EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000100241 (Gene tree)
Gene ID: 6305
Gene Symbol: SBF1
Alias: MTMR5|DENND7A
Full Name: SET binding factor 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 35,667 bases
Position: chr22:50,444,630-50,480,296
Accession: 10542
RBP type: non-canonical RBP
Summary: This gene encodes a member of the protein-tyrosine phosphatase family. However, the encoded protein does not appear to be a catalytically active phosphatase because it lacks several amino acids in the catalytic pocket. This protein contains a Guanine nucleotide exchange factor (GEF) domain which is necessary for its role in growth and differentiation. Mutations in this gene have been associated with Charcot-Marie-Tooth disease 4B3. Pseudogenes of this gene have been defined on chromosomes 1 and 8. [provided by RefSeq, Dec 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000348911	SBF1-201	6045	XM_005261935	ENSP00000252027	1868 (aa)	XP_005261992	O95248
ENST00000477234	SBF1-208	947	-	-	- (aa)	-	-
ENST00000380817	SBF1-202	8008	XM_011530709	ENSP00000370196	1893 (aa)	XP_011529011	O95248
ENST00000399627	SBF1-203	811	-	-	- (aa)	-	-
ENST00000470434	SBF1-205	2139	-	-	- (aa)	-	-
ENST00000418590	SBF1-204	1578	-	ENSP00000401538	415 (aa)	-	H0Y5W8
ENST00000476293	SBF1-207	399	-	-	- (aa)	-	-
ENST00000473724	SBF1-206	446	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000100241's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100241	Immunoglobulins	2E-6	23382691

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100241	rs5771040	22	50463961	G	IgG glycosylation	23382691	[0.093-0.226] unit decrease	0.1595	EFO_0005193
ENSG00000100241	rs4824117	22	50456704	?	Hypothyroidism	30595370			EFO_0004705

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100241's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005737	cytoplasm	16787938.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006470	protein dephosphorylation	9736772.	TAS	Process
GO:0006661	phosphatidylinositol biosynthetic process	-	TAS	Process
GO:0007283	spermatogenesis	-	IEA	Process
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	9736772.	TAS	Function
GO:0016021	integral component of membrane	9736772.	TAS	Component
GO:0016604	nuclear body	-	IDA	Component
GO:0016791	phosphatase activity	9537414.	IMP	Function
GO:0017112	Rab guanyl-nucleotide exchange factor activity	20937701.	IDA	Function
GO:0019208	phosphatase regulator activity	-	IEA	Function
GO:0043087	regulation of GTPase activity	-	IEA	Process
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr22	50462706	Silent	novel	P660P	0.74
ACC	chr22	50460636	Missense_Mutation	rs372268920	R1015Q	0.78
BLCA	chr22	50454695	Silent	novel	F1620F	0.32
BLCA	chr22	50462885	Silent	novel	V651V	0.31
BLCA	chr22	50447225	Missense_Mutation	rs754888523	R1867C	0.21
BLCA	chr22	50454531	Missense_Mutation	novel	A1675G	0.38
BLCA	chr22	50447227	Missense_Mutation	rs770090328	R1866H	0.36
BLCA	chr22	50460001	Missense_Mutation	NA	E1148Q	0.1
BLCA	chr22	50448594	Silent	rs371304311	T1700T	0.51
BLCA	chr22	50447319	Splice_Region	novel		0.22
BLCA	chr22	50465104	Missense_Mutation	novel	L410R	0.29
BLCA	chr22	50455308	Missense_Mutation	NA	F1490L	0.16
BLCA	chr22	50461593	Silent	novel	L923L	0.64
BLCA	chr22	50459561	Silent	rs754805260	S1199S	0.17
BLCA	chr22	50461247	Missense_Mutation	novel	A960V	0.62
BLCA	chr22	50461559	Missense_Mutation	novel	R935G	0.8
BRCA	chr22	50456670	Missense_Mutation	novel	K1303T	0.27
BRCA	chr22	50461618	Frame_Shift_Del	NA	*G915Afs47**	0.42
BRCA	chr22	50462087	Missense_Mutation	rs754556678	T810M	0.08
BRCA	chr22	50448551	Missense_Mutation	novel	D1715H	0.11
BRCA	chr22	50455602	Intron	novel		0.33
BRCA	chr22	50462000	Missense_Mutation	rs748349988	T839M	0.14
BRCA	chr22	50455086	Silent	rs745827632	L1537L	0.38
BRCA	chr22	50447423	Nonsense_Mutation	NA	E1828*	0.25
BRCA	chr22	50466419	Missense_Mutation	NA	S240Y	0.25
BRCA	chr22	50460536	Splice_Region	NA	L1048L	0.21
BRCA	chr22	50460632	Nonsense_Mutation	NA	Y1016*	0.4
BRCA	chr22	50461176	Missense_Mutation	NA	R984C	0.37
BRCA	chr22	50467824	Missense_Mutation	NA	A81T	0.42
BRCA	chr22	50454830	Missense_Mutation	rs774485881	A1599V	0.13
CESC	chr22	50465797	Missense_Mutation	rs370145179	P352L	0.22
CESC	chr22	50464394	Missense_Mutation	NA	R562W	0.46
CESC	chr22	50446745	3'UTR	novel		0.31
CESC	chr22	50446748	3'UTR	novel		0.46
CESC	chr22	50464538	Frame_Shift_Del	NA	M545*	0.08
CESC	chr22	50462628	Missense_Mutation	novel	F686L	0.36
CESC	chr22	50459522	Silent	novel	L1212L	0.13
CESC	chr22	50460607	Frame_Shift_Ins	novel	*A1025Cfs63**	0.19
CESC	chr22	50459269	Missense_Mutation	novel	H1271R	0.23
CESC	chr22	50459536	Missense_Mutation	novel	R1208C	0.33
CESC	chr22	50447190	Silent	rs571562651	S1878S	0.59
CESC	chr22	50454539	Silent	rs747994905	Q1672Q	0.45
CESC	chr22	50462697	Silent	rs751999953	T663T	0.14
CESC	chr22	50465807	Missense_Mutation	rs767336585	A349T	0.21
CESC	chr22	50461683	In_Frame_Ins	novel	E893_E894insDLG	0.09
CESC	chr22	50455059	Missense_Mutation	NA	F1546L	0.22
CESC	chr22	50445135	3'UTR	novel		0.22
CESC	chr22	50464836	Missense_Mutation	novel	E472Q	0.47
COAD	chr22	50457058	Missense_Mutation	NA	A1294T	0.39
COAD	chr22	50462307	Missense_Mutation	novel	S765N	0.31
COAD	chr22	50447109	3'UTR	novel		0.17
COAD	chr22	50459299	Missense_Mutation	rs780313800	R1261H	0.2
COAD	chr22	50463344	Missense_Mutation	rs754441426	R613H	0.35
COAD	chr22	50447368	Missense_Mutation	NA	P1846H	0.12
COAD	chr22	50460326	Frame_Shift_Ins	rs771002611	*S1077Qfs11**	0.32
COAD	chr22	50461955	Missense_Mutation	NA	M854K	0.36
COAD	chr22	50464443	Splice_Site	novel	X546_splice	0.33
COAD	chr22	50447224	Missense_Mutation	NA	R1867H	0.29
COAD	chr22	50460327	Frame_Shift_Del	rs775294940	*S1077Afs28**	0.34
COAD	chr22	50465240	Missense_Mutation	novel	P393L	0.1
COAD	chr22	50466405	Missense_Mutation	rs767703972	R245W	0.24
COAD	chr22	50460669	Missense_Mutation	rs759902083	A1004V	0.71
COAD	chr22	50460635	Silent	novel	R1015R	0.23
COAD	chr22	50460630	Missense_Mutation	rs780146082	P1017L	0.36
COAD	chr22	50461526	Frame_Shift_Del	rs34743427	*L946Wfs16**	0.26
COAD	chr22	50459491	Missense_Mutation	novel	A1223T	0.1
COAD	chr22	50462652	Silent	rs139798340	T678T	0.34
COAD	chr22	50454826	Silent	NA	P1600P	0.3
COAD	chr22	50464583	Frame_Shift_Ins	novel	*A530Sfs46**	0.17
COAD	chr22	50461661	Missense_Mutation	rs766669723	R901C	0.57
COAD	chr22	50460326	Frame_Shift_Ins	rs771002611	*S1077Qfs11**	0.37
COAD	chr22	50464675	Nonsense_Mutation	NA	R499*	0.2
COAD	chr22	50448638	Silent	novel	L1686L	0.43
COAD	chr22	50447441	Missense_Mutation	NA	D1822N	0.9
COAD	chr22	50460327	Frame_Shift_Del	rs775294940	*S1077Afs28**	0.34
COAD	chr22	50459301	Silent	novel	G1260G	0.35
COAD	chr22	50465093	Missense_Mutation	NA	D414N	0.27
COAD	chr22	50459292	Silent	rs765489326	T1263T	0.33
COAD	chr22	50447053	3'UTR	novel		0.17
COAD	chr22	50460155	Silent	NA	S1096S	0.21
COAD	chr22	50464721	Silent	NA	A483A	0.09
COAD	chr22	50459293	Missense_Mutation	NA	T1263M	0.09
COAD	chr22	50463387	Missense_Mutation	rs578021802	R599C	0.47
COAD	chr22	50464556	Silent	rs374717820	T538T	0.48
COAD	chr22	50460327	Frame_Shift_Del	rs775294940	*S1077Afs28**	0.24
COAD	chr22	50467419	Silent	rs781517999	H156H	0.25
ESCA	chr22	50446724	3'UTR	novel		0.22
ESCA	chr22	50446994	3'UTR	rs556415507		0.19
ESCA	chr22	50447421	Silent	novel	E1828E	0.22
ESCA	chr22	50462357	In_Frame_Del	novel	K748del	0.4
ESCA	chr22	50446662	3'UTR	novel		0.15
GBM	chr22	50455280	Missense_Mutation	novel	G1500R	0.28
GBM	chr22	50448414	Missense_Mutation	rs747746536	A1728T	0.21
GBM	chr22	50455101	Missense_Mutation	novel	F1532L	0.49
GBM	chr22	50467828	Nonsense_Mutation	novel	Y79*	0.94
GBM	chr22	50463318	Missense_Mutation	NA	D622H	0.46
GBM	chr22	50448284	Missense_Mutation	rs559286048	R1771H	0.36
HNSC	chr22	50467888	Missense_Mutation	novel	E59D	0.38
HNSC	chr22	50464655	Silent	NA	F505F	0.14
HNSC	chr22	50466071	Missense_Mutation	novel	D301N	0.38
HNSC	chr22	50460003	Missense_Mutation	novel	S1147C	0.12
HNSC	chr22	50447382	Silent	novel	V1841V	0.27
HNSC	chr22	50460599	Silent	rs776163511	T1027T	0.36
HNSC	chr22	50465972	Missense_Mutation	novel	V334M	0.18
HNSC	chr22	50459381	Missense_Mutation	novel	A1234S	0.47
HNSC	chr22	50448551	Missense_Mutation	novel	D1715H	0.1
HNSC	chr22	50459355	In_Frame_Del	rs758613709	E1242del	0.16
HNSC	chr22	50464562	Missense_Mutation	novel	R536S	0.39
HNSC	chr22	50466202	Missense_Mutation	NA	T282M	0.34
HNSC	chr22	50455081	Missense_Mutation	novel	Y1539C	0.17
HNSC	chr22	50461143	Splice_Site	novel	X989_splice	0.34
HNSC	chr22	50465263	Nonsense_Mutation	novel	C385*	0.29
KICH	chr22	50455727	Intron	novel		0.33
KIRC	chr22	50464704	Missense_Mutation	NA	V489A	0.29
KIRC	chr22	50464843	Silent	NA	E469E	0.07
KIRC	chr22	50454914	Missense_Mutation	NA	R1571K	0.31
KIRC	chr22	50466031	Missense_Mutation	NA	I314T	0.25
KIRC	chr22	50454634	Missense_Mutation	NA	P1641S	0.23
KIRP	chr22	50460598	Silent	novel	L1028L	0.35
KIRP	chr22	50465027	Missense_Mutation	NA	Y436H	0.19
KIRP	chr22	50464871	Missense_Mutation	NA	P460L	0.37
KIRP	chr22	50447230	Missense_Mutation	NA	T1865R	0.22
LGG	chr22	50462277	Missense_Mutation	rs556408484	K775R	0.47
LGG	chr22	50459579	Silent	rs374190021	P1193P	0.08
LGG	chr22	50459585	Silent	novel	R1191R	0.35
LGG	chr22	50459991	Missense_Mutation	rs749321273	R1151H	0.14
LGG	chr22	50462394	Missense_Mutation	novel	T736I	0.15
LGG	chr22	50467545	Missense_Mutation	rs376741098	T142M	0.61
LGG	chr22	50462019	Missense_Mutation	NA	F833I	0.34
LIHC	chr22	50456346	Missense_Mutation	novel	V1379A	0.45
LIHC	chr22	50468444	Missense_Mutation	NA	G25C	0.28
LIHC	chr22	50467412	Missense_Mutation	NA	G159S	0.13
LIHC	chr22	50465014	Missense_Mutation	novel	D440G	0.29
LIHC	chr22	50448292	Silent	NA	A1768A	0.71
LIHC	chr22	50454843	Missense_Mutation	novel	N1595Y	0.4
LUAD	chr22	50466255	Missense_Mutation	NA	F264L	0.53
LUAD	chr22	50464627	Missense_Mutation	novel	W515R	0.29
LUAD	chr22	50461826	Silent	NA	R871R	0.26
LUAD	chr22	50467683	Missense_Mutation	NA	T96R	0.19
LUAD	chr22	50460079	Missense_Mutation	novel	V1122L	0.18
LUAD	chr22	50464404	Silent	NA	N558N	0.28
LUAD	chr22	50465965	Missense_Mutation	novel	S336N	0.38
LUAD	chr22	50467431	Silent	novel	I152I	0.06
LUAD	chr22	50460126	Missense_Mutation	rs368716467	P1106L	0.05
LUAD	chr22	50462257	Frame_Shift_Del	novel	*R777Vfs41**	0.13
LUAD	chr22	50467647	Missense_Mutation	novel	G108V	0.17
LUAD	chr22	50459470	Missense_Mutation	novel	G1230C	0.21
LUAD	chr22	50461181	Missense_Mutation	novel	Q982L	0.14
LUSC	chr22	50466192	Silent	novel	I285I	0.66
LUSC	chr22	50467434	Silent	rs772026338	L151L	0.64
LUSC	chr22	50468435	Silent	novel	L28L	0.57
LUSC	chr22	50466246	Silent	novel	V267V	0.16
LUSC	chr22	50459507	Silent	rs749839491	V1217V	0.42
LUSC	chr22	50456510	Silent	novel	G1356G	0.31
LUSC	chr22	50454714	Missense_Mutation	rs773366726	N1614S	0.47
LUSC	chr22	50455378	Missense_Mutation	NA	P1467L	0.46
LUSC	chr22	50461717	Splice_Site	novel	X882_splice	0.32
LUSC	chr22	50461571	Missense_Mutation	NA	L931F	0.25
LUSC	chr22	50459561	Silent	rs754805260	S1199S	0.64
LUSC	chr22	50455522	Missense_Mutation	novel	V1443M	0.24
LUSC	chr22	50462045	Missense_Mutation	novel	G824V	0.87
LUSC	chr22	50459573	Silent	rs777461626	V1195V	0.35
LUSC	chr22	50456303	Silent	novel	L1393L	0.15
MESO	chr22	50465039	Missense_Mutation	NA	R432C	0.76
OV	chr22	50464393	Missense_Mutation	NA	R562P	0.23
OV	chr22	50465107	Missense_Mutation	NA	G409V	0.42
OV	chr22	50455111	Missense_Mutation	novel	F1529C	0.45
OV	chr22	50460566	Silent	rs755290851	P1038P	0.52
OV	chr22	50447362	Missense_Mutation	novel	M1848R	0.11
PAAD	chr22	50464905	Missense_Mutation	novel	E449K	0.16
PAAD	chr22	50466003	Silent	novel	L323L	0.16
PAAD	chr22	50467415	Nonsense_Mutation	novel	E158*	0.21
PCPG	chr22	50464650	Missense_Mutation	novel	R507L	0.06
PRAD	chr22	50454549	Missense_Mutation	rs376409019	P1669L	0.17
PRAD	chr22	50462055	Missense_Mutation	NA	D821N	0.3
PRAD	chr22	50461645	Missense_Mutation	rs775026638	P906L	0.13
PRAD	chr22	50462881	Missense_Mutation	novel	A653T	0.36
PRAD	chr22	50463304	Silent	novel	R626R	0.41
READ	chr22	50462652	Silent	rs139798340	T678T	0.32
READ	chr22	50447370	Silent	rs372974901	T1845T	0.3
READ	chr22	50462306	Missense_Mutation	NA	S765R	0.83
SARC	chr22	50447449	Missense_Mutation	NA	R1819H	0.07
SARC	chr22	50454582	Missense_Mutation	rs550773035	R1658H	0.39
SARC	chr22	50461809	Missense_Mutation	rs528597678	P877L	0.35
SKCM	chr22	50459507	Silent	rs749839491	V1217V	0.11
SKCM	chr22	50461579	Missense_Mutation	novel	A928V	0.51
SKCM	chr22	50461203	Nonsense_Mutation	novel	Q975*	0.2
SKCM	chr22	50464695	Missense_Mutation	novel	P492L	0.17
SKCM	chr22	50464664	Silent	novel	P502P	0.32
SKCM	chr22	50461262	Missense_Mutation	rs752102454	S955F	0.75
SKCM	chr22	50464557	Missense_Mutation	novel	T538I	0.75
SKCM	chr22	50459633	Silent	NA	V1175V	0.52
SKCM	chr22	50456613	Missense_Mutation	rs775760879	S1322F	0.25
SKCM	chr22	50465062	Missense_Mutation	NA	A424V	0.33
SKCM	chr22	50460123	Missense_Mutation	NA	S1107F	0.47
SKCM	chr22	50467559	Silent	rs769350649	S137S	0.51
SKCM	chr22	50459992	Missense_Mutation	novel	R1151C	0.15
SKCM	chr22	50456231	Silent	NA	S1417S	0.22
SKCM	chr22	50460109	Missense_Mutation	rs183944303	P1112S	0.33
SKCM	chr22	50447238	Splice_Region	NA	V1862V	0.42
SKCM	chr22	50467603	Missense_Mutation	novel	P123S	0.37
SKCM	chr22	50464541	Silent	NA	P543P	0.16
SKCM	chr22	50468391	Silent	NA	P42P	0.39
SKCM	chr22	50455308	Silent	NA	F1490F	0.61
SKCM	chr22	50462707	Missense_Mutation	rs777899824	P660L	0.37
SKCM	chr22	50465804	Missense_Mutation	novel	F350L	0.25
SKCM	chr22	50462229	Missense_Mutation	NA	A791G	0.29
SKCM	chr22	50446843	3'UTR	novel		0.38
SKCM	chr22	50460574	Missense_Mutation	rs375210922	R1036W	0.32
SKCM	chr22	50464658	Silent	NA	P504P	0.19
SKCM	chr22	50461191	Missense_Mutation	NA	D979N	0.31
SKCM	chr22	50461161	Nonsense_Mutation	novel	Q989*	0.27
SKCM	chr22	50461162	Silent	NA	F988F	0.27
SKCM	chr22	50467553	Silent	rs561411708	L139L	0.24
SKCM	chr22	50454627	Missense_Mutation	rs777083733	P1643L	0.32
SKCM	chr22	50467853	Missense_Mutation	NA	T71I	0.73
SKCM	chr22	50467624	Silent	NA	L116L	0.38
SKCM	chr22	50456256	Missense_Mutation	NA	S1409F	0.17
SKCM	chr22	50464601	Silent	NA	K523K	0.83
SKCM	chr22	50454852	Missense_Mutation	novel	V1592L	0.19
SKCM	chr22	50455389	Silent	NA	L1463L	0.13
SKCM	chr22	50446821	3'UTR	novel		0.88
SKCM	chr22	50457109	Missense_Mutation	novel	P1277S	0.53
SKCM	chr22	50462416	Missense_Mutation	novel	E729K	0.19
STAD	chr22	50455313	Missense_Mutation	rs748910673	R1489C	0.33
STAD	chr22	50447340	Silent	rs201685920	D1855D	0.36
STAD	chr22	50462100	Missense_Mutation	NA	E806K	0.28
STAD	chr22	50461701	Silent	rs773683768	P887P	0.23
STAD	chr22	50448543	Splice_Region	rs779453976	R1717R	0.23
STAD	chr22	50454532	Missense_Mutation	NA	A1675T	0.19
STAD	chr22	50465980	Missense_Mutation	rs544578906	T331M	0.43
STAD	chr22	50455265	Missense_Mutation	NA	F1505L	0.34
STAD	chr22	50460327	Frame_Shift_Del	rs775294940	*S1077Afs28**	0.32
STAD	chr22	50460297	Frame_Shift_Ins	novel	E1087*	0.24
STAD	chr22	50447345	Missense_Mutation	rs763649071	V1854M	0.16
STAD	chr22	50463378	Missense_Mutation	NA	A602T	0.24
STAD	chr22	50447119	3'UTR	novel		0.39
STAD	chr22	50462407	Missense_Mutation	rs377118893	R732C	0.4
STAD	chr22	50447370	Silent	rs372974901	T1845T	0.24
STAD	chr22	50460658	Missense_Mutation	rs772770639	R1008C	0.19
STAD	chr22	50448446	Splice_Site	NA	X1718_splice	0.38
STAD	chr22	50467851	Missense_Mutation	rs556200860	D72N	0.32
STAD	chr22	50455018	Missense_Mutation	novel	L1560P	0.28
STAD	chr22	50454829	Silent	rs771134293	A1599A	0.29
STAD	chr22	50456376	Frame_Shift_Ins	novel	*L1369Pfs10**	0.44
STAD	chr22	50456638	Missense_Mutation	rs200718883	S1314G	0.9
STAD	chr22	50460155	Silent	NA	S1096S	0.41
STAD	chr22	50467438	Missense_Mutation	rs768308575	G150D	0.15
STAD	chr22	50463309	Missense_Mutation	rs146850293	V625I	0.25
STAD	chr22	50455593	Intron	novel		0.33
STAD	chr22	50462907	Missense_Mutation	NA	A644E	0.1
STAD	chr22	50447224	Missense_Mutation	NA	R1867H	0.38
STAD	chr22	50466034	Missense_Mutation	rs762534000	T313I	0.1
STAD	chr22	50454530	Silent	NA	A1675A	0.09
STAD	chr22	50455028	Missense_Mutation	rs767346084	R1557C	0.31
STAD	chr22	50460327	Frame_Shift_Del	rs775294940	*S1077Afs28**	0.48
STAD	chr22	50460327	Frame_Shift_Del	rs775294940	*S1077Afs28**	0.24
STAD	chr22	50461705	Missense_Mutation	NA	R886Q	0.23
STAD	chr22	50462471	Splice_Region	NA	E710E	0.06
STAD	chr22	50459547	Missense_Mutation	rs773094340	A1204V	0.43
STAD	chr22	50462283	Missense_Mutation	rs763014252	S773N	0.25
STAD	chr22	50447156	Frame_Shift_Del	novel	*L1890Cfs40**	0.11
STAD	chr22	50447084	3'UTR	novel		0.75
STAD	chr22	50467564	Missense_Mutation	NA	V136L	0.69
STAD	chr22	50459304	Silent	rs373494342	S1259S	0.16
STAD	chr22	50460090	Missense_Mutation	rs371928484	M1118T	0.2
STAD	chr22	50467829	Missense_Mutation	rs764108351	Y79C	0.16
STAD	chr22	50464597	Nonsense_Mutation	NA	Q525*	0.21
STAD	chr22	50447565	Missense_Mutation	NA	P1803H	0.13
TGCT	chr22	50467683	Missense_Mutation	novel	T96K	0.06
THCA	chr22	50456342	Missense_Mutation	novel	F1380L	0.09
THCA	chr22	50462351	In_Frame_Del	novel	E749_E750del	0.06
UCEC	chr22	50460282	Silent	NA	D1091D	0.33
UCEC	chr22	50457063	Missense_Mutation	NA	A1292V	0.37
UCEC	chr22	50460103	Missense_Mutation	rs369626870	D1114N	0.39
UCEC	chr22	50465023	Missense_Mutation	NA	R437H	0.18
UCEC	chr22	50462056	Silent	rs752069912	C820C	0.3
UCEC	chr22	50468381	Missense_Mutation	novel	E46K	0.25
UCEC	chr22	50459611	Missense_Mutation	rs370664525	V1183M	0.45
UCEC	chr22	50466450	Missense_Mutation	novel	A230T	0.35
UCEC	chr22	50467638	Missense_Mutation	NA	G111E	0.08
UCEC	chr22	50457083	Silent	rs770879316	T1285T	0.11
UCEC	chr22	50462569	Missense_Mutation	novel	A706V	0.26
UCEC	chr22	50462697	Silent	rs751999953	T663T	0.33
UCEC	chr22	50465249	Missense_Mutation	novel	R390H	0.4
UCEC	chr22	50460327	Frame_Shift_Del	rs775294940	*S1077Afs28**	0.46
UCEC	chr22	50464533	Splice_Site	NA	X546_splice	0.25
UCEC	chr22	50466682	Missense_Mutation	rs768921617	R193Q	0.47
UCEC	chr22	50461982	Missense_Mutation	novel	S845N	0.38
UCEC	chr22	50467559	Silent	rs769350649	S137S	0.39
UCEC	chr22	50447425	Missense_Mutation	NA	T1827I	0.17
UCEC	chr22	50465790	Silent	novel	T354T	0.14
UCEC	chr22	50467591	Silent	novel	L127L	0.14
UCEC	chr22	50460566	Silent	rs755290851	P1038P	0.32
UCEC	chr22	50455044	Silent	rs200816076	L1551L	0.28
UCEC	chr22	50456237	Missense_Mutation	NA	E1415D	0.5
UCEC	chr22	50461221	Missense_Mutation	rs543518148	V969I	0.4
UCEC	chr22	50459256	Splice_Region	rs762500203	H1275H	0.74
UCEC	chr22	50467868	Missense_Mutation	NA	F66S	0.18
UCEC	chr22	50446679	3'UTR	novel		0.36
UCEC	chr22	50455658	Intron	novel		0.35
UCEC	chr22	50456368	Missense_Mutation	novel	W1372R	0.38
UCEC	chr22	50467862	Missense_Mutation	novel	A68D	0.31
UCEC	chr22	50459365	Missense_Mutation	novel	L1239P	0.19
UCEC	chr22	50461226	Missense_Mutation	novel	I967T	0.49
UCEC	chr22	50454812	Splice_Site	novel	X1604_splice	0.4
UCEC	chr22	50464612	Missense_Mutation	novel	A520T	0.46
UCEC	chr22	50468386	Missense_Mutation	novel	G44D	0.38
UCEC	chr22	50460327	Frame_Shift_Del	rs775294940	*S1077Afs28**	0.41
UCEC	chr22	50454721	Missense_Mutation	rs370715026	V1612M	0.43
UCEC	chr22	50465082	Missense_Mutation	novel	M417I	0.36
UCEC	chr22	50462251	Missense_Mutation	rs368432657	G784R	0.15
UCEC	chr22	50447345	Missense_Mutation	rs763649071	V1854M	0.36
UCEC	chr22	50465062	Missense_Mutation	NA	A424V	0.35
UCEC	chr22	50459309	Missense_Mutation	rs370712299	A1258T	0.71
UCEC	chr22	50460048	Missense_Mutation	rs754136581	R1132H	0.57
UCEC	chr22	50467851	Missense_Mutation	rs556200860	D72N	0.1
UCEC	chr22	50468381	Missense_Mutation	novel	E46K	0.36
UCEC	chr22	50447578	Missense_Mutation	novel	A1799T	0.49
UCEC	chr22	50461196	Missense_Mutation	NA	L977Q	0.44
UCEC	chr22	50459292	Silent	rs765489326	T1263T	0.35
UCEC	chr22	50461808	Silent	rs748830273	P877P	0.38
UCEC	chr22	50448236	Missense_Mutation	novel	N1787T	0.37
UCEC	chr22	50460324	Silent	rs758221298	S1077S	0.25
UCEC	chr22	50447599	Missense_Mutation	novel	G1792S	0.14
UCEC	chr22	50461228	Silent	novel	R966R	0.29
UCEC	chr22	50464851	Missense_Mutation	rs192339446	V467I	0.32
UCEC	chr22	50461244	Missense_Mutation	NA	L961P	0.38
UCEC	chr22	50462230	Missense_Mutation	rs558438739	A791T	0.41
UCEC	chr22	50447099	3'UTR	rs182855637		0.4
UCEC	chr22	50463297	Missense_Mutation	novel	N629D	0.4
UCEC	chr22	50461221	Missense_Mutation	rs543518148	V969I	0.36
UCEC	chr22	50461808	Silent	rs748830273	P877P	0.35
UCEC	chr22	50459661	Frame_Shift_Del	novel	*P1166Qfs4**	0.52
UCEC	chr22	50463341	Missense_Mutation	rs183532262	A614V	0.13
UCEC	chr22	50448286	Silent	novel	R1770R	0.06
UCEC	chr22	50459486	Missense_Mutation	novel	Q1224H	0.61
UCEC	chr22	50460657	Missense_Mutation	rs769275880	R1008H	0.46
UCEC	chr22	50462103	Missense_Mutation	NA	A805T	0.35
UCEC	chr22	50462055	Missense_Mutation	NA	D821N	0.11
UCEC	chr22	50460327	Frame_Shift_Del	rs775294940	*S1077Afs28**	0.49
UCEC	chr22	50459610	Missense_Mutation	novel	V1183A	0.16
UCEC	chr22	50464634	Silent	NA	T512T	0.43
UCEC	chr22	50465062	Missense_Mutation	NA	A424V	0.2
UCEC	chr22	50466178	Missense_Mutation	rs764238173	A290V	0.33
UCEC	chr22	50467341	Silent	NA	S182S	0.46
UCEC	chr22	50460288	Missense_Mutation	novel	Q1089H	0.34
UCEC	chr22	50456518	Missense_Mutation	novel	I1354V	0.24
UCEC	chr22	50460012	Missense_Mutation	novel	R1144Q	0.28
UCEC	chr22	50462619	Silent	NA	D689D	0.28
UCEC	chr22	50454893	Missense_Mutation	novel	S1578F	0.25
UCEC	chr22	50455043	Missense_Mutation	novel	D1552N	0.22
UCEC	chr22	50462313	Missense_Mutation	rs200624784	R763H	0.32
UCEC	chr22	50465068	Missense_Mutation	novel	G422D	0.32
UCEC	chr22	50447441	Missense_Mutation	NA	D1822N	0.39
UCEC	chr22	50461809	Missense_Mutation	rs528597678	P877L	0.35
UCEC	chr22	50465255	Missense_Mutation	novel	V388D	0.37
UCEC	chr22	50457059	Silent	novel	S1293S	0.43
UCEC	chr22	50464856	Missense_Mutation	rs199833729	R465H	0.47
UCEC	chr22	50467338	Splice_Region	novel	Q183Q	0.33
UCEC	chr22	50460138	Missense_Mutation	novel	S1102N	0.29
UCEC	chr22	50462086	Silent	rs761498880	T810T	0.3
UCEC	chr22	50466349	Splice_Site	novel	X263_splice	0.37
UCEC	chr22	50467557	Missense_Mutation	rs765643685	R138Q	0.31
UCEC	chr22	50467908	Missense_Mutation	novel	G53R	0.34
UCEC	chr22	50460327	Frame_Shift_Del	rs775294940	*S1077Afs28**	0.4
UCS	chr22	50460073	Missense_Mutation	rs748976030	R1124G	0.92
UVM	chr22	50460630	Missense_Mutation	rs780146082	P1017L	0.25

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.3603	4.8268e-05
BRCA	DEL	0.4046	0.036477
CESC	DEL	0.2169	0.0012154
COAD	DEL	0.2971	0.00060241
DLBC	DEL	0.0833	0.21158
GBM	DEL	0.3172	3.4736e-11
LGG	DEL	0.1228	0.0042376
LIHC	DEL	0.1784	0.05307
LUAD	DEL	0.345	2.7153e-11
LUSC	DEL	0.1776	0.006888
OV	DEL	0.8446	2.4599e-67
PAAD	DEL	0.2391	0.0001774
PCPG	DEL	0.3272	0.044123
READ	DEL	0.3333	0.00082955
SARC	DEL	0.2763	0.016841
STAD	DEL	0.2472	0.010201
THCA	DEL	0.1563	0.011063
THYM	DEL	0.065	0.063154
UCEC	DEL	0.243	7.1065e-19
UCS	DEL	0.6429	0.0013619

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0069	Kaplan-Meier Survival Analysis
STAD	0.03	Kaplan-Meier Survival Analysis
MESO	0.04	Kaplan-Meier Survival Analysis
ACC	0.0002	Kaplan-Meier Survival Analysis
HNSC	0.00011	Kaplan-Meier Survival Analysis
LUSC	0.016	Kaplan-Meier Survival Analysis
ESCA	0.0033	Kaplan-Meier Survival Analysis
KIRP	0.018	Kaplan-Meier Survival Analysis
PCPG	0.022	Kaplan-Meier Survival Analysis
READ	0.041	Kaplan-Meier Survival Analysis
LIHC	0.0037	Kaplan-Meier Survival Analysis
LGG	0.0014	Kaplan-Meier Survival Analysis
THCA	0.024	Kaplan-Meier Survival Analysis
OV	0.0024	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742