EuRBPDB

Description

Ensembl ID: ENSG00000100014 (Gene tree)
Gene ID: 23384
Gene Symbol: SPECC1L
Alias: KIAA0376|CYTSA
Full Name: sperm antigen with calponin homology and coiled-coil domains 1 like
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 146,924 bases
Position: chr22:24,270,817-24,417,740
Accession: 29022
RBP type: non-canonical RBP
Summary: This gene encodes a coiled-coil domain containing protein. The encoded protein may play a critical role in actin-cytoskeletal reorganization during facial morphogenesis. Mutations in this gene are a cause of oblique facial clefting-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A read-through transcript composed of SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and the downstream ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000437398	SPECC1L-204	6674	-	ENSP00000393363	1117 (aa)	-	Q69YQ0
ENST00000472799	SPECC1L-206	767	-	-	- (aa)	-	-
ENST00000416735	SPECC1L-202	566	-	-	- (aa)	-	-
ENST00000421374	SPECC1L-203	2565	-	ENSP00000405671	788 (aa)	-	C9J8U1
ENST00000314328	SPECC1L-201	6756	-	ENSP00000325785	1117 (aa)	-	Q69YQ0
ENST00000440893	SPECC1L-205	612	-	ENSP00000414354	175 (aa)	-	C9JLY8
ENST00000541492	SPECC1L-207	3525	-	ENSP00000439633	1078 (aa)	-	Q69YQ0

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100014	Gastrointestinal Microbiome	3E-7	26528553

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100014	rs201838815	22	24357056	?	Severity of nausea and vomiting of pregnancy	29563502	[0.105-0.212] unit decrease	0.159	EFO_0009265
ENSG00000100014	rs3747113	22	24321550	?	Gut microbiome composition (summer)	26528553	[0.5-1.1] unit increase	0.8011847	EFO_0007753

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100014	SPECC1L	100	95.170	ENSMUSG00000033444	Specc1l	100	95.170	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005815	microtubule organizing center	21873635.	IBA	Component
GO:0005819	spindle	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005921	gap junction	-	IEA	Component
GO:0007049	cell cycle	-	IEA	Process
GO:0007155	cell adhesion	21703590.	IDA	Process
GO:0015629	actin cytoskeleton	-	IDA	Component
GO:0030036	actin cytoskeleton organization	21873635.	IBA	Process
GO:0031941	filamentous actin	21873635.	IBA	Component
GO:0051301	cell division	-	IEA	Process