Protein ID | Domain | Pfam ID | E-value | Domain number | Total number |
---|---|---|---|---|---|
ENSP00000442803 | RIO1 | PF01163.22 | 2e-05 | 1 | 1 |
ENSP00000479667 | RIO1 | PF01163.22 | 2e-05 | 1 | 1 |
PID | Title | Article | Time | Author | Doi |
---|---|---|---|---|---|
12235136 |
Transcript ID | Name | Length | RefSeq ID | Protein ID | Length | RefSeq ID | UniportKB ID |
---|---|---|---|---|---|---|---|
ENST00000556178 | RPS6KA5-204 | 2118 | - | ENSP00000451305 | 79 (aa) | - | H0YJE1 |
ENST00000556304 | RPS6KA5-205 | 278 | - | - | - (aa) | - | - |
ENST00000418736 | RPS6KA5-201 | 2249 | - | ENSP00000402787 | 549 (aa) | - | O75582 |
ENST00000536315 | RPS6KA5-202 | 2993 | XM_017021786 | ENSP00000442803 | 723 (aa) | XP_016877275 | O75582 |
ENST00000556594 | RPS6KA5-206 | 596 | - | ENSP00000451736 | 83 (aa) | - | G3V4D7 |
ENST00000648062 | RPS6KA5-208 | 4065 | - | ENSP00000497354 | 207 (aa) | - | - |
ENST00000554206 | RPS6KA5-203 | 1420 | - | ENSP00000450591 | 219 (aa) | - | G3V2D1 |
ENST00000614987 | RPS6KA5-207 | 26795 | - | ENSP00000479667 | 802 (aa) | - | O75582 |
Pathway ID | Pathway Name | Source |
---|---|---|
hsa04010 | MAPK signaling pathway | KEGG |
hsa04261 | Adrenergic signaling in cardiomyocytes | KEGG |
hsa04668 | TNF signaling pathway | KEGG |
hsa04713 | Circadian entrainment | KEGG |
hsa04722 | Neurotrophin signaling pathway | KEGG |
hsa05200 | Pathways in cancer | KEGG |
hsa05206 | MicroRNAs in cancer | KEGG |
hsa05219 | Bladder cancer | KEGG |
ensgID | SNP | Chromosome | Position | SNP-risk | Trait | PubmedID | 95% CI | Or or BEAT | EFO ID |
---|---|---|---|---|---|---|---|---|---|
ENSG00000100784 | rs1286063 | 14 | 90986497 | T | Femoral neck bone mineral density | 29499414 | [0.03-0.064] unit decrease | 0.0468 | EFO_0007785 |
ENSG00000100784 | rs1286063 | 14 | 90986497 | T | Lumbar spine bone mineral density | 29499414 | [0.047-0.085] unit decrease | 0.066 | EFO_0007701 |
ENSG00000100784 | rs1286083 | 14 | 90976435 | T | Bone mineral density | 22504420 | [NR] unit decrease | 0.05 | EFO_0003923 |
ENSG00000100784 | rs75055810 | 14 | 90863042 | T | Total body bone mineral density | 29304378 | unit decrease | 0.0377 | EFO_0003923 |
ENSG00000100784 | rs1286150 | 14 | 90998546 | T | Total body bone mineral density | 29304378 | unit decrease | 0.0549 | EFO_0003923 |
ENSG00000100784 | rs1286079 | 14 | 90978818 | T | Total body bone mineral density | 29304378 | unit increase | 0.0552 | EFO_0003923 |
ENSG00000100784 | rs1286083 | 14 | 90976435 | T | Fractures | 30158200 | [1.04-1.07] | 1.05 | EFO_0003931 |
ENSG00000100784 | rs1286075 | 14 | 90980452 | ? | Heel bone mineral density | 30048462 | [0.027-0.038] unit decrease | 0.0326471 | EFO_0009270 |
ENSG00000100784 | rs765754428 | 14 | 90983810 | ? | Heel bone mineral density | 30048462 | [0.033-0.047] unit decrease | 0.0402437 | EFO_0009270 |
ENSG00000100784 | rs1286075 | 14 | 90980452 | C | Heel bone mineral density | 30598549 | [0.026-0.036] unit decrease | 0.0310889 | EFO_0009270 |
ENSG00000100784 | rs1285997 | 14 | 91046685 | ? | Body mass index | 30595370 | EFO_0004340 | ||
ENSG00000100784 | rs1286127 | 14 | 90923997 | T | Alcohol consumption (drinks per week) (MTAG) | 30643251 | [0.0052-0.0104] unit decrease | 0.00776001 | EFO_0007878 |
ENSG00000100784 | rs1286075 | 14 | 90980452 | ? | Heel bone mineral density | 30595370 | EFO_0009270 |
Ensembl ID | Gene Symbol | Coverage | Identiy | Ortholog | Gene Symbol | Coverage | Identiy | Species |
---|---|---|---|---|---|---|---|---|
ENSG00000100784 | RPS6KA5 | 99 | 99.583 | ENSANAG00000024304 | RPS6KA5 | 100 | 99.250 | Aotus_nancymaae |
ENSG00000100784 | RPS6KA5 | 97 | 93.266 | ENSTSYG00000013264 | RPS6KA5 | 100 | 93.266 | Carlito_syrichta |
ENSG00000100784 | RPS6KA5 | 99 | 99.583 | ENSCCAG00000028076 | RPS6KA5 | 100 | 99.125 | Cebus_capucinus |
ENSG00000100784 | RPS6KA5 | 100 | 99.862 | ENSCATG00000038443 | RPS6KA5 | 100 | 99.862 | Cercocebus_atys |
ENSG00000100784 | RPS6KA5 | 100 | 99.862 | ENSCSAG00000011413 | RPS6KA5 | 99 | 99.352 | Chlorocebus_sabaeus |
ENSG00000100784 | RPS6KA5 | 91 | 98.611 | ENSCHOG00000010636 | RPS6KA5 | 78 | 98.795 | Choloepus_hoffmanni |
ENSG00000100784 | RPS6KA5 | 99 | 92.308 | ENSCPBG00000008594 | RPS6KA5 | 100 | 91.944 | Chrysemys_picta_bellii |
ENSG00000100784 | RPS6KA5 | 99 | 94.872 | ENSCGRG00000003352 | Rps6ka5 | 89 | 99.027 | Cricetulus_griseus_crigri |
ENSG00000100784 | RPS6KA5 | 64 | 74.615 | ENSEBUG00000016059 | - | 85 | 74.903 | Eptatretus_burgeri |
ENSG00000100784 | RPS6KA5 | 98 | 83.259 | ENSEEUG00000001209 | RPS6KA5 | 100 | 83.259 | Erinaceus_europaeus |
ENSG00000100784 | RPS6KA5 | 99 | 92.308 | ENSFALG00000012181 | RPS6KA5 | 100 | 91.123 | Ficedula_albicollis |
ENSG00000100784 | RPS6KA5 | 99 | 92.308 | ENSGALG00000030580 | RPS6KA5 | 98 | 91.484 | Gallus_gallus |
ENSG00000100784 | RPS6KA5 | 99 | 91.528 | ENSGAGG00000017243 | RPS6KA5 | 99 | 90.667 | Gopherus_agassizii |
ENSG00000100784 | RPS6KA5 | 100 | 100.000 | ENSGGOG00000004254 | RPS6KA5 | 100 | 100.000 | Gorilla_gorilla |
ENSG00000100784 | RPS6KA5 | 99 | 97.922 | ENSJJAG00000013380 | Rps6ka5 | 99 | 96.875 | Jaculus_jaculus |
ENSG00000100784 | RPS6KA5 | 99 | 89.744 | ENSLACG00000011467 | RPS6KA5 | 100 | 86.571 | Latimeria_chalumnae |
ENSG00000100784 | RPS6KA5 | 97 | 94.920 | ENSLAFG00000000120 | RPS6KA5 | 100 | 94.920 | Loxodonta_africana |
ENSG00000100784 | RPS6KA5 | 100 | 99.862 | ENSMFAG00000041703 | RPS6KA5 | 100 | 99.862 | Macaca_fascicularis |
ENSG00000100784 | RPS6KA5 | 100 | 99.862 | ENSMNEG00000038026 | RPS6KA5 | 100 | 99.862 | Macaca_nemestrina |
ENSG00000100784 | RPS6KA5 | 100 | 99.585 | ENSMLEG00000044092 | RPS6KA5 | 100 | 99.609 | Mandrillus_leucophaeus |
ENSG00000100784 | RPS6KA5 | 99 | 92.308 | ENSMGAG00000013061 | RPS6KA5 | 100 | 91.406 | Meleagris_gallopavo |
ENSG00000100784 | RPS6KA5 | 99 | 98.056 | ENSMAUG00000014082 | Rps6ka5 | 100 | 97.372 | Mesocricetus_auratus |
ENSG00000100784 | RPS6KA5 | 99 | 99.167 | ENSMICG00000005008 | RPS6KA5 | 99 | 96.352 | Microcebus_murinus |
ENSG00000100784 | RPS6KA5 | 99 | 96.250 | ENSMODG00000002626 | RPS6KA5 | 98 | 96.159 | Monodelphis_domestica |
ENSG00000100784 | RPS6KA5 | 98 | 97.595 | ENSMLUG00000005590 | RPS6KA5 | 98 | 97.606 | Myotis_lucifugus |
ENSG00000100784 | RPS6KA5 | 100 | 100.000 | ENSNLEG00000017068 | RPS6KA5 | 100 | 100.000 | Nomascus_leucogenys |
ENSG00000100784 | RPS6KA5 | 99 | 91.026 | ENSMEUG00000003826 | - | 97 | 71.225 | Notamacropus_eugenii |
ENSG00000100784 | RPS6KA5 | 99 | 95.659 | ENSOANG00000015363 | RPS6KA5 | 99 | 95.659 | Ornithorhynchus_anatinus |
ENSG00000100784 | RPS6KA5 | 100 | 96.135 | ENSOCUG00000008913 | RPS6KA5 | 98 | 96.807 | Oryctolagus_cuniculus |
ENSG00000100784 | RPS6KA5 | 99 | 96.399 | ENSOGAG00000013852 | RPS6KA5 | 100 | 94.868 | Otolemur_garnettii |
ENSG00000100784 | RPS6KA5 | 100 | 100.000 | ENSPPAG00000038077 | RPS6KA5 | 100 | 100.000 | Pan_paniscus |
ENSG00000100784 | RPS6KA5 | 100 | 100.000 | ENSPTRG00000006631 | RPS6KA5 | 100 | 100.000 | Pan_troglodytes |
ENSG00000100784 | RPS6KA5 | 93 | 77.223 | ENSPMAG00000006686 | rps6ka5 | 94 | 77.419 | Petromyzon_marinus |
ENSG00000100784 | RPS6KA5 | 99 | 96.667 | ENSPCIG00000021180 | RPS6KA5 | 97 | 96.667 | Phascolarctos_cinereus |
ENSG00000100784 | RPS6KA5 | 100 | 99.626 | ENSPPYG00000006063 | RPS6KA5 | 90 | 99.626 | Pongo_abelii |
ENSG00000100784 | RPS6KA5 | 99 | 97.087 | ENSRNOG00000004362 | Rps6ka5 | 100 | 96.621 | Rattus_norvegicus |
ENSG00000100784 | RPS6KA5 | 99 | 99.851 | ENSRBIG00000041964 | RPS6KA5 | 100 | 99.851 | Rhinopithecus_bieti |
ENSG00000100784 | RPS6KA5 | 99 | 99.851 | ENSRROG00000032635 | RPS6KA5 | 100 | 99.851 | Rhinopithecus_roxellana |
ENSG00000100784 | RPS6KA5 | 99 | 99.861 | ENSSBOG00000021798 | RPS6KA5 | 100 | 99.500 | Saimiri_boliviensis_boliviensis |
ENSG00000100784 | RPS6KA5 | 99 | 96.250 | ENSSHAG00000013938 | RPS6KA5 | 97 | 95.903 | Sarcophilus_harrisii |
ENSG00000100784 | RPS6KA5 | 99 | 91.389 | ENSSPUG00000006255 | RPS6KA5 | 100 | 91.389 | Sphenodon_punctatus |
ENSG00000100784 | RPS6KA5 | 99 | 92.308 | ENSTGUG00000012514 | - | 99 | 90.269 | Taeniopygia_guttata |
Go ID | Go_term | PubmedID | Evidence | Category |
---|---|---|---|---|
GO:0000287 | magnesium ion binding | - | IEA | Function |
GO:0001818 | negative regulation of cytokine production | 18508628. | TAS | Process |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | - | TAS | Process |
GO:0004672 | protein kinase activity | 9873047. | IDA | Function |
GO:0004674 | protein serine/threonine kinase activity | 21873635. | IBA | Function |
GO:0004674 | protein serine/threonine kinase activity | 9687510. | IDA | Function |
GO:0004674 | protein serine/threonine kinase activity | 12773393. | IMP | Function |
GO:0004674 | protein serine/threonine kinase activity | - | TAS | Function |
GO:0005515 | protein binding | 12628924.21988832.25241761.25535969. | IPI | Function |
GO:0005524 | ATP binding | 9687510. | IDA | Function |
GO:0005634 | nucleus | 21873635. | IBA | Component |
GO:0005634 | nucleus | 9687510.18511904. | IDA | Component |
GO:0005634 | nucleus | 12628924. | IMP | Component |
GO:0005654 | nucleoplasm | - | IDA | Component |
GO:0005654 | nucleoplasm | - | TAS | Component |
GO:0005737 | cytoplasm | 21873635. | IBA | Component |
GO:0005737 | cytoplasm | 18511904. | IDA | Component |
GO:0006355 | regulation of transcription, DNA-templated | 9687510. | IDA | Process |
GO:0006355 | regulation of transcription, DNA-templated | 12763138. | IMP | Process |
GO:0006468 | protein phosphorylation | 21873635. | IBA | Process |
GO:0006468 | protein phosphorylation | 9687510. | IDA | Process |
GO:0006954 | inflammatory response | - | IEA | Process |
GO:0007173 | epidermal growth factor receptor signaling pathway | 9873047. | TAS | Process |
GO:0007411 | axon guidance | - | TAS | Process |
GO:0016572 | histone phosphorylation | 9873047. | IDA | Process |
GO:0016572 | histone phosphorylation | 20018936. | TAS | Process |
GO:0032793 | positive regulation of CREB transcription factor activity | 18508628. | TAS | Process |
GO:0033129 | positive regulation of histone phosphorylation | 20018936. | IMP | Process |
GO:0035066 | positive regulation of histone acetylation | 20018936. | IMP | Process |
GO:0035556 | intracellular signal transduction | 21873635. | IBA | Process |
GO:0035556 | intracellular signal transduction | 9687510. | IDA | Process |
GO:0043987 | histone H3-S10 phosphorylation | 12773393. | IMP | Process |
GO:0043988 | histone H3-S28 phosphorylation | 12773393. | IMP | Process |
GO:0043990 | histone H2A-S1 phosphorylation | 15010469. | IDA | Process |
GO:0045892 | negative regulation of transcription, DNA-templated | 15010469. | IDA | Process |
GO:0045944 | positive regulation of transcription by RNA polymerase II | 20018936. | IMP | Process |
GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 12628924.18511904. | IMP | Process |
GO:0070498 | interleukin-1-mediated signaling pathway | 20018936. | IMP | Process |
Cancer | Chr | Position | Mutation Type | dbSNP | Protein-change | Allele Freq | RBD |
---|---|---|---|---|---|---|---|
BLCA | |||||||
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CESC | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
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CESC | |||||||
CESC | |||||||
CESC | |||||||
CHOL | |||||||
CHOL | |||||||
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COAD | |||||||
COAD | |||||||
COAD | |||||||
DLBC | |||||||
ESCA | |||||||
ESCA | |||||||
ESCA | |||||||
ESCA | |||||||
ESCA | |||||||
ESCA | |||||||
GBM | |||||||
GBM | |||||||
HNSC | |||||||
HNSC | |||||||
HNSC | |||||||
HNSC | |||||||
KICH | |||||||
KIRC | |||||||
KIRP | |||||||
KIRP | |||||||
LGG | |||||||
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LIHC | |||||||
LIHC | |||||||
LIHC | |||||||
LIHC | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
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LUAD | |||||||
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LUAD | |||||||
LUSC | |||||||
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LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
OV | |||||||
OV | |||||||
PAAD | |||||||
PAAD | |||||||
PCPG | |||||||
PRAD | |||||||
PRAD | |||||||
PRAD | |||||||
READ | |||||||
READ | |||||||
READ | |||||||
READ | |||||||
READ | |||||||
SKCM | |||||||
SKCM | |||||||
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SKCM | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
TGCT | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
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UCEC | |||||||
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UCEC | |||||||
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UCEC | |||||||
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UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCS |
Cancer | Type | Freq | Q-value |
---|---|---|---|
BRCA | |||
CESC | |||
CHOL | |||
COAD | |||
GBM | |||
HNSC | |||
KIRC | |||
KIRP | |||
LGG | |||
LUAD | |||
MESO | |||
PAAD | |||
READ | |||
SKCM |
Cancer | P-value | Q-value |
---|---|---|
KIRC | ||
STAD | ||
HNSC | ||
SKCM | ||
LUSC | ||
KIRP | ||
COAD | ||
CESC | ||
UCEC | ||
LGG | ||
LUAD |