EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100413 (Gene tree)
Gene ID: 171568
Gene Symbol: POLR3H
Alias: RPC8|KIAA1665
Full Name: RNA polymerase III subunit H
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 18,808 bases
Position: chr22:41,525,799-41,544,606
Accession: 30349
RBP type: canonical RBP
Summary: POLR3H (RNA Polymerase III Subunit H) is a Protein Coding gene. Diseases associated with POLR3H include Optic Atrophy 9 and Infantile Cerebellar-Retinal Degeneration. Among its related pathways are RNA Polymerase III Transcription Initiation and Transcription of tRNA. Gene Ontology (GO) annotations related to this gene include DNA-directed 5'-3' RNA polymerase activity and RNA polymerase III activity. An important paralog of this gene is TWISTNB.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000347345	RNA_pol_Rbc25	PF08292.12	3.9e-42	1	1
ENSP00000379761	RNA_pol_Rbc25	PF08292.12	3.9e-42	1	1
ENSP00000385315	RNA_pol_Rbc25	PF08292.12	3.9e-42	1	1
ENSP00000337627	RNA_pol_Rbc25	PF08292.12	9.7e-34	1	1
ENSP00000347345	SHS2_Rpb7-N	PF03876.17	7e-20	1	1
ENSP00000379761	SHS2_Rpb7-N	PF03876.17	7e-20	1	1
ENSP00000385315	SHS2_Rpb7-N	PF03876.17	7e-20	1	1
ENSP00000337627	SHS2_Rpb7-N	PF03876.17	1.6e-15	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000483837	POLR3H-209	1829	-	-	- (aa)	-	-
ENST00000407461	POLR3H-204	802	-	ENSP00000385315	204 (aa)	-	Q9Y535
ENST00000431534	POLR3H-206	1464	-	ENSP00000395674	123 (aa)	-	F8WDV1
ENST00000396504	POLR3H-203	4176	-	ENSP00000379761	204 (aa)	-	Q9Y535
ENST00000337566	POLR3H-201	1330	-	ENSP00000337627	175 (aa)	-	Q9Y535
ENST00000355209	POLR3H-202	4416	XM_011529993	ENSP00000347345	204 (aa)	XP_011528295	Q9Y535
ENST00000442616	POLR3H-208	553	-	ENSP00000408083	70 (aa)	-	E7ERZ2
ENST00000420561	POLR3H-205	517	-	-	- (aa)	-	-
ENST00000432789	POLR3H-207	1598	-	ENSP00000415053	160 (aa)	-	F8WDS5

Gene Model

Click here to download ENSG00000100413's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03020	RNA polymerase	KEGG
hsa04623	Cytosolic DNA-sensing pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100413	Platelet Function Tests	6.7067068E-007	-
ENSG00000100413	Platelet Function Tests	6.7067068E-007	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100413's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100413	POLR3H	99	86.957	ENSAPOG00000011407	polr3h	100	77.419	Acanthochromis_polyacanthus
ENSG00000100413	POLR3H	99	98.551	ENSAMEG00000015630	POLR3H	100	97.059	Ailuropoda_melanoleuca
ENSG00000100413	POLR3H	99	85.507	ENSACIG00000010128	polr3h	100	78.818	Amphilophus_citrinellus
ENSG00000100413	POLR3H	99	89.855	ENSAOCG00000019002	polr3h	100	79.907	Amphiprion_ocellaris
ENSG00000100413	POLR3H	99	89.855	ENSAPEG00000012507	polr3h	100	79.439	Amphiprion_percula
ENSG00000100413	POLR3H	99	86.957	ENSATEG00000008085	polr3h	100	78.037	Anabas_testudineus
ENSG00000100413	POLR3H	99	91.304	ENSAPLG00000005063	POLR3H	100	86.603	Anas_platyrhynchos
ENSG00000100413	POLR3H	99	91.304	ENSACAG00000011213	POLR3H	100	88.350	Anolis_carolinensis
ENSG00000100413	POLR3H	100	99.429	ENSANAG00000025122	POLR3H	100	99.429	Aotus_nancymaae
ENSG00000100413	POLR3H	99	86.957	ENSACLG00000014650	polr3h	100	78.505	Astatotilapia_calliptera
ENSG00000100413	POLR3H	99	88.406	ENSAMXG00000015544	polr3h	100	83.251	Astyanax_mexicanus
ENSG00000100413	POLR3H	99	100.000	ENSBTAG00000005311	POLR3H	100	96.078	Bos_taurus
ENSG00000100413	POLR3H	99	39.409	WBGene00014111	rpc-25	82	38.835	Caenorhabditis_elegans
ENSG00000100413	POLR3H	99	100.000	ENSCJAG00000005072	POLR3H	100	98.857	Callithrix_jacchus
ENSG00000100413	POLR3H	100	96.569	ENSCAFG00000001053	POLR3H	100	96.569	Canis_familiaris
ENSG00000100413	POLR3H	100	96.569	ENSCAFG00020001964	POLR3H	100	96.569	Canis_lupus_dingo
ENSG00000100413	POLR3H	99	100.000	ENSCHIG00000013984	POLR3H	100	96.078	Capra_hircus
ENSG00000100413	POLR3H	99	100.000	ENSTSYG00000003484	POLR3H	100	98.857	Carlito_syrichta
ENSG00000100413	POLR3H	74	92.667	ENSCAPG00000003786	POLR3H	100	92.667	Cavia_aperea
ENSG00000100413	POLR3H	99	95.652	ENSCPOG00000012650	POLR3H	100	92.647	Cavia_porcellus
ENSG00000100413	POLR3H	100	99.429	ENSCCAG00000025802	POLR3H	100	99.429	Cebus_capucinus
ENSG00000100413	POLR3H	100	100.000	ENSCATG00000018316	POLR3H	100	100.000	Cercocebus_atys
ENSG00000100413	POLR3H	99	95.652	ENSCLAG00000016948	POLR3H	100	92.157	Chinchilla_lanigera
ENSG00000100413	POLR3H	100	99.510	ENSCSAG00000005798	POLR3H	86	99.510	Chlorocebus_sabaeus
ENSG00000100413	POLR3H	99	92.754	ENSCPBG00000020544	POLR3H	100	89.806	Chrysemys_picta_bellii
ENSG00000100413	POLR3H	99	71.078	ENSCING00000012767	-	99	71.078	Ciona_intestinalis
ENSG00000100413	POLR3H	99	67.980	ENSCSAVG00000010448	-	99	67.980	Ciona_savignyi
ENSG00000100413	POLR3H	100	99.429	ENSCANG00000035073	POLR3H	100	99.429	Colobus_angolensis_palliatus
ENSG00000100413	POLR3H	84	95.322	ENSCGRG00001023556	Polr3h	99	95.322	Cricetulus_griseus_chok1gshd
ENSG00000100413	POLR3H	99	100.000	ENSCGRG00000017869	Polr3h	100	97.714	Cricetulus_griseus_crigri
ENSG00000100413	POLR3H	99	86.957	ENSCSEG00000006721	polr3h	97	77.778	Cynoglossus_semilaevis
ENSG00000100413	POLR3H	99	84.058	ENSCVAG00000010996	polr3h	100	78.037	Cyprinodon_variegatus
ENSG00000100413	POLR3H	99	85.507	ENSDARG00000102590	polr3h	100	78.972	Danio_rerio
ENSG00000100413	POLR3H	99	98.551	ENSDNOG00000025527	POLR3H	100	96.078	Dasypus_novemcinctus
ENSG00000100413	POLR3H	99	100.000	ENSDORG00000002215	Polr3h	100	97.549	Dipodomys_ordii
ENSG00000100413	POLR3H	99	59.420	FBgn0036188	CG7339	88	55.814	Drosophila_melanogaster
ENSG00000100413	POLR3H	100	93.627	ENSETEG00000010746	POLR3H	100	93.627	Echinops_telfairi
ENSG00000100413	POLR3H	99	81.159	ENSEBUG00000005511	polr3h	100	73.059	Eptatretus_burgeri
ENSG00000100413	POLR3H	99	100.000	ENSEASG00005001539	POLR3H	100	97.059	Equus_asinus_asinus
ENSG00000100413	POLR3H	99	100.000	ENSECAG00000019715	POLR3H	100	97.143	Equus_caballus
ENSG00000100413	POLR3H	99	100.000	ENSEEUG00000010464	POLR3H	100	93.659	Erinaceus_europaeus
ENSG00000100413	POLR3H	99	84.058	ENSELUG00000007834	polr3h	100	80.769	Esox_lucius
ENSG00000100413	POLR3H	99	100.000	ENSFCAG00000006684	POLR3H	100	97.714	Felis_catus
ENSG00000100413	POLR3H	99	92.754	ENSFALG00000011952	POLR3H	100	88.835	Ficedula_albicollis
ENSG00000100413	POLR3H	99	95.652	ENSFDAG00000008844	POLR3H	100	92.647	Fukomys_damarensis
ENSG00000100413	POLR3H	99	89.855	ENSFHEG00000020517	polr3h	100	78.972	Fundulus_heteroclitus
ENSG00000100413	POLR3H	99	84.058	ENSGMOG00000001934	polr3h	100	74.299	Gadus_morhua
ENSG00000100413	POLR3H	99	92.754	ENSGALG00000011947	POLR3H	100	88.350	Gallus_gallus
ENSG00000100413	POLR3H	99	89.855	ENSGAFG00000010908	polr3h	100	80.841	Gambusia_affinis
ENSG00000100413	POLR3H	99	85.507	ENSGACG00000007549	polr3h	100	76.636	Gasterosteus_aculeatus
ENSG00000100413	POLR3H	99	92.754	ENSGAGG00000017507	POLR3H	100	89.320	Gopherus_agassizii
ENSG00000100413	POLR3H	100	100.000	ENSGGOG00000038191	POLR3H	100	100.000	Gorilla_gorilla
ENSG00000100413	POLR3H	99	86.957	ENSHBUG00000017295	polr3h	100	78.505	Haplochromis_burtoni
ENSG00000100413	POLR3H	100	90.686	ENSHGLG00000014795	POLR3H	100	90.686	Heterocephalus_glaber_female
ENSG00000100413	POLR3H	100	90.686	ENSHGLG00100014750	POLR3H	100	90.686	Heterocephalus_glaber_male
ENSG00000100413	POLR3H	99	85.507	ENSHCOG00000006814	polr3h	100	76.526	Hippocampus_comes
ENSG00000100413	POLR3H	99	86.957	ENSIPUG00000019750	polr3h	99	79.343	Ictalurus_punctatus
ENSG00000100413	POLR3H	99	100.000	ENSSTOG00000016215	POLR3H	100	98.529	Ictidomys_tridecemlineatus
ENSG00000100413	POLR3H	99	100.000	ENSJJAG00000017986	Polr3h	100	97.549	Jaculus_jaculus
ENSG00000100413	POLR3H	99	86.957	ENSKMAG00000014797	polr3h	100	78.505	Kryptolebias_marmoratus
ENSG00000100413	POLR3H	99	76.355	ENSLBEG00000010889	polr3h	100	76.847	Labrus_bergylta
ENSG00000100413	POLR3H	99	87.671	ENSLACG00000011734	POLR3H	100	86.058	Latimeria_chalumnae
ENSG00000100413	POLR3H	99	88.406	ENSLOCG00000011621	polr3h	86	77.833	Lepisosteus_oculatus
ENSG00000100413	POLR3H	99	100.000	ENSLAFG00000006033	POLR3H	100	96.078	Loxodonta_africana
ENSG00000100413	POLR3H	100	100.000	ENSMFAG00000001153	POLR3H	100	100.000	Macaca_fascicularis
ENSG00000100413	POLR3H	100	100.000	ENSMMUG00000001459	POLR3H	100	100.000	Macaca_mulatta
ENSG00000100413	POLR3H	100	100.000	ENSMNEG00000022264	POLR3H	100	100.000	Macaca_nemestrina
ENSG00000100413	POLR3H	82	98.810	ENSMLEG00000024568	POLR3H	99	98.810	Mandrillus_leucophaeus
ENSG00000100413	POLR3H	99	85.507	ENSMAMG00000007445	polr3h	100	79.439	Mastacembelus_armatus
ENSG00000100413	POLR3H	99	86.957	ENSMZEG00005003756	polr3h	100	78.505	Maylandia_zebra
ENSG00000100413	POLR3H	99	92.754	ENSMGAG00000012126	POLR3H	100	86.124	Meleagris_gallopavo
ENSG00000100413	POLR3H	99	100.000	ENSMAUG00000022215	Polr3h	100	97.549	Mesocricetus_auratus
ENSG00000100413	POLR3H	100	97.714	ENSMICG00000013546	POLR3H	100	97.714	Microcebus_murinus
ENSG00000100413	POLR3H	99	98.551	ENSMOCG00000018747	Polr3h	100	97.059	Microtus_ochrogaster
ENSG00000100413	POLR3H	99	86.957	ENSMMOG00000002705	polr3h	100	79.310	Mola_mola
ENSG00000100413	POLR3H	100	93.627	ENSMODG00000016563	POLR3H	100	93.627	Monodelphis_domestica
ENSG00000100413	POLR3H	99	88.406	ENSMALG00000013403	polr3h	100	79.803	Monopterus_albus
ENSG00000100413	POLR3H	99	100.000	MGP_CAROLIEiJ_G0020063	Polr3h	100	97.549	Mus_caroli
ENSG00000100413	POLR3H	99	100.000	ENSMUSG00000022476	Polr3h	100	98.286	Mus_musculus
ENSG00000100413	POLR3H	99	100.000	MGP_PahariEiJ_G0020065	Polr3h	100	97.549	Mus_pahari
ENSG00000100413	POLR3H	99	100.000	MGP_SPRETEiJ_G0020964	Polr3h	100	98.039	Mus_spretus
ENSG00000100413	POLR3H	99	100.000	ENSMPUG00000016395	POLR3H	100	98.039	Mustela_putorius_furo
ENSG00000100413	POLR3H	99	100.000	ENSMLUG00000002487	POLR3H	100	95.098	Myotis_lucifugus
ENSG00000100413	POLR3H	100	96.569	ENSNGAG00000015009	Polr3h	100	96.569	Nannospalax_galili
ENSG00000100413	POLR3H	99	86.957	ENSNBRG00000003286	polr3h	87	78.788	Neolamprologus_brichardi
ENSG00000100413	POLR3H	100	98.857	ENSNLEG00000015536	POLR3H	100	98.857	Nomascus_leucogenys
ENSG00000100413	POLR3H	99	97.101	ENSMEUG00000002041	POLR3H	99	90.686	Notamacropus_eugenii
ENSG00000100413	POLR3H	100	95.714	ENSODEG00000013641	-	70	95.714	Octodon_degus
ENSG00000100413	POLR3H	99	86.957	ENSONIG00000008444	polr3h	100	78.505	Oreochromis_niloticus
ENSG00000100413	POLR3H	100	95.714	ENSOANG00000031578	-	53	95.714	Ornithorhynchus_anatinus
ENSG00000100413	POLR3H	100	88.235	ENSOANG00000004374	-	100	88.235	Ornithorhynchus_anatinus
ENSG00000100413	POLR3H	99	100.000	ENSOCUG00000007275	POLR3H	100	97.059	Oryctolagus_cuniculus
ENSG00000100413	POLR3H	99	85.507	ENSORLG00000014160	polr3h	100	77.570	Oryzias_latipes
ENSG00000100413	POLR3H	99	86.957	ENSORLG00020007765	polr3h	100	78.037	Oryzias_latipes_hni
ENSG00000100413	POLR3H	99	86.957	ENSORLG00015019039	polr3h	100	78.037	Oryzias_latipes_hsok
ENSG00000100413	POLR3H	99	85.507	ENSOMEG00000005764	polr3h	100	77.103	Oryzias_melastigma
ENSG00000100413	POLR3H	99	100.000	ENSOGAG00000002850	-	100	97.549	Otolemur_garnettii
ENSG00000100413	POLR3H	100	88.725	ENSOGAG00000030416	-	100	88.725	Otolemur_garnettii
ENSG00000100413	POLR3H	99	100.000	ENSOARG00000018319	POLR3H	100	96.078	Ovis_aries
ENSG00000100413	POLR3H	100	100.000	ENSPPAG00000031000	POLR3H	100	100.000	Pan_paniscus
ENSG00000100413	POLR3H	99	100.000	ENSPPRG00000005361	POLR3H	100	97.714	Panthera_pardus
ENSG00000100413	POLR3H	99	100.000	ENSPTIG00000016286	POLR3H	100	97.143	Panthera_tigris_altaica
ENSG00000100413	POLR3H	100	100.000	ENSPTRG00000051865	POLR3H	100	100.000	Pan_troglodytes
ENSG00000100413	POLR3H	100	100.000	ENSPANG00000015758	POLR3H	100	100.000	Papio_anubis
ENSG00000100413	POLR3H	99	88.406	ENSPKIG00000008527	polr3h	100	83.173	Paramormyrops_kingsleyae
ENSG00000100413	POLR3H	99	91.304	ENSPSIG00000008284	POLR3H	89	88.835	Pelodiscus_sinensis
ENSG00000100413	POLR3H	99	82.609	ENSPMGG00000018036	polr3h	85	71.163	Periophthalmus_magnuspinnatus
ENSG00000100413	POLR3H	99	100.000	ENSPEMG00000000726	Polr3h	100	96.569	Peromyscus_maniculatus_bairdii
ENSG00000100413	POLR3H	84	70.492	ENSPMAG00000007847	polr3h	97	70.492	Petromyzon_marinus
ENSG00000100413	POLR3H	100	98.551	ENSPCIG00000026413	POLR3H	100	72.587	Phascolarctos_cinereus
ENSG00000100413	POLR3H	99	89.855	ENSPFOG00000013681	polr3h	100	78.802	Poecilia_formosa
ENSG00000100413	POLR3H	99	89.855	ENSPLAG00000017503	polr3h	100	80.841	Poecilia_latipinna
ENSG00000100413	POLR3H	99	89.855	ENSPMEG00000018334	polr3h	100	80.374	Poecilia_mexicana
ENSG00000100413	POLR3H	51	80.899	ENSPREG00000007035	-	91	44.444	Poecilia_reticulata
ENSG00000100413	POLR3H	100	97.059	ENSPPYG00000010689	-	100	97.059	Pongo_abelii
ENSG00000100413	POLR3H	99	100.000	ENSPPYG00000011872	-	100	98.039	Pongo_abelii
ENSG00000100413	POLR3H	99	97.101	ENSPCAG00000009882	POLR3H	58	96.639	Procavia_capensis
ENSG00000100413	POLR3H	99	100.000	ENSPCOG00000013751	POLR3H	100	98.286	Propithecus_coquereli
ENSG00000100413	POLR3H	99	98.551	ENSPVAG00000001164	POLR3H	100	97.059	Pteropus_vampyrus
ENSG00000100413	POLR3H	99	86.957	ENSPNYG00000024040	polr3h	100	78.505	Pundamilia_nyererei
ENSG00000100413	POLR3H	99	84.058	ENSPNAG00000004860	polr3h	100	78.404	Pygocentrus_nattereri
ENSG00000100413	POLR3H	99	100.000	ENSRNOG00000004471	Polr3h	100	98.039	Rattus_norvegicus
ENSG00000100413	POLR3H	100	87.255	ENSRBIG00000040089	POLR3H	100	87.255	Rhinopithecus_bieti
ENSG00000100413	POLR3H	100	99.429	ENSRROG00000033728	POLR3H	100	99.429	Rhinopithecus_roxellana
ENSG00000100413	POLR3H	96	47.761	YKL144C	RPC25	99	42.991	Saccharomyces_cerevisiae
ENSG00000100413	POLR3H	99	100.000	ENSSBOG00000020652	POLR3H	100	98.857	Saimiri_boliviensis_boliviensis
ENSG00000100413	POLR3H	99	98.551	ENSSHAG00000010196	POLR3H	100	93.627	Sarcophilus_harrisii
ENSG00000100413	POLR3H	99	88.406	ENSSFOG00015011506	polr3h	100	83.173	Scleropages_formosus
ENSG00000100413	POLR3H	99	85.507	ENSSMAG00000005784	polr3h	100	76.168	Scophthalmus_maximus
ENSG00000100413	POLR3H	99	88.406	ENSSDUG00000014946	polr3h	100	77.674	Seriola_dumerili
ENSG00000100413	POLR3H	99	86.957	ENSSLDG00000018207	polr3h	100	77.209	Seriola_lalandi_dorsalis
ENSG00000100413	POLR3H	99	92.754	ENSSPUG00000011619	POLR3H	100	90.686	Sphenodon_punctatus
ENSG00000100413	POLR3H	99	86.957	ENSSPAG00000017974	polr3h	100	79.907	Stegastes_partitus
ENSG00000100413	POLR3H	99	100.000	ENSSSCG00000000063	POLR3H	100	96.078	Sus_scrofa
ENSG00000100413	POLR3H	99	92.754	ENSTGUG00000009901	POLR3H	100	88.038	Taeniopygia_guttata
ENSG00000100413	POLR3H	99	86.957	ENSTRUG00000004012	polr3h	100	80.000	Takifugu_rubripes
ENSG00000100413	POLR3H	54	83.333	ENSTNIG00000019623	-	75	88.764	Tetraodon_nigroviridis
ENSG00000100413	POLR3H	99	84.058	ENSTNIG00000004956	polr3h	100	77.778	Tetraodon_nigroviridis
ENSG00000100413	POLR3H	99	98.551	ENSTBEG00000011425	POLR3H	100	95.588	Tupaia_belangeri
ENSG00000100413	POLR3H	82	97.605	ENSTTRG00000003373	POLR3H	100	97.605	Tursiops_truncatus
ENSG00000100413	POLR3H	99	100.000	ENSUAMG00000022585	POLR3H	100	98.039	Ursus_americanus
ENSG00000100413	POLR3H	100	90.196	ENSUMAG00000021018	POLR3H	100	90.196	Ursus_maritimus
ENSG00000100413	POLR3H	100	96.569	ENSVVUG00000003543	POLR3H	100	96.569	Vulpes_vulpes
ENSG00000100413	POLR3H	99	91.304	ENSXETG00000034216	polr3h	100	87.440	Xenopus_tropicalis
ENSG00000100413	POLR3H	99	89.855	ENSXCOG00000016022	polr3h	100	80.788	Xiphophorus_couchianus
ENSG00000100413	POLR3H	99	88.406	ENSXMAG00000006921	polr3h	100	80.000	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001056	RNA polymerase III activity	21873635.	IBA	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	21873635.	IBA	Function
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	12391170.	IDA	Function
GO:0005654	nucleoplasm	12391170.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005666	RNA polymerase III complex	21873635.	IBA	Component
GO:0005666	RNA polymerase III complex	12391170.	IDA	Component
GO:0005813	centrosome	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006139	nucleobase-containing compound metabolic process	12391170.	IDA	Process
GO:0006383	transcription by RNA polymerase III	12391170.	IDA	Process
GO:0006384	transcription initiation from RNA polymerase III promoter	21873635.	IBA	Process
GO:0032481	positive regulation of type I interferon production	-	TAS	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0045087	innate immune response	-	IEA	Process
GO:0051607	defense response to virus	-	IEA	Process