EuRBPDB

Description

Ensembl ID: ENSG00000100442 (Gene tree)
Gene ID: 2287
Gene Symbol: FKBP3
Alias: FKBP-25|PPIase
Full Name: FKBP prolyl isomerase 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 19,721 bases
Position: chr14:45,115,599-45,135,319
Accession: 3719
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29036638	The basic tilted helix bundle domain of the prolyl isomerase FKBP25 is a novel double-stranded RNA binding module.	Nucleic Acids Res	2017 Nov 16	Dilworth D	doi: 10.1093/nar/gkx852.
29361176	The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability.	Nucleic Acids Res	2018 Mar 16	Dilworth D	doi: 10.1093/nar/gky008.
27011170	LARP6 Meets Collagen mRNA: Specific Regulation of Type I Collagen Expression.	Int J Mol Sci	2016 Mar 22	Zhang Y	doi: 10.3390/ijms17030419.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000396062	FKBP3-202	1346	XM_011536565	ENSP00000379374	224 (aa)	XP_011534867	Q00688
ENST00000216330	FKBP3-201	1684	-	ENSP00000216330	224 (aa)	-	Q00688
ENST00000556231	FKBP3-203	704	-	-	- (aa)	-	-
ENST00000557324	FKBP3-204	643	-	ENSP00000452322	65 (aa)	-	G3V5F2

Gene Model

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100442	FKBP3	100	94.196	ENSMUSG00000020949	Fkbp3	99	96.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000413	protein peptidyl-prolyl isomerization	-	IEA	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	-	IEA	Function
GO:0005515	protein binding	19166840.21812934.	IPI	Function
GO:0005528	FK506 binding	1374240.	TAS	Function
GO:0005634	nucleus	-	IEA	Component
GO:0038023	signaling receptor activity	1374240.	TAS	Function