EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000100207 (Gene tree)
Gene ID: 6942
Gene Symbol: TCF20
Alias: AR1|SPBP
Full Name: transcription factor 20
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 183,604 bases
Position: chr22:42,160,013-42,343,616
Accession: 11631
RBP type: non-canonical RBP
Summary: This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000335626	TCF20-201	6237	XM_011530354	ENSP00000335561	1938 (aa)	XP_011528656	Q9UGU0
ENST00000404876	TCF20-203	1058	-	ENSP00000385531	250 (aa)	-	A9JX13
ENST00000515426	TCF20-204	633	-	ENSP00000458948	153 (aa)	-	I3L1M7
ENST00000359486	TCF20-202	7410	XM_005261722	ENSP00000352463	1960 (aa)	XP_005261779	Q9UGU0

Gene Model

Click here to download ENSG00000100207's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100207	Cholesterol	8.7080000E-005	-
ENSG00000100207	Interleukin-8	7.2670000E-005	-
ENSG00000100207	Insulin-Like Growth Factor I	3.9020000E-005	-
ENSG00000100207	Insulin-Like Growth Factor I	4.0940000E-005	-
ENSG00000100207	Insulin-Like Growth Factor I	5.2760000E-005	-
ENSG00000100207	Hypertension	3.2335514E-005	-
ENSG00000100207	Cognition	1E-6	25644384
ENSG00000100207	Body Mass Index	7E-6	25673413
ENSG00000100207	Schizophrenia	2E-9	25056061
ENSG00000100207	Schizophrenia	6E-10	26198764

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100207	rs760648	22	42175022	A	Autism spectrum disorder or schizophrenia	28540026	[1.04-1.08]	1.06	EFO_0000692\|EFO_0003756
ENSG00000100207	rs6002655	22	42207808	T	Schizophrenia	25056061	[1.044-1.088]	1.066	EFO_0000692
ENSG00000100207	rs134882	22	42274959	?	Bipolar disorder and schizophrenia	20889312	[NR]	1.2196	EFO_0000677
ENSG00000100207	rs6002655	22	42207808	T	Schizophrenia	26198764	[NR]	1.07	EFO_0000692
ENSG00000100207	rs2413685	22	42321584	A	Cognitive performance	30038396	[0.01-0.022] unit decrease	0.0159	EFO_0008354
ENSG00000100207	rs2413685	22	42321584	A	Cognitive performance (MTAG)	30038396	[0.0083-0.0173] unit decrease	0.0128	EFO_0008354
ENSG00000100207	rs4822112	22	42335534	?	Surgical necrotising enterocolitis in extremely premature birth	29538362			EFO_0003928\|EFO_0003917
ENSG00000100207	rs187166731	22	42270020	C	Interleukin-1-receptor antagonist levels	27989323	[0.13-0.33] SD units increase	0.2325	EFO_0004754
ENSG00000100207	rs5758659	22	42225997	?	Cognitive function	25644384	[0.016-0.038] unit decrease	0.027	EFO_0004337
ENSG00000100207	rs134871	22	42256710	?	General cognitive ability	29844566	z-score increase	5.178	EFO_0004337
ENSG00000100207	rs4822112	22	42335534	T	Intelligence	29942086	z-score decrease	5.943	EFO_0004337
ENSG00000100207	rs6002655	22	42207808	?	Schizophrenia	29483656	[1.06-1.10]	1.0775862	EFO_0000692
ENSG00000100207	rs5758667	22	42237198	A	Red vs. brown/black hair color	30531825	NR	39.43	EFO_0003924
ENSG00000100207	rs73169175	22	42325368	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000100207	rs4822107	22	42308828	?	Morning person	30595370			EFO_0008328
ENSG00000100207	rs4822108	22	42309864	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000100207	rs762995	22	42276118	?	Smoking status	30595370			EFO_0006527
ENSG00000100207	rs6002676	22	42301210	A	Risk-taking tendency (4-domain principal component model)	30643258	[0.0096-0.02] unit increase	0.014796305	EFO_0008579
ENSG00000100207	rs760648	22	42175022	A	Schizophrenia	30285260	[1.06-1.1]	1.079	EFO_0000692
ENSG00000100207	rs6002655	22	42207808	T	Schizophrenia	30285260	[1.04-1.08]	1.059	EFO_0000692
ENSG00000100207	rs4822103	22	42302568	C	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0055-0.0099] unit decrease	0.00770318	EFO_0006527
ENSG00000100207	rs4822102	22	42302424	T	Smoking initiation (ever regular vs never regular)	30643251	[0.011-0.022] unit decrease	0.016542807	EFO_0006527
ENSG00000100207	rs762995	22	42276118	A	Chronotype	30696823	[0.0083-0.0149] unit decrease	0.0115978	EFO_0008328

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100207's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003677	DNA binding	10995766.	NAS	Function
GO:0003700	DNA-binding transcription factor activity	21873635.	IBA	Function
GO:0003713	transcription coactivator activity	10995766.	NAS	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	17913746.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	10995766.	NAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0006355	regulation of transcription, DNA-templated	10995766.	NAS	Process
GO:0016604	nuclear body	-	IDA	Component
GO:0044212	transcription regulatory region DNA binding	21873635.	IBA	Function
GO:0045944	positive regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0046872	metal ion binding	-	IEA	Function