EuRBPDB

Description

Ensembl ID: ENSG00000100325 (Gene tree)
Gene ID: 84164
Gene Symbol: ASCC2
Alias: ASC1p100|FLJ21588|DKFZp586O0223
Full Name: activating signal cointegrator 1 complex subunit 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 49,697 bases
Position: chr22:29,788,608-29,838,304
Accession: 24103
RBP type: non-canonical RBP
Summary: (Activating Signal Cointegrator 1 Complex Subunit 2) is a Protein Coding gene. Diseases associated with ASCC2 include Trichothiodystrophy 1, Photosensitive. Among its related pathways are DNA Damage Reversal and DNA Double-Strand Break Repair.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000411532	ASCC2-203	261	-	ENSP00000414545	87 (aa)	-	H7C3Y4
ENST00000463203	ASCC2-212	385	-	-	- (aa)	-	-
ENST00000449900	ASCC2-206	580	-	ENSP00000397077	78 (aa)	-	F8WAQ6
ENST00000487486	ASCC2-219	1596	-	-	- (aa)	-	-
ENST00000412689	ASCC2-204	742	-	-	- (aa)	-	-
ENST00000495967	ASCC2-222	554	-	-	- (aa)	-	-
ENST00000464287	ASCC2-213	538	-	-	- (aa)	-	-
ENST00000453160	ASCC2-207	529	-	ENSP00000410531	54 (aa)	-	H7C395
ENST00000478812	ASCC2-217	827	-	-	- (aa)	-	-
ENST00000495681	ASCC2-221	536	-	-	- (aa)	-	-
ENST00000458594	ASCC2-209	2753	-	ENSP00000403031	37 (aa)	-	F2Z2W4
ENST00000492821	ASCC2-220	562	-	-	- (aa)	-	-
ENST00000454854	ASCC2-208	469	-	ENSP00000408930	37 (aa)	-	F2Z2W4
ENST00000483380	ASCC2-218	198	-	-	- (aa)	-	-
ENST00000542393	ASCC2-223	2594	XM_011530448	ENSP00000437570	681 (aa)	XP_011528750	Q9H1I8
ENST00000465667	ASCC2-214	876	-	-	- (aa)	-	-
ENST00000460313	ASCC2-210	568	-	-	- (aa)	-	-
ENST00000431535	ASCC2-205	873	-	ENSP00000412382	240 (aa)	-	B1AH59
ENST00000397771	ASCC2-202	2823	XM_005261775	ENSP00000380877	757 (aa)	XP_005261832	Q9H1I8
ENST00000462454	ASCC2-211	491	-	-	- (aa)	-	-
ENST00000307790	ASCC2-201	2793	XM_011530446	ENSP00000305502	757 (aa)	XP_011528748	Q9H1I8
ENST00000477074	ASCC2-216	554	-	-	- (aa)	-	-
ENST00000472433	ASCC2-215	536	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100325	Attention Deficit Disorder with Hyperactivity	6E-7	27890468
ENSG00000100325	Bipolar Disorder	6E-7	27890468
ENSG00000100325	Telomere	9E-6	24478790

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100325	rs9608816	22	29820911	?	Bipolar disorder or attention deficit hyperactivity disorder	27890468			EFO_0003888\|EFO_0000289
ENSG00000100325	rs73394838	22	29829984	G	Telomere length	24478790	[NR]		EFO_0004505
ENSG00000100325	rs737945	22	29806785	C	Educational attainment (MTAG)	30038396	[0.0083-0.0133] unit decrease	0.0108	EFO_0004784
ENSG00000100325	rs249394	22	29803349	C	Immature fraction of reticulocytes	27863252	[0.041-0.065] unit decrease	0.05341759	EFO_0007986
ENSG00000100325	rs140147	22	29788610	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000100325	rs737945	22	29806785	C	Educational attainment (years of education)	30038396	[0.0088-0.0142] unit decrease	0.0115	EFO_0004784
ENSG00000100325	rs28265	22	29804772	C	Type 2 diabetes (adjusted for BMI)	29632382	[1.07-1.12]	1.09	EFO_0001360
ENSG00000100325	rs28265	22	29804772	C	Type 2 diabetes (adjusted for BMI)	29632382	[1.06-1.12]	1.09	EFO_0001360

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005634	nucleus	12077347.26924529.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006307	DNA dealkylation involved in DNA repair	-	TAS	Process
GO:0006355	regulation of transcription, DNA-templated	12077347.	IDA	Process
GO:0016607	nuclear speck	-	IEA	Component
GO:0099053	activating signal cointegrator 1 complex	12077347.	IDA	Component