EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100412 (Gene tree)
Gene ID: 50
Gene Symbol: ACO2
Alias: ACONM
Full Name: aconitase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 59,865 bases
Position: chr22:41,469,125-41,528,989
Accession: 118
RBP type: canonical RBP
Summary: The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000216254	Aconitase	PF00330.20	6.1e-148	1	1
ENSP00000379769	Aconitase	PF00330.20	1.3e-141	1	2
ENSP00000379769	Aconitase	PF00330.20	1.3e-141	2	2
ENSP00000216254	Aconitase_C	PF00694.19	1.4e-47	1	1
ENSP00000379769	Aconitase_C	PF00694.19	1.5e-47	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24728987	Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions.	Nucleic Acids Res	2014 Jun	Khan MA	doi: 10.1093/nar/gku248
11238861	Mitochondrial aconitase binds to the 3' untranslated region of the mouse hepatitis virus genome.	J Virol	2001 Apr	Nanda SK	-
17205209	Metabolic regulation of citrate and iron by aconitases: role of iron-sulfur cluster biogenesis.	Biometals	2007 Jun	Tong WH	-
19720833	Direct Fe2+ sensing by iron-responsive messenger RNA:repressor complexes weakens binding.	J Biol Chem	2009 Oct 30	Khan MA	doi: 10.1074/jbc.M109.041061
28819260	Thermodynamic and Kinetic Analyses of Iron Response Element (IRE)-mRNA Binding to Iron Regulatory Protein, IRP1.	Sci Rep	2017 Aug 17	Khan MA	doi: 10.1038/s41598-017-09093-5.
11812787	Structural changes associated with switching activities of human iron regulatory protein 1.	J Biol Chem	2002 Apr 5	Brazzolotto X	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000466237	ACO2-203	747	-	-	- (aa)	-	-
ENST00000471094	ACO2-204	699	-	-	- (aa)	-	-
ENST00000216254	ACO2-201	2741	XM_017028812	ENSP00000216254	780 (aa)	XP_016884301	Q99798
ENST00000481310	ACO2-206	330	-	-	- (aa)	-	-
ENST00000396512	ACO2-202	2811	-	ENSP00000379769	805 (aa)	-	A2A274
ENST00000482208	ACO2-207	624	-	-	- (aa)	-	-
ENST00000478010	ACO2-205	644	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000100412's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00020	Citrate cycle (TCA cycle)	KEGG
hsa00630	Glyoxylate and dicarboxylate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa01210	2-Oxocarboxylic acid metabolism	KEGG
hsa01230	Biosynthesis of amino acids	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100412	Crohn Disease	2E-10	26192919
ENSG00000100412	Inflammatory Bowel Diseases	3E-6	26192919

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100412	rs727563	22	41471373	G	Inflammatory bowel disease	26192919	[1.03-1.08]	1.0581502	EFO_0003767
ENSG00000100412	rs727563	22	41471373	G	Crohn's disease	26192919	[1.07-1.12]	1.0965022	EFO_0000384
ENSG00000100412	rs9611602	22	41512401	?	Respiratory diseases	30595370			EFO_0000684
ENSG00000100412	rs117078955	22	41501983	T	Breast cancer	29059683	[0.074-0.173] unit increase	0.1235	EFO_0000305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100412's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100412	ACO2	99	80.282	ENSAPOG00000011484	ACO2	100	80.282	Acanthochromis_polyacanthus
ENSG00000100412	ACO2	100	79.923	ENSAPOG00000017786	aco2	100	79.923	Acanthochromis_polyacanthus
ENSG00000100412	ACO2	100	95.155	ENSAMEG00000015641	ACO2	100	95.155	Ailuropoda_melanoleuca
ENSG00000100412	ACO2	82	81.123	ENSACIG00000021636	aco2	99	81.123	Amphilophus_citrinellus
ENSG00000100412	ACO2	99	80.922	ENSAOCG00000019100	ACO2	100	80.922	Amphiprion_ocellaris
ENSG00000100412	ACO2	100	79.795	ENSAOCG00000020887	aco2	99	81.123	Amphiprion_ocellaris
ENSG00000100412	ACO2	99	81.178	ENSAPEG00000012427	ACO2	100	81.178	Amphiprion_percula
ENSG00000100412	ACO2	100	79.795	ENSAPEG00000020171	aco2	100	79.795	Amphiprion_percula
ENSG00000100412	ACO2	100	80.307	ENSATEG00000006397	aco2	99	81.435	Anabas_testudineus
ENSG00000100412	ACO2	100	80.307	ENSATEG00000007473	aco2	99	81.435	Anabas_testudineus
ENSG00000100412	ACO2	99	81.818	ENSATEG00000008001	ACO2	100	81.818	Anabas_testudineus
ENSG00000100412	ACO2	99	91.902	ENSAPLG00000005198	ACO2	99	91.902	Anas_platyrhynchos
ENSG00000100412	ACO2	100	90.537	ENSACAG00000004677	-	99	90.537	Anolis_carolinensis
ENSG00000100412	ACO2	100	97.308	ENSANAG00000029281	ACO2	100	97.308	Aotus_nancymaae
ENSG00000100412	ACO2	100	79.795	ENSACLG00000019179	aco2	100	79.795	Astatotilapia_calliptera
ENSG00000100412	ACO2	100	82.353	ENSAMXG00000008808	aco2	100	82.353	Astyanax_mexicanus
ENSG00000100412	ACO2	86	81.746	ENSAMXG00000015485	ACO2	99	81.746	Astyanax_mexicanus
ENSG00000100412	ACO2	100	96.667	ENSBTAG00000006429	ACO2	100	96.667	Bos_taurus
ENSG00000100412	ACO2	98	74.507	WBGene00000041	aco-2	99	76.211	Caenorhabditis_elegans
ENSG00000100412	ACO2	100	97.640	ENSCJAG00000005004	ACO2	100	97.640	Callithrix_jacchus
ENSG00000100412	ACO2	100	96.538	ENSCAFG00000001075	ACO2	99	96.538	Canis_familiaris
ENSG00000100412	ACO2	100	96.538	ENSCAFG00020001976	ACO2	99	96.538	Canis_lupus_dingo
ENSG00000100412	ACO2	100	96.410	ENSCHIG00000007877	ACO2	100	96.410	Capra_hircus
ENSG00000100412	ACO2	100	97.436	ENSTSYG00000001084	ACO2	100	97.436	Carlito_syrichta
ENSG00000100412	ACO2	100	95.769	ENSCAPG00000017225	ACO2	100	95.769	Cavia_aperea
ENSG00000100412	ACO2	100	97.051	ENSCPOG00000012642	ACO2	100	97.051	Cavia_porcellus
ENSG00000100412	ACO2	100	97.949	ENSCCAG00000028378	ACO2	100	97.949	Cebus_capucinus
ENSG00000100412	ACO2	100	98.718	ENSCATG00000030437	ACO2	100	98.718	Cercocebus_atys
ENSG00000100412	ACO2	93	72.300	ENSCATG00000000038	-	100	61.026	Cercocebus_atys
ENSG00000100412	ACO2	77	75.833	ENSCATG00000026864	-	100	75.833	Cercocebus_atys
ENSG00000100412	ACO2	100	96.410	ENSCLAG00000016998	ACO2	100	96.410	Chinchilla_lanigera
ENSG00000100412	ACO2	100	98.718	ENSCSAG00000005807	ACO2	100	98.718	Chlorocebus_sabaeus
ENSG00000100412	ACO2	70	95.161	ENSCHOG00000003549	ACO2	81	95.161	Choloepus_hoffmanni
ENSG00000100412	ACO2	100	91.816	ENSCPBG00000020545	ACO2	99	91.816	Chrysemys_picta_bellii
ENSG00000100412	ACO2	53	74.818	ENSCING00000008967	-	99	74.818	Ciona_intestinalis
ENSG00000100412	ACO2	98	70.869	ENSCSAVG00000007584	-	99	78.708	Ciona_savignyi
ENSG00000100412	ACO2	98	93.552	ENSCANG00000018904	ACO2	97	93.552	Colobus_angolensis_palliatus
ENSG00000100412	ACO2	90	94.845	ENSCGRG00001009672	-	92	94.845	Cricetulus_griseus_chok1gshd
ENSG00000100412	ACO2	100	96.795	ENSCGRG00001023335	Aco2	100	96.795	Cricetulus_griseus_chok1gshd
ENSG00000100412	ACO2	100	96.795	ENSCGRG00000005122	Aco2	100	96.795	Cricetulus_griseus_crigri
ENSG00000100412	ACO2	90	94.845	ENSCGRG00000002318	-	92	94.845	Cricetulus_griseus_crigri
ENSG00000100412	ACO2	82	76.024	ENSCSEG00000020501	aco2	99	76.024	Cynoglossus_semilaevis
ENSG00000100412	ACO2	99	81.562	ENSCSEG00000006701	ACO2	100	81.562	Cynoglossus_semilaevis
ENSG00000100412	ACO2	99	80.154	ENSCVAG00000010923	ACO2	100	81.769	Cyprinodon_variegatus
ENSG00000100412	ACO2	98	75.294	ENSCVAG00000006081	aco2	99	75.294	Cyprinodon_variegatus
ENSG00000100412	ACO2	100	83.120	ENSDARG00000007294	aco2	99	83.120	Danio_rerio
ENSG00000100412	ACO2	99	87.984	ENSDNOG00000018156	ACO2	99	87.117	Dasypus_novemcinctus
ENSG00000100412	ACO2	99	95.871	ENSDORG00000002209	Aco2	100	95.871	Dipodomys_ordii
ENSG00000100412	ACO2	98	72.208	FBgn0010100	Acon	99	71.959	Drosophila_melanogaster
ENSG00000100412	ACO2	98	70.341	FBgn0037862	CG4706	97	70.341	Drosophila_melanogaster
ENSG00000100412	ACO2	81	95.058	ENSETEG00000010742	ACO2	81	95.058	Echinops_telfairi
ENSG00000100412	ACO2	81	80.328	ENSEBUG00000009201	aco2	98	79.239	Eptatretus_burgeri
ENSG00000100412	ACO2	100	97.051	ENSEASG00005001546	ACO2	98	97.051	Equus_asinus_asinus
ENSG00000100412	ACO2	100	96.923	ENSECAG00000023762	ACO2	98	96.923	Equus_caballus
ENSG00000100412	ACO2	100	87.324	ENSEEUG00000010201	ACO2	100	87.324	Erinaceus_europaeus
ENSG00000100412	ACO2	99	80.051	ENSELUG00000019769	aco2	100	80.051	Esox_lucius
ENSG00000100412	ACO2	99	81.154	ENSELUG00000007787	ACO2	99	82.500	Esox_lucius
ENSG00000100412	ACO2	99	94.900	ENSFCAG00000018526	ACO2	100	94.900	Felis_catus
ENSG00000100412	ACO2	96	92.369	ENSFALG00000011957	ACO2	99	92.369	Ficedula_albicollis
ENSG00000100412	ACO2	100	96.923	ENSFDAG00000010448	ACO2	100	96.923	Fukomys_damarensis
ENSG00000100412	ACO2	100	79.540	ENSFHEG00000012709	aco2	100	79.540	Fundulus_heteroclitus
ENSG00000100412	ACO2	99	80.538	ENSFHEG00000020556	ACO2	100	82.172	Fundulus_heteroclitus
ENSG00000100412	ACO2	99	72.471	ENSGMOG00000001946	-	100	72.471	Gadus_morhua
ENSG00000100412	ACO2	99	78.462	ENSGMOG00000013297	aco2	100	78.462	Gadus_morhua
ENSG00000100412	ACO2	100	91.560	ENSGALG00000011950	ACO2	99	91.560	Gallus_gallus
ENSG00000100412	ACO2	99	79.898	ENSGAFG00000010889	ACO2	100	79.898	Gambusia_affinis
ENSG00000100412	ACO2	100	79.284	ENSGAFG00000008252	aco2	100	79.284	Gambusia_affinis
ENSG00000100412	ACO2	100	78.772	ENSGACG00000004686	aco2	99	80.295	Gasterosteus_aculeatus
ENSG00000100412	ACO2	100	91.432	ENSGAGG00000017500	ACO2	99	91.432	Gopherus_agassizii
ENSG00000100412	ACO2	100	99.744	ENSGGOG00000001107	ACO2	100	99.744	Gorilla_gorilla
ENSG00000100412	ACO2	92	75.926	ENSGGOG00000037860	-	100	76.486	Gorilla_gorilla
ENSG00000100412	ACO2	100	79.795	ENSHBUG00000004106	aco2	100	79.795	Haplochromis_burtoni
ENSG00000100412	ACO2	100	96.154	ENSHGLG00000015463	Aco2	100	96.154	Heterocephalus_glaber_female
ENSG00000100412	ACO2	100	95.513	ENSHGLG00100010294	ACO2	100	95.513	Heterocephalus_glaber_male
ENSG00000100412	ACO2	99	80.922	ENSHCOG00000006890	ACO2	100	80.922	Hippocampus_comes
ENSG00000100412	ACO2	100	79.923	ENSHCOG00000010190	aco2	100	79.923	Hippocampus_comes
ENSG00000100412	ACO2	99	81.946	ENSIPUG00000001101	aco2	99	83.125	Ictalurus_punctatus
ENSG00000100412	ACO2	100	97.308	ENSSTOG00000016210	ACO2	100	97.308	Ictidomys_tridecemlineatus
ENSG00000100412	ACO2	89	89.733	ENSJJAG00000014029	Aco2	99	89.733	Jaculus_jaculus
ENSG00000100412	ACO2	56	81.693	ENSKMAG00000021995	aco2	91	81.693	Kryptolebias_marmoratus
ENSG00000100412	ACO2	99	80.282	ENSKMAG00000014823	ACO2	100	80.282	Kryptolebias_marmoratus
ENSG00000100412	ACO2	100	78.517	ENSLBEG00000002060	aco2	99	80.187	Labrus_bergylta
ENSG00000100412	ACO2	81	79.528	ENSLACG00000011854	ACO2	100	79.528	Latimeria_chalumnae
ENSG00000100412	ACO2	89	72.365	ENSLOCG00000011607	aco2	98	72.365	Lepisosteus_oculatus
ENSG00000100412	ACO2	99	96.662	ENSLAFG00000006030	ACO2	100	96.662	Loxodonta_africana
ENSG00000100412	ACO2	81	75.197	ENSMFAG00000041445	-	96	75.197	Macaca_fascicularis
ENSG00000100412	ACO2	100	98.974	ENSMFAG00000043571	ACO2	100	98.974	Macaca_fascicularis
ENSG00000100412	ACO2	100	98.974	ENSMMUG00000001454	ACO2	100	98.974	Macaca_mulatta
ENSG00000100412	ACO2	100	98.718	ENSMNEG00000044522	ACO2	100	98.718	Macaca_nemestrina
ENSG00000100412	ACO2	100	72.308	ENSMLEG00000042289	-	100	72.308	Mandrillus_leucophaeus
ENSG00000100412	ACO2	100	98.846	ENSMLEG00000031603	ACO2	100	98.846	Mandrillus_leucophaeus
ENSG00000100412	ACO2	99	81.050	ENSMAMG00000007378	ACO2	100	82.574	Mastacembelus_armatus
ENSG00000100412	ACO2	100	78.772	ENSMAMG00000003762	aco2	99	79.875	Mastacembelus_armatus
ENSG00000100412	ACO2	100	79.795	ENSMZEG00005019194	aco2	100	79.795	Maylandia_zebra
ENSG00000100412	ACO2	99	91.517	ENSMGAG00000012110	ACO2	99	91.517	Meleagris_gallopavo
ENSG00000100412	ACO2	100	96.923	ENSMAUG00000007598	Aco2	100	96.923	Mesocricetus_auratus
ENSG00000100412	ACO2	100	87.860	ENSMICG00000013529	ACO2	100	87.860	Microcebus_murinus
ENSG00000100412	ACO2	100	96.667	ENSMOCG00000008387	Aco2	100	96.667	Microtus_ochrogaster
ENSG00000100412	ACO2	82	79.719	ENSMMOG00000003639	aco2	99	79.719	Mola_mola
ENSG00000100412	ACO2	99	81.178	ENSMMOG00000002702	ACO2	100	81.178	Mola_mola
ENSG00000100412	ACO2	100	93.606	ENSMODG00000016560	ACO2	100	93.606	Monodelphis_domestica
ENSG00000100412	ACO2	99	79.615	ENSMALG00000008744	aco2	100	81.074	Monopterus_albus
ENSG00000100412	ACO2	99	80.538	ENSMALG00000013359	ACO2	100	80.538	Monopterus_albus
ENSG00000100412	ACO2	100	96.795	ENSMUSG00000022477	Aco2	100	96.795	Mus_musculus
ENSG00000100412	ACO2	100	96.667	MGP_PahariEiJ_G0020064	Aco2	100	96.667	Mus_pahari
ENSG00000100412	ACO2	100	96.795	MGP_SPRETEiJ_G0020963	Aco2	100	96.795	Mus_spretus
ENSG00000100412	ACO2	100	97.179	ENSMPUG00000016396	ACO2	99	97.179	Mustela_putorius_furo
ENSG00000100412	ACO2	99	93.806	ENSMLUG00000002472	ACO2	99	93.806	Myotis_lucifugus
ENSG00000100412	ACO2	100	71.319	ENSNGAG00000014065	-	100	71.319	Nannospalax_galili
ENSG00000100412	ACO2	100	94.615	ENSNGAG00000015866	-	100	94.615	Nannospalax_galili
ENSG00000100412	ACO2	100	79.923	ENSNBRG00000004766	aco2	100	79.923	Neolamprologus_brichardi
ENSG00000100412	ACO2	99	77.649	ENSNLEG00000036269	-	100	77.649	Nomascus_leucogenys
ENSG00000100412	ACO2	100	98.974	ENSNLEG00000015482	ACO2	100	98.974	Nomascus_leucogenys
ENSG00000100412	ACO2	89	92.642	ENSMEUG00000002023	ACO2	91	92.642	Notamacropus_eugenii
ENSG00000100412	ACO2	100	95.553	ENSOPRG00000000365	ACO2	100	95.553	Ochotona_princeps
ENSG00000100412	ACO2	100	96.538	ENSODEG00000012550	ACO2	100	96.538	Octodon_degus
ENSG00000100412	ACO2	100	79.668	ENSONIG00000019690	aco2	94	79.668	Oreochromis_niloticus
ENSG00000100412	ACO2	99	91.451	ENSOANG00000003550	ACO2	99	91.451	Ornithorhynchus_anatinus
ENSG00000100412	ACO2	100	97.051	ENSOCUG00000021368	ACO2	98	97.051	Oryctolagus_cuniculus
ENSG00000100412	ACO2	100	80.051	ENSORLG00000002618	aco2	99	80.051	Oryzias_latipes
ENSG00000100412	ACO2	100	80.307	ENSORLG00020007394	aco2	99	80.307	Oryzias_latipes_hni
ENSG00000100412	ACO2	100	79.795	ENSORLG00015006146	aco2	99	79.795	Oryzias_latipes_hsok
ENSG00000100412	ACO2	100	80.435	ENSOMEG00000000704	aco2	99	80.435	Oryzias_melastigma
ENSG00000100412	ACO2	93	91.188	ENSOGAG00000002845	ACO2	100	91.188	Otolemur_garnettii
ENSG00000100412	ACO2	99	94.581	ENSOARG00000018307	ACO2	99	94.581	Ovis_aries
ENSG00000100412	ACO2	78	79.528	ENSPPAG00000041996	-	100	77.003	Pan_paniscus
ENSG00000100412	ACO2	100	99.872	ENSPPAG00000019653	ACO2	100	99.872	Pan_paniscus
ENSG00000100412	ACO2	100	97.308	ENSPPRG00000005996	ACO2	99	97.308	Panthera_pardus
ENSG00000100412	ACO2	100	97.051	ENSPTIG00000014744	ACO2	99	97.051	Panthera_tigris_altaica
ENSG00000100412	ACO2	100	99.872	ENSPTRG00000014428	ACO2	100	99.872	Pan_troglodytes
ENSG00000100412	ACO2	78	79.790	ENSPTRG00000048121	-	100	77.261	Pan_troglodytes
ENSG00000100412	ACO2	91	76.705	ENSPANG00000032070	-	100	76.705	Papio_anubis
ENSG00000100412	ACO2	99	98.613	ENSPANG00000024107	-	99	98.613	Papio_anubis
ENSG00000100412	ACO2	100	81.458	ENSPKIG00000008567	aco2	99	82.527	Paramormyrops_kingsleyae
ENSG00000100412	ACO2	100	73.529	ENSPKIG00000003055	ACO2	100	73.529	Paramormyrops_kingsleyae
ENSG00000100412	ACO2	100	91.176	ENSPSIG00000007077	ACO2	99	91.176	Pelodiscus_sinensis
ENSG00000100412	ACO2	100	73.785	ENSPMGG00000003518	aco2	100	73.785	Periophthalmus_magnuspinnatus
ENSG00000100412	ACO2	100	97.179	ENSPEMG00000021158	Aco2	100	97.179	Peromyscus_maniculatus_bairdii
ENSG00000100412	ACO2	100	92.967	ENSPCIG00000026414	ACO2	100	92.967	Phascolarctos_cinereus
ENSG00000100412	ACO2	100	79.284	ENSPFOG00000016765	aco2	100	79.284	Poecilia_formosa
ENSG00000100412	ACO2	99	80.282	ENSPLAG00000017481	ACO2	100	80.282	Poecilia_latipinna
ENSG00000100412	ACO2	100	78.900	ENSPLAG00000001300	aco2	100	78.900	Poecilia_latipinna
ENSG00000100412	ACO2	99	80.794	ENSPMEG00000018305	ACO2	100	80.794	Poecilia_mexicana
ENSG00000100412	ACO2	100	79.284	ENSPMEG00000010286	aco2	100	79.284	Poecilia_mexicana
ENSG00000100412	ACO2	99	78.105	ENSPREG00000017594	ACO2	100	78.489	Poecilia_reticulata
ENSG00000100412	ACO2	100	79.156	ENSPREG00000020672	aco2	100	79.156	Poecilia_reticulata
ENSG00000100412	ACO2	100	98.974	ENSPPYG00000011871	ACO2	100	98.974	Pongo_abelii
ENSG00000100412	ACO2	100	94.472	ENSPCAG00000009742	ACO2	100	94.472	Procavia_capensis
ENSG00000100412	ACO2	100	97.051	ENSPCOG00000017488	ACO2	100	97.051	Propithecus_coquereli
ENSG00000100412	ACO2	100	94.534	ENSPVAG00000001163	ACO2	100	94.534	Pteropus_vampyrus
ENSG00000100412	ACO2	100	79.668	ENSPNYG00000004399	aco2	100	79.668	Pundamilia_nyererei
ENSG00000100412	ACO2	100	80.946	ENSPNAG00000013876	ACO2	100	80.946	Pygocentrus_nattereri
ENSG00000100412	ACO2	100	96.410	ENSRNOG00000024128	Aco2	100	96.410	Rattus_norvegicus
ENSG00000100412	ACO2	90	100.000	ENSRBIG00000035174	ACO2	100	100.000	Rhinopithecus_bieti
ENSG00000100412	ACO2	100	98.718	ENSRROG00000005066	ACO2	100	98.718	Rhinopithecus_roxellana
ENSG00000100412	ACO2	97	67.280	YLR304C	ACO1	98	67.280	Saccharomyces_cerevisiae
ENSG00000100412	ACO2	83	96.711	ENSSBOG00000021699	-	100	96.711	Saimiri_boliviensis_boliviensis
ENSG00000100412	ACO2	100	88.077	ENSSBOG00000029050	-	100	88.077	Saimiri_boliviensis_boliviensis
ENSG00000100412	ACO2	99	93.645	ENSSHAG00000010092	ACO2	99	92.848	Sarcophilus_harrisii
ENSG00000100412	ACO2	99	82.714	ENSSFOG00015013704	aco2	99	84.796	Scleropages_formosus
ENSG00000100412	ACO2	99	80.641	ENSSMAG00000005805	ACO2	97	80.641	Scophthalmus_maximus
ENSG00000100412	ACO2	100	79.540	ENSSMAG00000007063	aco2	99	80.967	Scophthalmus_maximus
ENSG00000100412	ACO2	99	80.794	ENSSDUG00000014898	ACO2	100	80.794	Seriola_dumerili
ENSG00000100412	ACO2	100	79.540	ENSSDUG00000008036	aco2	99	80.655	Seriola_dumerili
ENSG00000100412	ACO2	99	80.666	ENSSLDG00000018236	ACO2	100	80.666	Seriola_lalandi_dorsalis
ENSG00000100412	ACO2	100	79.540	ENSSLDG00000009538	aco2	100	79.540	Seriola_lalandi_dorsalis
ENSG00000100412	ACO2	62	100.000	ENSSARG00000004424	-	62	100.000	Sorex_araneus
ENSG00000100412	ACO2	100	88.235	ENSSPUG00000011600	ACO2	99	88.235	Sphenodon_punctatus
ENSG00000100412	ACO2	100	79.412	ENSSPAG00000022958	aco2	100	79.412	Stegastes_partitus
ENSG00000100412	ACO2	99	81.491	ENSSPAG00000017882	ACO2	100	82.976	Stegastes_partitus
ENSG00000100412	ACO2	100	97.051	ENSSSCG00000000064	ACO2	99	97.051	Sus_scrofa
ENSG00000100412	ACO2	98	92.157	ENSTGUG00000009907	ACO2	99	92.157	Taeniopygia_guttata
ENSG00000100412	ACO2	100	79.028	ENSTRUG00000017021	aco2	100	79.028	Takifugu_rubripes
ENSG00000100412	ACO2	100	79.028	ENSTNIG00000012938	aco2	100	79.028	Tetraodon_nigroviridis
ENSG00000100412	ACO2	100	96.795	ENSTBEG00000011060	ACO2	100	96.795	Tupaia_belangeri
ENSG00000100412	ACO2	100	92.422	ENSTTRG00000003371	ACO2	99	92.422	Tursiops_truncatus
ENSG00000100412	ACO2	100	97.051	ENSUAMG00000022582	ACO2	98	97.051	Ursus_americanus
ENSG00000100412	ACO2	100	97.051	ENSUMAG00000021024	ACO2	99	97.051	Ursus_maritimus
ENSG00000100412	ACO2	56	92.537	ENSVPAG00000002616	-	59	92.537	Vicugna_pacos
ENSG00000100412	ACO2	100	96.538	ENSVVUG00000003619	ACO2	99	96.538	Vulpes_vulpes
ENSG00000100412	ACO2	99	75.159	ENSXETG00000006892	aco2	100	75.159	Xenopus_tropicalis
ENSG00000100412	ACO2	82	80.343	ENSXCOG00000000374	aco2	99	80.343	Xiphophorus_couchianus
ENSG00000100412	ACO2	99	77.452	ENSXCOG00000016019	ACO2	100	77.452	Xiphophorus_couchianus
ENSG00000100412	ACO2	99	79.898	ENSXMAG00000006870	ACO2	100	79.898	Xiphophorus_maculatus
ENSG00000100412	ACO2	100	79.284	ENSXMAG00000000683	aco2	100	79.284	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001889	liver development	-	IEA	Process
GO:0003994	aconitate hydratase activity	1052766.	EXP	Function
GO:0003994	aconitate hydratase activity	21873635.	IBA	Function
GO:0005506	iron ion binding	9630632.	IDA	Function
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0006091	generation of precursor metabolites and energy	9630632.	TAS	Process
GO:0006099	tricarboxylic acid cycle	21873635.	IBA	Process
GO:0006099	tricarboxylic acid cycle	9630632.	IDA	Process
GO:0006099	tricarboxylic acid cycle	-	IEA	Process
GO:0006099	tricarboxylic acid cycle	-	TAS	Process
GO:0006101	citrate metabolic process	9630632.	IDA	Process
GO:0006102	isocitrate metabolic process	-	IEA	Process
GO:0035900	response to isolation stress	-	IEA	Process
GO:0051538	3 iron, 4 sulfur cluster binding	-	IEA	Function
GO:0051539	4 iron, 4 sulfur cluster binding	21873635.	IBA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23550275	Decreased expression of the mitochondrial metabolic enzyme aconitase (ACO2) is associated with poor prognosis in gastric cancer.	Med Oncol	2013 Jun	Wang P	-
12746427	Mutation and LOH analysis of ACO2 in colorectal cancer: no evidence of biallelic genetic inactivation.	J Med Genet	2003 May	Laiho P	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr22	41527341	Silent	rs757964630	S669S	0.47
BLCA	chr22	41522877	Missense_Mutation	NA	S396T	0.18
BLCA	chr22	41499732	Missense_Mutation	novel	L15V	0.22
BLCA	chr22	41518566	Silent	novel	L342L	0.12
BLCA	chr22	41520243	Missense_Mutation	novel	E369K	0.51
BLCA	chr22	41469164	Silent	NA	L6L	0.18
BLCA	chr22	41517625	Missense_Mutation	NA	R312G	0.25
BLCA	chr22	41515838	Silent	NA	A252A	0.1
BLCA	chr22	41527369	Missense_Mutation	rs747898560	R679C	0.13	Aconitase
BRCA	chr22	41469160	Missense_Mutation	novel	S5I	0.88
BRCA	chr22	41527993	Missense_Mutation	NA	Q727E	0.21	Aconitase
BRCA	chr22	41507924	Missense_Mutation	NA	A103S	0.43
BRCA	chr22	41527395	Silent	NA	I687I	0.32
BRCA	chr22	41527283	Splice_Region	novel		0.3
BRCA	chr22	41469174	Missense_Mutation	NA	R10G	0.28
BRCA	chr22	41525253	Missense_Mutation	NA	V556M	0.19
CESC	chr22	41524843	Splice_Region	novel		0.21
CESC	chr22	41522926	Missense_Mutation	novel	S412F	0.4
CESC	chr22	41524897	Missense_Mutation	rs775616803	D512N	0.22
CHOL	chr22	41515818	Missense_Mutation	novel	D246N	0.21
COAD	chr22	41518537	Missense_Mutation	NA	H333N	0.25
COAD	chr22	41499856	Missense_Mutation	rs534016929	R56H	0.46
COAD	chr22	41511890	Missense_Mutation	novel	E149D	0.35
COAD	chr22	41528024	Splice_Site	novel	X736_splice	0.07
COAD	chr22	41523273	Nonsense_Mutation	NA	W455*	0.21
COAD	chr22	41526443	Missense_Mutation	rs755695367	R648H	0.5	Aconitase
COAD	chr22	41526426	Silent	rs150391290	P642P	0.54
COAD	chr22	41526443	Missense_Mutation	rs755695367	R648H	0.21	Aconitase
COAD	chr22	41527320	Silent	rs760073057	D662D	0.15
COAD	chr22	41520179	Silent	novel	P347P	0.35
COAD	chr22	41520181	Missense_Mutation	novel	H348R	0.31
COAD	chr22	41507899	Silent	rs142651093	D94D	0.31
COAD	chr22	41525259	Missense_Mutation	NA	V558M	0.1
ESCA	chr22	41469174	Missense_Mutation	NA	R10G	0.54
GBM	chr22	41517543	Nonsense_Mutation	novel	C284*	0.23
GBM	chr22	41499742	Missense_Mutation	rs200327053	R18Q	0.37
HNSC	chr22	41526440	Missense_Mutation	novel	A647G	0.28	Aconitase
HNSC	chr22	41523932	Silent	rs148997312	T491T	0.2
HNSC	chr22	41522880	Missense_Mutation	novel	A397S	0.3
HNSC	chr22	41522848	Missense_Mutation	NA	T386I	0.11
KIRC	chr22	41518518	Silent	NA	L326L	0.18
KIRP	chr22	41515892	Silent	NA	P270P	0.54
LAML	chr22	41507907	Missense_Mutation	novel	A97G	0.08
LGG	chr22	41507978	Missense_Mutation	novel	P121S	0.12
LGG	chr22	41523933	Missense_Mutation	novel	S492P	0.58
LGG	chr22	41507919	Missense_Mutation	novel	A101V	0.19
LIHC	chr22	41507892	Missense_Mutation	rs147763800	R92Q	0.32
LIHC	chr22	41499730	Missense_Mutation	NA	A14G	0.36
LUAD	chr22	41528508	Missense_Mutation	novel	N746K	0.16
LUAD	chr22	41517576	Silent	rs560040600	S295S	0.07
LUAD	chr22	41515484	Silent	rs1049859	A211A	0.13
LUAD	chr22	41499788	Silent	NA	A33A	0.16
LUAD	chr22	41527332	Silent	NA	G666G	0.11
LUAD	chr22	41523904	Missense_Mutation	NA	A482V	0.35
LUAD	chr22	41523914	Silent	novel	E485E	0.23
LUAD	chr22	41525279	Silent	novel	R564R	0.35
LUSC	chr22	41507792	Missense_Mutation	novel	L59M	0.41
LUSC	chr22	41511945	Missense_Mutation	NA	P168T	0.26
LUSC	chr22	41515917	Missense_Mutation	NA	G279C	0.41
MESO	chr22	41526427	Missense_Mutation	rs387907390	V643I	0.83	Aconitase
OV	chr22	41525259	In_Frame_Ins	novel	V558delinsEHNRHLLQQEL	0.2
OV	chr22	41526331	Missense_Mutation	NA	D611N	0.3	Aconitase
OV	chr22	41526386	Missense_Mutation	novel	A629D	0.06	Aconitase
PRAD	chr22	41515448	Silent	rs374086380	G199G	0.34
SARC	chr22	41528552	Missense_Mutation	rs142767544	T761M	0.43
SKCM	chr22	41517576	Silent	rs560040600	S295S	0.35
SKCM	chr22	41522982	Missense_Mutation	NA	G431R	0.11
SKCM	chr22	41523871	Missense_Mutation	NA	S471F	0.29
SKCM	chr22	41523922	Missense_Mutation	novel	A488V	0.39
SKCM	chr22	41523923	Silent	novel	A488A	0.39
SKCM	chr22	41523912	Missense_Mutation	rs778052352	E485K	0.49
SKCM	chr22	41527419	Missense_Mutation	NA	H695Q	0.39	Aconitase
SKCM	chr22	41499855	Missense_Mutation	rs746995807	R56C	0.33
SKCM	chr22	41515843	In_Frame_Del	novel	L255del	0.33
SKCM	chr22	41499764	Silent	NA	V25V	0.09
SKCM	chr22	41527961	Missense_Mutation	novel	N716S	0.48	Aconitase
SKCM	chr22	41499779	Silent	rs778272400	A30A	0.21
SKCM	chr22	41525264	Silent	novel	S559S	0.68
SKCM	chr22	41499819	Missense_Mutation	novel	H44Y	0.64
STAD	chr22	41508039	Missense_Mutation	rs370417583	R141H	0.18
STAD	chr22	41527302	Silent	rs377371545	R656R	0.21
STAD	chr22	41507877	Missense_Mutation	rs777420895	S87L	0.36
STAD	chr22	41528548	Missense_Mutation	rs115203053	E760K	0.29
STAD	chr22	41527349	Frame_Shift_Del	novel	*H673Lfs25**	0.24	Aconitase
STAD	chr22	41522962	Missense_Mutation	rs752600434	R424H	0.41
STAD	chr22	41526397	Missense_Mutation	novel	R633C	0.04	Aconitase
STAD	chr22	41523890	Silent	rs200407418	T477T	0.29
STAD	chr22	41524919	Missense_Mutation	NA	G519D	0.32
STAD	chr22	41526361	Missense_Mutation	novel	A621T	0.32	Aconitase
STAD	chr22	41523845	Frame_Shift_Del	novel	*E464Rfs51**	0.23
STAD	chr22	41527388	Missense_Mutation	NA	A685V	0.21	Aconitase
UCEC	chr22	41524896	Silent	rs772113275	T511T	0.44
UCEC	chr22	41515776	Missense_Mutation	NA	V232M	0.3
UCEC	chr22	41508038	Missense_Mutation	rs745801074	R141C	0.31
UCEC	chr22	41525277	Missense_Mutation	rs781117483	R564C	0.19
UCEC	chr22	41522831	Splice_Region	novel	G380G	0.29
UCEC	chr22	41523861	Missense_Mutation	novel	I468V	0.57
UCEC	chr22	41499856	Missense_Mutation	rs534016929	R56H	0.35
UCEC	chr22	41522964	Missense_Mutation	rs147361669	A425T	0.35
UCEC	chr22	41522963	Silent	rs368067033	R424R	0.41
UCEC	chr22	41511898	Missense_Mutation	NA	N152T	0.39
UCEC	chr22	41507956	Silent	rs138373868	S113S	0.22
UCEC	chr22	41511949	Missense_Mutation	NA	G169E	0.3
UCEC	chr22	41523213	Silent	rs745392648	I435I	0.26
UCEC	chr22	41526398	Missense_Mutation	rs371183037	R633H	0.13	Aconitase
UCEC	chr22	41508035	Missense_Mutation	novel	L140M	0.19
UCEC	chr22	41515928	Intron	rs369933665		0.28
UCEC	chr22	41507904	Missense_Mutation	novel	V96A	0.41
UCEC	chr22	41526347	Missense_Mutation	novel	N616S	0.21	Aconitase
UCEC	chr22	41528548	Missense_Mutation	rs115203053	E760K	0.33
UCEC	chr22	41515485	Missense_Mutation	novel	D212N	0.56
UCEC	chr22	41515891	Missense_Mutation	novel	P270L	0.11
UCEC	chr22	41526362	Missense_Mutation	rs61757465	A621V	0.34	Aconitase
UCEC	chr22	41528509	Missense_Mutation	rs768151174	G747R	0.42
UCEC	chr22	41515448	Silent	rs374086380	G199G	0.37
UCEC	chr22	41515940	Intron	rs373316100		0.14
UCEC	chr22	41523864	Missense_Mutation	rs202122407	V469I	0.56
UCEC	chr22	41515874	Silent	rs748474998	I264I	0.35
UCEC	chr22	41522964	Missense_Mutation	rs147361669	A425T	0.32
UCEC	chr22	41525277	Missense_Mutation	rs781117483	R564C	0.14
UCEC	chr22	41527387	Missense_Mutation	NA	A685T	0.34	Aconitase
UCEC	chr22	41507901	Missense_Mutation	rs760882521	R95H	0.53
UCEC	chr22	41518496	Missense_Mutation	novel	A319D	0.43
UCEC	chr22	41528572	Missense_Mutation	rs1804785	A768T	0.92
UCEC	chr22	41508025	Silent	rs543394003	G136G	0.12
UCEC	chr22	41520195	Missense_Mutation	novel	F353V	0.41
UCEC	chr22	41528013	Silent	NA	T733T	0.06
UCEC	chr22	41528490	Silent	novel	C740C	0.46
UCEC	chr22	41511877	Missense_Mutation	novel	D145G	0.24
UCEC	chr22	41517607	Missense_Mutation	novel	Y306H	0.3
UCEC	chr22	41507992	Missense_Mutation	novel	H125Q	0.06

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0417	0.21158
PCPG	DEL	0.3395	0.044123
THCA	DEL	0.1563	0.046486
THYM	DEL	0.065	0.063154

Survival Analysis

Cancer	P-value	Q-value
STAD	0.0097	Kaplan-Meier Survival Analysis
MESO	0.0014	Kaplan-Meier Survival Analysis
ACC	0.0091	Kaplan-Meier Survival Analysis
SKCM	0.015	Kaplan-Meier Survival Analysis
KIRP	0.00055	Kaplan-Meier Survival Analysis
BLCA	0.045	Kaplan-Meier Survival Analysis
LAML	0.00024	Kaplan-Meier Survival Analysis
KICH	0.031	Kaplan-Meier Survival Analysis
LIHC	0.0065	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.015	Kaplan-Meier Survival Analysis
UVM	0.032	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742