EuRBPDB

Description

Ensembl ID: ENSG00000100296 (Gene tree)
Gene ID: 8563
Gene Symbol: THOC5
Alias: PK1.3|KIAA0983|Fmip|fSAP79|C22orf19
Full Name: THO complex 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 49,338 bases
Position: chr22:29,505,879-29,555,216
Accession: 19074
RBP type: non-canonical RBP
Summary: (THO Complex 5) is a Protein Coding gene. Among its related pathways are Transport of Mature Transcript to Cytoplasm and RNA Polymerase II Transcription Termination. Gene Ontology (GO) annotations related to this gene include mRNA binding.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22893130	TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export.	Nat Commun	2012	Viphakone N	doi: 10.1038/ncomms2005.
19165146	Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.	EMBO J	2009 Mar 4	Katahira J	doi: 10.1038/emboj.2009.5

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000397873	THOC5-204	2374	XM_005261798	ENSP00000380971	683 (aa)	XP_005261855	Q13769
ENST00000397872	THOC5-203	2676	XM_006724347	ENSP00000380970	683 (aa)	XP_006724410	Q13769
ENST00000397871	THOC5-202	2560	XM_005261799	ENSP00000380969	683 (aa)	XP_005261856	Q13769
ENST00000484924	THOC5-214	909	-	-	- (aa)	-	-
ENST00000472164	THOC5-212	529	-	-	- (aa)	-	-
ENST00000488052	THOC5-215	526	-	-	- (aa)	-	-
ENST00000414902	THOC5-205	484	-	ENSP00000393420	43 (aa)	-	F8WES8
ENST00000475187	THOC5-213	1935	-	-	- (aa)	-	-
ENST00000358079	THOC5-201	2427	-	ENSP00000444493	127 (aa)	-	F5GZF3
ENST00000490103	THOC5-216	4753	XM_005261797	ENSP00000420306	683 (aa)	XP_005261854	Q13769
ENST00000442555	THOC5-209	3012	-	ENSP00000416500	343 (aa)	-	F8WCP5
ENST00000428374	THOC5-207	729	-	ENSP00000416804	161 (aa)	-	C9JCL9
ENST00000492707	THOC5-217	550	-	-	- (aa)	-	-
ENST00000440771	THOC5-208	1006	-	ENSP00000413505	223 (aa)	-	C9JXG5
ENST00000443089	THOC5-210	786	-	ENSP00000393247	262 (aa)	-	H7C072
ENST00000418021	THOC5-206	738	-	ENSP00000388039	93 (aa)	-	C9JXU6
ENST00000455450	THOC5-211	579	-	ENSP00000415425	176 (aa)	-	H7C441

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100296	Interleukin-10	3.5340000E-005	-
ENSG00000100296	Citalopram	3.9880000E-005	-
ENSG00000100296	Cholesterol, HDL	2E-7	24023261

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100296	rs8135828	22	29533250	A	Lipid traits	24023261	[0.034-0.186] unit decrease	0.11	EFO_0004612
ENSG00000100296	rs73159014	22	29537298	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100296	THOC5	100	96.894	ENSMUSG00000034274	Thoc5	100	96.047	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000228	nuclear chromosome	21873635.	IBA	Component
GO:0000346	transcription export complex	15833825.15998806.	IDA	Component
GO:0000347	THO complex	15998806.	IDA	Component
GO:0000445	THO complex part of transcription export complex	21873635.	IBA	Component
GO:0000445	THO complex part of transcription export complex	15998806.	IDA	Component
GO:0000784	nuclear chromosome, telomeric region	24270157.	IDA	Component
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0005515	protein binding	19059247.19165146.22365833.23299939.26382858.26496610.	IPI	Function
GO:0005634	nucleus	19059247.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006405	RNA export from nucleus	-	TAS	Process
GO:0006406	mRNA export from nucleus	21873635.	IBA	Process
GO:0006406	mRNA export from nucleus	17190602.	IDA	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0008380	RNA splicing	-	IEA	Process
GO:0030224	monocyte differentiation	19015024.	IDA	Process
GO:0031124	mRNA 3'-end processing	-	TAS	Process
GO:0032786	positive regulation of DNA-templated transcription, elongation	21873635.	IBA	Process
GO:0032786	positive regulation of DNA-templated transcription, elongation	22144908.	IMP	Process
GO:0046784	viral mRNA export from host cell nucleus	18974867.	IDA	Process
GO:0060215	primitive hemopoiesis	-	ISS	Process
GO:2000002	negative regulation of DNA damage checkpoint	22144908.	IMP	Process