EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100650 (Gene tree)
Gene ID: 6430
Gene Symbol: SRSF5
Alias: SRP40|HRS|SFRS5
Full Name: serine and arginine rich splicing factor 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 45,106 bases
Position: chr14:69,726,900-69,772,005
Accession: 10787
RBP type: canonical RBP
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000377892	RRM_1	PF00076.22	3.7e-30	1	2
ENSP00000377892	RRM_1	PF00076.22	3.7e-30	2	2
ENSP00000451088	RRM_1	PF00076.22	3.7e-30	1	2
ENSP00000451088	RRM_1	PF00076.22	3.7e-30	2	2
ENSP00000452123	RRM_1	PF00076.22	3.7e-30	1	2
ENSP00000452123	RRM_1	PF00076.22	3.7e-30	2	2
ENSP00000451391	RRM_1	PF00076.22	5.6e-24	1	2
ENSP00000451391	RRM_1	PF00076.22	5.6e-24	2	2
ENSP00000452090	RRM_1	PF00076.22	7.2e-17	1	1
ENSP00000452400	RRM_1	PF00076.22	9.2e-17	1	1
ENSP00000450918	RRM_1	PF00076.22	9.6e-17	1	1
ENSP00000452449	RRM_1	PF00076.22	9.6e-17	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29175331	Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins.	Biochem Biophys Res Commun	2018 Jan 1	Fujita T	doi: 10.1016/j.bbrc.2017.11.136
9434190	Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes.	Gene	1997 Dec 19	Du K	-
9037021	Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer.	Proc Natl Acad Sci U S A	1997 Feb 18	Tacke R	-
23284704	Regulation of Mcl-1 by SRSF1 and SRSF5 in cancer cells.	PLoS One	2012	Gautrey HL	doi: 10.1371/journal.pone.0051497
14703492	[Construction of subtracted cDNA library in human Jurkat T cell line induced by arsenic trioxide in vitro].	Zhonghua Yu Fang Yi Xue Za Zhi	2003 Nov	Zhang YX	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000557154	SRSF5-217	1500	XM_005267999	ENSP00000451088	272 (aa)	XP_005268056	Q13243
ENST00000556647	SRSF5-216	644	-	-	- (aa)	-	-
ENST00000394366	SRSF5-201	1638	XM_017021593	ENSP00000377892	272 (aa)	XP_016877082	Q13243
ENST00000553548	SRSF5-204	526	-	ENSP00000452400	99 (aa)	-	G3V5K8
ENST00000554465	SRSF5-207	3044	-	-	- (aa)	-	-
ENST00000556184	SRSF5-212	2443	-	-	- (aa)	-	-
ENST00000557435	SRSF5-218	622	-	-	- (aa)	-	-
ENST00000554929	SRSF5-208	947	-	-	- (aa)	-	-
ENST00000553635	SRSF5-205	1412	-	ENSP00000451391	269 (aa)	-	Q13243
ENST00000555349	SRSF5-209	565	-	ENSP00000452090	124 (aa)	-	B4DJK0
ENST00000556587	SRSF5-215	1863	-	-	- (aa)	-	-
ENST00000554021	SRSF5-206	567	-	ENSP00000450918	138 (aa)	-	B4DUA4
ENST00000553369	SRSF5-202	613	-	ENSP00000452449	138 (aa)	-	B4DUA4
ENST00000556436	SRSF5-214	611	-	-	- (aa)	-	-
ENST00000555547	SRSF5-211	2057	-	ENSP00000474409	138 (aa)	-	B4DUA4
ENST00000557460	SRSF5-219	939	-	-	- (aa)	-	-
ENST00000555412	SRSF5-210	572	-	-	- (aa)	-	-
ENST00000553521	SRSF5-203	2815	-	ENSP00000452123	272 (aa)	-	Q13243
ENST00000556330	SRSF5-213	546	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000100650's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100650	rs1275824	14	69727846	?	Red blood cell count	30595370			EFO_0004305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100650's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000100650	SRSF5	85	35.484	ENSG00000234414	RBMY1A1	81	34.848
ENSG00000100650	SRSF5	96	43.548	ENSG00000136450	SRSF1	78	61.404
ENSG00000100650	SRSF5	85	35.484	ENSG00000242875	RBMY1B	81	34.848
ENSG00000100650	SRSF5	85	35.484	ENSG00000244395	RBMY1D	81	34.848
ENSG00000100650	SRSF5	95	45.455	ENSG00000115875	SRSF7	65	39.423
ENSG00000100650	SRSF5	78	33.708	ENSG00000099622	CIRBP	93	32.432
ENSG00000100650	SRSF5	95	36.290	ENSG00000111786	SRSF9	98	31.707
ENSG00000100650	SRSF5	82	35.366	ENSG00000092199	HNRNPC	76	42.000
ENSG00000100650	SRSF5	71	36.620	ENSG00000125970	RALY	75	37.313
ENSG00000100650	SRSF5	73	40.000	ENSG00000147274	RBMX	82	43.750
ENSG00000100650	SRSF5	95	62.295	ENSG00000124193	SRSF6	50	71.642
ENSG00000100650	SRSF5	85	35.484	ENSG00000242389	RBMY1E	81	34.848
ENSG00000100650	SRSF5	76	47.561	ENSG00000112081	SRSF3	83	44.340
ENSG00000100650	SRSF5	51	43.137	ENSG00000184672	RALYL	60	43.137

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100650	SRSF5	98	76.562	ENSAPOG00000008642	srsf5b	63	85.405	Acanthochromis_polyacanthus
ENSG00000100650	SRSF5	100	100.000	ENSAMEG00000014574	SRSF5	100	98.540	Ailuropoda_melanoleuca
ENSG00000100650	SRSF5	99	76.154	ENSACIG00000010742	srsf5b	87	73.188	Amphilophus_citrinellus
ENSG00000100650	SRSF5	98	76.562	ENSAOCG00000005719	srsf5b	63	85.405	Amphiprion_ocellaris
ENSG00000100650	SRSF5	98	76.562	ENSAPEG00000007830	srsf5b	63	85.405	Amphiprion_percula
ENSG00000100650	SRSF5	98	75.781	ENSATEG00000019112	srsf5b	63	82.258	Anabas_testudineus
ENSG00000100650	SRSF5	98	92.884	ENSAPLG00000014681	SRSF5	67	94.444	Anas_platyrhynchos
ENSG00000100650	SRSF5	100	99.000	ENSACAG00000005143	SRSF5	100	95.604	Anolis_carolinensis
ENSG00000100650	SRSF5	100	98.990	ENSANAG00000037529	-	96	97.581	Aotus_nancymaae
ENSG00000100650	SRSF5	100	100.000	ENSANAG00000027977	-	100	100.000	Aotus_nancymaae
ENSG00000100650	SRSF5	98	76.562	ENSACLG00000026424	srsf5b	63	84.324	Astatotilapia_calliptera
ENSG00000100650	SRSF5	98	80.000	ENSAMXG00000011932	srsf5b	88	77.863	Astyanax_mexicanus
ENSG00000100650	SRSF5	100	100.000	ENSBTAG00000011596	SRSF5	100	98.540	Bos_taurus
ENSG00000100650	SRSF5	100	100.000	ENSCJAG00000014884	SRSF5	100	100.000	Callithrix_jacchus
ENSG00000100650	SRSF5	100	100.000	ENSCAFG00000016589	SRSF5	100	98.540	Canis_familiaris
ENSG00000100650	SRSF5	100	100.000	ENSCAFG00020005661	SRSF5	100	98.540	Canis_lupus_dingo
ENSG00000100650	SRSF5	100	100.000	ENSCHIG00000016794	SRSF5	100	97.826	Capra_hircus
ENSG00000100650	SRSF5	100	100.000	ENSTSYG00000007786	SRSF5	100	100.000	Carlito_syrichta
ENSG00000100650	SRSF5	100	100.000	ENSCAPG00000008801	SRSF5	100	97.101	Cavia_aperea
ENSG00000100650	SRSF5	100	100.000	ENSCPOG00000039926	SRSF5	65	100.000	Cavia_porcellus
ENSG00000100650	SRSF5	100	100.000	ENSCCAG00000029002	SRSF5	100	100.000	Cebus_capucinus
ENSG00000100650	SRSF5	100	100.000	ENSCATG00000045051	SRSF5	100	100.000	Cercocebus_atys
ENSG00000100650	SRSF5	100	100.000	ENSCLAG00000004755	SRSF5	100	97.810	Chinchilla_lanigera
ENSG00000100650	SRSF5	100	100.000	ENSCSAG00000013041	SRSF5	100	100.000	Chlorocebus_sabaeus
ENSG00000100650	SRSF5	100	100.000	ENSCPBG00000021653	SRSF5	100	96.324	Chrysemys_picta_bellii
ENSG00000100650	SRSF5	100	100.000	ENSCANG00000030560	SRSF5	100	100.000	Colobus_angolensis_palliatus
ENSG00000100650	SRSF5	100	100.000	ENSCGRG00001015339	Srsf5	100	97.794	Cricetulus_griseus_chok1gshd
ENSG00000100650	SRSF5	100	100.000	ENSCGRG00000009833	Srsf5	100	98.162	Cricetulus_griseus_crigri
ENSG00000100650	SRSF5	98	75.385	ENSCSEG00000003801	srsf5b	64	82.353	Cynoglossus_semilaevis
ENSG00000100650	SRSF5	98	75.000	ENSCVAG00000017240	srsf5b	57	84.324	Cyprinodon_variegatus
ENSG00000100650	SRSF5	99	79.365	ENSDARG00000027734	srsf5b	91	82.540	Danio_rerio
ENSG00000100650	SRSF5	100	100.000	ENSDNOG00000006160	SRSF5	100	98.897	Dasypus_novemcinctus
ENSG00000100650	SRSF5	100	100.000	ENSDORG00000003989	Srsf5	100	98.897	Dipodomys_ordii
ENSG00000100650	SRSF5	100	92.647	ENSETEG00000020396	SRSF5	66	89.944	Echinops_telfairi
ENSG00000100650	SRSF5	98	61.600	ENSEBUG00000006229	srsf5b	68	65.730	Eptatretus_burgeri
ENSG00000100650	SRSF5	100	100.000	ENSEASG00005016615	SRSF5	100	98.540	Equus_asinus_asinus
ENSG00000100650	SRSF5	100	100.000	ENSECAG00000026873	SRSF5	100	99.275	Equus_caballus
ENSG00000100650	SRSF5	98	73.134	ENSELUG00000019852	srsf5b	88	69.536	Esox_lucius
ENSG00000100650	SRSF5	100	100.000	ENSFCAG00000008848	SRSF5	100	99.275	Felis_catus
ENSG00000100650	SRSF5	100	97.980	ENSFALG00000004979	SRSF5	67	94.972	Ficedula_albicollis
ENSG00000100650	SRSF5	100	100.000	ENSFDAG00000011562	SRSF5	100	98.897	Fukomys_damarensis
ENSG00000100650	SRSF5	98	74.219	ENSFHEG00000009476	srsf5b	60	84.324	Fundulus_heteroclitus
ENSG00000100650	SRSF5	99	71.533	ENSGMOG00000000595	srsf5b	97	67.117	Gadus_morhua
ENSG00000100650	SRSF5	100	97.980	ENSGALG00000009421	SRSF5	100	96.377	Gallus_gallus
ENSG00000100650	SRSF5	99	70.073	ENSGACG00000007834	srsf5b	89	70.922	Gasterosteus_aculeatus
ENSG00000100650	SRSF5	100	100.000	ENSGAGG00000004447	SRSF5	100	96.324	Gopherus_agassizii
ENSG00000100650	SRSF5	100	100.000	ENSGGOG00000016462	SRSF5	100	100.000	Gorilla_gorilla
ENSG00000100650	SRSF5	98	76.562	ENSHBUG00000012462	srsf5b	93	75.000	Haplochromis_burtoni
ENSG00000100650	SRSF5	100	100.000	ENSHGLG00000010147	SRSF5	100	98.897	Heterocephalus_glaber_female
ENSG00000100650	SRSF5	100	100.000	ENSHGLG00100015328	SRSF5	100	98.897	Heterocephalus_glaber_male
ENSG00000100650	SRSF5	100	66.667	ENSHGLG00100000095	-	62	65.517	Heterocephalus_glaber_male
ENSG00000100650	SRSF5	98	71.212	ENSHCOG00000005592	srsf5b	64	77.128	Hippocampus_comes
ENSG00000100650	SRSF5	100	100.000	ENSSTOG00000020672	SRSF5	100	99.265	Ictidomys_tridecemlineatus
ENSG00000100650	SRSF5	100	100.000	ENSJJAG00000001688	Srsf5	100	97.445	Jaculus_jaculus
ENSG00000100650	SRSF5	100	79.231	ENSKMAG00000020486	srsf5b	87	78.788	Kryptolebias_marmoratus
ENSG00000100650	SRSF5	98	73.846	ENSLBEG00000013647	srsf5b	63	82.353	Labrus_bergylta
ENSG00000100650	SRSF5	100	85.149	ENSLACG00000005874	SRSF5	67	90.608	Latimeria_chalumnae
ENSG00000100650	SRSF5	99	78.788	ENSLOCG00000012438	srsf5b	69	82.703	Lepisosteus_oculatus
ENSG00000100650	SRSF5	100	98.990	ENSLAFG00000005260	SRSF5	100	97.810	Loxodonta_africana
ENSG00000100650	SRSF5	100	100.000	ENSMFAG00000002393	SRSF5	100	100.000	Macaca_fascicularis
ENSG00000100650	SRSF5	100	100.000	ENSMNEG00000030872	SRSF5	100	100.000	Macaca_nemestrina
ENSG00000100650	SRSF5	100	100.000	ENSMLEG00000030017	SRSF5	100	100.000	Mandrillus_leucophaeus
ENSG00000100650	SRSF5	98	73.438	ENSMAMG00000002673	srsf5b	63	80.978	Mastacembelus_armatus
ENSG00000100650	SRSF5	98	76.562	ENSMZEG00005003550	srsf5b	63	84.324	Maylandia_zebra
ENSG00000100650	SRSF5	67	87.952	ENSMGAG00000011835	SRSF5	62	91.429	Meleagris_gallopavo
ENSG00000100650	SRSF5	100	100.000	ENSMAUG00000009544	Srsf5	100	98.162	Mesocricetus_auratus
ENSG00000100650	SRSF5	100	100.000	ENSMICG00000037432	-	100	100.000	Microcebus_murinus
ENSG00000100650	SRSF5	100	84.848	ENSMICG00000046738	-	98	72.500	Microcebus_murinus
ENSG00000100650	SRSF5	100	100.000	ENSMOCG00000013134	Srsf5	100	97.794	Microtus_ochrogaster
ENSG00000100650	SRSF5	99	73.643	ENSMMOG00000000137	srsf5b	97	61.481	Mola_mola
ENSG00000100650	SRSF5	100	100.000	ENSMODG00000011362	SRSF5	100	96.691	Monodelphis_domestica
ENSG00000100650	SRSF5	98	75.194	ENSMALG00000021875	srsf5b	88	74.627	Monopterus_albus
ENSG00000100650	SRSF5	100	100.000	ENSMUSG00000021134	Srsf5	100	98.162	Mus_musculus
ENSG00000100650	SRSF5	100	100.000	MGP_PahariEiJ_G0029659	Srsf5	100	98.162	Mus_pahari
ENSG00000100650	SRSF5	100	100.000	ENSMPUG00000007458	SRSF5	100	98.540	Mustela_putorius_furo
ENSG00000100650	SRSF5	100	100.000	ENSMLUG00000011939	SRSF5	100	96.429	Myotis_lucifugus
ENSG00000100650	SRSF5	100	100.000	ENSNGAG00000010073	-	100	98.529	Nannospalax_galili
ENSG00000100650	SRSF5	98	75.385	ENSNBRG00000001285	srsf5b	63	83.422	Neolamprologus_brichardi
ENSG00000100650	SRSF5	100	100.000	ENSNLEG00000001615	SRSF5	100	100.000	Nomascus_leucogenys
ENSG00000100650	SRSF5	100	100.000	ENSOPRG00000008286	SRSF5	100	96.786	Ochotona_princeps
ENSG00000100650	SRSF5	100	96.970	ENSODEG00000000700	-	68	97.765	Octodon_degus
ENSG00000100650	SRSF5	100	100.000	ENSODEG00000013469	-	100	98.162	Octodon_degus
ENSG00000100650	SRSF5	98	76.562	ENSONIG00000005759	srsf5b	63	84.324	Oreochromis_niloticus
ENSG00000100650	SRSF5	100	92.647	ENSOANG00000013336	SRSF5	67	93.296	Ornithorhynchus_anatinus
ENSG00000100650	SRSF5	100	100.000	ENSOCUG00000009274	SRSF5	100	96.763	Oryctolagus_cuniculus
ENSG00000100650	SRSF5	98	73.282	ENSORLG00000029854	srsf5b	58	79.787	Oryzias_latipes
ENSG00000100650	SRSF5	98	73.846	ENSORLG00015001720	srsf5b	63	81.818	Oryzias_latipes_hsok
ENSG00000100650	SRSF5	100	100.000	ENSOGAG00000015122	SRSF5	100	98.897	Otolemur_garnettii
ENSG00000100650	SRSF5	100	100.000	ENSPPAG00000029921	SRSF5	100	100.000	Pan_paniscus
ENSG00000100650	SRSF5	100	100.000	ENSPPRG00000012903	SRSF5	100	99.275	Panthera_pardus
ENSG00000100650	SRSF5	100	100.000	ENSPTIG00000018589	SRSF5	100	99.275	Panthera_tigris_altaica
ENSG00000100650	SRSF5	100	100.000	ENSPTRG00000006488	SRSF5	100	100.000	Pan_troglodytes
ENSG00000100650	SRSF5	100	100.000	ENSPANG00000021091	SRSF5	100	100.000	Papio_anubis
ENSG00000100650	SRSF5	100	100.000	ENSPSIG00000012522	SRSF5	100	95.956	Pelodiscus_sinensis
ENSG00000100650	SRSF5	100	79.231	ENSPMGG00000021646	srsf5b	86	81.250	Periophthalmus_magnuspinnatus
ENSG00000100650	SRSF5	100	100.000	ENSPEMG00000020173	Srsf5	100	97.794	Peromyscus_maniculatus_bairdii
ENSG00000100650	SRSF5	98	55.634	ENSPMAG00000007790	srsf5b	67	62.694	Petromyzon_marinus
ENSG00000100650	SRSF5	100	100.000	ENSPCIG00000011877	SRSF5	100	96.691	Phascolarctos_cinereus
ENSG00000100650	SRSF5	99	75.969	ENSPMEG00000012751	srsf5b	88	73.684	Poecilia_mexicana
ENSG00000100650	SRSF5	100	100.000	ENSPPYG00000005945	SRSF5	100	100.000	Pongo_abelii
ENSG00000100650	SRSF5	100	98.990	ENSPCAG00000004405	SRSF5	100	99.315	Procavia_capensis
ENSG00000100650	SRSF5	100	100.000	ENSPCOG00000014442	SRSF5	100	99.275	Propithecus_coquereli
ENSG00000100650	SRSF5	100	77.372	ENSPVAG00000009828	SRSF5	66	68.156	Pteropus_vampyrus
ENSG00000100650	SRSF5	99	76.744	ENSPNYG00000002669	srsf5b	96	74.615	Pundamilia_nyererei
ENSG00000100650	SRSF5	98	79.200	ENSPNAG00000011262	srsf5b	88	77.099	Pygocentrus_nattereri
ENSG00000100650	SRSF5	100	100.000	ENSRNOG00000005513	Srsf5	100	97.794	Rattus_norvegicus
ENSG00000100650	SRSF5	100	100.000	ENSRBIG00000013003	SRSF5	100	100.000	Rhinopithecus_bieti
ENSG00000100650	SRSF5	100	100.000	ENSRROG00000043407	SRSF5	100	100.000	Rhinopithecus_roxellana
ENSG00000100650	SRSF5	100	100.000	ENSSBOG00000030784	SRSF5	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000100650	SRSF5	100	100.000	ENSSHAG00000002871	SRSF5	100	96.691	Sarcophilus_harrisii
ENSG00000100650	SRSF5	98	70.213	ENSSMAG00000019728	srsf5b	61	79.695	Scophthalmus_maximus
ENSG00000100650	SRSF5	98	74.219	ENSSDUG00000005766	srsf5b	65	81.081	Seriola_dumerili
ENSG00000100650	SRSF5	98	74.219	ENSSLDG00000023255	srsf5b	88	73.684	Seriola_lalandi_dorsalis
ENSG00000100650	SRSF5	100	97.980	ENSSARG00000001059	SRSF5	66	86.034	Sorex_araneus
ENSG00000100650	SRSF5	100	100.000	ENSSPUG00000002464	SRSF5	100	93.197	Sphenodon_punctatus
ENSG00000100650	SRSF5	98	76.562	ENSSPAG00000015325	srsf5b	63	84.865	Stegastes_partitus
ENSG00000100650	SRSF5	100	100.000	ENSSSCG00000032583	SRSF5	100	97.810	Sus_scrofa
ENSG00000100650	SRSF5	100	97.980	ENSTGUG00000011425	SRSF5	67	94.972	Taeniopygia_guttata
ENSG00000100650	SRSF5	98	80.159	ENSTRUG00000017811	srsf5b	59	84.153	Takifugu_rubripes
ENSG00000100650	SRSF5	98	80.159	ENSTNIG00000016411	srsf5b	66	84.153	Tetraodon_nigroviridis
ENSG00000100650	SRSF5	100	100.000	ENSTBEG00000001972	SRSF5	100	96.377	Tupaia_belangeri
ENSG00000100650	SRSF5	99	100.000	ENSTTRG00000003318	SRSF5	100	97.818	Tursiops_truncatus
ENSG00000100650	SRSF5	100	100.000	ENSUAMG00000014184	SRSF5	100	98.540	Ursus_americanus
ENSG00000100650	SRSF5	100	100.000	ENSUMAG00000009827	SRSF5	100	98.175	Ursus_maritimus
ENSG00000100650	SRSF5	100	100.000	ENSVPAG00000006448	SRSF5	100	99.265	Vicugna_pacos
ENSG00000100650	SRSF5	100	100.000	ENSVVUG00000003790	SRSF5	100	98.540	Vulpes_vulpes
ENSG00000100650	SRSF5	99	87.129	ENSXETG00000002211	srsf5	67	92.308	Xenopus_tropicalis
ENSG00000100650	SRSF5	99	75.385	ENSXMAG00000026416	srsf5b	88	74.627	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0005515	protein binding	12762840.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006376	mRNA splice site selection	7556075.	TAS	Process
GO:0006397	mRNA processing	7556075.	TAS	Process
GO:0006405	RNA export from nucleus	-	TAS	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0016607	nuclear speck	21873635.	IBA	Component
GO:0016607	nuclear speck	-	ISS	Component
GO:0031124	mRNA 3'-end processing	-	TAS	Process
GO:0032869	cellular response to insulin stimulus	-	IEA	Process
GO:0033120	positive regulation of RNA splicing	-	IEA	Process
GO:0043422	protein kinase B binding	-	IEA	Function
GO:0045292	mRNA cis splicing, via spliceosome	21873635.	IBA	Process
GO:0051726	regulation of cell cycle	-	IEA	Process
GO:0097421	liver regeneration	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29857020	SRSF5 functions as a novel oncogenic splicing factor and is upregulated by oncogene SRSF3 in oral squamous cell carcinoma.	Biochim Biophys Acta Mol Cell Res	2018 Sep	Yang S	doi: 10.1016/j.bbamcr.2018.05.017
29942010	Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth.	Nat Commun	2018 Jun 25	Chen Y	doi: 10.1038/s41467-018-04815-3.
27565915	SRSF5: a novel marker for small-cell lung cancer and pleural metastatic cancer.	Lung Cancer	2016 Sep	Kim HR	doi: 10.1016/j.lungcan.2016.05.018

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr14	69768883	Nonsense_Mutation	NA	R95*	0.29
BLCA	chr14	69770410	Intron	novel		0.9
BLCA	chr14	69770481	Silent	rs768069967	F127F	0.83
BLCA	chr14	69768951	Intron	novel		0.14
BRCA	chr14	69771428	Silent	NA	R262R	0.05
BRCA	chr14	69769210	Missense_Mutation	NA	R109C	0.22
BRCA	chr14	69769457	Intron	novel		0.18
CESC	chr14	69771494	3'UTR	novel		0.3
CESC	chr14	69769235	Nonsense_Mutation	NA	S117*	0.28
CESC	chr14	69770434	Intron	novel		0.26
CESC	chr14	69768951	Intron	novel		0.48
CESC	chr14	69769283	Intron	novel		0.3
CESC	chr14	69769419	Intron	novel		0.33
CESC	chr14	69771256	Missense_Mutation	rs141668513	R205H	0.17
CESC	chr14	69769189	Missense_Mutation	rs746899808	P102S	0.28
CESC	chr14	69768194	Missense_Mutation	NA	P13R	0.29	RRM_1
CHOL	chr14	69771961	3'UTR	novel		0.09
COAD	chr14	69770379	Intron	novel		0.23
COAD	chr14	69771028	Missense_Mutation	NA	K158N	0.4
COAD	chr14	69771063	Missense_Mutation	novel	N170S	0.31
COAD	chr14	69769477	Intron	novel		0.43
COAD	chr14	69770510	Missense_Mutation	rs759069069	A137V	0.76
COAD	chr14	69770172	Intron	novel		0.22
COAD	chr14	69770393	Intron	novel		0.38
COAD	chr14	69770478	Missense_Mutation	novel	D126E	0.1
COAD	chr14	69770393	Intron	novel		0.08
COAD	chr14	69768222	Missense_Mutation	novel	R22S	0.04	RRM_1
COAD	chr14	69768902	Splice_Region	novel		0.15
COAD	chr14	69768904	Splice_Region	novel		0.07
COAD	chr14	69771052	Frame_Shift_Ins	novel	K167*	0.04
COAD	chr14	69771053	Frame_Shift_Ins	novel	*K167Nfs13**	0.03
COAD	chr14	69770393	Intron	novel		0.26
DLBC	chr14	69770367	Intron	novel		0.09
ESCA	chr14	69771463	3'UTR	novel		0.19
ESCA	chr14	69769095	Intron	novel		0.22
ESCA	chr14	69770393	Intron	novel		0.69
GBM	chr14	69768256	Missense_Mutation	NA	D34Y	0.25	RRM_1
GBM	chr14	69768268	Missense_Mutation	novel	G38C	0.28	RRM_1
GBM	chr14	69771400	Missense_Mutation	novel	S253Y	0.5
GBM	chr14	69771250	Missense_Mutation	rs763081161	R203Q	0.8
HNSC	chr14	69768831	Silent	novel	R77R	0.06
HNSC	chr14	69771424	Frame_Shift_Del	novel	*R262Dfs14**	0.18
HNSC	chr14	69771442	Missense_Mutation	novel	S267L	0.28
HNSC	chr14	69771038	Missense_Mutation	novel	E162K	0.22
HNSC	chr14	69768889	Missense_Mutation	novel	D97N	0.22
KIRC	chr14	69768935	Intron	novel		0.3
KIRC	chr14	69769420	Intron	novel		0.17
KIRC	chr14	69769422	Intron	novel		0.17
KIRP	chr14	69771450	Missense_Mutation	NA	S270G	0.15
KIRP	chr14	69769348	Intron	novel		0.62
LGG	chr14	69770510	Missense_Mutation	rs759069069	A137V	0.34
LGG	chr14	69771268	Missense_Mutation	rs780489147	R209H	0.35
LIHC	chr14	69771388	Frame_Shift_Ins	novel	*D255Gfs27**	0.39
LIHC	chr14	69771062	Missense_Mutation	NA	N170Y	0.5
LIHC	chr14	69771506	3'UTR	novel		0.14
LUAD	chr14	69771402	Missense_Mutation	NA	V254L	0.18
LUAD	chr14	69770389	Intron	novel		0.17
LUAD	chr14	69771256	Missense_Mutation	novel	R205L	0.25
LUSC	chr14	69769117	Intron	novel		0.22
OV	chr14	69770154	Intron	novel		0.67
OV	chr14	69768641	Missense_Mutation	novel	Y55C	0.03	RRM_1
OV	chr14	69769184	Missense_Mutation	novel	N100S	0.09
OV	chr14	69771010	Silent	rs777202427	A152A	0.26
READ	chr14	69768884	Missense_Mutation	NA	R95Q	0.24
READ	chr14	69769226	Missense_Mutation	novel	N114T	0.29
READ	chr14	69768658	Nonsense_Mutation	NA	E61*	0.4	RRM_1
READ	chr14	69768884	Missense_Mutation	NA	R95Q	0.24
READ	chr14	69769296	Intron	novel		0.21
SKCM	chr14	69771418	Missense_Mutation	NA	S259F	0.27
SKCM	chr14	69768883	Nonsense_Mutation	NA	R95*	0.3
SKCM	chr14	69771520	3'UTR	novel		0.44
SKCM	chr14	69771345	Missense_Mutation	rs142745234	V235M	0.31
SKCM	chr14	69771311	Silent	NA	S223S	0.31
SKCM	chr14	69768194	Missense_Mutation	NA	P13L	0.14	RRM_1
STAD	chr14	69768649	Missense_Mutation	novel	D58H	0.38	RRM_1
STAD	chr14	69771488	3'UTR	NA		0.25
STAD	chr14	69768875	Missense_Mutation	rs149440957	R92H	0.18
STAD	chr14	69769289	Intron	rs753340789		0.43
STAD	chr14	69768884	Missense_Mutation	NA	R95Q	0.35
STAD	chr14	69769211	Missense_Mutation	NA	R109H	0.28
STAD	chr14	69768951	Intron	novel		0.19
STAD	chr14	69768953	Intron	novel		0.18
STAD	chr14	69771488	3'UTR	NA		0.52
STAD	chr14	69770393	Intron	novel		0.29
STAD	chr14	69771511	3'UTR	novel		0.29
STAD	chr14	69771256	Missense_Mutation	rs141668513	R205H	0.12
STAD	chr14	69771488	3'UTR	NA		0.14
STAD	chr14	69768635	Missense_Mutation	NA	A53G	0.03	RRM_1
STAD	chr14	69770515	Missense_Mutation	NA	A139T	0.21
THCA	chr14	69771001	Silent	NA	V149V	0.24
UCEC	chr14	69768884	Missense_Mutation	NA	R95Q	0.32
UCEC	chr14	69768658	Nonsense_Mutation	NA	E61*	0.29	RRM_1
UCEC	chr14	69771494	3'UTR	rs771837923		0.39
UCEC	chr14	69768875	Missense_Mutation	rs149440957	R92H	0.36
UCEC	chr14	69771715	3'UTR	novel		0.39
UCEC	chr14	69768884	Missense_Mutation	NA	R95Q	0.33
UCEC	chr14	69770505	Silent	NA	T135T	0.37
UCEC	chr14	69771245	Silent	novel	R201R	0.29
UCEC	chr14	69771973	3'UTR	novel		0.33
UCEC	chr14	69771514	3'UTR	novel		0.34
UCEC	chr14	69770309	Intron	novel		0.32
UCEC	chr14	69771268	Missense_Mutation	rs780489147	R209H	0.38
UCEC	chr14	69768884	Missense_Mutation	NA	R95Q	0.19
UCEC	chr14	69771072	Missense_Mutation	novel	K173T	0.43
UCEC	chr14	69769238	Missense_Mutation	novel	R118I	0.13
UCEC	chr14	69769224	Missense_Mutation	novel	E113D	0.48
UCEC	chr14	69771367	Missense_Mutation	rs774183630	R242H	0.13
UCEC	chr14	69770393	Intron	novel		0.26
UCEC	chr14	69771970	3'UTR	novel		0.32
UCEC	chr14	69770522	Missense_Mutation	novel	R141Q	0.24
UCEC	chr14	69771856	3'UTR	novel		0.43
UCEC	chr14	69771945	3'UTR	novel		0.44
UCEC	chr14	69771062	Missense_Mutation	novel	N170H	0.07
UCEC	chr14	69770508	Missense_Mutation	novel	F136L	0.81
UCEC	chr14	69770393	Intron	novel		0.23
UCEC	chr14	69771992	3'Flank	rs759941437		0.11
UCEC	chr14	69770308	Intron	novel		0.42
UCEC	chr14	69771768	3'UTR	novel		0.19
UCEC	chr14	69768658	Nonsense_Mutation	NA	E61*	0.36	RRM_1
UCEC	chr14	69770505	Silent	NA	T135T	0.41
UCEC	chr14	69769105	Intron	rs748923565		0.27
UCEC	chr14	69769054	Intron	novel		0.2
UCEC	chr14	69769207	Missense_Mutation	novel	N108D	0.18
UCEC	chr14	69771747	3'UTR	novel		0.21
UCEC	chr14	69771244	Missense_Mutation	NA	R201H	0.36
UCEC	chr14	69769071	Intron	novel		0.2
UCEC	chr14	69768863	Missense_Mutation	novel	R88H	0.32
UCEC	chr14	69771268	Missense_Mutation	novel	R209L	0.04
UCEC	chr14	69771270	In_Frame_Ins	novel	K210delinsTQ	0.04
UCEC	chr14	69771478	3'UTR	novel		0.18
UCEC	chr14	69769166	Intron	rs752025363		0.29
UCEC	chr14	69771420	Missense_Mutation	rs188021188	R260W	0.43
UCEC	chr14	69770393	Intron	novel		0.64
UCEC	chr14	69768674	Missense_Mutation	NA	R66M	0.3	RRM_1
UCEC	chr14	69768883	Nonsense_Mutation	NA	R95*	0.25
UCEC	chr14	69771658	3'UTR	novel		0.13
UCEC	chr14	69770393	Intron	novel		0.35
UCEC	chr14	69771409	Missense_Mutation	rs758996473	R256H	0.9
UCS	chr14	69768670	Missense_Mutation	novel	E65K	0.4	RRM_1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1444	0.19769
BRCA	DEL	0.2713	6.1292e-10
CHOL	DEL	0.5556	0.00040262
COAD	DEL	0.2882	0.050084
GBM	DEL	0.2738	5.7274e-07
KIRC	DEL	0.3807	0.0074281
KIRP	DEL	0.1667	0.085174
LGG	DEL	0.2047	1.1681e-13
MESO	DEL	0.4023	0.088547
OV	DEL	0.4784	6.0694e-08
PAAD	DEL	0.0652	0.11332
READ	DEL	0.3636	0.189
SARC	DEL	0.2918	0.0013077

Survival Analysis

Cancer	P-value	Q-value
MESO	0.00042	Kaplan-Meier Survival Analysis
HNSC	0.019	Kaplan-Meier Survival Analysis
SKCM	0.005	Kaplan-Meier Survival Analysis
PRAD	0.0049	Kaplan-Meier Survival Analysis
BRCA	0.012	Kaplan-Meier Survival Analysis
PAAD	0.012	Kaplan-Meier Survival Analysis
BLCA	0.014	Kaplan-Meier Survival Analysis
CESC	0.001	Kaplan-Meier Survival Analysis
LGG	0.00068	Kaplan-Meier Survival Analysis
LUAD	0.05	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742