EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100519 (Gene tree)
Gene ID: 5706
Gene Symbol: PSMC6
Alias: p42
Full Name: proteasome 26S subunit, ATPase 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 21,425 bases
Position: chr14:52,707,163-52,728,587
Accession: 9553
RBP type: non-canonical RBP
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000445930	PSMC6-201	2188	-	ENSP00000401802	403 (aa)	-	A0A087X2I1
ENST00000555339	PSMC6-210	583	-	ENSP00000452048	194 (aa)	-	H0YJS8
ENST00000557240	PSMC6-214	625	-	ENSP00000452072	97 (aa)	-	H0YJT1
ENST00000612399	PSMC6-219	1590	-	ENSP00000484998	403 (aa)	-	A0A087X2I1
ENST00000553798	PSMC6-204	563	-	ENSP00000451241	33 (aa)	-	H0YJD2
ENST00000557085	PSMC6-213	890	-	-	- (aa)	-	-
ENST00000557517	PSMC6-215	580	-	ENSP00000452253	14 (aa)	-	H0YJW2
ENST00000556813	PSMC6-212	785	-	ENSP00000451156	262 (aa)	-	H0YJC0
ENST00000557632	PSMC6-217	611	-	-	- (aa)	-	-
ENST00000606149	PSMC6-218	1560	XM_017021472	ENSP00000475721	389 (aa)	XP_016876961	P62333
ENST00000458604	PSMC6-202	1093	-	-	- (aa)	-	-
ENST00000554952	PSMC6-207	1037	-	-	- (aa)	-	-
ENST00000551328	PSMC6-203	650	-	-	- (aa)	-	-
ENST00000554956	PSMC6-208	535	-	-	- (aa)	-	-
ENST00000557557	PSMC6-216	2939	-	-	- (aa)	-	-
ENST00000555175	PSMC6-209	752	-	ENSP00000452388	67 (aa)	-	H0YJX2
ENST00000554044	PSMC6-206	844	-	ENSP00000451340	70 (aa)	-	H0YJE9
ENST00000553899	PSMC6-205	706	-	ENSP00000452511	36 (aa)	-	H0YJY8
ENST00000555887	PSMC6-211	573	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000100519's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03050	Proteasome	KEGG
hsa05169	Epstein-Barr virus infection	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100519's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100519	PSMC6	99	51.515	WBGene00004501	rpt-1	71	48.534	Caenorhabditis_elegans
ENSG00000100519	PSMC6	99	50.000	WBGene00004503	rpt-3	84	44.220	Caenorhabditis_elegans
ENSG00000100519	PSMC6	99	42.424	WBGene00004502	rpt-2	79	41.429	Caenorhabditis_elegans
ENSG00000100519	PSMC6	96	54.688	ENSG00000087191	PSMC5	89	51.181	Homo_sapiens
ENSG00000100519	PSMC6	99	53.030	ENSG00000161057	PSMC2	78	50.323	Homo_sapiens
ENSG00000100519	PSMC6	99	46.970	ENSG00000100764	PSMC1	98	56.098	Homo_sapiens
ENSG00000100519	PSMC6	93	46.774	ENSG00000165916	PSMC3	78	46.129	Homo_sapiens
ENSG00000100519	PSMC6	96	51.562	YGL048C	RPT6	95	43.377	Saccharomyces_cerevisiae
ENSG00000100519	PSMC6	99	53.030	YKL145W	RPT1	69	48.750	Saccharomyces_cerevisiae
ENSG00000100519	PSMC6	99	45.455	YDL007W	RPT2	80	43.391	Saccharomyces_cerevisiae
ENSG00000100519	PSMC6	96	46.875	YDR394W	RPT3	84	39.833	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0000502	proteasome complex	9464850.17323924.	IDA	Component
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	-	TAS	Process
GO:0005515	protein binding	16189514.16763564.19490896.21516116.25416956.26496610.26871637.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	10419517.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006511	ubiquitin-dependent protein catabolic process	9464850.	IC	Process
GO:0006521	regulation of cellular amino acid metabolic process	-	TAS	Process
GO:0008540	proteasome regulatory particle, base subcomplex	21873635.	IBA	Component
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0016887	ATPase activity	9464850.	TAS	Function
GO:0022624	proteasome accessory complex	-	ISS	Component
GO:0030433	ubiquitin-dependent ERAD pathway	21873635.	IBA	Process
GO:0030674	protein binding, bridging	11590019.	NAS	Function
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	TAS	Process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0031597	cytosolic proteasome complex	21873635.	IBA	Component
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	Process
GO:0036402	proteasome-activating ATPase activity	-	IEA	Function
GO:0038061	NIK/NF-kappaB signaling	-	TAS	Process
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0042802	identical protein binding	25416956.	IPI	Function
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	21873635.	IBA	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	Process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	TAS	Process
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	Process
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:1901800	positive regulation of proteasomal protein catabolic process	-	IEA	Process
GO:1901990	regulation of mitotic cell cycle phase transition	-	TAS	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	-	TAS	Process