EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000100139 (Gene tree)
Gene ID: 85377
Gene Symbol: MICALL1
Alias: MIRAB13|KIAA1668|MICAL-L1
Full Name: MICAL like 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 37,166 bases
Position: chr22:37,905,657-37,942,822
Accession: 29804
RBP type: non-canonical RBP
Summary: (MICAL Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding and phosphatidic acid binding. An important paralog of this gene is MICALL2.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000424008	MICALL1-203	918	-	ENSP00000416766	186 (aa)	-	B0QY91
ENST00000445494	MICALL1-204	808	-	ENSP00000404543	210 (aa)	-	B0QY86
ENST00000454685	MICALL1-205	1108	-	ENSP00000406053	370 (aa)	-	H0Y6J8
ENST00000215957	MICALL1-201	4710	XM_005261791	ENSP00000215957	863 (aa)	XP_005261848	Q8N3F8
ENST00000489812	MICALL1-206	853	-	-	- (aa)	-	-
ENST00000402631	MICALL1-202	2734	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000100139's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100139	rs34834842	22	37932590	G	Platelet distribution width	27863252	[0.063-0.099] unit increase	0.08094431	EFO_0007984
ENSG00000100139	rs4254591	22	37908851	?	Heel bone mineral density	30048462	[0.013-0.022] unit decrease	0.0176222	EFO_0009270
ENSG00000100139	rs4254591	22	37908851	G	Heel bone mineral density	30598549	[0.012-0.02] unit decrease	0.0162358	EFO_0009270
ENSG00000100139	rs5750508	22	37907148	?	Body mass index	30595370			EFO_0004340
ENSG00000100139	rs3026629	22	37933278	A	Smoking status (ever vs never smokers)	30643258	[0.0075-0.0158] unit decrease	0.011653287	EFO_0004318

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100139's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	19864458.19945174.20801876.21951725.22284051.23596323.27189942.	IPI	Function
GO:0005769	early endosome	21795389.	IDA	Component
GO:0005770	late endosome	21795389.	IDA	Component
GO:0005802	trans-Golgi network	21795389.	IDA	Component
GO:0006612	protein targeting to membrane	19864458.	IMP	Process
GO:0006897	endocytosis	20801876.	IMP	Process
GO:0006898	receptor-mediated endocytosis	21795389.	IMP	Process
GO:0017137	Rab GTPase binding	19864458.21795389.	IPI	Function
GO:0019898	extrinsic component of membrane	19864458.	IDA	Component
GO:0031175	neuron projection development	-	ISS	Process
GO:0031902	late endosome membrane	-	IEA	Component
GO:0032458	slow endocytic recycling	19864458.	IMP	Process
GO:0036010	protein localization to endosome	23596323.	IMP	Process
GO:0042802	identical protein binding	23596323.	IPI	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0055038	recycling endosome membrane	19864458.21951725.	IDA	Component
GO:0055038	recycling endosome membrane	21795389.	IDA	Component
GO:0070300	phosphatidic acid binding	23596323.	IDA	Function
GO:0097320	plasma membrane tubulation	23596323.	IDA	Process
GO:1990090	cellular response to nerve growth factor stimulus	-	IEA	Process
GO:1990126	retrograde transport, endosome to plasma membrane	19864458.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28714518	Regulation of tubular recycling endosome biogenesis by the p53-MICALL1 pathway.	Int J Oncol	2017 Aug	Takahashi Y	doi: 10.3892/ijo.2017.4060

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr22	37932797	Splice_Site	novel	X715_splice	0.34
BLCA	chr22	37933078	Silent	NA	V758V	0.09
BLCA	chr22	37931858	Silent	novel	T647T	0.38
BLCA	chr22	37927558	Nonsense_Mutation	NA	S538*	0.11
BLCA	chr22	37912437	Silent	rs751212781	L94L	0.18
BLCA	chr22	37926032	Missense_Mutation	rs775080882	A485V	0.58
BLCA	chr22	37932832	Silent	NA	F726F	0.18
BLCA	chr22	37927558	Missense_Mutation	novel	S538L	0.11
BLCA	chr22	37932838	Silent	rs192522420	L728L	0.32
BLCA	chr22	37927804	Missense_Mutation	novel	S620L	0.29
BLCA	chr22	37937743	Splice_Region	novel		0.37
BRCA	chr22	37932618	Silent	NA	R694R	0.13
BRCA	chr22	37911953	Missense_Mutation	NA	D50Y	0.31
BRCA	chr22	37911996	Missense_Mutation	NA	R64P	0.2
BRCA	chr22	37937079	Splice_Site	NA	X770_splice	0.17
BRCA	chr22	37932804	Missense_Mutation	novel	R717H	0.23
CESC	chr22	37927711	Missense_Mutation	rs141260509	S589L	0.28
CESC	chr22	37937123	Silent	novel	L784L	0.39
CESC	chr22	37927742	Silent	novel	G599G	0.48
CESC	chr22	37932669	Silent	rs144278500	G711G	0.26
CHOL	chr22	37927494	Missense_Mutation	novel	E517Q	0.09
COAD	chr22	37906491	Missense_Mutation	novel	E23D	0.4
COAD	chr22	37912422	Silent	rs146083250	S89S	0.38
COAD	chr22	37925866	Missense_Mutation	novel	E430K	0.28
COAD	chr22	37940881	3'UTR	novel		0.2
COAD	chr22	37912413	Silent	novel	V86V	0.06
COAD	chr22	37922132	Nonsense_Mutation	NA	Q244*	0.41
COAD	chr22	37931845	Missense_Mutation	novel	A643E	0.83
COAD	chr22	37919053	Silent	NA	S148S	0.11
COAD	chr22	37932889	Splice_Site	novel	X745_splice	0.06
COAD	chr22	37919151	Missense_Mutation	novel	G181D	0.29
COAD	chr22	37927744	Missense_Mutation	novel	A600V	0.3
COAD	chr22	37940837	3'UTR	rs774906713		0.39
COAD	chr22	37937154	Missense_Mutation	novel	R795C	0.5
ESCA	chr22	37937771	Nonsense_Mutation	novel	E817*	0.17
GBM	chr22	37932883	Silent	novel	I743I	0.21
GBM	chr22	37940769	Missense_Mutation	novel	M844R	0.06
GBM	chr22	37933064	Missense_Mutation	rs776303100	R754C	0.47
GBM	chr22	37940777	Missense_Mutation	novel	L847M	0.1
HNSC	chr22	37933104	Missense_Mutation	novel	N767S	0.31
HNSC	chr22	37931849	Silent	novel	S644S	0.1
HNSC	chr22	37927535	Silent	rs138192828	P530P	0.38
HNSC	chr22	37940821	Silent	novel	D861D	0.18
HNSC	chr22	37932564	Missense_Mutation	novel	D676E	0.17
HNSC	chr22	37922035	Silent	novel	T211T	0.43
KIRP	chr22	37917737	Missense_Mutation	NA	A123V	0.26
KIRP	chr22	37932881	Missense_Mutation	NA	I743V	0.41
LAML	chr22	37927706	Silent	NA	G587G	0.35
LGG	chr22	37927445	Silent	rs201808090	P500P	0.43
LGG	chr22	37933064	Missense_Mutation	rs776303100	R754C	0.37
LGG	chr22	37927464	Missense_Mutation	NA	P507S	0.49
LGG	chr22	37937763	Missense_Mutation	novel	K814T	0.34
LIHC	chr22	37919094	Missense_Mutation	novel	S162N	0.47
LIHC	chr22	37922305	Silent	NA	P301P	0.57
LIHC	chr22	37922085	Missense_Mutation	novel	G228E	0.41
LIHC	chr22	37925659	Splice_Site	rs774299265	X361_splice	0.43
LIHC	chr22	37906527	Silent	novel	L35L	0.42
LIHC	chr22	37932555	Splice_Region	novel	V673V	0.51
LUAD	chr22	37912387	Missense_Mutation	novel	A78S	0.65
LUAD	chr22	37922092	Silent	novel	R230R	0.07
LUAD	chr22	37926029	Missense_Mutation	NA	S484T	0.39
LUAD	chr22	37932806	Missense_Mutation	NA	E718K	0.16
LUAD	chr22	37931851	Missense_Mutation	NA	P645L	0.27
LUAD	chr22	37925890	Missense_Mutation	NA	A438S	0.26
LUAD	chr22	37925883	Silent	novel	E435E	0.13
LUAD	chr22	37937743	Splice_Region	novel		0.43
LUSC	chr22	37926007	Missense_Mutation	rs141055585	R477C	0.33
LUSC	chr22	37927462	Missense_Mutation	NA	S506L	0.26
LUSC	chr22	37922046	Missense_Mutation	novel	A215E	0.07
LUSC	chr22	37927587	Missense_Mutation	novel	P548S	0.3
LUSC	chr22	37927588	Missense_Mutation	novel	P548L	0.31
LUSC	chr22	37927465	Missense_Mutation	NA	P507L	0.22
LUSC	chr22	37924661	Splice_Region	NA	G342G	0.41
LUSC	chr22	37927534	Missense_Mutation	rs200080428	P530L	0.15
LUSC	chr22	37932597	Silent	novel	E687E	0.28
OV	chr22	37924671	Nonsense_Mutation	NA	E346*	0.15
OV	chr22	37940908	3'UTR	novel		0.18
OV	chr22	37940802	Missense_Mutation	novel	K855M	0.54
OV	chr22	37927571	Silent	novel	V542V	0.15
OV	chr22	37931846	Silent	novel	A643A	0.09
OV	chr22	37940779	Silent	novel	L847L	0.06
PAAD	chr22	37912387	Missense_Mutation	rs114708609	A78T	0.18
PAAD	chr22	37912415	Missense_Mutation	NA	S87Y	0.21
PAAD	chr22	37927730	Silent	novel	K595K	0.18
PRAD	chr22	37931804	Silent	novel	S629S	0.1
PRAD	chr22	37940883	3'UTR	novel		0.07
PRAD	chr22	37922128	Silent	novel	Q242Q	0.33
PRAD	chr22	37932601	Missense_Mutation	NA	D689N	0.54
SARC	chr22	37927597	Frame_Shift_Del	novel	*P551Rfs19**	0.9
SKCM	chr22	37927794	Missense_Mutation	NA	P617S	0.45
SKCM	chr22	37917716	Missense_Mutation	rs778087097	S116L	0.55
SKCM	chr22	37925955	Silent	NA	S459S	0.4
SKCM	chr22	37922089	Silent	novel	T229T	0.27
SKCM	chr22	37932852	Missense_Mutation	novel	H733R	0.34
SKCM	chr22	37940812	Silent	novel	S858S	0.46
SKCM	chr22	37925810	Missense_Mutation	rs748065304	A411V	0.29
SKCM	chr22	37925811	Silent	novel	A411A	0.29
SKCM	chr22	37917749	Missense_Mutation	rs767394714	P127L	0.2
SKCM	chr22	37927572	Missense_Mutation	NA	H543Y	0.34
SKCM	chr22	37927462	Missense_Mutation	NA	S506L	0.24
SKCM	chr22	37927694	Silent	rs545892604	P583P	0.19
SKCM	chr22	37924712	Silent	rs145525171	S359S	0.45
SKCM	chr22	37922083	Silent	rs144508698	S227S	0.31
SKCM	chr22	37922084	Missense_Mutation	novel	G228R	0.29
SKCM	chr22	37940911	3'UTR	rs540174489		0.61
SKCM	chr22	37940912	3'UTR	novel		0.59
SKCM	chr22	37917733	Missense_Mutation	NA	L122F	0.46
SKCM	chr22	37932823	Silent	rs778562267	V723V	0.27
STAD	chr22	37925682	Frame_Shift_Del	NA	*P370Hfs197**	0.17
STAD	chr22	37922079	Missense_Mutation	rs777153477	R226Q	0.28
STAD	chr22	37926045	Splice_Site	NA	X489_splice	0.25
STAD	chr22	37925825	Missense_Mutation	rs759071883	T416M	0.48
STAD	chr22	37927784	Silent	NA	P613P	0.43
STAD	chr22	37927462	Missense_Mutation	NA	S506L	0.21
STAD	chr22	37927733	Silent	NA	P596P	0.26
STAD	chr22	37926033	Silent	rs149812469	A485A	0.32
STAD	chr22	37926017	Missense_Mutation	rs745831607	P480L	0.19
STAD	chr22	37926020	Missense_Mutation	rs372004472	R481H	0.6
STAD	chr22	37927462	Missense_Mutation	NA	S506L	0.45
STAD	chr22	37917782	Missense_Mutation	NA	E138G	0.2
STAD	chr22	37926018	Silent	rs557005557	P480P	0.16
THCA	chr22	37922074	Silent	NA	G224G	0.09
UCEC	chr22	37933078	Silent	rs752364347	V758V	0.37
UCEC	chr22	37911964	Silent	rs369045128	S53S	0.35
UCEC	chr22	37937154	Missense_Mutation	novel	R795C	0.07
UCEC	chr22	37932586	Missense_Mutation	novel	I684V	0.18
UCEC	chr22	37927583	Silent	novel	G546G	0.57
UCEC	chr22	37940832	3'UTR	novel		0.38
UCEC	chr22	37937165	Silent	novel	I798I	0.38
UCEC	chr22	37932582	Missense_Mutation	novel	E682D	0.28
UCEC	chr22	37922071	Silent	rs149289465	P223P	0.48
UCEC	chr22	37925745	Silent	novel	S389S	0.33
UCEC	chr22	37927828	Splice_Site	novel	X627_splice	0.26
UCEC	chr22	37919166	Missense_Mutation	novel	R186H	0.41
UCEC	chr22	37926032	Missense_Mutation	rs775080882	A485V	0.42
UCEC	chr22	37925871	Missense_Mutation	NA	E431D	0.22
UCEC	chr22	37927420	Missense_Mutation	NA	A492V	0.27
UCEC	chr22	37940968	3'UTR	novel		0.36
UCEC	chr22	37931928	Missense_Mutation	rs766639546	R671C	0.32
UCEC	chr22	37927445	Silent	rs201808090	P500P	0.12
UCEC	chr22	37919058	Missense_Mutation	novel	S150N	0.4
UCEC	chr22	37927756	Missense_Mutation	NA	P604H	0.21
UCEC	chr22	37927679	Silent	novel	S578S	0.14
UCEC	chr22	37925718	Missense_Mutation	novel	K380N	0.42
UCEC	chr22	37937175	Missense_Mutation	novel	L802M	0.42
UCEC	chr22	37937155	Missense_Mutation	novel	R795H	0.42
UCEC	chr22	37927571	Silent	rs141152922	V542V	0.18
UCEC	chr22	37932818	Missense_Mutation	novel	L722M	0.33
UCEC	chr22	37940922	3'UTR	novel		0.22
UCEC	chr22	37912353	Splice_Region	novel	A66A	0.41
UCEC	chr22	37927753	Missense_Mutation	NA	T603M	0.25
UCEC	chr22	37927499	Silent	rs752270992	S518S	0.48
UCS	chr22	37933078	Silent	rs752364347	V758V	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
PCPG	DEL	0.3272	0.044123
THCA	DEL	0.1563	0.046486
THYM	DEL	0.0732	0.063154

Survival Analysis

Cancer	P-value	Q-value
MESO	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
UCS	0.041	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
ESCA	0.009	Kaplan-Meier Survival Analysis
PAAD	0.0025	Kaplan-Meier Survival Analysis
LAML	0.0059	Kaplan-Meier Survival Analysis
LIHC	0.00021	Kaplan-Meier Survival Analysis
LUAD	0.04	Kaplan-Meier Survival Analysis
OV	0.044	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742