EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100603 (Gene tree)
Gene ID: 22938
Gene Symbol: SNW1
Alias: NCoA-62|SKIP|Prp45|PRPF45|Bx42|SKIP1|FUN20|SKIIP
Full Name: SNW domain containing 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 43,620 bases
Position: chr14:77,717,599-77,761,218
Accession: 16696
RBP type: non-canonical RBP
Summary: This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16116479	Profiling estrogen-regulated gene expression changes in normal and malignant human ovarian surface epithelial cells.	Oncogene	2005 Dec 8	Syed V	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000261531	SNW1-201	2163	-	ENSP00000261531	536 (aa)	-	Q13573
ENST00000554775	SNW1-204	1687	-	ENSP00000452059	374 (aa)	-	G3V4X8
ENST00000556428	SNW1-206	1966	-	ENSP00000451741	47 (aa)	-	G3V4E0
ENST00000553565	SNW1-202	564	-	-	- (aa)	-	-
ENST00000554324	SNW1-203	584	-	ENSP00000452473	185 (aa)	-	G3V5R3
ENST00000557663	SNW1-207	602	-	-	- (aa)	-	-
ENST00000555761	SNW1-205	1855	XM_005267413	ENSP00000451129	571 (aa)	XP_005267470	G3V3A4

Gene Model

Click here to download ENSG00000100603's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG
hsa04330	Notch signaling pathway	KEGG
hsa05169	Epstein-Barr virus infection	KEGG
hsa05203	Viral carcinogenesis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100603's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100603	SNW1	90	73.333	WBGene00004806	skp-1	96	56.546	Caenorhabditis_elegans
ENSG00000100603	SNW1	100	99.733	ENSMUSG00000021039	Snw1	100	99.254	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	14985122.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	15194481.28076346.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003713	transcription coactivator activity	11514567.14985122.23566155.	IDA	Function
GO:0003714	transcription corepressor activity	14985122.	IDA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005112	Notch binding	10713164.	IPI	Function
GO:0005515	protein binding	9569025.9632709.10713164.11278756.11371506.12529369.12840015.14985122.15316101.16102918.16595688.18729074.18794151.19934264.20368803.20467437.21460037.22365833.25277244.25416956.30021884.	IPI	Function
GO:0005634	nucleus	9569025.15878163.28076346.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	15194481.	IDA	Component
GO:0006357	regulation of transcription by RNA polymerase II	9632709.	TAS	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	Process
GO:0007219	Notch signaling pathway	-	TAS	Process
GO:0007221	positive regulation of transcription of Notch receptor target	-	TAS	Process
GO:0008024	cyclin/CDK positive transcription elongation factor complex	15905409.	IDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0016363	nuclear matrix	12840015.	IDA	Component
GO:0016604	nuclear body	-	IDA	Component
GO:0016607	nuclear speck	23566155.	IDA	Component
GO:0019899	enzyme binding	20007319.	IPI	Function
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	11278756.	IDA	Process
GO:0035257	nuclear hormone receptor binding	19934264.	IDA	Function
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	21460037.	IMP	Process
GO:0042809	vitamin D receptor binding	12529369.	IDA	Function
GO:0042974	retinoic acid receptor binding	11514567.	IDA	Function
GO:0043923	positive regulation by host of viral transcription	15905409.	IDA	Process
GO:0043923	positive regulation by host of viral transcription	19818711.	IMP	Process
GO:0045747	positive regulation of Notch signaling pathway	-	TAS	Process
GO:0045892	negative regulation of transcription, DNA-templated	10713164.15878163.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	14985122.19934264.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	TAS	Process
GO:0046332	SMAD binding	11278756.	IDA	Function
GO:0048026	positive regulation of mRNA splicing, via spliceosome	12840015.	IMP	Process
GO:0048384	retinoic acid receptor signaling pathway	19934264.	IDA	Process
GO:0048385	regulation of retinoic acid receptor signaling pathway	14985122.	IDA	Process
GO:0050681	androgen receptor binding	23566155.	IPI	Function
GO:0050769	positive regulation of neurogenesis	-	ISS	Process
GO:0051571	positive regulation of histone H3-K4 methylation	19818711.	IMP	Process
GO:0070562	regulation of vitamin D receptor signaling pathway	14985122.	IDA	Process
GO:0070564	positive regulation of vitamin D receptor signaling pathway	9632709.11514567.	IDA	Process
GO:0071007	U2-type catalytic step 2 spliceosome	28076346.	IDA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component
GO:0071300	cellular response to retinoic acid	19934264.	IDA	Process