EuRBPDB

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  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000099821 (Gene tree)
Gene ID
5442
Gene Symbol
POLRMT
Alias
h-mtRPOL|APOLMT|MTRNAP|MTRPOL
Full Name
RNA polymerase mitochondrial
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
16,382 bases
Position
chr19:617,223-633,604
Accession
9200
RBP type
canonical RBP
Summary
This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000465759RNA_polPF00940.196.7e-16311
ENSP00000468658RNA_polPF00940.191.7e-4111
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
19951946Nuclear respiratory factor 2 induces the expression of many but not all human proteins acting in mitochondrial DNA transcription and replication.J Biol Chem2010 Feb 5Bruni Fdoi: 10.1074/jbc.M109.044305
17557812Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression.Nucleic Acids Res2007Cotney J-
17392338Cloning of the sea urchin mitochondrial RNA polymerase and reconstitution of the transcription termination system.Nucleic Acids Res2007Polosa PL-
17337445Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression.J Biol Chem2007 Apr 27Wang Z-
25612828Suppression of Mic60 compromises mitochondrial transcription and oxidative phosphorylation.Sci Rep2015 Jan 23Yang RFdoi: 10.1038/srep07990.
30190598Structural basis of mitochondrial transcription.Nat Struct Mol Biol2018 SepHillen HSdoi: 10.1038/s41594-018-0122-9
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000589961POLRMT-203490--- (aa)--
ENST00000592633POLRMT-207469--- (aa)--
ENST00000587057POLRMT-2011229--- (aa)--
ENST00000592863POLRMT-208966-ENSP0000047352456 (aa)-R4GN79
ENST00000588649POLRMT-2023835XM_005259580ENSP000004657591230 (aa)XP_005259637O00411
ENST00000590573POLRMT-2051043-ENSP00000466504347 (aa)-K7EMH3
ENST00000590709POLRMT-2061106--- (aa)--
ENST00000590336POLRMT-204380-ENSP00000468658127 (aa)-K7ESD1
Gene Model
Click here to download ENSG00000099821's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000099821Platelet Function Tests1.9769800E-005-
ENSG00000099821Blood Pressure1.8383163E-005-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000099821's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000099821POLRMT6874.419ENSAPOG00000003942polrmt8050.185Acanthochromis_polyacanthus
ENSG00000099821POLRMT10070.257ENSAMEG00000002745POLRMT10070.257Ailuropoda_melanoleuca
ENSG00000099821POLRMT6673.810ENSACIG00000016078polrmt9847.520Amphilophus_citrinellus
ENSG00000099821POLRMT6874.419ENSAOCG00000020208polrmt9447.001Amphiprion_ocellaris
ENSG00000099821POLRMT6874.419ENSAPEG00000007949polrmt9247.073Amphiprion_percula
ENSG00000099821POLRMT7668.041ENSATEG00000024025polrmt9446.728Anabas_testudineus
ENSG00000099821POLRMT6975.862ENSAPLG00000003051POLRMT9953.314Anas_platyrhynchos
ENSG00000099821POLRMT9977.616ENSANAG00000032916POLRMT9977.616Aotus_nancymaae
ENSG00000099821POLRMT6673.810ENSACLG00000003766polrmt7851.275Astatotilapia_calliptera
ENSG00000099821POLRMT9360.903ENSAMXG00000018258polrmt9660.903Astyanax_mexicanus
ENSG00000099821POLRMT10068.006ENSBTAG00000015051POLRMT10068.006Bos_taurus
ENSG00000099821POLRMT6654.762WBGene00013680rpom-16435.294Caenorhabditis_elegans
ENSG00000099821POLRMT9975.912ENSCJAG00000012913POLRMT9975.912Callithrix_jacchus
ENSG00000099821POLRMT10070.170ENSCAFG00000019711POLRMT10070.170Canis_familiaris
ENSG00000099821POLRMT10070.170ENSCAFG00020016843POLRMT10070.170Canis_lupus_dingo
ENSG00000099821POLRMT10067.687ENSCHIG00000013267POLRMT10067.687Capra_hircus
ENSG00000099821POLRMT8971.451ENSCAPG00000016900POLRMT10071.451Cavia_aperea
ENSG00000099821POLRMT10061.421ENSCPOG00000023061POLRMT10061.421Cavia_porcellus
ENSG00000099821POLRMT10077.166ENSCCAG00000025014POLRMT10077.166Cebus_capucinus
ENSG00000099821POLRMT10087.551ENSCATG00000040393POLRMT10087.551Cercocebus_atys
ENSG00000099821POLRMT10064.948ENSCLAG00000007473POLRMT9064.948Chinchilla_lanigera
ENSG00000099821POLRMT10086.268ENSCSAG00000012942POLRMT10086.268Chlorocebus_sabaeus
ENSG00000099821POLRMT9750.456ENSCPBG00000009869POLRMT9951.167Chrysemys_picta_bellii
ENSG00000099821POLRMT7461.458ENSCING00000024450-10050.622Ciona_intestinalis
ENSG00000099821POLRMT8157.282ENSCSAVG00000000440-9944.621Ciona_savignyi
ENSG00000099821POLRMT10088.483ENSCANG00000038011POLRMT10088.483Colobus_angolensis_palliatus
ENSG00000099821POLRMT9578.029ENSCGRG00001021311Polrmt10078.029Cricetulus_griseus_chok1gshd
ENSG00000099821POLRMT10064.834ENSCGRG00000011134Polrmt10064.834Cricetulus_griseus_crigri
ENSG00000099821POLRMT7667.010ENSCSEG00000002734polrmt7751.976Cynoglossus_semilaevis
ENSG00000099821POLRMT9646.378ENSCVAG00000005949polrmt9846.378Cyprinodon_variegatus
ENSG00000099821POLRMT9746.457ENSDARG00000101220polrmt9646.457Danio_rerio
ENSG00000099821POLRMT9477.561ENSDORG00000014125Polrmt9977.561Dipodomys_ordii
ENSG00000099821POLRMT6768.235FBgn0261938mtRNApol7742.563Drosophila_melanogaster
ENSG00000099821POLRMT10064.943ENSETEG00000003476POLRMT10065.105Echinops_telfairi
ENSG00000099821POLRMT6575.904ENSEBUG00000013453-9949.353Eptatretus_burgeri
ENSG00000099821POLRMT10072.595ENSEASG00005021493POLRMT10072.838Equus_asinus_asinus
ENSG00000099821POLRMT10072.595ENSECAG00000032711POLRMT10072.757Equus_caballus
ENSG00000099821POLRMT7866.667ENSELUG00000019319polrmt9645.988Esox_lucius
ENSG00000099821POLRMT10071.625ENSFCAG00000018808POLRMT10071.706Felis_catus
ENSG00000099821POLRMT8447.564ENSFALG00000013910POLRMT9947.597Ficedula_albicollis
ENSG00000099821POLRMT10061.064ENSFDAG00000020312POLRMT10061.141Fukomys_damarensis
ENSG00000099821POLRMT8062.500ENSFHEG00000021239polrmt8849.327Fundulus_heteroclitus
ENSG00000099821POLRMT6774.419ENSGMOG00000011829polrmt10045.733Gadus_morhua
ENSG00000099821POLRMT6971.264ENSGALG00000001377POLRMT9848.118Gallus_gallus
ENSG00000099821POLRMT6972.414ENSGAFG00000003953polrmt7751.556Gambusia_affinis
ENSG00000099821POLRMT9546.307ENSGACG00000012957polrmt10046.307Gasterosteus_aculeatus
ENSG00000099821POLRMT9551.312ENSGAGG00000005522POLRMT10051.312Gopherus_agassizii
ENSG00000099821POLRMT9988.761ENSGGOG00000023264-9697.516Gorilla_gorilla
ENSG00000099821POLRMT6673.810ENSHBUG00000010005polrmt7651.176Haplochromis_burtoni
ENSG00000099821POLRMT9469.672ENSHGLG00000019286POLRMT9267.694Heterocephalus_glaber_female
ENSG00000099821POLRMT10063.835ENSHGLG00100005762POLRMT10064.320Heterocephalus_glaber_male
ENSG00000099821POLRMT8663.393ENSHCOG00000001565polrmt9646.344Hippocampus_comes
ENSG00000099821POLRMT9747.577ENSIPUG00000000789polrmt9647.419Ictalurus_punctatus
ENSG00000099821POLRMT9384.974ENSSTOG00000003431POLRMT9984.974Ictidomys_tridecemlineatus
ENSG00000099821POLRMT9476.812ENSJJAG00000012916Polrmt9976.812Jaculus_jaculus
ENSG00000099821POLRMT9745.565ENSKMAG00000004426polrmt9645.565Kryptolebias_marmoratus
ENSG00000099821POLRMT6675.000ENSLBEG00000016529polrmt9645.031Labrus_bergylta
ENSG00000099821POLRMT9747.961ENSLACG00000011518POLRMT9947.961Latimeria_chalumnae
ENSG00000099821POLRMT6774.118ENSLOCG00000005222polrmt9641.726Lepisosteus_oculatus
ENSG00000099821POLRMT9869.104ENSLAFG00000001860POLRMT9869.597Loxodonta_africana
ENSG00000099821POLRMT10087.551ENSMFAG00000031466POLRMT10087.551Macaca_fascicularis
ENSG00000099821POLRMT10087.470ENSMNEG00000039129POLRMT10087.470Macaca_nemestrina
ENSG00000099821POLRMT8892.918ENSMLEG00000037404POLRMT10092.918Mandrillus_leucophaeus
ENSG00000099821POLRMT8858.261ENSMAMG00000019284polrmt7751.074Mastacembelus_armatus
ENSG00000099821POLRMT6673.810ENSMZEG00005009932polrmt7851.275Maylandia_zebra
ENSG00000099821POLRMT9548.441ENSMGAG00000003243POLRMT9948.908Meleagris_gallopavo
ENSG00000099821POLRMT9479.160ENSMAUG00000019392Polrmt10079.160Mesocricetus_auratus
ENSG00000099821POLRMT10073.565ENSMICG00000016701POLRMT10073.565Microcebus_murinus
ENSG00000099821POLRMT10063.086ENSMOCG00000008868Polrmt10063.086Microtus_ochrogaster
ENSG00000099821POLRMT9143.438ENSMMOG00000000705polrmt9543.438Mola_mola
ENSG00000099821POLRMT9951.154ENSMODG00000006478POLRMT9950.994Monodelphis_domestica
ENSG00000099821POLRMT9744.917ENSMALG00000021224polrmt9644.917Monopterus_albus
ENSG00000099821POLRMT9478.744MGP_CAROLIEiJ_G0015538Polrmt10078.744Mus_caroli
ENSG00000099821POLRMT9479.388ENSMUSG00000020329Polrmt10079.388Mus_musculus
ENSG00000099821POLRMT9478.905MGP_PahariEiJ_G0030951Polrmt10078.905Mus_pahari
ENSG00000099821POLRMT9479.388MGP_SPRETEiJ_G0016356Polrmt10079.388Mus_spretus
ENSG00000099821POLRMT10068.790ENSMPUG00000009910POLRMT10068.790Mustela_putorius_furo
ENSG00000099821POLRMT10069.611ENSMLUG00000009223POLRMT10069.611Myotis_lucifugus
ENSG00000099821POLRMT9478.744ENSNGAG00000005498Polrmt10078.744Nannospalax_galili
ENSG00000099821POLRMT6673.810ENSNBRG00000023530polrmt7651.190Neolamprologus_brichardi
ENSG00000099821POLRMT10093.821ENSNLEG00000000718POLRMT10093.821Nomascus_leucogenys
ENSG00000099821POLRMT7076.952ENSOPRG00000013579POLRMT7376.952Ochotona_princeps
ENSG00000099821POLRMT6672.619ENSONIG00000002405polrmt10046.817Oreochromis_niloticus
ENSG00000099821POLRMT5074.603ENSOANG00000031632-6174.603Ornithorhynchus_anatinus
ENSG00000099821POLRMT7767.327ENSORLG00000004329polrmt9345.899Oryzias_latipes
ENSG00000099821POLRMT8763.717ENSORLG00020003896polrmt9645.953Oryzias_latipes_hni
ENSG00000099821POLRMT7767.327ENSORLG00015022238polrmt9445.732Oryzias_latipes_hsok
ENSG00000099821POLRMT7768.317ENSOMEG00000008292polrmt9647.165Oryzias_melastigma
ENSG00000099821POLRMT10073.888ENSOGAG00000007912POLRMT10073.888Otolemur_garnettii
ENSG00000099821POLRMT8876.240ENSOARG00000008898POLRMT9276.240Ovis_aries
ENSG00000099821POLRMT10097.321ENSPPAG00000030853POLRMT9997.321Pan_paniscus
ENSG00000099821POLRMT9994.959ENSPPAG00000043321-9994.959Pan_paniscus
ENSG00000099821POLRMT8781.766ENSPPRG00000001547POLRMT9381.766Panthera_pardus
ENSG00000099821POLRMT9995.673ENSPTRG00000039638-9995.673Pan_troglodytes
ENSG00000099821POLRMT10097.642ENSPTRG00000010157POLRMT9697.642Pan_troglodytes
ENSG00000099821POLRMT10086.500ENSPANG00000006649POLRMT10086.500Papio_anubis
ENSG00000099821POLRMT7866.990ENSPKIG00000024580polrmt9547.206Paramormyrops_kingsleyae
ENSG00000099821POLRMT6772.941ENSPMGG00000014627polrmt8551.275Periophthalmus_magnuspinnatus
ENSG00000099821POLRMT10064.677ENSPEMG00000011671Polrmt10064.677Peromyscus_maniculatus_bairdii
ENSG00000099821POLRMT7049.829ENSPMAG00000005070-9949.829Petromyzon_marinus
ENSG00000099821POLRMT9951.074ENSPCIG00000006103POLRMT9951.074Phascolarctos_cinereus
ENSG00000099821POLRMT9745.174ENSPFOG00000003911polrmt10044.502Poecilia_formosa
ENSG00000099821POLRMT8544.821ENSPLAG00000005743polrmt9444.821Poecilia_latipinna
ENSG00000099821POLRMT9745.922ENSPMEG00000008947polrmt9945.922Poecilia_mexicana
ENSG00000099821POLRMT7039.527ENSPMEG00000011484polrmt9539.527Poecilia_mexicana
ENSG00000099821POLRMT6972.414ENSPREG00000007650polrmt9644.801Poecilia_reticulata
ENSG00000099821POLRMT9495.708ENSPPYG00000009282POLRMT10095.708Pongo_abelii
ENSG00000099821POLRMT10062.339ENSPCAG00000010816POLRMT10062.339Procavia_capensis
ENSG00000099821POLRMT10071.417ENSPCOG00000014539POLRMT10071.417Propithecus_coquereli
ENSG00000099821POLRMT10069.992ENSPVAG00000008403POLRMT10070.073Pteropus_vampyrus
ENSG00000099821POLRMT6574.699ENSPNYG00000020790polrmt7650.980Pundamilia_nyererei
ENSG00000099821POLRMT9746.305ENSPNAG00000019790polrmt9647.127Pygocentrus_nattereri
ENSG00000099821POLRMT10064.891ENSRNOG00000024879Polrmt10064.891Rattus_norvegicus
ENSG00000099821POLRMT10088.889ENSRBIG00000006728POLRMT10088.889Rhinopithecus_bieti
ENSG00000099821POLRMT10088.340ENSRROG00000040809POLRMT10088.340Rhinopithecus_roxellana
ENSG00000099821POLRMT9975.507ENSSBOG00000025388POLRMT9975.507Saimiri_boliviensis_boliviensis
ENSG00000099821POLRMT6858.621ENSSHAG00000009387-10056.843Sarcophilus_harrisii
ENSG00000099821POLRMT6876.744ENSSFOG00015005074polrmt9946.954Scleropages_formosus
ENSG00000099821POLRMT6575.904ENSSMAG00000011851polrmt9644.237Scophthalmus_maximus
ENSG00000099821POLRMT7966.000ENSSDUG00000004410polrmt9646.366Seriola_dumerili
ENSG00000099821POLRMT7966.000ENSSLDG00000010643polrmt9646.147Seriola_lalandi_dorsalis
ENSG00000099821POLRMT7766.327ENSSPUG00000009181-10061.404Sphenodon_punctatus
ENSG00000099821POLRMT6675.000ENSSPAG00000018740polrmt7851.961Stegastes_partitus
ENSG00000099821POLRMT10070.508ENSSSCG00000035693POLRMT10070.588Sus_scrofa
ENSG00000099821POLRMT6579.518ENSTGUG00000000621POLRMT10055.341Taeniopygia_guttata
ENSG00000099821POLRMT9545.492ENSTRUG00000018040polrmt9445.575Takifugu_rubripes
ENSG00000099821POLRMT6675.000ENSTNIG00000010642polrmt10052.208Tetraodon_nigroviridis
ENSG00000099821POLRMT5267.241ENSTBEG00000001819-10067.241Tupaia_belangeri
ENSG00000099821POLRMT7679.765ENSTTRG00000011329POLRMT7579.765Tursiops_truncatus
ENSG00000099821POLRMT10070.493ENSUAMG00000019616POLRMT10070.574Ursus_americanus
ENSG00000099821POLRMT9767.024ENSVVUG00000022627POLRMT9967.024Vulpes_vulpes
ENSG00000099821POLRMT9748.847ENSXETG00000006545polrmt9648.847Xenopus_tropicalis
ENSG00000099821POLRMT9745.286ENSXMAG00000012464polrmt9845.286Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001018mitochondrial promoter sequence-specific DNA binding21873635.IBAFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003899DNA-directed 5'-3' RNA polymerase activity21873635.IBAFunction
GO:0003899DNA-directed 5'-3' RNA polymerase activity21278163.IDAFunction
GO:0003899DNA-directed 5'-3' RNA polymerase activity17337445.TASFunction
GO:0005515protein binding17337445.21278163.22003127.23283301.29445193.IPIFunction
GO:0005739mitochondrion17337445.IDAComponent
GO:0005759mitochondrial matrix29445193.IDAComponent
GO:0005759mitochondrial matrix-TASComponent
GO:0006390mitochondrial transcription21873635.IBAProcess
GO:0006390mitochondrial transcription21278163.IDAProcess
GO:0006390mitochondrial transcription17337445.TASProcess
GO:0006391transcription initiation from mitochondrial promoter-TASProcess
GO:0007005mitochondrion organization-TASProcess
GO:0032991protein-containing complex23283301.29445193.IDAComponent
GO:0034245mitochondrial DNA-directed RNA polymerase complex21873635.IBAComponent
GO:0042645mitochondrial nucleoid18063578.IDAComponent
GO:0043565sequence-specific DNA binding29445193.IDAFunction

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