EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100056 (Gene tree)
Gene ID: 8220
Gene Symbol: ESS2
Alias: DGSI|Es2el|ES2|DGS-H|ESS-2|bis1|DGCR13|DGCR14
Full Name: ess-2 splicing factor homolog
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 14,448 bases
Position: chr22:19,130,279-19,144,726
Accession: 16817
RBP type: canonical RBP
Summary: This gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The encoded protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000252137	Es2	PF09751.9	9.4e-74	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000469466	ESS2-203	581	-	-	- (aa)	-	-
ENST00000472073	ESS2-204	2101	-	-	- (aa)	-	-
ENST00000252137	ESS2-201	5392	XM_005261282	ENSP00000252137	476 (aa)	XP_005261339	Q96DF8
ENST00000434568	ESS2-202	1808	XM_011530403	ENSP00000388524	293 (aa)	XP_011528705	F8WEF8

Gene Model

Click here to download ENSG00000100056's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100056's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100056	ESS2	99	63.789	ENSAPOG00000014627	ess2	98	62.839	Acanthochromis_polyacanthus
ENSG00000100056	ESS2	100	91.649	ENSAMEG00000011256	ESS2	100	91.649	Ailuropoda_melanoleuca
ENSG00000100056	ESS2	93	68.161	ENSACIG00000016376	ess2	92	66.741	Amphilophus_citrinellus
ENSG00000100056	ESS2	99	63.789	ENSAOCG00000005751	ess2	98	62.839	Amphiprion_ocellaris
ENSG00000100056	ESS2	99	63.789	ENSAPEG00000010960	ess2	98	62.839	Amphiprion_percula
ENSG00000100056	ESS2	93	67.191	ENSATEG00000021644	ess2	92	67.191	Anabas_testudineus
ENSG00000100056	ESS2	100	72.765	ENSACAG00000002608	ESS2	100	72.765	Anolis_carolinensis
ENSG00000100056	ESS2	100	98.323	ENSANAG00000023850	ESS2	100	98.323	Aotus_nancymaae
ENSG00000100056	ESS2	94	67.188	ENSACLG00000016454	ess2	93	66.443	Astatotilapia_calliptera
ENSG00000100056	ESS2	95	66.004	ENSAMXG00000039721	ess2	97	65.121	Astyanax_mexicanus
ENSG00000100056	ESS2	100	90.167	ENSBTAG00000018534	ESS2	100	90.167	Bos_taurus
ENSG00000100056	ESS2	87	32.787	WBGene00018371	ess-2	88	31.976	Caenorhabditis_elegans
ENSG00000100056	ESS2	77	97.345	ENSCJAG00000001679	ESS2	91	86.029	Callithrix_jacchus
ENSG00000100056	ESS2	100	93.305	ENSCAFG00000014804	ESS2	100	93.933	Canis_familiaris
ENSG00000100056	ESS2	100	93.096	ENSCAFG00020010579	ESS2	100	93.724	Canis_lupus_dingo
ENSG00000100056	ESS2	100	89.958	ENSCHIG00000008099	ESS2	99	89.958	Capra_hircus
ENSG00000100056	ESS2	100	92.887	ENSTSYG00000003539	ESS2	100	92.887	Carlito_syrichta
ENSG00000100056	ESS2	91	79.398	ENSCAPG00000003617	ESS2	90	78.704	Cavia_aperea
ENSG00000100056	ESS2	100	92.857	ENSCPOG00000004596	ESS2	100	92.857	Cavia_porcellus
ENSG00000100056	ESS2	100	98.952	ENSCCAG00000021557	ESS2	100	98.952	Cebus_capucinus
ENSG00000100056	ESS2	100	99.370	ENSCATG00000044330	ESS2	100	99.370	Cercocebus_atys
ENSG00000100056	ESS2	100	95.168	ENSCLAG00000015255	ESS2	100	95.168	Chinchilla_lanigera
ENSG00000100056	ESS2	83	99.244	ENSCSAG00000011488	ESS2	100	99.244	Chlorocebus_sabaeus
ENSG00000100056	ESS2	99	75.000	ENSCPBG00000010360	ESS2	95	74.841	Chrysemys_picta_bellii
ENSG00000100056	ESS2	98	40.079	ENSCING00000016699	-	98	39.881	Ciona_intestinalis
ENSG00000100056	ESS2	100	96.218	ENSCANG00000001633	-	100	96.218	Colobus_angolensis_palliatus
ENSG00000100056	ESS2	100	99.160	ENSCANG00000031376	-	100	99.160	Colobus_angolensis_palliatus
ENSG00000100056	ESS2	100	93.067	ENSCGRG00001017846	Ess2	100	93.067	Cricetulus_griseus_chok1gshd
ENSG00000100056	ESS2	100	93.067	ENSCGRG00000002752	Ess2	100	93.067	Cricetulus_griseus_crigri
ENSG00000100056	ESS2	95	65.265	ENSCSEG00000015946	ess2	94	64.523	Cynoglossus_semilaevis
ENSG00000100056	ESS2	98	64.768	ENSCVAG00000021940	ess2	98	63.147	Cyprinodon_variegatus
ENSG00000100056	ESS2	93	67.191	ENSDARG00000060922	ess2	94	66.592	Danio_rerio
ENSG00000100056	ESS2	100	92.857	ENSDNOG00000031192	ESS2	100	92.857	Dasypus_novemcinctus
ENSG00000100056	ESS2	100	93.487	ENSDORG00000003784	Ess2	100	93.487	Dipodomys_ordii
ENSG00000100056	ESS2	93	35.477	FBgn0023506	Es2	91	35.062	Drosophila_melanogaster
ENSG00000100056	ESS2	51	52.245	ENSEBUG00000003457	ess2	83	52.245	Eptatretus_burgeri
ENSG00000100056	ESS2	100	89.518	ENSEASG00005006119	ESS2	100	89.937	Equus_asinus_asinus
ENSG00000100056	ESS2	78	90.086	ENSECAG00000014664	-	86	89.655	Equus_caballus
ENSG00000100056	ESS2	93	66.368	ENSELUG00000000923	ess2	93	66.368	Esox_lucius
ENSG00000100056	ESS2	100	94.748	ENSFCAG00000029613	ESS2	100	94.748	Felis_catus
ENSG00000100056	ESS2	93	73.318	ENSFALG00000007834	ESS2	92	72.646	Ficedula_albicollis
ENSG00000100056	ESS2	100	91.405	ENSFDAG00000010415	ESS2	100	92.872	Fukomys_damarensis
ENSG00000100056	ESS2	93	66.143	ENSFHEG00000013226	ess2	92	66.067	Fundulus_heteroclitus
ENSG00000100056	ESS2	93	63.288	ENSGMOG00000001357	ess2	97	62.613	Gadus_morhua
ENSG00000100056	ESS2	96	73.144	ENSGALG00000005885	ESS2	76	72.489	Gallus_gallus
ENSG00000100056	ESS2	93	65.541	ENSGAFG00000008767	ess2	92	65.471	Gambusia_affinis
ENSG00000100056	ESS2	93	65.991	ENSGACG00000016983	ess2	96	65.618	Gasterosteus_aculeatus
ENSG00000100056	ESS2	99	74.576	ENSGAGG00000015565	ESS2	95	74.419	Gopherus_agassizii
ENSG00000100056	ESS2	100	100.000	ENSGGOG00000006187	ESS2	100	100.000	Gorilla_gorilla
ENSG00000100056	ESS2	96	66.231	ENSHBUG00000019871	ess2	94	65.502	Haplochromis_burtoni
ENSG00000100056	ESS2	100	94.328	ENSHGLG00000000570	DGCR14	100	94.328	Heterocephalus_glaber_female
ENSG00000100056	ESS2	97	82.251	ENSHGLG00000013469	-	97	82.684	Heterocephalus_glaber_female
ENSG00000100056	ESS2	92	85.556	ENSHGLG00100008598	-	88	86.142	Heterocephalus_glaber_male
ENSG00000100056	ESS2	100	94.328	ENSHGLG00100009515	DGCR14	100	94.328	Heterocephalus_glaber_male
ENSG00000100056	ESS2	99	63.713	ENSHCOG00000001874	ess2	97	63.924	Hippocampus_comes
ENSG00000100056	ESS2	93	64.430	ENSIPUG00000024767	Dgcr14	94	63.371	Ictalurus_punctatus
ENSG00000100056	ESS2	100	94.538	ENSSTOG00000002817	ESS2	100	94.538	Ictidomys_tridecemlineatus
ENSG00000100056	ESS2	100	90.966	ENSJJAG00000002400	Ess2	100	90.966	Jaculus_jaculus
ENSG00000100056	ESS2	98	65.245	ENSKMAG00000007703	ess2	100	63.115	Kryptolebias_marmoratus
ENSG00000100056	ESS2	95	64.901	ENSLBEG00000019907	ess2	94	64.901	Labrus_bergylta
ENSG00000100056	ESS2	100	67.284	ENSLACG00000006647	ESS2	100	66.529	Latimeria_chalumnae
ENSG00000100056	ESS2	93	71.429	ENSLOCG00000004923	ess2	93	70.694	Lepisosteus_oculatus
ENSG00000100056	ESS2	100	87.474	ENSLAFG00000023365	ESS2	100	87.474	Loxodonta_africana
ENSG00000100056	ESS2	100	99.370	ENSMFAG00000042569	ESS2	100	99.370	Macaca_fascicularis
ENSG00000100056	ESS2	100	99.370	ENSMMUG00000017384	ESS2	100	99.370	Macaca_mulatta
ENSG00000100056	ESS2	100	99.160	ENSMNEG00000029888	ESS2	100	99.160	Macaca_nemestrina
ENSG00000100056	ESS2	100	98.739	ENSMLEG00000028952	ESS2	100	98.739	Mandrillus_leucophaeus
ENSG00000100056	ESS2	93	66.742	ENSMAMG00000011070	ess2	92	66.742	Mastacembelus_armatus
ENSG00000100056	ESS2	94	67.188	ENSMZEG00005026620	ess2	93	66.443	Maylandia_zebra
ENSG00000100056	ESS2	94	61.074	ENSMZEG00005018315	ess2	93	61.298	Maylandia_zebra
ENSG00000100056	ESS2	99	71.967	ENSMGAG00000007157	ESS2	99	71.130	Meleagris_gallopavo
ENSG00000100056	ESS2	100	93.277	ENSMAUG00000012831	Ess2	100	93.277	Mesocricetus_auratus
ENSG00000100056	ESS2	100	94.538	ENSMICG00000000068	ESS2	100	94.538	Microcebus_murinus
ENSG00000100056	ESS2	100	94.328	ENSMOCG00000019116	Ess2	100	94.328	Microtus_ochrogaster
ENSG00000100056	ESS2	93	65.618	ENSMMOG00000008171	ess2	92	64.560	Mola_mola
ENSG00000100056	ESS2	93	83.184	ENSMODG00000010066	ESS2	91	83.857	Monodelphis_domestica
ENSG00000100056	ESS2	93	65.315	ENSMALG00000005266	ess2	92	64.159	Monopterus_albus
ENSG00000100056	ESS2	100	91.042	MGP_CAROLIEiJ_G0020532	Ess2	100	92.083	Mus_caroli
ENSG00000100056	ESS2	100	92.693	ENSMUSG00000003527	Ess2	100	92.693	Mus_musculus
ENSG00000100056	ESS2	100	90.208	MGP_PahariEiJ_G0016237	Ess2	100	91.875	Mus_pahari
ENSG00000100056	ESS2	100	90.625	MGP_SPRETEiJ_G0021427	Ess2	100	91.667	Mus_spretus
ENSG00000100056	ESS2	100	92.887	ENSMPUG00000003809	ESS2	88	93.724	Mustela_putorius_furo
ENSG00000100056	ESS2	100	91.701	ENSMLUG00000007286	ESS2	100	92.324	Myotis_lucifugus
ENSG00000100056	ESS2	100	92.243	ENSNGAG00000015992	Ess2	100	92.872	Nannospalax_galili
ENSG00000100056	ESS2	96	65.939	ENSNBRG00000003063	ess2	94	65.939	Neolamprologus_brichardi
ENSG00000100056	ESS2	100	99.580	ENSNLEG00000005148	ESS2	100	99.580	Nomascus_leucogenys
ENSG00000100056	ESS2	90	76.869	ENSMEUG00000007959	ESS2	99	76.869	Notamacropus_eugenii
ENSG00000100056	ESS2	55	97.500	ENSOPRG00000011624	ESS2	75	97.500	Ochotona_princeps
ENSG00000100056	ESS2	100	89.496	ENSODEG00000016401	-	100	89.308	Octodon_degus
ENSG00000100056	ESS2	100	80.672	ENSODEG00000012930	-	100	80.672	Octodon_degus
ENSG00000100056	ESS2	93	66.890	ENSONIG00000013915	ess2	93	65.996	Oreochromis_niloticus
ENSG00000100056	ESS2	100	92.050	ENSOCUG00000007030	ESS2	100	91.632	Oryctolagus_cuniculus
ENSG00000100056	ESS2	98	63.617	ENSORLG00000008382	ess2	98	63.214	Oryzias_latipes
ENSG00000100056	ESS2	98	63.404	ENSORLG00020017161	ess2	98	63.002	Oryzias_latipes_hni
ENSG00000100056	ESS2	98	63.617	ENSORLG00015004248	ess2	98	63.214	Oryzias_latipes_hsok
ENSG00000100056	ESS2	99	63.103	ENSOMEG00000002329	ess2	97	61.954	Oryzias_melastigma
ENSG00000100056	ESS2	100	91.632	ENSOGAG00000007950	ESS2	100	91.423	Otolemur_garnettii
ENSG00000100056	ESS2	100	70.842	ENSOARG00000017154	ESS2	100	70.431	Ovis_aries
ENSG00000100056	ESS2	100	99.790	ENSPPAG00000034139	ESS2	100	99.790	Pan_paniscus
ENSG00000100056	ESS2	100	94.748	ENSPPRG00000006405	ESS2	100	94.748	Panthera_pardus
ENSG00000100056	ESS2	100	93.096	ENSPTIG00000007661	ESS2	100	93.724	Panthera_tigris_altaica
ENSG00000100056	ESS2	100	99.790	ENSPTRG00000014055	ESS2	100	99.790	Pan_troglodytes
ENSG00000100056	ESS2	100	99.160	ENSPANG00000001052	ESS2	100	99.160	Papio_anubis
ENSG00000100056	ESS2	93	69.369	ENSPKIG00000017140	ess2	93	69.369	Paramormyrops_kingsleyae
ENSG00000100056	ESS2	94	75.111	ENSPSIG00000005691	ESS2	100	75.111	Pelodiscus_sinensis
ENSG00000100056	ESS2	93	66.216	ENSPMGG00000012512	ess2	92	65.541	Periophthalmus_magnuspinnatus
ENSG00000100056	ESS2	100	93.697	ENSPEMG00000021417	Ess2	100	93.697	Peromyscus_maniculatus_bairdii
ENSG00000100056	ESS2	94	83.929	ENSPCIG00000001953	ESS2	92	84.375	Phascolarctos_cinereus
ENSG00000100056	ESS2	83	64.677	ENSPFOG00000019771	ess2	100	64.824	Poecilia_formosa
ENSG00000100056	ESS2	93	65.848	ENSPLAG00000023373	ess2	92	65.991	Poecilia_latipinna
ENSG00000100056	ESS2	93	65.848	ENSPMEG00000020331	ess2	92	65.991	Poecilia_mexicana
ENSG00000100056	ESS2	93	66.071	ENSPREG00000011686	ess2	92	65.324	Poecilia_reticulata
ENSG00000100056	ESS2	100	99.160	ENSPPYG00000011574	ESS2	100	99.160	Pongo_abelii
ENSG00000100056	ESS2	81	95.074	ENSPCAG00000010360	ESS2	81	95.074	Procavia_capensis
ENSG00000100056	ESS2	100	86.102	ENSPCOG00000026937	-	100	86.102	Propithecus_coquereli
ENSG00000100056	ESS2	94	86.861	ENSPCOG00000006014	-	94	74.769	Propithecus_coquereli
ENSG00000100056	ESS2	100	83.193	ENSPVAG00000001659	ESS2	100	83.193	Pteropus_vampyrus
ENSG00000100056	ESS2	96	66.231	ENSPNYG00000009361	ess2	94	65.502	Pundamilia_nyererei
ENSG00000100056	ESS2	93	66.667	ENSPNAG00000015902	ess2	95	65.919	Pygocentrus_nattereri
ENSG00000100056	ESS2	100	92.708	ENSRNOG00000000283	Ess2	100	92.708	Rattus_norvegicus
ENSG00000100056	ESS2	100	98.950	ENSRBIG00000039387	ESS2	100	98.950	Rhinopithecus_bieti
ENSG00000100056	ESS2	100	98.950	ENSRROG00000014140	ESS2	100	98.950	Rhinopithecus_roxellana
ENSG00000100056	ESS2	100	98.742	ENSSBOG00000032190	ESS2	100	98.742	Saimiri_boliviensis_boliviensis
ENSG00000100056	ESS2	70	86.486	ENSSHAG00000008002	ESS2	96	86.486	Sarcophilus_harrisii
ENSG00000100056	ESS2	93	69.507	ENSSFOG00015015525	dgcr14	98	66.878	Scleropages_formosus
ENSG00000100056	ESS2	96	65.208	ENSSMAG00000001404	ess2	95	65.208	Scophthalmus_maximus
ENSG00000100056	ESS2	95	67.105	ENSSDUG00000018455	ess2	94	66.447	Seriola_dumerili
ENSG00000100056	ESS2	95	67.325	ENSSLDG00000012960	ess2	94	66.667	Seriola_lalandi_dorsalis
ENSG00000100056	ESS2	60	89.313	ENSSARG00000014399	-	74	86.667	Sorex_araneus
ENSG00000100056	ESS2	93	76.072	ENSSPUG00000003923	ESS2	88	76.072	Sphenodon_punctatus
ENSG00000100056	ESS2	98	65.126	ENSSPAG00000012573	ess2	98	63.354	Stegastes_partitus
ENSG00000100056	ESS2	100	92.887	ENSSSCG00000010114	ESS2	100	92.050	Sus_scrofa
ENSG00000100056	ESS2	100	72.176	ENSTGUG00000008886	ESS2	100	71.548	Taeniopygia_guttata
ENSG00000100056	ESS2	93	62.640	ENSTRUG00000009168	ess2	92	62.500	Takifugu_rubripes
ENSG00000100056	ESS2	93	63.739	ENSTNIG00000009093	ess2	92	64.126	Tetraodon_nigroviridis
ENSG00000100056	ESS2	76	94.170	ENSTBEG00000014916	ESS2	100	81.361	Tupaia_belangeri
ENSG00000100056	ESS2	100	76.261	ENSTTRG00000006843	ESS2	100	76.261	Tursiops_truncatus
ENSG00000100056	ESS2	100	92.469	ENSUAMG00000021143	ESS2	100	93.096	Ursus_americanus
ENSG00000100056	ESS2	100	92.469	ENSUMAG00000004834	ESS2	100	93.096	Ursus_maritimus
ENSG00000100056	ESS2	100	92.887	ENSVVUG00000023785	ESS2	100	93.515	Vulpes_vulpes
ENSG00000100056	ESS2	93	65.714	ENSXETG00000022387	ess2	99	65.714	Xenopus_tropicalis
ENSG00000100056	ESS2	93	65.090	ENSXCOG00000004427	ess2	92	64.189	Xiphophorus_couchianus
ENSG00000100056	ESS2	93	65.695	ENSXMAG00000014151	ess2	92	65.247	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0003674	molecular_function	-	ND	Function
GO:0005515	protein binding	22365833.	IPI	Function
GO:0005634	nucleus	8703114.	ISS	Component
GO:0007399	nervous system development	8703114.	ISS	Process
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component