EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100784 (Gene tree)
Gene ID: 9252
Gene Symbol: RPS6KA5
Alias: MSK1|RLPK
Full Name: ribosomal protein S6 kinase A5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 212,788 bases
Position: chr14:90,847,862-91,060,649
Accession: 10434
RBP type: canonical RBP
Summary: RPS6KA5 (Ribosomal Protein S6 Kinase A5) is a Protein Coding gene. Among its related pathways are Developmental Biology and Type I Interferon Signaling Pathways. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KA4.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000442803	RIO1	PF01163.22	2e-05	1	1
ENSP00000479667	RIO1	PF01163.22	2e-05	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12235136	Bi-functional, substrate mimicking RNA inhibits MSK1-mediated cAMP-response element-binding protein phosphorylation and reveals magnesium ion-dependent conformational changes of the kinase.	J Biol Chem	2002 Nov 29	Hamm J	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000556178	RPS6KA5-204	2118	-	ENSP00000451305	79 (aa)	-	H0YJE1
ENST00000556304	RPS6KA5-205	278	-	-	- (aa)	-	-
ENST00000418736	RPS6KA5-201	2249	-	ENSP00000402787	549 (aa)	-	O75582
ENST00000536315	RPS6KA5-202	2993	XM_017021786	ENSP00000442803	723 (aa)	XP_016877275	O75582
ENST00000556594	RPS6KA5-206	596	-	ENSP00000451736	83 (aa)	-	G3V4D7
ENST00000648062	RPS6KA5-208	4065	-	ENSP00000497354	207 (aa)	-	-
ENST00000554206	RPS6KA5-203	1420	-	ENSP00000450591	219 (aa)	-	G3V2D1
ENST00000614987	RPS6KA5-207	26795	-	ENSP00000479667	802 (aa)	-	O75582

Gene Model

Click here to download ENSG00000100784's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04010	MAPK signaling pathway	KEGG
hsa04261	Adrenergic signaling in cardiomyocytes	KEGG
hsa04668	TNF signaling pathway	KEGG
hsa04713	Circadian entrainment	KEGG
hsa04722	Neurotrophin signaling pathway	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05206	MicroRNAs in cancer	KEGG
hsa05219	Bladder cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100784	Body Height	7.8770000E-006	-
ENSG00000100784	Body Height	1.7110000E-005	-
ENSG00000100784	Body Height	7.8880000E-006	-
ENSG00000100784	Platelet Function Tests	3.7559700E-005	-
ENSG00000100784	Platelet Function Tests	2.0899000E-005	-
ENSG00000100784	Bone Density	2E-15	22504420

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100784	rs1286063	14	90986497	T	Femoral neck bone mineral density	29499414	[0.03-0.064] unit decrease	0.0468	EFO_0007785
ENSG00000100784	rs1286063	14	90986497	T	Lumbar spine bone mineral density	29499414	[0.047-0.085] unit decrease	0.066	EFO_0007701
ENSG00000100784	rs1286083	14	90976435	T	Bone mineral density	22504420	[NR] unit decrease	0.05	EFO_0003923
ENSG00000100784	rs75055810	14	90863042	T	Total body bone mineral density	29304378	unit decrease	0.0377	EFO_0003923
ENSG00000100784	rs1286150	14	90998546	T	Total body bone mineral density	29304378	unit decrease	0.0549	EFO_0003923
ENSG00000100784	rs1286079	14	90978818	T	Total body bone mineral density	29304378	unit increase	0.0552	EFO_0003923
ENSG00000100784	rs1286083	14	90976435	T	Fractures	30158200	[1.04-1.07]	1.05	EFO_0003931
ENSG00000100784	rs1286075	14	90980452	?	Heel bone mineral density	30048462	[0.027-0.038] unit decrease	0.0326471	EFO_0009270
ENSG00000100784	rs765754428	14	90983810	?	Heel bone mineral density	30048462	[0.033-0.047] unit decrease	0.0402437	EFO_0009270
ENSG00000100784	rs1286075	14	90980452	C	Heel bone mineral density	30598549	[0.026-0.036] unit decrease	0.0310889	EFO_0009270
ENSG00000100784	rs1285997	14	91046685	?	Body mass index	30595370			EFO_0004340
ENSG00000100784	rs1286127	14	90923997	T	Alcohol consumption (drinks per week) (MTAG)	30643251	[0.0052-0.0104] unit decrease	0.00776001	EFO_0007878
ENSG00000100784	rs1286075	14	90980452	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100784's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100784	RPS6KA5	99	99.583	ENSANAG00000024304	RPS6KA5	100	99.250	Aotus_nancymaae
ENSG00000100784	RPS6KA5	97	93.266	ENSTSYG00000013264	RPS6KA5	100	93.266	Carlito_syrichta
ENSG00000100784	RPS6KA5	99	99.583	ENSCCAG00000028076	RPS6KA5	100	99.125	Cebus_capucinus
ENSG00000100784	RPS6KA5	100	99.862	ENSCATG00000038443	RPS6KA5	100	99.862	Cercocebus_atys
ENSG00000100784	RPS6KA5	100	99.862	ENSCSAG00000011413	RPS6KA5	99	99.352	Chlorocebus_sabaeus
ENSG00000100784	RPS6KA5	91	98.611	ENSCHOG00000010636	RPS6KA5	78	98.795	Choloepus_hoffmanni
ENSG00000100784	RPS6KA5	99	92.308	ENSCPBG00000008594	RPS6KA5	100	91.944	Chrysemys_picta_bellii
ENSG00000100784	RPS6KA5	99	94.872	ENSCGRG00000003352	Rps6ka5	89	99.027	Cricetulus_griseus_crigri
ENSG00000100784	RPS6KA5	64	74.615	ENSEBUG00000016059	-	85	74.903	Eptatretus_burgeri
ENSG00000100784	RPS6KA5	98	83.259	ENSEEUG00000001209	RPS6KA5	100	83.259	Erinaceus_europaeus
ENSG00000100784	RPS6KA5	99	92.308	ENSFALG00000012181	RPS6KA5	100	91.123	Ficedula_albicollis
ENSG00000100784	RPS6KA5	99	92.308	ENSGALG00000030580	RPS6KA5	98	91.484	Gallus_gallus
ENSG00000100784	RPS6KA5	99	91.528	ENSGAGG00000017243	RPS6KA5	99	90.667	Gopherus_agassizii
ENSG00000100784	RPS6KA5	100	100.000	ENSGGOG00000004254	RPS6KA5	100	100.000	Gorilla_gorilla
ENSG00000100784	RPS6KA5	99	97.922	ENSJJAG00000013380	Rps6ka5	99	96.875	Jaculus_jaculus
ENSG00000100784	RPS6KA5	99	89.744	ENSLACG00000011467	RPS6KA5	100	86.571	Latimeria_chalumnae
ENSG00000100784	RPS6KA5	97	94.920	ENSLAFG00000000120	RPS6KA5	100	94.920	Loxodonta_africana
ENSG00000100784	RPS6KA5	100	99.862	ENSMFAG00000041703	RPS6KA5	100	99.862	Macaca_fascicularis
ENSG00000100784	RPS6KA5	100	99.862	ENSMNEG00000038026	RPS6KA5	100	99.862	Macaca_nemestrina
ENSG00000100784	RPS6KA5	100	99.585	ENSMLEG00000044092	RPS6KA5	100	99.609	Mandrillus_leucophaeus
ENSG00000100784	RPS6KA5	99	92.308	ENSMGAG00000013061	RPS6KA5	100	91.406	Meleagris_gallopavo
ENSG00000100784	RPS6KA5	99	98.056	ENSMAUG00000014082	Rps6ka5	100	97.372	Mesocricetus_auratus
ENSG00000100784	RPS6KA5	99	99.167	ENSMICG00000005008	RPS6KA5	99	96.352	Microcebus_murinus
ENSG00000100784	RPS6KA5	99	96.250	ENSMODG00000002626	RPS6KA5	98	96.159	Monodelphis_domestica
ENSG00000100784	RPS6KA5	98	97.595	ENSMLUG00000005590	RPS6KA5	98	97.606	Myotis_lucifugus
ENSG00000100784	RPS6KA5	100	100.000	ENSNLEG00000017068	RPS6KA5	100	100.000	Nomascus_leucogenys
ENSG00000100784	RPS6KA5	99	91.026	ENSMEUG00000003826	-	97	71.225	Notamacropus_eugenii
ENSG00000100784	RPS6KA5	99	95.659	ENSOANG00000015363	RPS6KA5	99	95.659	Ornithorhynchus_anatinus
ENSG00000100784	RPS6KA5	100	96.135	ENSOCUG00000008913	RPS6KA5	98	96.807	Oryctolagus_cuniculus
ENSG00000100784	RPS6KA5	99	96.399	ENSOGAG00000013852	RPS6KA5	100	94.868	Otolemur_garnettii
ENSG00000100784	RPS6KA5	100	100.000	ENSPPAG00000038077	RPS6KA5	100	100.000	Pan_paniscus
ENSG00000100784	RPS6KA5	100	100.000	ENSPTRG00000006631	RPS6KA5	100	100.000	Pan_troglodytes
ENSG00000100784	RPS6KA5	93	77.223	ENSPMAG00000006686	rps6ka5	94	77.419	Petromyzon_marinus
ENSG00000100784	RPS6KA5	99	96.667	ENSPCIG00000021180	RPS6KA5	97	96.667	Phascolarctos_cinereus
ENSG00000100784	RPS6KA5	100	99.626	ENSPPYG00000006063	RPS6KA5	90	99.626	Pongo_abelii
ENSG00000100784	RPS6KA5	99	97.087	ENSRNOG00000004362	Rps6ka5	100	96.621	Rattus_norvegicus
ENSG00000100784	RPS6KA5	99	99.851	ENSRBIG00000041964	RPS6KA5	100	99.851	Rhinopithecus_bieti
ENSG00000100784	RPS6KA5	99	99.851	ENSRROG00000032635	RPS6KA5	100	99.851	Rhinopithecus_roxellana
ENSG00000100784	RPS6KA5	99	99.861	ENSSBOG00000021798	RPS6KA5	100	99.500	Saimiri_boliviensis_boliviensis
ENSG00000100784	RPS6KA5	99	96.250	ENSSHAG00000013938	RPS6KA5	97	95.903	Sarcophilus_harrisii
ENSG00000100784	RPS6KA5	99	91.389	ENSSPUG00000006255	RPS6KA5	100	91.389	Sphenodon_punctatus
ENSG00000100784	RPS6KA5	99	92.308	ENSTGUG00000012514	-	99	90.269	Taeniopygia_guttata

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	-	IEA	Function
GO:0001818	negative regulation of cytokine production	18508628.	TAS	Process
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0004672	protein kinase activity	9873047.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	9687510.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	12773393.	IMP	Function
GO:0004674	protein serine/threonine kinase activity	-	TAS	Function
GO:0005515	protein binding	12628924.21988832.25241761.25535969.	IPI	Function
GO:0005524	ATP binding	9687510.	IDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	9687510.18511904.	IDA	Component
GO:0005634	nucleus	12628924.	IMP	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	18511904.	IDA	Component
GO:0006355	regulation of transcription, DNA-templated	9687510.	IDA	Process
GO:0006355	regulation of transcription, DNA-templated	12763138.	IMP	Process
GO:0006468	protein phosphorylation	21873635.	IBA	Process
GO:0006468	protein phosphorylation	9687510.	IDA	Process
GO:0006954	inflammatory response	-	IEA	Process
GO:0007173	epidermal growth factor receptor signaling pathway	9873047.	TAS	Process
GO:0007411	axon guidance	-	TAS	Process
GO:0016572	histone phosphorylation	9873047.	IDA	Process
GO:0016572	histone phosphorylation	20018936.	TAS	Process
GO:0032793	positive regulation of CREB transcription factor activity	18508628.	TAS	Process
GO:0033129	positive regulation of histone phosphorylation	20018936.	IMP	Process
GO:0035066	positive regulation of histone acetylation	20018936.	IMP	Process
GO:0035556	intracellular signal transduction	21873635.	IBA	Process
GO:0035556	intracellular signal transduction	9687510.	IDA	Process
GO:0043987	histone H3-S10 phosphorylation	12773393.	IMP	Process
GO:0043988	histone H3-S28 phosphorylation	12773393.	IMP	Process
GO:0043990	histone H2A-S1 phosphorylation	15010469.	IDA	Process
GO:0045892	negative regulation of transcription, DNA-templated	15010469.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	20018936.	IMP	Process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	12628924.18511904.	IMP	Process
GO:0070498	interleukin-1-mediated signaling pathway	20018936.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28314603	Overexpression of MSK1 is associated with tumor aggressiveness and poor prognosis in colorectal cancer.	Dig Liver Dis	2017 Jun	Fu X	doi: 10.1016/j.dld.2017.02.009
29327245	High nuclear MSK1 is associated with longer survival in breast cancer patients.	J Cancer Res Clin Oncol	2018 Mar	Pu X	doi: 10.1007/s00432-018-2579-7
23604116	Activation of mitogen- and stress-activated kinase 1 is required for proliferation of breast cancer cells in response to estrogens or progestins.	Oncogene	2014 Mar 20	Reyes D	doi: 10.1038/onc.2013.95
20198339	Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway.	Int J Oncol	2010 Apr	Lee HY	-
20406806	MiR-148a attenuates paclitaxel resistance of hormone-refractory, drug-resistant prostate cancer PC3 cells by regulating MSK1 expression.	J Biol Chem	2010 Jun 18	Fujita Y	doi: 10.1074/jbc.M109.079525
27588146	p38-MAPK/MSK1-mediated overexpression of histone H3 serine 10 phosphorylation defines distance-dependent prognostic value of negative resection margin in gastric cancer.	Clin Epigenetics	2016 Aug 31	Khan SA	doi: 10.1186/s13148-016-0255-9
29358704	MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer.	Nat Cell Biol	2018 Feb	Gawrzak S	doi: 10.1038/s41556-017-0021-z

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr14	90875318	Nonsense_Mutation	rs747371219	R627*	0.18
BLCA	chr14	90900729	Missense_Mutation	NA	S376C	0.38
BLCA	chr14	90899346	Missense_Mutation	NA	E486K	0.43	RIO1
BLCA	chr14	91060399	Silent	novel	A12A	0.56
BLCA	chr14	90900127	Missense_Mutation	novel	V454I	0.36
BLCA	chr14	90872178	Missense_Mutation	rs748176348	H769Y	0.14
BLCA	chr14	90890532	Silent	rs139792854	N597N	0.21
BLCA	chr14	90906190	Missense_Mutation	NA	P306S	0.15
BLCA	chr14	90872092	Missense_Mutation	novel	F797L	0.41
BLCA	chr14	90900226	Missense_Mutation	NA	Q421E	0.48
BLCA	chr14	90900732	Missense_Mutation	novel	Y375F	0.52
BRCA	chr14	90906218	Missense_Mutation	NA	K296N	0.34
BRCA	chr14	90894415	Missense_Mutation	novel	E548K	0.18	RIO1
BRCA	chr14	90871891	3'UTR	novel		0.75
BRCA	chr14	90890605	Missense_Mutation	novel	P573L	0.1
BRCA	chr14	90894482	Missense_Mutation	NA	M525I	0.2	RIO1
BRCA	chr14	90906221	Missense_Mutation	novel	M295I	0.21
BRCA	chr14	90900165	Missense_Mutation	rs369503281	R441Q	0.3
BRCA	chr14	90894358	Intron	novel		0.38
BRCA	chr14	90872025	3'UTR	novel		0.33
BRCA	chr14	90872180	Missense_Mutation	novel	S768C	0.13
BRCA	chr14	90875299	Missense_Mutation	NA	S633N	0.26
BRCA	chr14	90871839	3'UTR	novel		0.27
CESC	chr14	90978435	Missense_Mutation	novel	V89I	0.41
CESC	chr14	90873761	Missense_Mutation	NA	K677N	0.44
CESC	chr14	90873662	Silent	novel	A710A	0.07
CESC	chr14	90947506	Missense_Mutation	NA	E147Q	0.47
CESC	chr14	90923186	Missense_Mutation	novel	A210V	0.38
CESC	chr14	90900145	Frame_Shift_Del	NA	*S448Vfs9**	0.32
CESC	chr14	90890602	Missense_Mutation	novel	P574Q	0.08
CESC	chr14	90947475	Missense_Mutation	novel	Y157S	0.45
CHOL	chr14	90873674	Silent	novel	S706S	0.13
CHOL	chr14	91060442	5'UTR	novel		0.14
COAD	chr14	90872286	Nonsense_Mutation	NA	Q733*	0.32
COAD	chr14	90947449	Missense_Mutation	NA	E166K	0.22
COAD	chr14	90902945	Missense_Mutation	rs376247617	A328T	0.3
COAD	chr14	91001159	Missense_Mutation	novel	A35D	0.07
COAD	chr14	90890496	Silent	rs765131434	G609G	0.16
COAD	chr14	90894343	Intron	novel		0.44
COAD	chr14	90872014	3'UTR	novel		0.33
COAD	chr14	90906232	Missense_Mutation	novel	R292S	0.12
COAD	chr14	90899391	Missense_Mutation	NA	A471T	0.34	RIO1
COAD	chr14	90900182	Silent	novel	G435G	0.13
COAD	chr14	90900211	Missense_Mutation	NA	D426Y	0.13
COAD	chr14	90947464	Missense_Mutation	novel	I161V	0.11
COAD	chr14	90875317	Missense_Mutation	rs373786141	R627Q	0.41
COAD	chr14	90947449	Missense_Mutation	NA	E166K	0.17
COAD	chr14	90978500	Missense_Mutation	rs756086272	R67H	0.05
COAD	chr14	90873662	Silent	rs562360365	A710A	0.17
DLBC	chr14	90900667	Missense_Mutation	novel	H397Y	0.31
ESCA	chr14	90900145	Frame_Shift_Del	NA	*S448Vfs9**	0.64
ESCA	chr14	90873661	Missense_Mutation	rs780918760	V711M	0.5
ESCA	chr14	90871977	3'UTR	novel		0.29
ESCA	chr14	90875324	Missense_Mutation	novel	H625D	0.35
ESCA	chr14	90894258	Intron	novel		0.33
ESCA	chr14	90894489	Missense_Mutation	novel	Y523C	0.24	RIO1
GBM	chr14	90920254	Missense_Mutation	novel	S253Y	0.27
GBM	chr14	90906232	Missense_Mutation	rs534048620	R292C	0.18
HNSC	chr14	90923193	Missense_Mutation	novel	E208Q	0.14
HNSC	chr14	90872082	Missense_Mutation	novel	V801I	0.3
HNSC	chr14	90894442	Missense_Mutation	novel	G539R	0.17	RIO1
HNSC	chr14	90900165	Frame_Shift_Del	novel	*R441Qfs16**	0.06
KICH	chr14	90900179	Missense_Mutation	novel	S436R	0.2
KIRC	chr14	90923204	Intron	novel		0.07
KIRP	chr14	90900667	In_Frame_Del	novel	P393_F396del	0.06
KIRP	chr14	90923138	Missense_Mutation	novel	R226K	0.31
LGG	chr14	90872118	Missense_Mutation	novel	N789D	0.21
LGG	chr14	90920235	Silent	novel	G259G	0.08
LIHC	chr14	90873781	Missense_Mutation	novel	D671Y	0.25
LIHC	chr14	90872223	Nonsense_Mutation	novel	E754*	0.9
LIHC	chr14	90872231	Missense_Mutation	NA	T751S	0.5
LIHC	chr14	90872231	Missense_Mutation	NA	T751S	0.12
LUAD	chr14	90894560	Silent	novel	E499E	0.08
LUAD	chr14	90890636	Missense_Mutation	novel	I563V	0.46	RIO1
LUAD	chr14	90890630	Missense_Mutation	novel	D565N	0.09	RIO1
LUAD	chr14	90871957	3'UTR	novel		0.29
LUAD	chr14	90923186	Missense_Mutation	novel	A210V	0.08
LUAD	chr14	90872234	Missense_Mutation	NA	S750I	0.18
LUAD	chr14	90920279	Missense_Mutation	novel	M245L	0.19
LUAD	chr14	90923138	Missense_Mutation	novel	R226T	0.05
LUAD	chr14	90890552	Missense_Mutation	novel	P591S	0.15
LUAD	chr14	90900145	Frame_Shift_Del	NA	*S448Vfs9**	0.24
LUAD	chr14	91001125	Missense_Mutation	novel	I46M	0.16
LUSC	chr14	90875252	Nonsense_Mutation	novel	E649*	0.47
LUSC	chr14	90902898	Missense_Mutation	NA	L343F	0.21
LUSC	chr14	91001104	Missense_Mutation	novel	K53N	0.47
LUSC	chr14	90871996	3'UTR	novel		0.49
LUSC	chr14	90978408	Missense_Mutation	NA	T98A	0.51
LUSC	chr14	90875351	Silent	novel	L616L	0.13
LUSC	chr14	90906203	Silent	novel	R301R	0.26
LUSC	chr14	90900191	Silent	novel	L432L	0.31
LUSC	chr14	90872123	Missense_Mutation	rs200886537	D787V	0.26
LUSC	chr14	90978370	Missense_Mutation	novel	Q110H	0.18
LUSC	chr14	90920288	Missense_Mutation	NA	G242C	0.16
OV	chr14	90920224	Missense_Mutation	NA	S263C	0.39
OV	chr14	90920293	Missense_Mutation	NA	S240N	0.11
PAAD	chr14	90894429	Missense_Mutation	novel	R543M	0.05	RIO1
PAAD	chr14	91060348	Silent	novel	K29K	0.26
PCPG	chr14	90872138	Missense_Mutation	novel	P782H	0.66
PRAD	chr14	90872160	Missense_Mutation	NA	T775S	0.46
PRAD	chr14	90894487	Missense_Mutation	NA	I524L	0.33	RIO1
PRAD	chr14	90978500	Missense_Mutation	rs756086272	R67H	0.32
READ	chr14	90875243	Missense_Mutation	rs747531260	A652S	0.39
READ	chr14	90875317	Missense_Mutation	rs373786141	R627Q	0.43
READ	chr14	90920226	Missense_Mutation	NA	N262K	0.44
READ	chr14	90943165	Silent	NA	D177D	0.41
READ	chr14	90947449	Missense_Mutation	NA	E166K	0.39
SKCM	chr14	90902905	Missense_Mutation	rs577750321	D341G	0.49
SKCM	chr14	90900675	Missense_Mutation	NA	L394P	0.33
SKCM	chr14	90894324	Intron	novel		0.23
SKCM	chr14	90871986	3'UTR	novel		0.59
SKCM	chr14	90894473	Silent	novel	L528L	0.39
SKCM	chr14	90872032	3'UTR	novel		0.4
SKCM	chr14	90947514	Missense_Mutation	NA	S144F	0.36
SKCM	chr14	90978464	Missense_Mutation	NA	A79V	0.26
SKCM	chr14	90899346	Missense_Mutation	NA	E486K	0.33	RIO1
SKCM	chr14	90920237	Nonsense_Mutation	novel	G259*	0.43
SKCM	chr14	90872267	Missense_Mutation	NA	P739L	0.26
SKCM	chr14	90920305	Missense_Mutation	NA	V236A	0.24
SKCM	chr14	90890525	Missense_Mutation	NA	D600N	0.44
SKCM	chr14	90920307	Splice_Region	novel	A235A	0.24
STAD	chr14	90947449	Missense_Mutation	NA	E166K	0.08
STAD	chr14	90920240	Missense_Mutation	rs746195386	D258N	0.14
STAD	chr14	90900145	Frame_Shift_Del	NA	*S448Vfs9**	0.24
STAD	chr14	90978359	Frame_Shift_Del	novel	*L114Wfs2**	0.37
STAD	chr14	90902870	Missense_Mutation	NA	T353A	0.4
STAD	chr14	90872170	Silent	NA	H771H	0.27
STAD	chr14	90902937	Frame_Shift_Del	NA	*V331Cfs13**	0.22
STAD	chr14	90900145	Frame_Shift_Del	NA	*S448Vfs9**	0.32
TGCT	chr14	90900190	Missense_Mutation	novel	G433R	0.16
UCEC	chr14	90894417	Missense_Mutation	NA	P547H	0.31	RIO1
UCEC	chr14	90923167	Silent	NA	T216T	0.31
UCEC	chr14	90875317	Missense_Mutation	rs373786141	R627Q	0.32
UCEC	chr14	90900135	Missense_Mutation	NA	A451D	0.34
UCEC	chr14	90873774	Frame_Shift_Del	novel	*N673Tfs9**	0.46
UCEC	chr14	90890495	Missense_Mutation	rs759541597	V610I	0.16
UCEC	chr14	90899329	Missense_Mutation	rs374856978	Q491H	0.14	RIO1
UCEC	chr14	90875235	Missense_Mutation	NA	K654N	0.46
UCEC	chr14	90890583	Missense_Mutation	NA	K580N	0.45
UCEC	chr14	91001136	Missense_Mutation	NA	K43Q	0.51
UCEC	chr14	90875319	Silent	novel	D626D	0.38
UCEC	chr14	90900144	Frame_Shift_Ins	novel	*S448Kfs2**	0.39
UCEC	chr14	90872020	3'UTR	novel		0.2
UCEC	chr14	90875213	Missense_Mutation	rs779496203	D662Y	0.17
UCEC	chr14	90906244	Missense_Mutation	novel	D288Y	0.15
UCEC	chr14	90943169	Missense_Mutation	rs199633732	R176H	0.1
UCEC	chr14	90947551	Splice_Site	NA	X132_splice	0.32
UCEC	chr14	90870823	3'UTR	novel		0.26
UCEC	chr14	90872293	Missense_Mutation	NA	F730L	0.28
UCEC	chr14	90978520	Nonsense_Mutation	novel	Y60*	0.01
UCEC	chr14	90873631	Splice_Site	novel	X720_splice	0.12
UCEC	chr14	90900700	Missense_Mutation	novel	R386C	0.37
UCEC	chr14	90890503	Missense_Mutation	NA	S607T	0.31
UCEC	chr14	90875283	Missense_Mutation	novel	M638I	0.12
UCEC	chr14	90943111	Missense_Mutation	novel	D195E	0.22
UCEC	chr14	90871908	3'UTR	novel		0.24
UCEC	chr14	90873747	Missense_Mutation	novel	R682M	0.15
UCEC	chr14	90894278	Intron	novel		0.28
UCEC	chr14	90875317	Missense_Mutation	rs373786141	R627Q	0.48
UCEC	chr14	90890496	Silent	rs765131434	G609G	0.42
UCEC	chr14	90947503	Missense_Mutation	rs747853891	R148C	0.36
UCEC	chr14	90871653	3'UTR	novel		0.56
UCEC	chr14	90947506	Nonsense_Mutation	novel	E147*	0.23
UCEC	chr14	90890562	Missense_Mutation	novel	H587Q	0.33
UCEC	chr14	90894518	Frame_Shift_Ins	novel	*K514Efs5**	0.47	RIO1
UCEC	chr14	90902936	Frame_Shift_Ins	novel	*V331Sfs6**	0.27
UCEC	chr14	90943092	Missense_Mutation	novel	F202L	0.22
UCEC	chr14	90947449	Missense_Mutation	NA	E166K	0.21
UCEC	chr14	90978367	Silent	rs776228610	S111S	0.18
UCEC	chr14	90875307	Silent	rs752292382	T630T	0.31
UCEC	chr14	90870839	3'UTR	rs535646164		0.36
UCEC	chr14	90890517	Silent	rs145941322	S602S	0.24
UCEC	chr14	90900709	Missense_Mutation	novel	L383I	0.21
UCEC	chr14	90943094	Missense_Mutation	novel	E201G	0.32
UCEC	chr14	90978471	Missense_Mutation	novel	L77M	0.22
UCEC	chr14	90872187	Missense_Mutation	NA	S766P	0.25
UCEC	chr14	90875260	Frame_Shift_Del	NA	*F646Sfs18**	0.3
UCEC	chr14	90890532	Silent	rs139792854	N597N	0.36
UCEC	chr14	90947458	Missense_Mutation	novel	L163I	0.24
UCEC	chr14	90894281	Intron	novel		0.44
UCEC	chr14	90873656	Silent	NA	H712H	0.53
UCEC	chr14	90978513	Missense_Mutation	NA	V63L	0.42
UCEC	chr14	90947508	Missense_Mutation	novel	R146I	0.36
UCEC	chr14	90890531	Missense_Mutation	rs765581206	G598S	0.19
UCEC	chr14	90902844	Silent	rs141403978	P361P	0.48
UCEC	chr14	90870925	3'UTR	novel		0.31
UCEC	chr14	90906265	Nonsense_Mutation	novel	E281*	0.47
UCEC	chr14	90890526	Silent	NA	Y599Y	0.29
UCEC	chr14	90875260	Missense_Mutation	novel	F646Y	0.47
UCEC	chr14	90872180	Missense_Mutation	novel	S768F	0.33
UCS	chr14	90872294	Missense_Mutation	novel	F730S	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2583	1.4717e-06
CESC	DEL	0.139	0.00086239
CHOL	DEL	0.5556	0.00040262
COAD	DEL	0.2927	0.050084
GBM	DEL	0.2496	5.7274e-07
HNSC	DEL	0.113	0.0057325
KIRC	DEL	0.3807	0.0074281
KIRP	DEL	0.1632	0.085174
LGG	DEL	0.1988	1.1681e-13
LUAD	DEL	0.1919	0.0018747
MESO	DEL	0.4138	0.088547
PAAD	DEL	0.0652	0.11332
READ	DEL	0.3697	0.189
SKCM	DEL	0.2888	0.10277

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0011	Kaplan-Meier Survival Analysis
STAD	0.018	Kaplan-Meier Survival Analysis
HNSC	0.00043	Kaplan-Meier Survival Analysis
SKCM	0.041	Kaplan-Meier Survival Analysis
LUSC	0.0004	Kaplan-Meier Survival Analysis
KIRP	0.0013	Kaplan-Meier Survival Analysis
COAD	0.0015	Kaplan-Meier Survival Analysis
CESC	0.0074	Kaplan-Meier Survival Analysis
UCEC	0.0044	Kaplan-Meier Survival Analysis
LGG	0.0002	Kaplan-Meier Survival Analysis
LUAD	0.0069	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742