EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000099917 (Gene tree)
Gene ID: 51586
Gene Symbol: MED15
Alias: TIG-1|CAG7A|Arc105|TNRC7|PCQAP
Full Name: mediator complex subunit 15
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 91,720 bases
Position: chr22:20,495,913-20,587,632
Accession: 14248
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000423862	MED15-207	581	-	ENSP00000408875	194 (aa)	-	H7C308
ENST00000451058	MED15-218	418	-	ENSP00000408742	105 (aa)	-	C9JM58
ENST00000476767	MED15-224	590	-	-	- (aa)	-	-
ENST00000382974	MED15-203	2235	-	ENSP00000372434	677 (aa)	-	Q96RN5
ENST00000493216	MED15-231	4701	-	-	- (aa)	-	-
ENST00000445987	MED15-217	590	-	ENSP00000407742	120 (aa)	-	C9JZV5
ENST00000414658	MED15-205	717	-	ENSP00000392738	141 (aa)	-	C9J1I1
ENST00000457322	MED15-219	623	-	ENSP00000415778	160 (aa)	-	C9JJ12
ENST00000420849	MED15-206	430	-	ENSP00000416109	36 (aa)	-	F8WCS1
ENST00000441501	MED15-214	840	-	ENSP00000413636	61 (aa)	-	F8WEJ4
ENST00000432052	MED15-210	598	-	ENSP00000408794	105 (aa)	-	C9JLN7
ENST00000489651	MED15-229	3563	-	-	- (aa)	-	-
ENST00000438962	MED15-213	573	-	ENSP00000410173	119 (aa)	-	C9JEM1
ENST00000487550	MED15-228	587	-	-	- (aa)	-	-
ENST00000433831	MED15-211	3267	-	ENSP00000391108	55 (aa)	-	F2Z2B7
ENST00000428629	MED15-209	572	-	ENSP00000413603	82 (aa)	-	C9JWK5
ENST00000486656	MED15-227	577	-	-	- (aa)	-	-
ENST00000473244	MED15-222	2733	-	-	- (aa)	-	-
ENST00000476187	MED15-223	593	-	-	- (aa)	-	-
ENST00000406969	MED15-204	3210	-	ENSP00000384344	722 (aa)	-	G3V1P5
ENST00000478831	MED15-226	707	-	-	- (aa)	-	-
ENST00000461076	MED15-220	826	-	-	- (aa)	-	-
ENST00000445189	MED15-216	596	-	ENSP00000390498	124 (aa)	-	C9JGN2
ENST00000263205	MED15-201	3351	-	ENSP00000263205	788 (aa)	-	Q96RN5
ENST00000492381	MED15-230	3619	-	-	- (aa)	-	-
ENST00000436496	MED15-212	393	-	-	- (aa)	-	-
ENST00000477824	MED15-225	571	-	-	- (aa)	-	-
ENST00000292733	MED15-202	3252	-	ENSP00000292733	748 (aa)	-	Q96RN5
ENST00000444094	MED15-215	551	-	ENSP00000409578	54 (aa)	-	F8WDM6
ENST00000424287	MED15-208	589	-	ENSP00000396461	165 (aa)	-	C9JCQ3
ENST00000473028	MED15-221	556	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000099917's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000099917	Platelet Function Tests	1.6993300E-005	-
ENSG00000099917	Platelet Function Tests	1.0517800E-005	-
ENSG00000099917	Platelet Function Tests	1.3335900E-005	-
ENSG00000099917	Platelet Function Tests	1.3335900E-005	-
ENSG00000099917	Platelet Function Tests	2.3858300E-005	-
ENSG00000099917	Platelet Function Tests	1.4629700E-005	-
ENSG00000099917	Platelet Function Tests	1.9104900E-005	-
ENSG00000099917	Platelet Function Tests	1.9104900E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000099917	rs1771149	22	20529162	T	Self-reported math ability	30038396	[0.0088-0.0182] unit decrease	0.0135	EFO_0004875
ENSG00000099917	rs1771149	22	20529162	T	Self-reported math ability (MTAG)	30038396	[0.0096-0.0182] unit decrease	0.0139	EFO_0004875
ENSG00000099917	rs1771149	22	20529162	T	Highest math class taken (MTAG)	30038396	[0.0079-0.0157] unit decrease	0.0118	EFO_0004875
ENSG00000099917	rs4820216	22	20499874	?	Lung function (FEV1)	30061609	[10.3-26.18] unit decrease	18.24	EFO_0004314
ENSG00000099917	rs4820216	22	20499874	T	Lung function (FEV1/FVC)	30061609	[0.002-0.004] unit decrease	0.003	EFO_0004713
ENSG00000099917	rs4820216	22	20499874	T	Lung function (FEV1/FVC)	30061609	[0.0028-0.0052] unit decrease	0.004	EFO_0004713

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000099917's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003712	transcription coregulator activity	-	IEA	Function
GO:0005515	protein binding	16799563.16904669.17500595.18385733.18568018.24882805.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016592	mediator complex	-	IEA	Component
GO:0019827	stem cell population maintenance	-	IEA	Process