EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100764 (Gene tree)
Gene ID: 5700
Gene Symbol: PSMC1
Alias: S4|p56
Full Name: proteasome 26S subunit, ATPase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 18,935 bases
Position: chr14:90,256,495-90,275,429
Accession: 9547
RBP type: non-canonical RBP
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19587378	Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance.	Blood	2009 Oct 8	Blotta S	doi: 10.1182/blood-2009-04-219436

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000543772	PSMC1-202	1389	XM_017021470	ENSP00000445147	367 (aa)	XP_016876959	P62191
ENST00000261303	PSMC1-201	4448	-	ENSP00000261303	440 (aa)	-	P62191
ENST00000557357	PSMC1-207	581	-	-	- (aa)	-	-
ENST00000553835	PSMC1-203	390	-	ENSP00000452049	84 (aa)	-	G3V4X1
ENST00000554624	PSMC1-204	577	-	-	- (aa)	-	-
ENST00000555787	PSMC1-206	2246	-	-	- (aa)	-	-
ENST00000555679	PSMC1-205	606	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000100764's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03050	Proteasome	KEGG
hsa05165	Human papillomavirus infection	KEGG
hsa05169	Epstein-Barr virus infection	KEGG
hsa05203	Viral carcinogenesis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100764's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100764	PSMC1	99	90.361	WBGene00004502	rpt-2	94	85.337	Caenorhabditis_elegans
ENSG00000100764	PSMC1	98	54.878	WBGene00004503	rpt-3	89	52.162	Caenorhabditis_elegans
ENSG00000100764	PSMC1	95	62.500	WBGene00004501	rpt-1	78	47.198	Caenorhabditis_elegans
ENSG00000100764	PSMC1	99	65.060	ENSG00000087191	PSMC5	83	55.932	Homo_sapiens
ENSG00000100764	PSMC1	95	61.250	ENSG00000165916	PSMC3	90	45.119	Homo_sapiens
ENSG00000100764	PSMC1	95	60.000	ENSG00000161057	PSMC2	84	47.321	Homo_sapiens
ENSG00000100764	PSMC1	98	56.098	ENSG00000100519	PSMC6	99	46.970	Homo_sapiens
ENSG00000100764	PSMC1	99	84.337	YDL007W	RPT2	95	73.317	Saccharomyces_cerevisiae
ENSG00000100764	PSMC1	98	60.976	YDR394W	RPT3	87	49.330	Saccharomyces_cerevisiae
ENSG00000100764	PSMC1	99	62.651	YGL048C	RPT6	80	51.235	Saccharomyces_cerevisiae
ENSG00000100764	PSMC1	95	61.250	YKL145W	RPT1	58	53.532	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0000502	proteasome complex	17323924.	IDA	Component
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	-	TAS	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	9452483.16189514.16990800.19060904.19490896.22901813.23455924.25416956.26496610.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006457	protein folding	-	TAS	Process
GO:0006521	regulation of cellular amino acid metabolic process	-	TAS	Process
GO:0008540	proteasome regulatory particle, base subcomplex	21873635.	IBA	Component
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0016887	ATPase activity	1429620.	ISS	Function
GO:0017025	TBP-class protein binding	21873635.	IBA	Function
GO:0022624	proteasome accessory complex	-	ISS	Component
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	TAS	Process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	Process
GO:0036402	proteasome-activating ATPase activity	21873635.	IBA	Function
GO:0038061	NIK/NF-kappaB signaling	-	TAS	Process
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	Process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	TAS	Process
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	Process
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:1901215	negative regulation of neuron death	-	IEA	Process
GO:1901800	positive regulation of proteasomal protein catabolic process	-	IEA	Process
GO:1901990	regulation of mitotic cell cycle phase transition	-	TAS	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	-	TAS	Process