EuRBPDB

Description

Ensembl ID: ENSG00000100294 (Gene tree)
Gene ID: 27349
Gene Symbol: MCAT
Alias: MT|MCT|fabD|FASN2C|NET62|MCT1
Full Name: malonyl-CoA-acyl carrier protein transacylase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 11,192 bases
Position: chr22:43,132,206-43,143,397
Accession: 29622
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000608052	MCAT-204	459	-	ENSP00000477216	87 (aa)	-	V9GYY6
ENST00000290429	MCAT-201	2056	XM_011530156	ENSP00000290429	390 (aa)	XP_011528458	Q8IVS2
ENST00000327555	MCAT-202	1134	-	ENSP00000331306	180 (aa)	-	Q8IVS2
ENST00000464244	MCAT-203	549	-	-	- (aa)	-	-

Gene Model

Pathways

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100294	Basophils	2.6430000E-005	21738480
ENSG00000100294	Basophils	1.2980000E-005	21738480

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100294	MCAT	79	49.355	FBgn0036691	beg	82	49.355	Drosophila_melanogaster
ENSG00000100294	MCAT	99	75.389	ENSMUSG00000048755	Mcat	97	88.406	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0004312	fatty acid synthase activity	12882974.	IDA	Function
GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	21873635.	IBA	Function
GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	12882974.	IDA	Function
GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	-	TAS	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	12882974.	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0006633	fatty acid biosynthetic process	21873635.	IBA	Process
GO:0006633	fatty acid biosynthetic process	12882974.	IDA	Process
GO:0006633	fatty acid biosynthetic process	-	IEA	Process
GO:0006635	fatty acid beta-oxidation	-	TAS	Process