98.493	Choloepus_hoffmanni
ENSG00000099783	HNRNPM	61	90.000	ENSCPBG00000017053	-	72	90.000	Chrysemys_picta_bellii
ENSG00000099783	HNRNPM	99	72.330	ENSCPBG00000017052	-	100	76.396	Chrysemys_picta_bellii
ENSG00000099783	HNRNPM	89	94.175	ENSCANG00000041671	-	99	77.798	Colobus_angolensis_palliatus
ENSG00000099783	HNRNPM	95	97.845	ENSCANG00000043491	HNRNPM	100	97.845	Colobus_angolensis_palliatus
ENSG00000099783	HNRNPM	100	74.384	ENSCGRG00001008003	-	98	73.361	Cricetulus_griseus_chok1gshd
ENSG00000099783	HNRNPM	86	90.588	ENSCGRG00001021244	-	83	93.976	Cricetulus_griseus_chok1gshd
ENSG00000099783	HNRNPM	98	90.265	ENSCGRG00001022655	-	98	90.265	Cricetulus_griseus_chok1gshd
ENSG00000099783	HNRNPM	96	96.743	ENSCGRG00001012021	-	94	96.743	Cricetulus_griseus_chok1gshd
ENSG00000099783	HNRNPM	100	66.017	ENSCGRG00001004249	-	97	64.454	Cricetulus_griseus_chok1gshd
ENSG00000099783	HNRNPM	94	82.258	ENSCGRG00001004486	-	99	76.409	Cricetulus_griseus_chok1gshd
ENSG00000099783	HNRNPM	100	74.384	ENSCGRG00000012006	-	98	73.361	Cricetulus_griseus_crigri
ENSG00000099783	HNRNPM	98	91.584	ENSCGRG00000010065	-	91	91.584	Cricetulus_griseus_crigri
ENSG00000099783	HNRNPM	94	82.258	ENSCGRG00000003596	-	99	76.409	Cricetulus_griseus_crigri
ENSG00000099783	HNRNPM	82	93.827	ENSCGRG00000018196	-	82	72.358	Cricetulus_griseus_crigri
ENSG00000099783	HNRNPM	100	96.849	ENSCGRG00000012441	-	100	96.849	Cricetulus_griseus_crigri
ENSG00000099783	HNRNPM	93	68.103	ENSCSEG00000014980	hnrnpm	86	68.103	Cynoglossus_semilaevis
ENSG00000099783	HNRNPM	80	85.000	ENSCVAG00000020838	hnrnpm	87	63.333	Cyprinodon_variegatus
ENSG00000099783	HNRNPM	93	70.796	ENSDARG00000061735	hnrnpm	87	70.796	Danio_rerio
ENSG00000099783	HNRNPM	100	98.698	ENSDNOG00000012157	HNRNPM	91	98.698	Dasypus_novemcinctus
ENSG00000099783	HNRNPM	100	99.132	ENSDORG00000008105	Hnrnpm	100	99.132	Dipodomys_ordii
ENSG00000099783	HNRNPM	98	94.979	ENSETEG00000019712	HNRNPM	98	94.979	Echinops_telfairi
ENSG00000099783	HNRNPM	100	99.132	ENSEASG00005022434	HNRNPM	91	99.132	Equus_asinus_asinus
ENSG00000099783	HNRNPM	100	99.132	ENSECAG00000023868	HNRNPM	91	99.132	Equus_caballus
ENSG00000099783	HNRNPM	62	88.525	ENSEEUG00000001929	-	65	78.704	Erinaceus_europaeus
ENSG00000099783	HNRNPM	85	85.000	ENSELUG00000021183	hnrnpm	90	63.910	Esox_lucius
ENSG00000099783	HNRNPM	100	95.759	ENSFCAG00000015218	HNRNPM	98	95.682	Felis_catus
ENSG00000099783	HNRNPM	83	86.585	ENSFALG00000001059	HNRNPM	100	74.957	Ficedula_albicollis
ENSG00000099783	HNRNPM	100	98.263	ENSFDAG00000014680	HNRNPM	100	98.263	Fukomys_damarensis
ENSG00000099783	HNRNPM	78	85.000	ENSFHEG00000006712	hnrnpm	84	68.966	Fundulus_heteroclitus
ENSG00000099783	HNRNPM	76	76.768	ENSGMOG00000009724	hnrnpm	98	47.293	Gadus_morhua
ENSG00000099783	HNRNPM	95	72.549	ENSGALG00000000377	HNRNPM	98	71.739	Gallus_gallus
ENSG00000099783	HNRNPM	95	65.079	ENSGAFG00000013798	hnrnpm	98	66.116	Gambusia_affinis
ENSG00000099783	HNRNPM	87	63.836	ENSGACG00000010265	hnrnpm	100	54.661	Gasterosteus_aculeatus
ENSG00000099783	HNRNPM	64	90.476	ENSGAGG00000019123	-	85	76.829	Gopherus_agassizii
ENSG00000099783	HNRNPM	99	72.087	ENSGAGG00000019124	-	100	75.917	Gopherus_agassizii
ENSG00000099783	HNRNPM	100	100.000	ENSGGOG00000003498	HNRNPM	100	100.000	Gorilla_gorilla
ENSG00000099783	HNRNPM	83	87.500	ENSHBUG00000023451	hnrnpm	91	64.800	Haplochromis_burtoni
ENSG00000099783	HNRNPM	99	83.168	ENSHGLG00000004652	-	65	84.706	Heterocephalus_glaber_female
ENSG00000099783	HNRNPM	100	95.080	ENSHGLG00000009796	-	100	95.080	Heterocephalus_glaber_female
ENSG00000099783	HNRNPM	100	96.712	ENSHGLG00100006675	-	100	96.849	Heterocephalus_glaber_male
ENSG00000099783	HNRNPM	99	83.168	ENSHGLG00100011755	-	65	84.706	Heterocephalus_glaber_male
ENSG00000099783	HNRNPM	82	74.336	ENSHCOG00000019984	hnrnpm	99	52.051	Hippocampus_comes
ENSG00000099783	HNRNPM	84	81.250	ENSIPUG00000025097	hnrnpm	98	54.897	Ictalurus_punctatus
ENSG00000099783	HNRNPM	100	99.566	ENSSTOG00000008112	HNRNPM	100	99.566	Ictidomys_tridecemlineatus
ENSG00000099783	HNRNPM	100	97.397	ENSJJAG00000017319	Hnrnpm	100	97.397	Jaculus_jaculus
ENSG00000099783	HNRNPM	78	86.250	ENSKMAG00000022136	hnrnpm	85	69.298	Kryptolebias_marmoratus
ENSG00000099783	HNRNPM	79	85.000	ENSLBEG00000004545	hnrnpm	86	68.966	Labrus_bergylta
ENSG00000099783	HNRNPM	94	51.485	ENSLACG00000016814	HNRNPM	99	50.353	Latimeria_chalumnae
ENSG00000099783	HNRNPM	84	81.250	ENSLOCG00000004456	hnrnpm	99	56.084	Lepisosteus_oculatus
ENSG00000099783	HNRNPM	100	96.712	ENSLAFG00000013603	HNRNPM	100	96.712	Loxodonta_africana
ENSG00000099783	HNRNPM	100	100.000	ENSMFAG00000037617	HNRNPM	100	100.000	Macaca_fascicularis
ENSG00000099783	HNRNPM	100	100.000	ENSMMUG00000018806	HNRNPM	100	100.000	Macaca_mulatta
ENSG00000099783	HNRNPM	100	100.000	ENSMNEG00000036546	HNRNPM	100	100.000	Macaca_nemestrina
ENSG00000099783	HNRNPM	100	100.000	ENSMLEG00000042113	HNRNPM	100	100.000	Mandrillus_leucophaeus
ENSG00000099783	HNRNPM	81	87.500	ENSMAMG00000005612	hnrnpm	85	68.333	Mastacembelus_armatus
ENSG00000099783	HNRNPM	83	88.750	ENSMZEG00005002512	hnrnpm	88	67.200	Maylandia_zebra
ENSG00000099783	HNRNPM	89	92.395	ENSMGAG00000000700	HNRNPM	100	79.310	Meleagris_gallopavo
ENSG00000099783	HNRNPM	100	98.408	ENSMAUG00000017476	Hnrnpm	100	98.408	Mesocricetus_auratus
ENSG00000099783	HNRNPM	100	99.178	ENSMICG00000002532	-	100	99.178	Microcebus_murinus
ENSG00000099783	HNRNPM	98	92.625	ENSMICG00000028503	-	100	90.476	Microcebus_murinus
ENSG00000099783	HNRNPM	100	98.119	ENSMOCG00000005769	Hnrnpm	100	98.119	Microtus_ochrogaster
ENSG00000099783	HNRNPM	81	75.676	ENSMMOG00000019610	hnrnpm	96	51.763	Mola_mola
ENSG00000099783	HNRNPM	94	95.652	ENSMODG00000003801	-	98	89.182	Monodelphis_domestica
ENSG00000099783	HNRNPM	100	85.614	ENSMODG00000003473	-	98	79.553	Monodelphis_domestica
ENSG00000099783	HNRNPM	80	87.500	ENSMALG00000014280	hnrnpm	88	67.521	Monopterus_albus
ENSG00000099783	HNRNPM	100	97.829	MGP_CAROLIEiJ_G0021413	Hnrnpm	100	97.829	Mus_caroli
ENSG00000099783	HNRNPM	100	97.540	ENSMUSG00000059208	Hnrnpm	100	97.540	Mus_musculus
ENSG00000099783	HNRNPM	100	97.685	MGP_PahariEiJ_G0020418	Hnrnpm	100	97.685	Mus_pahari
ENSG00000099783	HNRNPM	100	97.685	MGP_SPRETEiJ_G0022325	Hnrnpm	100	97.904	Mus_spretus
ENSG00000099783	HNRNPM	100	96.610	ENSMPUG00000007241	HNRNPM	92	92.809	Mustela_putorius_furo
ENSG00000099783	HNRNPM	100	94.172	ENSMLUG00000025231	-	95	94.393	Myotis_lucifugus
ENSG00000099783	HNRNPM	100	98.842	ENSMLUG00000006696	-	98	98.842	Myotis_lucifugus
ENSG00000099783	HNRNPM	100	98.408	ENSNGAG00000003707	Hnrnpm	100	98.408	Nannospalax_galili
ENSG00000099783	HNRNPM	100	80.645	ENSNGAG00000017657	-	97	69.892	Nannospalax_galili
ENSG00000099783	HNRNPM	95	67.021	ENSNGAG00000005331	-	84	66.304	Nannospalax_galili
ENSG00000099783	HNRNPM	83	87.500	ENSNBRG00000015999	hnrnpm	90	64.800	Neolamprologus_brichardi
ENSG00000099783	HNRNPM	96	100.000	ENSNLEG00000001884	-	95	100.000	Nomascus_leucogenys
ENSG00000099783	HNRNPM	94	94.737	ENSMEUG00000004789	HNRNPM	98	86.092	Notamacropus_eugenii
ENSG00000099783	HNRNPM	89	96.538	ENSOPRG00000001943	HNRNPM	80	91.549	Ochotona_princeps
ENSG00000099783	HNRNPM	100	95.161	ENSODEG00000009194	-	98	84.389	Octodon_degus
ENSG00000099783	HNRNPM	100	88.000	ENSODEG00000008501	-	82	88.506	Octodon_degus
ENSG00000099783	HNRNPM	98	92.784	ENSODEG00000010737	-	85	94.048	Octodon_degus
ENSG00000099783	HNRNPM	93	94.949	ENSODEG00000011442	-	98	91.013	Octodon_degus
ENSG00000099783	HNRNPM	95	96.809	ENSODEG00000017356	-	100	95.146	Octodon_degus
ENSG00000099783	HNRNPM	98	94.565	ENSODEG00000010314	-	98	94.194	Octodon_degus
ENSG00000099783	HNRNPM	84	93.548	ENSODEG00000004347	-	100	83.728	Octodon_degus
ENSG00000099783	HNRNPM	79	87.500	ENSONIG00000001758	hnrnpm	86	69.231	Oreochromis_niloticus
ENSG00000099783	HNRNPM	73	92.937	ENSOANG00000005883	-	98	94.030	Ornithorhynchus_anatinus
ENSG00000099783	HNRNPM	99	80.547	ENSOANG00000010259	HNRNPM	100	85.906	Ornithorhynchus_anatinus
ENSG00000099783	HNRNPM	84	66.019	ENSOCUG00000025284	-	96	51.449	Oryctolagus_cuniculus
ENSG00000099783	HNRNPM	93	97.980	ENSOCUG00000024611	-	98	90.883	Oryctolagus_cuniculus
ENSG00000099783	HNRNPM	88	89.216	ENSOCUG00000023204	-	99	86.909	Oryctolagus_cuniculus
ENSG00000099783	HNRNPM	100	98.263	ENSOCUG00000000552	-	98	98.263	Oryctolagus_cuniculus
ENSG00000099783	HNRNPM	80	86.250	ENSORLG00000005400	hnrnpm	88	62.393	Oryzias_latipes
ENSG00000099783	HNRNPM	79	86.250	ENSORLG00020022108	hnrnpm	90	62.393	Oryzias_latipes_hni
ENSG00000099783	HNRNPM	79	86.250	ENSORLG00015019809	hnrnpm	88	62.393	Oryzias_latipes_hsok
ENSG00000099783	HNRNPM	81	86.250	ENSOMEG00000013075	hnrnpm	86	67.500	Oryzias_melastigma
ENSG00000099783	HNRNPM	97	80.059	ENSOGAG00000032900	-	96	80.299	Otolemur_garnettii
ENSG00000099783	HNRNPM	100	99.566	ENSOGAG00000030987	HNRNPM	98	99.566	Otolemur_garnettii
ENSG00000099783	HNRNPM	100	98.844	ENSOARG00000003961	HNRNPM	100	96.816	Ovis_aries
ENSG00000099783	HNRNPM	100	100.000	ENSPPAG00000039365	HNRNPM	100	100.000	Pan_paniscus
ENSG00000099783	HNRNPM	100	99.421	ENSPPRG00000009284	HNRNPM	100	99.421	Panthera_pardus
ENSG00000099783	HNRNPM	95	95.809	ENSPTIG00000003024	HNRNPM	95	95.809	Panthera_tigris_altaica
ENSG00000099783	HNRNPM	100	100.000	ENSPTRG00000010424	HNRNPM	100	100.000	Pan_troglodytes
ENSG00000099783	HNRNPM	100	100.000	ENSPANG00000000283	HNRNPM	100	100.000	Papio_anubis
ENSG00000099783	HNRNPM	88	80.702	ENSPKIG00000001332	hnrnpm	99	55.525	Paramormyrops_kingsleyae
ENSG00000099783	HNRNPM	95	72.346	ENSPSIG00000011477	HNRNPM	99	72.067	Pelodiscus_sinensis
ENSG00000099783	HNRNPM	82	75.221	ENSPMGG00000012793	hnrnpm	97	62.500	Periophthalmus_magnuspinnatus
ENSG00000099783	HNRNPM	100	98.553	ENSPEMG00000009260	Hnrnpm	100	98.553	Peromyscus_maniculatus_bairdii
ENSG00000099783	HNRNPM	100	91.786	ENSPCIG00000020115	HNRNPM	100	86.587	Phascolarctos_cinereus
ENSG00000099783	HNRNPM	81	76.991	ENSPFOG00000013612	hnrnpm	100	49.240	Poecilia_formosa
ENSG00000099783	HNRNPM	78	83.750	ENSPLAG00000011139	hnrnpm	88	64.706	Poecilia_latipinna
ENSG00000099783	HNRNPM	78	83.750	ENSPMEG00000011182	hnrnpm	87	64.706	Poecilia_mexicana
ENSG00000099783	HNRNPM	96	82.500	ENSPREG00000016114	hnrnpm	91	67.227	Poecilia_reticulata
ENSG00000099783	HNRNPM	100	99.855	ENSPPYG00000009506	HNRNPM	100	99.855	Pongo_abelii
ENSG00000099783	HNRNPM	100	97.260	ENSPCAG00000009678	HNRNPM	100	97.260	Procavia_capensis
ENSG00000099783	HNRNPM	100	99.178	ENSPCOG00000020227	HNRNPM	100	99.178	Propithecus_coquereli
ENSG00000099783	HNRNPM	100	98.331	ENSPVAG00000009647	HNRNPM	100	98.331	Pteropus_vampyrus
ENSG00000099783	HNRNPM	83	87.500	ENSPNYG00000006542	hnrnpm	91	64.800	Pundamilia_nyererei
ENSG00000099783	HNRNPM	83	82.301	ENSPNAG00000020740	hnrnpm	97	53.986	Pygocentrus_nattereri
ENSG00000099783	HNRNPM	100	79.798	ENSRNOG00000056969	AABR07008911.1	86	80.233	Rattus_norvegicus
ENSG00000099783	HNRNPM	100	98.119	ENSRNOG00000007921	Hnrnpm	100	98.119	Rattus_norvegicus
ENSG00000099783	HNRNPM	100	79.798	ENSRNOG00000060222	AC113901.1	86	80.233	Rattus_norvegicus
ENSG00000099783	HNRNPM	99	99.738	ENSRBIG00000039870	-	99	96.038	Rhinopithecus_bieti
ENSG00000099783	HNRNPM	99	96.073	ENSRBIG00000041503	HNRNPM	100	97.368	Rhinopithecus_bieti
ENSG00000099783	HNRNPM	100	99.589	ENSRROG00000038240	-	100	99.589	Rhinopithecus_roxellana
ENSG00000099783	HNRNPM	99	99.738	ENSRROG00000033189	-	98	97.106	Rhinopithecus_roxellana
ENSG00000099783	HNRNPM	100	99.589	ENSSBOG00000032416	HNRNPM	100	99.589	Saimiri_boliviensis_boliviensis
ENSG00000099783	HNRNPM	91	100.000	ENSSBOG00000022413	-	99	87.114	Saimiri_boliviensis_boliviensis
ENSG00000099783	HNRNPM	99	90.314	ENSSHAG00000005864	HNRNPM	100	89.514	Sarcophilus_harrisii
ENSG00000099783	HNRNPM	93	80.702	ENSSFOG00015008815	hnrnpm	100	54.791	Scleropages_formosus
ENSG00000099783	HNRNPM	79	86.250	ENSSMAG00000003992	hnrnpm	88	70.940	Scophthalmus_maximus
ENSG00000099783	HNRNPM	94	53.061	ENSSDUG00000002188	hnrnpm	91	71.121	Seriola_dumerili
ENSG00000099783	HNRNPM	85	87.500	ENSSLDG00000016713	hnrnpm	88	67.521	Seriola_lalandi_dorsalis
ENSG00000099783	HNRNPM	96	97.552	ENSSARG00000000267	HNRNPM	72	100.000	Sorex_araneus
ENSG00000099783	HNRNPM	95	71.268	ENSSPUG00000002270	HNRNPM	98	71.348	Sphenodon_punctatus
ENSG00000099783	HNRNPM	84	86.250	ENSSPAG00000023132	hnrnpm	89	68.103	Stegastes_partitus
ENSG00000099783	HNRNPM	100	99.421	ENSSSCG00000013602	HNRNPM	100	99.650	Sus_scrofa
ENSG00000099783	HNRNPM	99	71.859	ENSTGUG00000000938	HNRNPM	100	74.435	Taeniopygia_guttata
ENSG00000099783	HNRNPM	94	53.308	ENSTRUG00000013783	hnrnpm	98	50.357	Takifugu_rubripes
ENSG00000099783	HNRNPM	82	75.221	ENSTNIG00000015530	hnrnpm	100	54.305	Tetraodon_nigroviridis
ENSG00000099783	HNRNPM	89	97.087	ENSTBEG00000008718	HNRNPM	78	92.593	Tupaia_belangeri
ENSG00000099783	HNRNPM	100	99.329	ENSTTRG00000009769	HNRNPM	98	94.700	Tursiops_truncatus
ENSG00000099783	HNRNPM	99	99.738	ENSUAMG00000005710	HNRNPM	99	98.085	Ursus_americanus
ENSG00000099783	HNRNPM	99	95.250	ENSUMAG00000014575	HNRNPM	100	97.023	Ursus_maritimus
ENSG00000099783	HNRNPM	93	100.000	ENSVPAG00000004215	HNRNPM	100	87.870	Vicugna_pacos
ENSG00000099783	HNRNPM	93	100.000	ENSVVUG00000024984	HNRNPM	100	94.371	Vulpes_vulpes
ENSG00000099783	HNRNPM	94	59.659	ENSXETG00000001777	hnrnpm	100	59.065	Xenopus_tropicalis
ENSG00000099783	HNRNPM	84	83.750	ENSXCOG00000002651	hnrnpm	98	45.308	Xiphophorus_couchianus
ENSG00000099783	HNRNPM	90	61.818	ENSXMAG00000018502	hnrnpm	84	64.151	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000380	alternative mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000380	alternative mRNA splicing, via spliceosome	19874820.	IMP	Process
GO:0000398	mRNA splicing, via spliceosome	9731529.11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	9731529.	NAS	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0005515	protein binding	17435768.18457437.19874820.20467437.21988832.24965446.25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	19874820.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	9731529.	IDA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016070	RNA metabolic process	-	TAS	Process
GO:0016363	nuclear matrix	19874820.	IDA	Component
GO:0019904	protein domain specific binding	11984006.	IPI	Function
GO:0042382	paraspeckles	19874820.	IDA	Component
GO:0062023	collagen-containing extracellular matrix	23658023.	HDA	Component
GO:0070062	extracellular exosome	23533145.	HDA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component
GO:0071014	post-mRNA release spliceosomal complex	21873635.	IBA	Component
GO:1990904	ribonucleoprotein complex	21873635.	IBA	Component
GO:2000815	regulation of mRNA stability involved in response to oxidative stress	21873635.	IBA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24840202	Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing.	Genes Dev	2014 Jun 1	Xu Y	doi: 10.1101/gad.241968.114
18790094	cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins.	Biochim Biophys Acta	2008 Dec	Russo A	doi: 10.1016/j.bbagrm.2008.08.006
24381081	Identification of HnRNP M as a novel biomarker for colorectal carcinoma by quantitative proteomics.	Am J Physiol Gastrointest Liver Physiol	2014 Mar 1	Chen S	doi: 10.1152/ajpgi.00328.2013
28609484	The clinical and prognostic correlation of HRNPM and SLC1A5 in pathogenesis and prognosis in epithelial ovarian cancer.	PLoS One	2017 Jun 13	Bjersand K	doi: 10.1371/journal.pone.0179363
28393427	HnRNPM and CD44s expression affects tumor aggressiveness and predicts poor prognosis in breast cancer with axillary lymph node metastases.	Genes Chromosomes Cancer	2017 Aug	Sun H	doi: 10.1002/gcc.22463

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr19	8466335	Missense_Mutation	novel	R244H	0.38
BLCA	chr19	8445082	Silent	novel	P28P	0.8
BLCA	chr19	8488759	Missense_Mutation	novel	E700Q	0.41
BLCA	chr19	8488944	3'UTR	novel		0.33
BLCA	chr19	8468803	Silent	NA	F288F	0.33
BLCA	chr19	8488922	3'UTR	novel		0.4
BLCA	chr19	8462577	Nonsense_Mutation	novel	S111*	0.3
BLCA	chr19	8485688	Silent	rs76937953	G420G	0.25
BLCA	chr19	8486222	Silent	novel	P598P	0.27
BRCA	chr19	8468777	Missense_Mutation	NA	E280K	0.18
BRCA	chr19	8486156	Silent	novel	L576L	0.09
BRCA	chr19	8485828	Missense_Mutation	novel	S467F	0.28
BRCA	chr19	8485615	Missense_Mutation	NA	G396E	0.34
BRCA	chr19	8466334	Missense_Mutation	NA	R244C	0.14
CESC	chr19	8489041	3'UTR	novel		0.16
CESC	chr19	8486020	Missense_Mutation	novel	R531P	0.07
CESC	chr19	8486118	In_Frame_Ins	novel	E564delinsAQ	0.07
CESC	chr19	8486119	Frame_Shift_Ins	novel	*E564Dfs42**	0.07
CESC	chr19	8483182	Missense_Mutation	novel	R382I	0.4
CESC	chr19	8485914	Missense_Mutation	novel	R496C	0.2
CESC	chr19	8486097	Missense_Mutation	novel	R557C	0.37
CESC	chr19	8487074	Splice_Region	rs758539257	C676C	0.31
CESC	chr19	8471385	Missense_Mutation	novel	H319Y	0.37
CESC	chr19	8468806	Silent	novel	F289F	0.22
CESC	chr19	8474237	Silent	rs746832500	R371R	0.25
CESC	chr19	8467581	Missense_Mutation	novel	K277N	0.47
CHOL	chr19	8462574	Missense_Mutation	novel	K110T	0.31
COAD	chr19	8488777	Missense_Mutation	novel	E706K	0.08
COAD	chr19	8473699	Frame_Shift_Del	novel	*M346Wfs22**	0.25
COAD	chr19	8485659	Missense_Mutation	novel	L411F	0.19
COAD	chr19	8467547	Missense_Mutation	NA	G266D	0.35
COAD	chr19	8488704	Silent	rs754289633	Y681Y	0.26
COAD	chr19	8463619	Missense_Mutation	novel	S124I	0.22
COAD	chr19	8468834	Missense_Mutation	novel	H299Y	0.14
COAD	chr19	8488650	Intron	novel		0.3
COAD	chr19	8489077	3'UTR	novel		0.43
COAD	chr19	8488708	Missense_Mutation	NA	D683N	0.33
COAD	chr19	8488678	Intron	novel		0.25
COAD	chr19	8483159	Missense_Mutation	NA	E374D	0.17
COAD	chr19	8486077	Missense_Mutation	rs775519970	R550H	0.24
COAD	chr19	8463687	Splice_Site	novel	X146_splice	0.08
COAD	chr19	8463688	Splice_Region	novel		0.07
COAD	chr19	8463656	Silent	rs778365609	S136S	0.17
ESCA	chr19	8485777	Missense_Mutation	novel	M450R	0.31
ESCA	chr19	8485885	Missense_Mutation	novel	M486T	0.3
GBM	chr19	8455454	Missense_Mutation	novel	K55Q	0.53
GBM	chr19	8488631	Intron	novel		0.16
GBM	chr19	8463619	Missense_Mutation	novel	S124N	0.52
GBM	chr19	8485735	Missense_Mutation	rs767065531	R436H	0.11
GBM	chr19	8487033	Missense_Mutation	novel	D663N	0.27
GBM	chr19	8463594	Missense_Mutation	novel	V116L	0.17
HNSC	chr19	8486014	Missense_Mutation	NA	M529T	0.48
HNSC	chr19	8466358	Missense_Mutation	novel	E252Q	0.05
HNSC	chr19	8487021	Splice_Region	novel		0.13
HNSC	chr19	8488876	3'UTR	novel		0.34
HNSC	chr19	8487068	Silent	rs753706820	N674N	0.11
HNSC	chr19	8485622	Silent	novel	V398V	0.19
HNSC	chr19	8485623	Missense_Mutation	novel	P399S	0.19
HNSC	chr19	8486144	Frame_Shift_Ins	novel	*A573Gfs33**	0.21
KIRC	chr19	8463622	Missense_Mutation	NA	M125K	0.21
KIRP	chr19	8486274	Missense_Mutation	rs199749036	G616S	0.37
KIRP	chr19	8488870	3'UTR	novel		0.35
LAML	chr19	8485647	Missense_Mutation	novel	G407S	0.05
LAML	chr19	8486168	Silent	novel	G580G	0.14
LAML	chr19	8455464	Missense_Mutation	novel	G58D	0.06
LGG	chr19	8463497	Missense_Mutation	novel	G113R	0.17
LIHC	chr19	8455545	Missense_Mutation	NA	Q85R	0.32
LIHC	chr19	8485730	Frame_Shift_Del	novel	*I434Mfs94**	0.38
LUAD	chr19	8468819	Missense_Mutation	novel	P294S	0.29
LUAD	chr19	8463647	Missense_Mutation	NA	N133K	0.21
LUAD	chr19	8485844	Missense_Mutation	novel	M472I	0.28
LUAD	chr19	8486269	Missense_Mutation	novel	G614V	0.94
LUAD	chr19	8485774	Missense_Mutation	NA	R449L	0.54
LUAD	chr19	8474167	Missense_Mutation	novel	G348V	0.24
LUAD	chr19	8485725	Missense_Mutation	NA	E433K	0.07
LUAD	chr19	8462561	Missense_Mutation	NA	D106N	0.26
LUAD	chr19	8483162	Missense_Mutation	NA	I375M	0.19
LUSC	chr19	8488794	Missense_Mutation	novel	M711I	0.24
LUSC	chr19	8485797	Missense_Mutation	rs760285171	M457V	0.17
LUSC	chr19	8485840	Missense_Mutation	NA	R471P	0.22
LUSC	chr19	8466235	Splice_Region	NA	L211L	0.2
OV	chr19	8455506	In_Frame_Ins	novel	R72_A73insVLLCCP	0.04
OV	chr19	8465461	Missense_Mutation	novel	E192D	0.18	HnRNP_M
OV	chr19	8485846	Missense_Mutation	novel	G473V	0.26
OV	chr19	8485847	Silent	rs754042490	G473G	0.26
OV	chr19	8465329	Silent	novel	P148P	0.42
OV	chr19	8488663	Intron	novel		0.18
OV	chr19	8466248	Missense_Mutation	novel	V215A	0.04
OV	chr19	8485658	Frame_Shift_Del	novel	*L411Sfs117**	0.08
PAAD	chr19	8463631	Missense_Mutation	novel	A128D	0.21
PAAD	chr19	8483173	Missense_Mutation	novel	A379V	0.12
PAAD	chr19	8485999	Missense_Mutation	NA	R524H	0.19
PAAD	chr19	8486019	Missense_Mutation	novel	R531C	0.18
PAAD	chr19	8486330	Silent	rs779025522	F634F	0.11
READ	chr19	8488758	Silent	rs201359498	F699F	0.36
READ	chr19	8463684	Nonsense_Mutation	novel	E146*	0.23
READ	chr19	8485720	Missense_Mutation	NA	G431D	0.23
SARC	chr19	8473704	Missense_Mutation	rs140407642	M346I	0.19
SARC	chr19	8489013	3'UTR	novel		0.16
SARC	chr19	8486046	Missense_Mutation	novel	G540S	0.28
SARC	chr19	8471421	Missense_Mutation	novel	P331S	0.7
SKCM	chr19	8485612	Missense_Mutation	NA	G395E	0.46
SKCM	chr19	8465468	Missense_Mutation	NA	H195Y	0.27	HnRNP_M
SKCM	chr19	8485632	Missense_Mutation	novel	E402K	0.23
SKCM	chr19	8485763	Silent	rs374672886	G445G	0.33
SKCM	chr19	8465327	Missense_Mutation	novel	P148S	0.1
SKCM	chr19	8465328	Missense_Mutation	novel	P148L	0.09
SKCM	chr19	8466365	Missense_Mutation	novel	S254F	0.26
SKCM	chr19	8466366	Silent	NA	S254S	0.26
SKCM	chr19	8488876	3'UTR	novel		0.29
SKCM	chr19	8462579	Missense_Mutation	NA	R112G	0.58
SKCM	chr19	8486076	Missense_Mutation	rs775936036	R550C	0.43
SKCM	chr19	8485743	Silent	NA	L439L	0.09
SKCM	chr19	8488680	Intron	novel		0.36
SKCM	chr19	8474220	Missense_Mutation	NA	G366R	0.16
SKCM	chr19	8485624	Missense_Mutation	novel	P399L	0.44
SKCM	chr19	8474193	Missense_Mutation	NA	M357L	0.22
SKCM	chr19	8471358	Missense_Mutation	NA	P310S	0.62
SKCM	chr19	8485713	Missense_Mutation	rs770127136	R429C	0.33
SKCM	chr19	8485722	Frame_Shift_Del	novel	*S432Pfs96**	0.27
SKCM	chr19	8485723	Missense_Mutation	novel	S432C	0.28
SKCM	chr19	8488673	Intron	novel		0.23
SKCM	chr19	8465486	Missense_Mutation	NA	R201G	0.38	HnRNP_M
STAD	chr19	8486184	Missense_Mutation	novel	A586T	0.19
STAD	chr19	8486245	Missense_Mutation	rs759532478	R606H	0.21
STAD	chr19	8488830	Silent	rs760801677	D723D	0.59
STAD	chr19	8466327	Silent	NA	G241G	0.38
STAD	chr19	8455445	Frame_Shift_Del	novel	*N53Tfs2**	0.21
STAD	chr19	8462546	Missense_Mutation	NA	V101M	0.1
STAD	chr19	8465355	Missense_Mutation	NA	M157T	0.07
STAD	chr19	8471402	Silent	rs17179758	I324I	0.36
STAD	chr19	8468816	Missense_Mutation	NA	R293C	0.38
STAD	chr19	8468835	Splice_Site	NA	X299_splice	0.24
STAD	chr19	8471328	Missense_Mutation	novel	G300S	0.62
STAD	chr19	8485754	Silent	NA	D442D	0.08
STAD	chr19	8471388	Silent	NA	L320L	0.12
STAD	chr19	8466327	Silent	NA	G241G	0.17
STAD	chr19	8483176	Missense_Mutation	NA	L380P	0.16
STAD	chr19	8462564	Missense_Mutation	novel	A107T	0.36
STAD	chr19	8463624	Frame_Shift_Del	novel	*A128Lfs5**	0.2
STAD	chr19	8485662	Frame_Shift_Del	novel	*G413Vfs115**	0.09
STAD	chr19	8485882	Missense_Mutation	NA	R485H	0.23
STAD	chr19	8485875	Missense_Mutation	rs746414049	V483M	0.18
STAD	chr19	8485656	Missense_Mutation	NA	R410C	0.09
STAD	chr19	8486031	Missense_Mutation	rs770001698	A535T	0.2
TGCT	chr19	8474222	Silent	novel	G366G	0.13
UCEC	chr19	8485773	Missense_Mutation	NA	R449C	0.57
UCEC	chr19	8489044	3'UTR	novel		0.17
UCEC	chr19	8468824	Missense_Mutation	novel	Q295H	0.48
UCEC	chr19	8488882	3'UTR	rs751099556		0.46
UCEC	chr19	8485680	Missense_Mutation	novel	R418C	0.37
UCEC	chr19	8471402	Silent	rs17179758	I324I	0.49
UCEC	chr19	8489097	3'UTR	novel		0.31
UCEC	chr19	8468803	Missense_Mutation	novel	F288L	0.37
UCEC	chr19	8474208	Nonsense_Mutation	novel	R362*	0.32
UCEC	chr19	8483172	Missense_Mutation	novel	A379T	0.36
UCEC	chr19	8487044	Nonsense_Mutation	novel	W666*	0.08
UCEC	chr19	8467576	Missense_Mutation	NA	V276I	0.16
UCEC	chr19	8473684	Nonsense_Mutation	novel	G340*	0.18
UCEC	chr19	8486011	Missense_Mutation	novel	S528N	0.33
UCEC	chr19	8486304	Nonsense_Mutation	novel	E626*	0.18
UCEC	chr19	8488848	Silent	rs377572358	N729N	0.29
UCEC	chr19	8486352	Missense_Mutation	novel	G642R	0.38
UCEC	chr19	8467576	Missense_Mutation	NA	V276I	0.05
UCEC	chr19	8465336	Nonsense_Mutation	novel	E151*	0.31
UCEC	chr19	8486244	Missense_Mutation	rs753670215	R606C	0.16
UCEC	chr19	8467586	Splice_Site	novel	X278_splice	0.29
UCEC	chr19	8488895	3'UTR	novel		0.42
UCEC	chr19	8486387	Silent	novel	C653C	0.22
UCEC	chr19	8465373	Missense_Mutation	rs370089104	T163M	0.33
UCEC	chr19	8485881	Missense_Mutation	rs746553013	R485C	0.35
UCEC	chr19	8486330	Silent	rs779025522	F634F	0.35
UCEC	chr19	8488652	Intron	rs771427264		0.32
UCEC	chr19	8466370	Nonsense_Mutation	novel	E256*	0.3
UCEC	chr19	8487033	Missense_Mutation	novel	D663N	0.37
UCEC	chr19	8455485	Missense_Mutation	novel	A65V	0.49
UCEC	chr19	8466278	Missense_Mutation	novel	S225N	0.36
UCEC	chr19	8487039	Missense_Mutation	novel	T665A	0.43
UCEC	chr19	8455445	Frame_Shift_Del	novel	*N53Tfs2**	0.44
UCEC	chr19	8488706	Missense_Mutation	NA	A682V	0.2
UCEC	chr19	8485734	Missense_Mutation	novel	R436C	0.41
UCEC	chr19	8455568	Nonsense_Mutation	NA	E93*	0.09
UCEC	chr19	8486211	Missense_Mutation	rs761146065	A595T	0.31
UCEC	chr19	8485677	Missense_Mutation	novel	E417K	0.28
UCEC	chr19	8485838	Missense_Mutation	novel	E470D	0.2
UCEC	chr19	8473703	Missense_Mutation	novel	M346R	0.17
UCEC	chr19	8488822	Missense_Mutation	novel	E721K	0.23
UCEC	chr19	8489028	3'UTR	novel		0.14
UCEC	chr19	8486175	Missense_Mutation	rs773146380	R583C	0.42
UCEC	chr19	8485808	Silent	novel	L460L	0.34
UCEC	chr19	8466334	Missense_Mutation	NA	R244C	0.37
UCEC	chr19	8485932	Missense_Mutation	rs758640078	D502N	0.42
UCEC	chr19	8486019	Missense_Mutation	novel	R531C	0.27
UCEC	chr19	8488758	Silent	rs201359498	F699F	0.6
UCEC	chr19	8486082	Missense_Mutation	NA	A552T	0.33
UCEC	chr19	8466239	Missense_Mutation	novel	D212G	0.11
UCEC	chr19	8488665	Intron	rs374678635		0.16
UCEC	chr19	8465393	Nonsense_Mutation	novel	G170*	0.6
UCEC	chr19	8485957	Missense_Mutation	rs780668980	R510H	0.14
UCEC	chr19	8463663	Missense_Mutation	rs770428991	G139R	0.41
UCEC	chr19	8488764	Silent	rs115721524	S701S	0.47
UCEC	chr19	8445046	Silent	NA	I16I	0.32
UCEC	chr19	8486393	Missense_Mutation	novel	I655M	0.19
UCEC	chr19	8485780	Missense_Mutation	novel	G451V	0.13
UCEC	chr19	8486330	Silent	rs779025522	F634F	0.18
UCEC	chr19	8488758	Silent	rs201359498	F699F	0.45
UCEC	chr19	8463624	Frame_Shift_Del	novel	*A128Lfs5**	0.31
UCEC	chr19	8485794	Missense_Mutation	NA	R456C	0.29
UCEC	chr19	8489041	3'UTR	novel		0.25
UCEC	chr19	8455574	Missense_Mutation	NA	V95F	0.21
UCEC	chr19	8463643	Missense_Mutation	NA	L132P	0.37
UCEC	chr19	8466334	Missense_Mutation	NA	R244C	0.37
UCEC	chr19	8485794	Missense_Mutation	NA	R456C	0.4
UCEC	chr19	8486330	Silent	rs779025522	F634F	0.37
UCEC	chr19	8465497	Silent	novel	S204S	0.29
UCEC	chr19	8467574	Missense_Mutation	novel	H275R	0.37
UCEC	chr19	8486145	Missense_Mutation	rs778586401	A573T	0.54
UCEC	chr19	8488835	Missense_Mutation	novel	R725Q	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
READ	DEL	0.103	0.23023
THCA	DEL	0.014	0.10598

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0022	Kaplan-Meier Survival Analysis
KIRC	0.00012	Kaplan-Meier Survival Analysis
STAD	0.0033	Kaplan-Meier Survival Analysis
SARC	0.013	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
HNSC	0.012	Kaplan-Meier Survival Analysis
PRAD	0.03	Kaplan-Meier Survival Analysis
KIRP	0.027	Kaplan-Meier Survival Analysis
PAAD	0.0094	Kaplan-Meier Survival Analysis
READ	0.0037	Kaplan-Meier Survival Analysis
LIHC	0.00012	Kaplan-Meier Survival Analysis
DLBC	0.0097	Kaplan-Meier Survival Analysis
LUAD	0.03	Kaplan-Meier Survival Analysis
UVM	0.011	Kaplan-Meier Survival Analysis
OV	0.048	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742