EuRBPDB

Description

Ensembl ID: ENSG00000100280 (Gene tree)
Gene ID: 162
Gene Symbol: AP1B1
Alias: BAM22|AP105A|ADTB1|CLAPB2
Full Name: adaptor related protein complex 1 subunit beta 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 95,500 bases
Position: chr22:29,327,680-29,423,179
Accession: 554
RBP type: non-canonical RBP
Summary: Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000432560	AP1B1-208	4146	-	ENSP00000400065	939 (aa)	-	Q10567
ENST00000421126	AP1B1-207	1908	-	ENSP00000400022	578 (aa)	-	C9J1E7
ENST00000472057	AP1B1-209	727	-	-	- (aa)	-	-
ENST00000402502	AP1B1-203	2935	-	ENSP00000386071	939 (aa)	-	Q10567
ENST00000317368	AP1B1-201	3903	-	ENSP00000319361	919 (aa)	-	Q10567
ENST00000415447	AP1B1-205	2838	-	ENSP00000387612	939 (aa)	-	Q10567
ENST00000482818	AP1B1-211	3560	-	-	- (aa)	-	-
ENST00000415756	AP1B1-206	519	-	ENSP00000392735	173 (aa)	-	H7C034
ENST00000473606	AP1B1-210	560	-	-	- (aa)	-	-
ENST00000405198	AP1B1-204	3838	-	ENSP00000384194	949 (aa)	-	Q10567
ENST00000357586	AP1B1-202	4176	-	ENSP00000350199	949 (aa)	-	Q10567

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04142	Lysosome	KEGG
hsa05170	Human immunodeficiency virus 1 infection	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100280	rs2267137	22	29397536	C	High light scatter reticulocyte count	27863252	[0.015-0.03] unit decrease	0.02256278	EFO_0007986
ENSG00000100280	rs2267137	22	29397536	C	High light scatter reticulocyte percentage of red cells	27863252	[0.016-0.03] unit decrease	0.02315204	EFO_0007986
ENSG00000100280	rs2267138	22	29397652	?	Myopia (pathological)	23049088	[NR]		EFO_0004207
ENSG00000100280	rs13056435	22	29412174	C	Heel bone mineral density	28869591	[0.038-0.071] unit increase	0.0548708	EFO_0009270
ENSG00000100280	rs13056435	22	29412174	C	Heel bone mineral density	28869591	[0.036-0.06] unit increase	0.0480958	EFO_0009270
ENSG00000100280	rs174775	22	29395245	G	Immature fraction of reticulocytes	27863252	[0.017-0.032] unit decrease	0.02447633	EFO_0007986
ENSG00000100280	rs75337432	22	29337521	?	Heel bone mineral density	30048462	[0.032-0.047] unit increase	0.0395155	EFO_0009270
ENSG00000100280	rs13056435	22	29412174	?	Heel bone mineral density	30048462	[0.031-0.046] unit increase	0.0387759	EFO_0009270
ENSG00000100280	rs34583478	22	29339658	C	Heel bone mineral density	30598549	[0.024-0.038] unit increase	0.0309925	EFO_0009270
ENSG00000100280	rs34583478	22	29339658	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100280	AP1B1	100	99.827	ENSMUSG00000009090	Ap1b1	100	96.925	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	TAS	Component
GO:0005215	transporter activity	7987321.	TAS	Function
GO:0005515	protein binding	9733768.23415225.24843023.	IPI	Function
GO:0005765	lysosomal membrane	-	TAS	Component
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006886	intracellular protein transport	-	IEA	Process
GO:0007368	determination of left/right symmetry	-	IEA	Process
GO:0007507	heart development	-	IEA	Process
GO:0016192	vesicle-mediated transport	-	IEA	Process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0019901	protein kinase binding	-	ISS	Function
GO:0030131	clathrin adaptor complex	-	IEA	Component
GO:0030276	clathrin binding	-	IEA	Function
GO:0030659	cytoplasmic vesicle membrane	-	TAS	Component
GO:0030665	clathrin-coated vesicle membrane	-	IEA	Component
GO:0032588	trans-Golgi network membrane	-	TAS	Component
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0050690	regulation of defense response to virus by virus	-	TAS	Process