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  • Basic Information
  • Cancer Related Information

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000100097 (Gene tree)
Gene ID
3956
Gene Symbol
LGALS1
Alias
GBP
Full Name
galectin 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
4,201 bases
Position
chr22:37,675,606-37,679,806
Accession
6561
RBP type
non-canonical RBP
Summary
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
16738225Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss.Biol Reprod2006 SepLiu AX-
18637021Galectin-1 on cervical epithelial cells is a receptor for the sexually transmitted human parasite Trichomonas vaginalis.Cell Microbiol2008 OctOkumura CYdoi: 10.1111/j.1462-5822.2008.01190.x
8872948Expression of the 14 kDa galactose-binding protein, galectin-1, on human tubular epithelial cells.Kidney Int1996 SepBurger A-
19061643A ncRNA modulates histone modification and mRNA induction in the yeast GAL gene cluster.Mol Cell2008 Dec 5Houseley Jdoi: 10.1016/j.molcel.2008.09.027.
17620414Chd1 and yFACT act in opposition in regulating transcription.Mol Cell Biol2007 SepBiswas D-
28607146Epigenetic Transcriptional Memory of GAL Genes Depends on Growth in Glucose and the Tup1 Transcription Factor in Saccharomyces cerevisiae.Genetics2017 AugSood Vdoi: 10.1534/genetics.117.201632
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000480207LGALS1-206185--- (aa)--
ENST00000454173LGALS1-203331-ENSP0000038829638 (aa)-F8WEI7
ENST00000472321LGALS1-205546--- (aa)--
ENST00000215909LGALS1-201560-ENSP00000215909135 (aa)-P09382
ENST00000489315LGALS1-207516--- (aa)--
ENST00000425542LGALS1-202637-ENSP0000040441469 (aa)-F8WCQ5
ENST00000464120LGALS1-204303--- (aa)--
Gene Model
Click here to download ENSG00000100097's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000100097HIV-15E-621897333
ENSG00000100097Body Fat Distribution5E-621897333
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100097's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000100097LGALS110088.148ENSMUSG00000068220Lgals110088.148Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0002317plasma cell differentiation-IEAProcess
GO:0003723RNA binding22658674.HDAFunction
GO:0005515protein binding10369126.23131994.24529377.24945728.IPIFunction
GO:0005576extracellular region27068509.HDAComponent
GO:0005615extracellular space20551380.HDAComponent
GO:0005634nucleus-IEAComponent
GO:0005737cytoplasm16130169.TASComponent
GO:0005788endoplasmic reticulum lumen-TASComponent
GO:0005829cytosol-IEAComponent
GO:0006915apoptotic process-IEAProcess
GO:0009986cell surface-IEAComponent
GO:0010812negative regulation of cell-substrate adhesion-IEAProcess
GO:0010977negative regulation of neuron projection development-IEAProcess
GO:0030395lactose binding-IEAFunction
GO:0031295T cell costimulation-IEAProcess
GO:0034120positive regulation of erythrocyte aggregation-IEAProcess
GO:0035900response to isolation stress-IEAProcess
GO:0042493response to drug-IEAProcess
GO:0042803protein homodimerization activity-IEAFunction
GO:0042981regulation of apoptotic process16130169.TASProcess
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling12761501.HMPProcess
GO:0043236laminin binding-IEAFunction
GO:0043687post-translational protein modification-TASProcess
GO:0044267cellular protein metabolic process-TASProcess
GO:0045445myoblast differentiation-IEAProcess
GO:0046598positive regulation of viral entry into host cell21670307.IDAProcess
GO:0048678response to axon injury-IEAProcess
GO:0062023collagen-containing extracellular matrix23979707.25037231.27559042.28675934.HDAComponent
GO:0062023collagen-containing extracellular matrix20551380.28327460.HDAComponent
GO:0062023collagen-containing extracellular matrix22261194.ISSComponent
GO:0070062extracellular exosome23533145.HDAComponent
GO:0071333cellular response to glucose stimulus-IEAProcess
GO:0071407cellular response to organic cyclic compound-IEAProcess
GO:2001200positive regulation of dendritic cell differentiation16116184.IDAProcess

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29615514Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor-stroma crosstalk.Proc Natl Acad Sci U S A2018 Apr 17Orozco CAdoi: 10.1073/pnas.1722434115
17043243Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.Proc Natl Acad Sci U S A2006 Oct 24Thijssen VL-
26413750LYAR promotes colorectal cancer cell mobility by activating galectin-1 expression.Oncotarget2015 Oct 20Wu Ydoi: 10.18632/oncotarget.5335.
17304502Galectin-1 expression in cancer-associated stromal cells correlates tumor invasiveness and tumor progression in breast cancer.Int J Cancer2007 Jun 1Jung EJ-
22546645Galectins testing: new promises for the diagnosis and risk stratification of chronic diseases?Clin Biochem2012 JulGruson Ddoi: 10.1016/j.clinbiochem.2012.04.009
27440446Role of galectin-1 in urinary bladder urothelial carcinoma cell invasion through the JNK pathway.Cancer Sci2016 OctShen KHdoi: 10.1111/cas.13016
22696230Galectin-1 promotes lung cancer progression and chemoresistance by upregulating p38 MAPK, ERK, and cyclooxygenase-2.Clin Cancer Res2012 Aug 1Chung LY-
22291012Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor-associated dendritic cells by expressing heparin-binding EGF-like growth factor.J Biol Chem2012 Mar 23Kuo PLdoi: 10.1074/jbc.M111.321190
29926280Expression of Galectins-1 and Galectin-3 in Stomach and Colorectal Cancer with Tissue Eosinophilia.Bull Exp Biol Med2018 JunKolobovnikova YVdoi: 10.1007/s10517-018-4142-6
26876172Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells.Cell Rep2016 Feb 23Tesone AJdoi: 10.1016/j.celrep.2016.01.056
19171142Galectin-1 is a novel functional receptor for tissue plasminogen activator in pancreatic cancer.Gastroenterology2009 AprRoda Odoi: 10.1053/j.gastro.2008.12.039
12125737Galectin-1 modulates human glioblastoma cell migration into the brain through modifications to the actin cytoskeleton and levels of expression of small GTPases.J Neuropathol Exp Neurol2002 JulCamby I-
22844466Identification of galectin-1 as a critical factor in function of mouse mesenchymal stromal cell-mediated tumor promotion.PLoS One2012Szebeni GJdoi: 10.1371/journal.pone.0041372
22583806Galectin-1, a gene preferentially expressed at the tumor margin, promotes glioblastoma cell invasion.Mol Cancer2012 May 14Toussaint LG 3rddoi: 10.1186/1476-4598-11-32.
18671640Role of galectin-1 in migration and invasion of human glioblastoma multiforme cell lines.J Neurosurg2008 AugJung TYdoi: 10.3171/JNS/2008/109/8/0273.
15050916Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege.Cancer Cell2004 MarRubinstein N-
24503185Interleukin-1-induced changes in the glioblastoma secretome suggest its role in tumor progression.J Proteomics2014 Mar 17Tarassishin Ldoi: 10.1016/j.jprot.2014.01.024
26551914Galectin-1 Controls the Proliferation and Migration of Liver Sinusoidal Endothelial Cells and Their Interaction With Hepatocarcinoma Cells.J Cell Physiol2016 JulManzi Mdoi: 10.1002/jcp.25244
21391228Novel roles of galectin-1 in hepatocellular carcinoma cell adhesion, polarization, and in vivo tumor growth.Hepatology2011 JunEspelt MVdoi: 10.1002/hep.24294.
24468067Myosin IIa activation is crucial in breast cancer derived galectin-1 mediated tolerogenic dendritic cell differentiation.Biochim Biophys Acta2014 JunCheng DEdoi: 10.1016/j.bbagen.2014.01.026
14769876Galectin-1 induces cell adhesion to the extracellular matrix and apoptosis of non-adherent human colon cancer Colo201 cells.J Biochem2003 DecHoriguchi N-
21397408Significance of galectins-1, -3, -4 and -7 in the progression of squamous cell carcinoma of the tongue.Pathol Res Pract2011 Apr 15Alves PMdoi: 10.1016/j.prp.2011.02.004
28677745Galectin-1 is a diagnostic marker involved in thyroid cancer progression.Int J Oncol2017 SepArcolia Vdoi: 10.3892/ijo.2017.4065
29389859Role of Galectins in Tumors and in Clinical Immunotherapy.Int J Mol Sci2018 Feb 1Chou FCdoi: 10.3390/ijms19020430.
25725585Apoptosis and anergy of T cell induced by pancreatic stellate cells-derived galectin-1 in pancreatic cancer.Tumour Biol2015 JulTang Ddoi: 10.1007/s13277-015-3233-5
25230369Expression of galectin-1 in carcinoma-associated fibroblasts promotes gastric cancer cell invasion through upregulation of integrin β1.Cancer Sci2014 NovHe XJdoi: 10.1111/cas.12539
24595374Pancreatic satellite cells derived galectin-1 increase the progression and less survival of pancreatic ductal adenocarcinoma.PLoS One2014 Mar 4Tang Ddoi: 10.1371/journal.pone.0090476
28212576Galectin-1 knockdown improves drug sensitivity of breast cancer by reducing P-glycoprotein expression through inhibiting the Raf-1/AP-1 signaling pathway.Oncotarget2017 Apr 11Wang Fdoi: 10.18632/oncotarget.15341.
28512172In Vivo Hemin Conditioning Targets the Vascular and Immunologic Compartments and Restrains Prostate Tumor Development.Clin Cancer Res2017 Sep 1Jaworski FMdoi: 10.1158/1078-0432.CCR-17-0112
30453284Galectin-1 Promotes Metastasis in Gastric Cancer Through a Sphingosine-1-Phosphate Receptor 1-Dependent Mechanism.Cell Physiol Biochem2018You Xdoi: 10.1159/000495157
27837433TLR4-mediated galectin-1 production triggers epithelial-mesenchymal transition in colon cancer cells through ADAM10- and ADAM17-associated lactate production.Mol Cell Biochem2017 JanPark GBdoi: 10.1007/s11010-016-2873-0
26759008Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread.Cancer Immunol Immunother2016 FebChawla Sdoi: 10.1007/s00262-015-1788-z
22939954Galectin 1 expression is associated with tumor invasion and metastasis in stage IB to IIA cervical cancer.Hum Pathol2013 JanKim HJdoi: 10.1016/j.humpath.2012.04.010
15862866IgA1 is the premier serum glycoprotein recognized by human galectin-1 since T antigen (Galbeta1-->3GalNAc-) is far superior to non-repeating N-acetyl lactosamine as ligand.Int J Biol Macromol2005 JunSangeetha SR-
24241899High expressions of galectin-1 and VEGF are associated with poor prognosis in gastric cancer patients.Tumour Biol2014 MarChen Jdoi: 10.1007/s13277-013-1332-8
26224120Galectin-Binding O-Glycosylations as Regulators of Malignancy.Cancer Res2015 Aug 15Dimitroff CJdoi: 10.1158/0008-5472.CAN-15-0834
24407244Galectin-1 overexpression promotes progression and chemoresistance to cisplatin in epithelial ovarian cancer.Cell Death Dis2014 Jan 9Zhang Pdoi: 10.1038/cddis.2013.526.
20525878Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells.Carcinogenesis2010 AugZhao XYdoi: 10.1093/carcin/bgq116
21122983Galectin-1 is silenced by promoter hypermethylation and its re-expression induces apoptosis in human colorectal cancer cells.Cancer Lett2011 Feb 1Satelli Adoi: 10.1016/j.canlet.2010.10.027
22447203Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: increased expression of galectin-1 and induction of poor prognosis factors.Int J Cancer2012 Dec 1Valach Jdoi: 10.1002/ijc.27550
26168351Galectin-3 Binding Protein and Galectin-1 Interaction in Breast Cancer Cell Aggregation and Metastasis.J Am Chem Soc2015 Aug 5Lin TWdoi: 10.1021/jacs.5b04744
23599627Clinicopathological and prognostic significance of galectin-1 and vascular endothelial growth factor expression in gastric cancer.World J Gastroenterol2013 Apr 7Chen Jdoi: 10.3748/wjg.v19.i13.2073.
21191065Lung cancer-derived galectin-1 mediates dendritic cell anergy through inhibitor of DNA binding 3/IL-10 signaling pathway.J Immunol2011 Feb 1Kuo PLdoi: 10.4049/jimmunol.1002940
22386573High galectin-1 expression correlates with poor prognosis and is involved in epithelial ovarian cancer proliferation and invasion.Eur J Cancer2012 AugKim HJdoi: 10.1016/j.ejca.2012.02.005
21780106High expression of Galectin-1 in pancreatic stellate cells plays a role in the development and maintenance of an immunosuppressive microenvironment in pancreatic cancer.Int J Cancer2012 May 15Tang Ddoi: 10.1002/ijc.26290
27025601Galectin-1 knockdown in carcinoma-associated fibroblasts inhibits migration and invasion of human MDA-MB-231 breast cancer cells by modulating MMP-9 expression.Acta Biochim Biophys Sin (Shanghai)2016 MayZhu Xdoi: 10.1093/abbs/gmw019
17616672O-glycosylation regulates LNCaP prostate cancer cell susceptibility to apoptosis induced by galectin-1.Cancer Res2007 Jul 1Valenzuela HF-
28108653Galectin-1 expression is associated with tumour immunity and prognosis in gingival squamous cell carcinoma.J Clin Pathol2017 FebNoda Ydoi: 10.1136/jclinpath-2016-203754
26448934Circulating Galectin-1 and 90K/Mac-2BP Correlated with the Tumor Stages of Patients with Colorectal Cancer.Biomed Res Int2015Wu KLdoi: 10.1155/2015/306964
23389289Galectin-1 promotes lung cancer tumor metastasis by potentiating integrin α6β4 and Notch1/Jagged2 signaling pathway.Carcinogenesis2013 JunHsu YLdoi: 10.1093/carcin/bgt040
23431236Expression of annexin-A1 and galectin-1 anti-inflammatory proteins and mRNA in chronic gastritis and gastric cancer.Mediators Inflamm2013Jorge YCdoi: 10.1155/2013/152860
28350104Induction of galectin-1 by TLR-dependent PI3K activation enhances epithelial-mesenchymal transition of metastatic ovarian cancer cells.Oncol Rep2017 MayPark GBdoi: 10.3892/or.2017.5533
27437940ASPP2 Is a Novel Pan-Ras Nanocluster Scaffold.PLoS One2016 Jul 20Posada IMdoi: 10.1371/journal.pone.0159677
27836001Galectin-1 from cancer-associated fibroblasts induces epithelial-mesenchymal transition through β1 integrin-mediated upregulation of Gli1 in gastric cancer.J Exp Clin Cancer Res2016 Nov 11Chong Y-
27835885Galectin-1 induces invasion and the epithelial-mesenchymal transition in human gastric cancer cells via non-canonical activation of the hedgehog signaling pathway.Oncotarget2016 Dec 13Chong Ydoi: 10.18632/oncotarget.13201.
28594391Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients.Int J Mol Sci2017 Jun 8Schulz Hdoi: 10.3390/ijms18061230.
28415760Binding of galectin-1 to integrin β1 potentiates drug resistance by promoting survivin expression in breast cancer cells.Oncotarget2017 May 30Nam Kdoi: 10.18632/oncotarget.16208.
29328490Galectin-1 expression in activated pancreatic satellite cells promotes fibrosis in chronic pancreatitis/pancreatic cancer via the TGF-β1/Smad pathway.Oncol Rep2018 MarTang Ddoi: 10.3892/or.2018.6202

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2237677006SilentnovelL10L0.18
BRCAchr2237678652Missense_MutationNAE87Q0.31
BRCAchr2237677038Missense_MutationNAR21Q0.28
BRCAchr2237679648Missense_MutationNAD103Y0.29
CESCchr2237677031Missense_MutationnovelR19G0.21
CESCchr22376797933'UTRnovel0.45
COADchr2237678606Silentrs4888T71T0.29
COADchr2237678564SilentNAN57N0.29
COADchr2237679657Missense_MutationNAE106K0.36
HNSCchr2237679652Missense_MutationnovelG104V0.17
HNSCchr2237677063Missense_Mutationrs572130887K29N0.08
LGGchr2237679657Missense_MutationNAE106K0.47
LGGchr2237677052Missense_Mutationrs765635524P26S0.39
LUADchr2237679696Missense_MutationnovelN119D0.19
LUSCchr2237679640Missense_MutationNAK100R0.23
LUSCchr2237679707SilentnovelA122A0.29
OVchr2237679719Missense_MutationnovelD126E0.07
OVchr22376797513'UTRnovel0.07
PAADchr2237679636Missense_Mutationrs375290542V99I0.26
SARCchr22376756325'UTRnovel0.69
SKCMchr2237678616Frame_Shift_InsnovelA76Gfs*490.94
SKCMchr22376797613'UTRnovel0.52
STADchr2237678501SilentNAG36G0.55
STADchr2237679617Silentrs370097853F92F0.08
UCECchr2237678521Missense_MutationNAC43Y0.17
UCECchr2237679656Silentrs369424642Y105Y0.27
UCECchr22376797963'UTRnovel0.33
UCECchr2237678539Missense_Mutationrs111700736R49H0.2
UCECchr22376797803'UTRnovel0.13

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
PCPGDEL0.3210.044123
THCADEL0.15630.046486
THYMDEL0.07320.063154

Survival Analysis
CancerP-value Q-value
KIRC0.00011

Kaplan-Meier Survival Analysis

STAD0.0098

Kaplan-Meier Survival Analysis

MESO0.00014

Kaplan-Meier Survival Analysis

ACC0.015

Kaplan-Meier Survival Analysis

HNSC0.0051

Kaplan-Meier Survival Analysis

PAAD0.02

Kaplan-Meier Survival Analysis

PCPG0.039

Kaplan-Meier Survival Analysis

BLCA0.0014

Kaplan-Meier Survival Analysis

LAML0.00012

Kaplan-Meier Survival Analysis

UCEC0.00037

Kaplan-Meier Survival Analysis

GBM0.0011

Kaplan-Meier Survival Analysis

LIHC0.0024

Kaplan-Meier Survival Analysis

CHOL0.042

Kaplan-Meier Survival Analysis

LUAD0.049

Kaplan-Meier Survival Analysis

UVM0.00011

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742


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