EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100401 (Gene tree)
Gene ID: 5905
Gene Symbol: RANGAP1
Alias: Fug1|KIAA1835|SD
Full Name: Ran GTPase activating protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 57,434 bases
Position: chr22:41,244,777-41,302,210
Accession: 9854
RBP type: non-canonical RBP
Summary: This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27164557	Genetic Relationship between Schizophrenia and Nicotine Dependence.	Sci Rep	2016 May 10	Chen J	doi: 10.1038/srep25671.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000405486	RANGAP1-202	3469	XM_005261695	ENSP00000385866	587 (aa)	XP_005261752	P46060
ENST00000446258	RANGAP1-205	759	-	ENSP00000393407	253 (aa)	-	H0Y4Q3
ENST00000356244	RANGAP1-201	3060	XM_006724289	ENSP00000348577	587 (aa)	XP_006724352	P46060
ENST00000455915	RANGAP1-207	4222	XM_005261696	ENSP00000401470	587 (aa)	XP_005261753	P46060
ENST00000418067	RANGAP1-203	650	-	ENSP00000408743	100 (aa)	-	B0QYT5
ENST00000452543	RANGAP1-206	603	-	ENSP00000394787	133 (aa)	-	B0QYT4
ENST00000422838	RANGAP1-204	946	-	ENSP00000404842	37 (aa)	-	B0QYT6

Gene Model

Click here to download ENSG00000100401's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100401	Insulin-Like Growth Factor Binding Protein 1	6.4180000E-005	-
ENSG00000100401	Hypersensitivity	4E-6	23817569

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100401	rs2235852	22	41265150	T	Self-reported allergy	23817569	[0.033-0.082] unit increase	0.0577	EFO_0003785
ENSG00000100401	rs3171692	22	41246208	T	Feeling tense	29500382	z score increase	5.66	EFO_0009596
ENSG00000100401	rs139498	22	41248230	C	Adventurousness	30643258	[0.009-0.0167] unit increase	0.012839883	EFO_0008579

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100401's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100401	RANGAP1	100	45.113	FBgn0003346	RanGAP	57	44.575	Drosophila_melanogaster
ENSG00000100401	RANGAP1	100	97.297	ENSMUSG00000022391	Rangap1	100	95.833	Mus_musculus
ENSG00000100401	RANGAP1	83	32.456	YMR235C		79	30.675	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000776	kinetochore	17363900.	IDA	Component
GO:0000777	condensed chromosome kinetochore	-	IEA	Component
GO:0003723	RNA binding	26308891.	IDA	Function
GO:0005096	GTPase activator activity	16428860.	IDA	Function
GO:0005515	protein binding	14729961.16732283.17000644.17036045.17099698.17099700.18093978.19549727.20414307.21988832.23395904.26496610.	IPI	Function
GO:0005635	nuclear envelope	25468996.	IDA	Component
GO:0005635	nuclear envelope	-	TAS	Component
GO:0005643	nuclear pore	8978815.	TAS	Component
GO:0005654	nucleoplasm	-	IEA	Component
GO:0005737	cytoplasm	8978815.	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0007165	signal transduction	-	IEA	Process
GO:0008536	Ran GTPase binding	16428860.	IPI	Function
GO:0016235	aggresome	-	IDA	Component
GO:0016925	protein sumoylation	-	TAS	Process
GO:0030425	dendrite	-	IEA	Component
GO:0031625	ubiquitin protein ligase binding	-	IEA	Function
GO:0031965	nuclear membrane	-	IDA	Component
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0044614	nuclear pore cytoplasmic filaments	-	IEA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046826	negative regulation of protein export from nucleus	16449645.	IDA	Process
GO:0048471	perinuclear region of cytoplasm	26308891.	IDA	Component
GO:0048678	response to axon injury	-	IEA	Process
GO:0072686	mitotic spindle	-	IEA	Component
GO:0090630	activation of GTPase activity	16428860.	IDA	Process
GO:1904115	axon cytoplasm	-	IEA	Component
GO:1904117	cellular response to vasopressin	-	IEA	Process
GO:1990723	cytoplasmic periphery of the nuclear pore complex	-	IEA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr22	41254325	Silent	novel	L415L	0.2
BLCA	chr22	41281014	Missense_Mutation	novel	E11K	0.26
BLCA	chr22	41261443	Splice_Region	rs775116116		0.07
BLCA	chr22	41256228	Missense_Mutation	NA	M317I	0.45
BLCA	chr22	41261560	Silent	rs751689271	T167T	0.19
BLCA	chr22	41251078	Missense_Mutation	NA	S471Y	0.18
BLCA	chr22	41249810	Silent	novel	L497L	0.25
BRCA	chr22	41281546	Intron	novel		0.32
BRCA	chr22	41256042	Missense_Mutation	NA	A351V	0.37
BRCA	chr22	41280996	Missense_Mutation	NA	Q17E	0.23
BRCA	chr22	41254386	Silent	NA	E394E	0.1
BRCA	chr22	41246543	3'UTR	novel		0.62
CESC	chr22	41253016	Intron	novel		0.29
COAD	chr22	41254431	Silent	NA	E379E	0.14
COAD	chr22	41268131	Missense_Mutation	novel	T89M	0.07
COAD	chr22	41256022	Missense_Mutation	novel	S358C	0.27
COAD	chr22	41249786	Silent	rs376593623	S505S	0.15
COAD	chr22	41268120	Missense_Mutation	rs776060557	R93W	0.4
COAD	chr22	41256042	Missense_Mutation	NA	A351V	0.28
COAD	chr22	41246536	3'UTR	novel		0.13
COAD	chr22	41268104	Missense_Mutation	novel	P98Q	0.35
COAD	chr22	41249342	Missense_Mutation	rs748108526	A561V	0.32
COAD	chr22	41256732	Silent	rs531001209	R289R	0.35
COAD	chr22	41246642	Silent	rs555171214	F575F	0.27
COAD	chr22	41268098	Missense_Mutation	NA	L100P	0.31
COAD	chr22	41254383	Silent	rs771108482	E395E	0.08
COAD	chr22	41254383	Silent	rs771108482	E395E	0.11
COAD	chr22	41258077	Missense_Mutation	novel	M215I	0.08
COAD	chr22	41256728	Missense_Mutation	rs143560227	G291S	0.43
ESCA	chr22	41281042	Translation_Start_Site	novel	M1?	0.39
GBM	chr22	41254463	Missense_Mutation	novel	G369R	0.29
GBM	chr22	41281118	Intron	novel		0.2
GBM	chr22	41251020	Silent	novel	V490V	0.28
GBM	chr22	41254479	Frame_Shift_Del	novel	*D362Gfs21**	0.06
GBM	chr22	41258020	Silent	novel	V234V	0.21
HNSC	chr22	41256026	Silent	rs150178245	S356S	0.44
KIRC	chr22	41281167	Intron	novel		0.75
KIRP	chr22	41246573	3'UTR	novel		0.42
LIHC	chr22	41256808	Missense_Mutation	rs567605253	R264Q	0.14
LUAD	chr22	41256739	Missense_Mutation	NA	A287V	0.28
LUAD	chr22	41249434	Missense_Mutation	NA	K530N	0.15
LUAD	chr22	41274680	Silent	NA	L54L	0.07
LUAD	chr22	41261527	Missense_Mutation	NA	K178N	0.26
LUSC	chr22	41281076	5'UTR	novel		0.03
LUSC	chr22	41274651	Silent	NA	V63V	0.25
LUSC	chr22	41264672	Missense_Mutation	novel	G158S	0.31
LUSC	chr22	41256067	Missense_Mutation	NA	E343K	0.2
LUSC	chr22	41246669	Frame_Shift_Del	novel	*N567Tfs43**	0.5
LUSC	chr22	41254420	Missense_Mutation	novel	D383V	0.11
LUSC	chr22	41251057	Missense_Mutation	novel	S478F	0.15
LUSC	chr22	41256100	Missense_Mutation	novel	T332S	0.5
LUSC	chr22	41249401	Silent	novel	A541A	0.38
OV	chr22	41261484	Frame_Shift_Ins	novel	*E193Lfs12**	0.07
OV	chr22	41281087	Splice_Region	novel		0.23
OV	chr22	41261490	Missense_Mutation	novel	R191G	0.18
OV	chr22	41281004	Missense_Mutation	novel	A14G	0.07
PAAD	chr22	41254334	Missense_Mutation	rs139571477	R412W	0.2
PAAD	chr22	41249749	Missense_Mutation	rs770249841	V518M	0.2
PAAD	chr22	41254398	Missense_Mutation	novel	E390D	0.15
PAAD	chr22	41254458	Silent	novel	E370E	0.19
SARC	chr22	41246610	Missense_Mutation	novel	K586R	0.21
SKCM	chr22	41258014	Silent	NA	P236P	0.33
SKCM	chr22	41264762	Missense_Mutation	NA	G128S	0.21
SKCM	chr22	41249338	Silent	rs754533610	F562F	0.34
SKCM	chr22	41274624	Silent	rs781273674	A72A	0.29
SKCM	chr22	41252891	Missense_Mutation	NA	S454F	0.23
SKCM	chr22	41264748	Silent	rs754622496	F132F	0.14
SKCM	chr22	41281071	5'UTR	novel		0.15
SKCM	chr22	41251092	Silent	rs774244432	P466P	0.34
SKCM	chr22	41264831	Missense_Mutation	rs767290351	E105K	0.3
STAD	chr22	41264822	Missense_Mutation	rs143626610	I108V	0.14
STAD	chr22	41256732	Silent	rs531001209	R289R	0.16
STAD	chr22	41254386	Silent	NA	E394E	0.53
STAD	chr22	41256102	Missense_Mutation	NA	N331S	0.35
STAD	chr22	41264670	Silent	rs773090708	G158G	0.23
STAD	chr22	41249449	Splice_Region	rs576341365	S525S	0.18
STAD	chr22	41261473	Silent	rs200548054	G196G	0.42
STAD	chr22	41261528	Missense_Mutation	NA	K178R	0.13
STAD	chr22	41256060	Missense_Mutation	NA	L345P	0.33
STAD	chr22	41254398	Silent	NA	E390E	0.29
STAD	chr22	41280934	Splice_Region	rs757412279	D37D	0.05
STAD	chr22	41258060	Missense_Mutation	rs144343100	N221S	0.72
STAD	chr22	41280979	Silent	NA	Q22Q	0.38
STAD	chr22	41254401	Silent	rs776143659	E389E	0.3
STAD	chr22	41274682	Missense_Mutation	NA	A53V	0.37
STAD	chr22	41252909	Missense_Mutation	NA	R448H	0.33
STAD	chr22	41280989	Missense_Mutation	NA	A19V	0.3
THCA	chr22	41281136	Intron	novel		0.9
UCEC	chr22	41254446	Missense_Mutation	NA	E374D	0.11
UCEC	chr22	41252953	Silent	novel	D433D	0.55
UCEC	chr22	41274718	Missense_Mutation	novel	V41A	0.28
UCEC	chr22	41254488	Silent	rs200379863	D360D	0.32
UCEC	chr22	41258081	Missense_Mutation	novel	H214R	0.5
UCEC	chr22	41246649	Missense_Mutation	novel	C573Y	0.09
UCEC	chr22	41256277	Nonsense_Mutation	novel	S301*	0.22
UCEC	chr22	41249343	Missense_Mutation	novel	A561S	0.42
UCEC	chr22	41246435	3'UTR	novel		0.34
UCEC	chr22	41254386	Silent	NA	E394E	0.37
UCEC	chr22	41246526	3'UTR	novel		0.22
UCEC	chr22	41274609	Silent	rs776267502	S77S	0.34
UCEC	chr22	41249369	Missense_Mutation	novel	P552H	0.31
UCEC	chr22	41249341	Silent	rs545542836	A561A	0.3
UCEC	chr22	41256265	Missense_Mutation	NA	I305T	0.43
UCEC	chr22	41261478	Missense_Mutation	NA	D195N	0.36
UCEC	chr22	41281450	Intron	novel		0.41
UCEC	chr22	41264766	Silent	rs531319204	P126P	0.51
UCEC	chr22	41261473	Silent	rs200548054	G196G	0.33
UCEC	chr22	41274609	Silent	rs776267502	S77S	0.46
UCEC	chr22	41281180	Intron	novel		0.5
UCEC	chr22	41281756	Intron	novel		0.29
UCEC	chr22	41249349	Silent	novel	L559L	0.31
UCEC	chr22	41249728	Splice_Site	novel	X524_splice	0.33
UCEC	chr22	41274719	Missense_Mutation	novel	V41M	0.26
UCEC	chr22	41254386	Silent	NA	E394E	0.2
UCEC	chr22	41246535	3'UTR	rs557412992		0.31
UCEC	chr22	41256240	Silent	novel	V313V	0.13
UCEC	chr22	41264748	Silent	rs754622496	F132F	0.4
UCEC	chr22	41256723	Silent	novel	L292L	0.33
UCS	chr22	41258013	Silent	novel	L237L	0.47

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0417	0.21158
PCPG	DEL	0.3395	0.044123
SKCM	AMP	0.3379	1.0172e-08
THCA	DEL	0.1563	0.046486
THYM	DEL	0.065	0.063154

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.00078	Kaplan-Meier Survival Analysis
SARC	0.026	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
SKCM	0.012	Kaplan-Meier Survival Analysis
KIRP	0.022	Kaplan-Meier Survival Analysis
PCPG	0.011	Kaplan-Meier Survival Analysis
CESC	0.022	Kaplan-Meier Survival Analysis
READ	0.026	Kaplan-Meier Survival Analysis
LAML	0.0019	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
DLBC	0.024	Kaplan-Meier Survival Analysis
LUAD	0.0022	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742