EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100416 (Gene tree)
Gene ID: 55687
Gene Symbol: TRMU
Alias: FLJ10140|MTO2|TRMT
Full Name: tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 26,466 bases
Position: chr22:46,330,875-46,357,340
Accession: 25481
RBP type: canonical RBP
Summary: This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000290846	tRNA_Me_trans	PF03054.16	1.6e-144	1	1
ENSP00000496496	tRNA_Me_trans	PF03054.16	1.6e-144	1	1
ENSP00000370407	tRNA_Me_trans	PF03054.16	2.8e-127	1	1
ENSP00000494255	tRNA_Me_trans	PF03054.16	5e-116	1	1
ENSP00000495331	tRNA_Me_trans	PF03054.16	1.3e-109	1	1
ENSP00000494679	tRNA_Me_trans	PF03054.16	9.6e-23	1	2
ENSP00000494679	tRNA_Me_trans	PF03054.16	9.6e-23	2	2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28784718	TRMT1-Catalyzed tRNA Modifications Are Required for Redox Homeostasis To Ensure Proper Cellular Proliferation and Oxidative Stress Survival.	Mol Cell Biol	2017 Oct 13	Dewe JM	doi: 10.1128/MCB.00214-17

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000381019	TRMU-202	1381	XM_011530273	ENSP00000370407	376 (aa)	XP_011528575	O75648
ENST00000463785	TRMU-208	557	-	-	- (aa)	-	-
ENST00000493556	TRMU-217	591	-	-	- (aa)	-	-
ENST00000456595	TRMU-206	1688	-	ENSP00000413880	99 (aa)	-	Q2PPL5
ENST00000496831	TRMU-218	576	-	-	- (aa)	-	-
ENST00000642562	TRMU-219	347	-	ENSP00000494679	102 (aa)	-	A0A2R8YDK3
ENST00000470831	TRMU-210	1860	-	-	- (aa)	-	-
ENST00000485559	TRMU-214	2653	-	-	- (aa)	-	-
ENST00000441818	TRMU-204	1793	-	ENSP00000393014	99 (aa)	-	Q2PPL5
ENST00000290846	TRMU-201	1940	-	ENSP00000290846	421 (aa)	-	O75648
ENST00000645190	TRMU-224	1651	XM_005261678	ENSP00000496496	421 (aa)	XP_005261735	O75648
ENST00000476901	TRMU-211	1476	-	-	- (aa)	-	-
ENST00000644006	TRMU-222	1258	-	ENSP00000493778	131 (aa)	-	B4DZN5
ENST00000381021	TRMU-203	1830	-	ENSP00000370409	99 (aa)	-	Q2PPL5
ENST00000485175	TRMU-213	731	-	-	- (aa)	-	-
ENST00000491612	TRMU-216	2933	-	-	- (aa)	-	-
ENST00000647301	TRMU-225	1688	-	ENSP00000496641	207 (aa)	-	A0A2R8YFQ3
ENST00000479648	TRMU-212	574	-	-	- (aa)	-	-
ENST00000643137	TRMU-221	1633	XM_005261681	ENSP00000495331	341 (aa)	XP_005261738	A0A2R8Y6L6
ENST00000465378	TRMU-209	1401	-	-	- (aa)	-	-
ENST00000457572	TRMU-207	1882	-	ENSP00000407700	166 (aa)	-	O75648
ENST00000453630	TRMU-205	1775	-	ENSP00000398488	99 (aa)	-	Q2PPL5
ENST00000645026	TRMU-223	1376	-	-	- (aa)	-	-
ENST00000642923	TRMU-220	1232	XM_011530271	ENSP00000494255	331 (aa)	XP_011528573	A0A2R8Y4R7
ENST00000486620	TRMU-215	814	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000100416's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100416's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000100416	TRMU	56	33.065	ENSG00000213339	QTRT1	59	33.065

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100416	TRMU	99	78.571	ENSAPOG00000014458	trmu	99	70.120	Acanthochromis_polyacanthus
ENSG00000100416	TRMU	100	93.353	ENSAMEG00000003319	TRMU	100	90.647	Ailuropoda_melanoleuca
ENSG00000100416	TRMU	96	74.214	ENSACIG00000002101	trmu	99	69.007	Amphilophus_citrinellus
ENSG00000100416	TRMU	100	78.571	ENSAOCG00000013155	trmu	99	70.602	Amphiprion_ocellaris
ENSG00000100416	TRMU	100	78.571	ENSAPEG00000013350	trmu	99	70.120	Amphiprion_percula
ENSG00000100416	TRMU	100	78.571	ENSATEG00000007814	trmu	99	69.512	Anabas_testudineus
ENSG00000100416	TRMU	100	80.060	ENSAPLG00000016380	TRMU	98	78.961	Anas_platyrhynchos
ENSG00000100416	TRMU	100	82.667	ENSACAG00000007720	TRMU	99	77.163	Anolis_carolinensis
ENSG00000100416	TRMU	100	94.864	ENSANAG00000038053	TRMU	100	93.839	Aotus_nancymaae
ENSG00000100416	TRMU	96	76.730	ENSACLG00000005395	trmu	99	70.460	Astatotilapia_calliptera
ENSG00000100416	TRMU	100	82.143	ENSAMXG00000005282	trmu	99	70.146	Astyanax_mexicanus
ENSG00000100416	TRMU	100	91.843	ENSBTAG00000005595	TRMU	99	90.625	Bos_taurus
ENSG00000100416	TRMU	100	38.462	WBGene00007114	mttu-1	98	40.464	Caenorhabditis_elegans
ENSG00000100416	TRMU	100	93.656	ENSCJAG00000000198	TRMU	100	92.637	Callithrix_jacchus
ENSG00000100416	TRMU	100	93.958	ENSCAFG00000000779	TRMU	99	91.686	Canis_familiaris
ENSG00000100416	TRMU	100	93.958	ENSCAFG00020009184	TRMU	99	91.686	Canis_lupus_dingo
ENSG00000100416	TRMU	100	92.857	ENSCHIG00000017074	TRMU	100	90.736	Capra_hircus
ENSG00000100416	TRMU	100	91.843	ENSTSYG00000003853	TRMU	100	89.549	Carlito_syrichta
ENSG00000100416	TRMU	100	84.527	ENSCAPG00000013034	TRMU	99	82.506	Cavia_aperea
ENSG00000100416	TRMU	100	96.429	ENSCPOG00000020780	TRMU	99	87.828	Cavia_porcellus
ENSG00000100416	TRMU	100	95.166	ENSCCAG00000021641	TRMU	100	93.349	Cebus_capucinus
ENSG00000100416	TRMU	100	96.375	ENSCATG00000032800	TRMU	99	95.000	Cercocebus_atys
ENSG00000100416	TRMU	100	93.333	ENSCLAG00000017269	TRMU	99	89.021	Chinchilla_lanigera
ENSG00000100416	TRMU	100	96.677	ENSCSAG00000005279	TRMU	99	95.476	Chlorocebus_sabaeus
ENSG00000100416	TRMU	100	78.852	ENSCPBG00000011621	TRMU	93	79.839	Chrysemys_picta_bellii
ENSG00000100416	TRMU	97	58.140	ENSCING00000019371	-	96	48.469	Ciona_intestinalis
ENSG00000100416	TRMU	100	96.677	ENSCANG00000041645	TRMU	99	94.947	Colobus_angolensis_palliatus
ENSG00000100416	TRMU	100	92.000	ENSCGRG00001001739	Trmu	99	89.737	Cricetulus_griseus_chok1gshd
ENSG00000100416	TRMU	100	96.429	ENSCGRG00000002781	Trmu	99	82.816	Cricetulus_griseus_crigri
ENSG00000100416	TRMU	99	75.676	ENSCSEG00000012382	trmu	99	67.633	Cynoglossus_semilaevis
ENSG00000100416	TRMU	100	78.571	ENSCVAG00000001366	trmu	99	69.471	Cyprinodon_variegatus
ENSG00000100416	TRMU	100	75.000	ENSDARG00000043734	trmu	95	68.766	Danio_rerio
ENSG00000100416	TRMU	57	83.158	ENSDNOG00000047245	-	84	80.335	Dasypus_novemcinctus
ENSG00000100416	TRMU	100	96.000	ENSDORG00000007455	Trmu	100	89.781	Dipodomys_ordii
ENSG00000100416	TRMU	100	40.483	FBgn0040337	CG3021	95	42.857	Drosophila_melanogaster
ENSG00000100416	TRMU	82	92.593	ENSETEG00000009394	-	66	91.525	Echinops_telfairi
ENSG00000100416	TRMU	96	59.524	ENSEBUG00000007454	trmu	99	53.769	Eptatretus_burgeri
ENSG00000100416	TRMU	100	93.353	ENSEASG00005021725	TRMU	100	90.736	Equus_asinus_asinus
ENSG00000100416	TRMU	100	93.353	ENSECAG00000000467	TRMU	99	91.789	Equus_caballus
ENSG00000100416	TRMU	75	68.421	ENSEEUG00000000074	-	78	92.593	Erinaceus_europaeus
ENSG00000100416	TRMU	99	78.571	ENSELUG00000009464	trmu	99	67.663	Esox_lucius
ENSG00000100416	TRMU	100	93.656	ENSFCAG00000006533	TRMU	100	91.211	Felis_catus
ENSG00000100416	TRMU	100	77.581	ENSFALG00000010035	TRMU	98	76.904	Ficedula_albicollis
ENSG00000100416	TRMU	100	90.634	ENSFDAG00000017472	TRMU	99	88.491	Fukomys_damarensis
ENSG00000100416	TRMU	96	76.730	ENSFHEG00000003162	trmu	98	72.207	Fundulus_heteroclitus
ENSG00000100416	TRMU	95	72.656	ENSGMOG00000001323	trmu	100	63.882	Gadus_morhua
ENSG00000100416	TRMU	100	86.667	ENSGALG00000031922	TRMU	96	78.870	Gallus_gallus
ENSG00000100416	TRMU	99	77.551	ENSGAFG00000013331	trmu	99	77.551	Gambusia_affinis
ENSG00000100416	TRMU	96	72.289	ENSGACG00000019024	trmu	99	66.746	Gasterosteus_aculeatus
ENSG00000100416	TRMU	100	99.698	ENSGGOG00000000203	TRMU	100	99.525	Gorilla_gorilla
ENSG00000100416	TRMU	96	76.101	ENSHBUG00000023421	trmu	99	69.976	Haplochromis_burtoni
ENSG00000100416	TRMU	100	96.429	ENSHGLG00000009278	TRMU	99	86.158	Heterocephalus_glaber_female
ENSG00000100416	TRMU	100	96.429	ENSHGLG00100018863	TRMU	99	86.158	Heterocephalus_glaber_male
ENSG00000100416	TRMU	100	78.571	ENSHCOG00000013459	trmu	99	69.175	Hippocampus_comes
ENSG00000100416	TRMU	100	78.571	ENSIPUG00000009785	trmu	98	70.529	Ictalurus_punctatus
ENSG00000100416	TRMU	100	93.333	ENSSTOG00000010993	TRMU	99	90.215	Ictidomys_tridecemlineatus
ENSG00000100416	TRMU	100	96.429	ENSJJAG00000000667	Trmu	99	90.361	Jaculus_jaculus
ENSG00000100416	TRMU	99	75.000	ENSKMAG00000008516	trmu	99	68.841	Kryptolebias_marmoratus
ENSG00000100416	TRMU	96	76.101	ENSLBEG00000018831	trmu	99	68.765	Labrus_bergylta
ENSG00000100416	TRMU	99	78.667	ENSLACG00000013713	TRMU	99	73.445	Latimeria_chalumnae
ENSG00000100416	TRMU	99	78.378	ENSLOCG00000016066	trmu	100	71.801	Lepisosteus_oculatus
ENSG00000100416	TRMU	100	89.286	ENSLAFG00000005129	TRMU	99	76.611	Loxodonta_africana
ENSG00000100416	TRMU	100	96.979	ENSMFAG00000039767	TRMU	99	96.543	Macaca_fascicularis
ENSG00000100416	TRMU	100	96.979	ENSMMUG00000000807	TRMU	99	95.714	Macaca_mulatta
ENSG00000100416	TRMU	100	96.979	ENSMNEG00000028164	TRMU	99	96.543	Macaca_nemestrina
ENSG00000100416	TRMU	100	96.677	ENSMLEG00000033884	TRMU	99	95.238	Mandrillus_leucophaeus
ENSG00000100416	TRMU	99	78.571	ENSMAMG00000004717	trmu	99	69.976	Mastacembelus_armatus
ENSG00000100416	TRMU	96	76.730	ENSMZEG00005015797	trmu	96	71.930	Maylandia_zebra
ENSG00000100416	TRMU	86	77.133	ENSMGAG00000007550	TRMU	95	77.607	Meleagris_gallopavo
ENSG00000100416	TRMU	100	93.333	ENSMAUG00000022282	Trmu	99	89.499	Mesocricetus_auratus
ENSG00000100416	TRMU	100	97.333	ENSMICG00000029046	TRMU	100	92.086	Microcebus_murinus
ENSG00000100416	TRMU	100	96.429	ENSMOCG00000014641	Trmu	99	89.499	Microtus_ochrogaster
ENSG00000100416	TRMU	96	77.358	ENSMMOG00000007229	trmu	97	70.471	Mola_mola
ENSG00000100416	TRMU	100	78.979	ENSMODG00000007433	TRMU	96	78.282	Monodelphis_domestica
ENSG00000100416	TRMU	100	75.000	ENSMALG00000007721	trmu	96	69.173	Monopterus_albus
ENSG00000100416	TRMU	100	94.667	MGP_CAROLIEiJ_G0020134	Trmu	100	91.228	Mus_caroli
ENSG00000100416	TRMU	100	94.667	ENSMUSG00000022386	Trmu	98	91.228	Mus_musculus
ENSG00000100416	TRMU	100	93.333	MGP_PahariEiJ_G0020139	Trmu	100	89.474	Mus_pahari
ENSG00000100416	TRMU	100	94.667	MGP_SPRETEiJ_G0021031	Trmu	100	91.228	Mus_spretus
ENSG00000100416	TRMU	100	93.353	ENSMPUG00000002523	TRMU	100	91.211	Mustela_putorius_furo
ENSG00000100416	TRMU	100	93.333	ENSNGAG00000005132	Trmu	100	89.183	Nannospalax_galili
ENSG00000100416	TRMU	96	76.101	ENSNBRG00000022690	trmu	99	70.864	Neolamprologus_brichardi
ENSG00000100416	TRMU	100	98.240	ENSNLEG00000015773	TRMU	100	96.912	Nomascus_leucogenys
ENSG00000100416	TRMU	98	81.081	ENSMEUG00000000216	TRMU	99	70.732	Notamacropus_eugenii
ENSG00000100416	TRMU	100	93.333	ENSODEG00000014745	TRMU	99	88.783	Octodon_degus
ENSG00000100416	TRMU	96	74.843	ENSONIG00000009821	trmu	96	71.429	Oreochromis_niloticus
ENSG00000100416	TRMU	95	86.400	ENSOANG00000001891	TRMU	99	77.919	Ornithorhynchus_anatinus
ENSG00000100416	TRMU	100	90.937	ENSOCUG00000003664	TRMU	97	87.561	Oryctolagus_cuniculus
ENSG00000100416	TRMU	99	70.270	ENSORLG00000019015	trmu	98	68.642	Oryzias_latipes
ENSG00000100416	TRMU	99	70.270	ENSORLG00020006830	trmu	98	68.642	Oryzias_latipes_hni
ENSG00000100416	TRMU	99	70.270	ENSORLG00015003907	trmu	98	68.642	Oryzias_latipes_hsok
ENSG00000100416	TRMU	99	73.469	ENSOMEG00000015518	-	99	73.469	Oryzias_melastigma
ENSG00000100416	TRMU	58	67.876	ENSOMEG00000015541	trmu	87	66.805	Oryzias_melastigma
ENSG00000100416	TRMU	100	94.667	ENSOGAG00000008096	TRMU	99	90.120	Otolemur_garnettii
ENSG00000100416	TRMU	100	92.857	ENSOARG00000019475	TRMU	99	82.410	Ovis_aries
ENSG00000100416	TRMU	100	100.000	ENSPPAG00000033944	TRMU	100	99.525	Pan_paniscus
ENSG00000100416	TRMU	100	94.260	ENSPPRG00000004197	TRMU	100	91.686	Panthera_pardus
ENSG00000100416	TRMU	95	95.200	ENSPTIG00000014122	TRMU	98	92.509	Panthera_tigris_altaica
ENSG00000100416	TRMU	100	100.000	ENSPTRG00000014510	TRMU	100	99.525	Pan_troglodytes
ENSG00000100416	TRMU	100	96.677	ENSPANG00000023074	TRMU	99	96.011	Papio_anubis
ENSG00000100416	TRMU	96	75.472	ENSPKIG00000002849	trmu	99	68.689	Paramormyrops_kingsleyae
ENSG00000100416	TRMU	95	85.600	ENSPSIG00000013020	TRMU	95	80.769	Pelodiscus_sinensis
ENSG00000100416	TRMU	100	78.571	ENSPMGG00000004083	trmu	99	69.903	Periophthalmus_magnuspinnatus
ENSG00000100416	TRMU	100	93.333	ENSPEMG00000014007	Trmu	99	89.737	Peromyscus_maniculatus_bairdii
ENSG00000100416	TRMU	100	79.456	ENSPCIG00000009923	TRMU	98	77.885	Phascolarctos_cinereus
ENSG00000100416	TRMU	100	71.299	ENSPFOG00000008197	trmu	90	68.657	Poecilia_formosa
ENSG00000100416	TRMU	96	76.101	ENSPLAG00000008414	trmu	99	70.602	Poecilia_latipinna
ENSG00000100416	TRMU	96	76.101	ENSPMEG00000004326	trmu	99	70.843	Poecilia_mexicana
ENSG00000100416	TRMU	96	76.730	ENSPREG00000007980	trmu	99	70.433	Poecilia_reticulata
ENSG00000100416	TRMU	100	99.396	ENSPPYG00000011949	TRMU	100	98.337	Pongo_abelii
ENSG00000100416	TRMU	95	88.000	ENSPCAG00000013462	TRMU	100	78.261	Procavia_capensis
ENSG00000100416	TRMU	100	97.333	ENSPCOG00000016539	TRMU	100	91.686	Propithecus_coquereli
ENSG00000100416	TRMU	96	93.125	ENSPVAG00000013202	TRMU	100	81.535	Pteropus_vampyrus
ENSG00000100416	TRMU	96	76.730	ENSPNYG00000005629	trmu	99	69.976	Pundamilia_nyererei
ENSG00000100416	TRMU	100	75.000	ENSPNAG00000006339	trmu	93	71.139	Pygocentrus_nattereri
ENSG00000100416	TRMU	100	93.333	ENSRNOG00000016465	Trmu	99	89.737	Rattus_norvegicus
ENSG00000100416	TRMU	100	96.677	ENSRBIG00000038973	TRMU	99	95.213	Rhinopithecus_bieti
ENSG00000100416	TRMU	100	96.979	ENSRROG00000004267	TRMU	99	95.213	Rhinopithecus_roxellana
ENSG00000100416	TRMU	90	31.172	YDL033C	SLM3	91	31.172	Saccharomyces_cerevisiae
ENSG00000100416	TRMU	100	94.562	ENSSBOG00000030184	TRMU	100	93.349	Saimiri_boliviensis_boliviensis
ENSG00000100416	TRMU	100	69.486	ENSSFOG00015020664	trmu	98	69.251	Scleropages_formosus
ENSG00000100416	TRMU	99	78.571	ENSSMAG00000019450	trmu	99	69.007	Scophthalmus_maximus
ENSG00000100416	TRMU	99	78.571	ENSSDUG00000011913	trmu	99	70.773	Seriola_dumerili
ENSG00000100416	TRMU	99	78.571	ENSSLDG00000011684	trmu	99	71.014	Seriola_lalandi_dorsalis
ENSG00000100416	TRMU	98	96.154	ENSSPUG00000017123	TRMU	97	68.049	Sphenodon_punctatus
ENSG00000100416	TRMU	100	78.571	ENSSPAG00000021875	trmu	99	69.565	Stegastes_partitus
ENSG00000100416	TRMU	100	96.429	ENSSSCG00000000007	TRMU	100	88.599	Sus_scrofa
ENSG00000100416	TRMU	100	78.313	ENSTGUG00000003663	-	100	79.088	Taeniopygia_guttata
ENSG00000100416	TRMU	93	77.419	ENSTRUG00000003403	-	94	77.419	Takifugu_rubripes
ENSG00000100416	TRMU	96	78.616	ENSTRUG00000001231	trmu	100	69.976	Takifugu_rubripes
ENSG00000100416	TRMU	96	78.395	ENSTNIG00000010484	trmu	100	69.340	Tetraodon_nigroviridis
ENSG00000100416	TRMU	100	52.568	ENSTBEG00000011276	-	100	55.980	Tupaia_belangeri
ENSG00000100416	TRMU	100	93.958	ENSTTRG00000004160	TRMU	100	90.261	Tursiops_truncatus
ENSG00000100416	TRMU	100	92.000	ENSUAMG00000024825	TRMU	97	92.440	Ursus_americanus
ENSG00000100416	TRMU	95	94.400	ENSUMAG00000019079	TRMU	97	91.829	Ursus_maritimus
ENSG00000100416	TRMU	95	72.000	ENSVPAG00000000685	-	100	78.995	Vicugna_pacos
ENSG00000100416	TRMU	100	94.667	ENSVVUG00000024963	TRMU	100	91.686	Vulpes_vulpes
ENSG00000100416	TRMU	100	78.667	ENSXETG00000023304	trmu	99	73.522	Xenopus_tropicalis
ENSG00000100416	TRMU	95	75.806	ENSXCOG00000015105	trmu	99	68.409	Xiphophorus_couchianus
ENSG00000100416	TRMU	96	76.730	ENSXMAG00000006697	trmu	99	70.433	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	-	IEA	Function
GO:0002143	tRNA wobble position uridine thiolation	21873635.	IBA	Process
GO:0005524	ATP binding	-	IEA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005739	mitochondrion	-	ISS	Component
GO:0016783	sulfurtransferase activity	-	IEA	Function