EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100813 (Gene tree)
Gene ID: 22985
Gene Symbol: ACIN1
Alias: KIAA0670|fSAP152|ACINUS
Full Name: apoptotic chromatin condensation inducer 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 37,051 bases
Position: chr14:23,058,564-23,095,614
Accession: 17066
RBP type: canonical RBP
Summary: Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000474349	SAP	PF02037.27	2.2e-07	1	1
ENSP00000405677	SAP	PF02037.27	2.2e-07	1	1
ENSP00000451328	SAP	PF02037.27	2.2e-07	1	1
ENSP00000262710	SAP	PF02037.27	2.3e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11431691	Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.	Nat Genet	2001 Jul	Ma Z	-
30042883	Crystal structure of human Acinus RNA recognition motif domain.	PeerJ	2018 Jul 4	Fernandes H	doi: 10.7717/peerj.5163
22388736	The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex.	Nat Struct Mol Biol	2012 Mar 4	Murachelli AG	doi: 10.1038/nsmb.2242.
27365209	The RNA-binding profile of Acinus, a peripheral component of the exon junction complex, reveals its role in splicing regulation.	RNA	2016 Sep	Rodor J	doi: 10.1261/rna.057158.116
31070279	The arginine and serine-rich domains of Acinus modulate splicing.	Cell Biol Int	2019 Aug	Deka B	doi: 10.1002/cbin.11163

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000397341	ACIN1-204	2738	XM_005267418	ENSP00000380502	583 (aa)	XP_005267475	Q9UKV3
ENST00000553790	ACIN1-209	756	-	-	- (aa)	-	-
ENST00000554979	ACIN1-212	366	-	-	- (aa)	-	-
ENST00000555395	ACIN1-215	514	-	-	- (aa)	-	-
ENST00000555807	ACIN1-218	928	-	-	- (aa)	-	-
ENST00000557515	ACIN1-222	2751	-	ENSP00000451138	582 (aa)	-	G3V3B0
ENST00000555352	ACIN1-214	579	-	ENSP00000481955	82 (aa)	-	A0A087WYN3
ENST00000553721	ACIN1-208	610	-	-	- (aa)	-	-
ENST00000605057	ACIN1-223	4474	-	ENSP00000474349	1283 (aa)	-	S4R3H4
ENST00000473758	ACIN1-206	3540	-	ENSP00000483298	36 (aa)	-	A0A087X0D2
ENST00000555566	ACIN1-217	734	-	ENSP00000451410	194 (aa)	-	G3V3T3
ENST00000556052	ACIN1-219	746	-	-	- (aa)	-	-
ENST00000338631	ACIN1-202	2445	-	ENSP00000345541	614 (aa)	-	Q9UKV3
ENST00000457657	ACIN1-205	4815	-	ENSP00000405677	1301 (aa)	-	E7EQT4
ENST00000557039	ACIN1-220	727	-	-	- (aa)	-	-
ENST00000554708	ACIN1-211	736	-	-	- (aa)	-	-
ENST00000357481	ACIN1-203	2563	-	ENSP00000350073	583 (aa)	-	Q9UKV3
ENST00000555053	ACIN1-213	4173	XM_005267416	ENSP00000451328	1328 (aa)	XP_005267473	Q9UKV3
ENST00000557432	ACIN1-221	642	-	-	- (aa)	-	-
ENST00000554680	ACIN1-210	888	-	-	- (aa)	-	-
ENST00000553501	ACIN1-207	716	-	-	- (aa)	-	-
ENST00000555478	ACIN1-216	1017	-	-	- (aa)	-	-
ENST00000262710	ACIN1-201	4935	XM_005267415	ENSP00000262710	1341 (aa)	XP_005267472	Q9UKV3

Gene Model

Click here to download ENSG00000100813's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa03015	mRNA surveillance pathway	KEGG
hsa03040	Spliceosome	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100813	rs11851603	14	23082156	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100813's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100813	ACIN1	99	96.540	ENSAMEG00000007576	ACIN1	100	90.713	Ailuropoda_melanoleuca
ENSG00000100813	ACIN1	68	60.993	ENSACIG00000006218	acin1a	62	82.178	Amphilophus_citrinellus
ENSG00000100813	ACIN1	99	98.791	ENSANAG00000034343	ACIN1	100	94.355	Aotus_nancymaae
ENSG00000100813	ACIN1	99	97.565	ENSBTAG00000011571	ACIN1	100	91.878	Bos_taurus
ENSG00000100813	ACIN1	99	99.478	ENSCJAG00000008076	ACIN1	100	96.140	Callithrix_jacchus
ENSG00000100813	ACIN1	99	97.913	ENSCAFG00000011427	ACIN1	100	90.565	Canis_familiaris
ENSG00000100813	ACIN1	99	97.913	ENSCAFG00020007637	ACIN1	100	90.490	Canis_lupus_dingo
ENSG00000100813	ACIN1	99	97.391	ENSCHIG00000017602	ACIN1	100	92.027	Capra_hircus
ENSG00000100813	ACIN1	99	98.783	ENSTSYG00000011584	ACIN1	100	93.160	Carlito_syrichta
ENSG00000100813	ACIN1	99	97.391	ENSCPOG00000027234	ACIN1	99	89.406	Cavia_porcellus
ENSG00000100813	ACIN1	99	98.957	ENSCCAG00000029776	ACIN1	100	96.134	Cebus_capucinus
ENSG00000100813	ACIN1	99	99.826	ENSCATG00000044489	ACIN1	100	97.987	Cercocebus_atys
ENSG00000100813	ACIN1	99	96.870	ENSCLAG00000010588	ACIN1	100	88.624	Chinchilla_lanigera
ENSG00000100813	ACIN1	99	100.000	ENSCSAG00000016098	ACIN1	100	97.841	Chlorocebus_sabaeus
ENSG00000100813	ACIN1	96	87.879	ENSCHOG00000006414	ACIN1	79	87.994	Choloepus_hoffmanni
ENSG00000100813	ACIN1	86	68.191	ENSCPBG00000026078	ACIN1	57	73.362	Chrysemys_picta_bellii
ENSG00000100813	ACIN1	99	100.000	ENSCANG00000032999	ACIN1	100	97.688	Colobus_angolensis_palliatus
ENSG00000100813	ACIN1	99	96.522	ENSCGRG00001010945	Acin1	100	87.241	Cricetulus_griseus_chok1gshd
ENSG00000100813	ACIN1	96	86.869	ENSCGRG00000012504	Acin1	100	83.717	Cricetulus_griseus_crigri
ENSG00000100813	ACIN1	77	52.767	ENSCSEG00000004364	acin1b	50	73.276	Cynoglossus_semilaevis
ENSG00000100813	ACIN1	92	52.870	ENSDARG00000054290	acin1a	66	83.696	Danio_rerio
ENSG00000100813	ACIN1	99	97.232	ENSDNOG00000047667	ACIN1	99	88.270	Dasypus_novemcinctus
ENSG00000100813	ACIN1	99	93.217	ENSETEG00000000033	ACIN1	91	100.000	Echinops_telfairi
ENSG00000100813	ACIN1	99	97.913	ENSEASG00005011704	ACIN1	100	92.480	Equus_asinus_asinus
ENSG00000100813	ACIN1	99	97.913	ENSECAG00000021097	ACIN1	100	92.405	Equus_caballus
ENSG00000100813	ACIN1	99	98.087	ENSFCAG00000002332	ACIN1	100	90.327	Felis_catus
ENSG00000100813	ACIN1	99	96.718	ENSFDAG00000011979	ACIN1	100	88.724	Fukomys_damarensis
ENSG00000100813	ACIN1	74	54.721	ENSGAFG00000015171	-	72	81.081	Gambusia_affinis
ENSG00000100813	ACIN1	100	99.079	ENSGGOG00000007403	ACIN1	100	99.079	Gorilla_gorilla
ENSG00000100813	ACIN1	99	95.826	ENSHGLG00000018997	-	100	90.591	Heterocephalus_glaber_female
ENSG00000100813	ACIN1	100	85.981	ENSHGLG00100018921	-	99	85.019	Heterocephalus_glaber_male
ENSG00000100813	ACIN1	92	52.113	ENSHCOG00000000814	acin1b	59	75.000	Hippocampus_comes
ENSG00000100813	ACIN1	85	54.688	ENSIPUG00000006269	acin1b	62	84.783	Ictalurus_punctatus
ENSG00000100813	ACIN1	99	98.609	ENSSTOG00000007169	ACIN1	100	90.930	Ictidomys_tridecemlineatus
ENSG00000100813	ACIN1	99	97.913	ENSLAFG00000003679	ACIN1	100	89.161	Loxodonta_africana
ENSG00000100813	ACIN1	99	100.000	ENSMFAG00000044437	ACIN1	100	98.285	Macaca_fascicularis
ENSG00000100813	ACIN1	99	100.000	ENSMMUG00000012979	ACIN1	100	98.285	Macaca_mulatta
ENSG00000100813	ACIN1	99	100.000	ENSMNEG00000035938	ACIN1	100	97.092	Macaca_nemestrina
ENSG00000100813	ACIN1	99	100.000	ENSMLEG00000036983	ACIN1	100	98.061	Mandrillus_leucophaeus
ENSG00000100813	ACIN1	55	83.607	ENSMAUG00000000504	Acin1	75	95.000	Mesocricetus_auratus
ENSG00000100813	ACIN1	99	98.783	ENSMICG00000002575	ACIN1	100	92.628	Microcebus_murinus
ENSG00000100813	ACIN1	70	56.036	ENSMMOG00000013326	acin1a	64	73.636	Mola_mola
ENSG00000100813	ACIN1	95	85.787	ENSMODG00000005083	ACIN1	100	71.204	Monodelphis_domestica
ENSG00000100813	ACIN1	96	90.860	MGP_CAROLIEiJ_G0019267	Acin1	100	85.725	Mus_caroli
ENSG00000100813	ACIN1	96	90.860	ENSMUSG00000022185	Acin1	100	85.364	Mus_musculus
ENSG00000100813	ACIN1	95	90.811	MGP_PahariEiJ_G0030286	Acin1	100	84.898	Mus_pahari
ENSG00000100813	ACIN1	96	91.935	MGP_SPRETEiJ_G0020157	Acin1	100	85.587	Mus_spretus
ENSG00000100813	ACIN1	99	98.087	ENSMPUG00000006822	ACIN1	100	91.398	Mustela_putorius_furo
ENSG00000100813	ACIN1	99	100.000	ENSNLEG00000014920	ACIN1	100	98.064	Nomascus_leucogenys
ENSG00000100813	ACIN1	95	75.127	ENSMEUG00000015219	ACIN1	99	71.264	Notamacropus_eugenii
ENSG00000100813	ACIN1	96	91.919	ENSOPRG00000016402	ACIN1	94	94.628	Ochotona_princeps
ENSG00000100813	ACIN1	99	98.261	ENSOCUG00000001678	ACIN1	100	91.654	Oryctolagus_cuniculus
ENSG00000100813	ACIN1	100	90.147	ENSOGAG00000012605	ACIN1	99	91.973	Otolemur_garnettii
ENSG00000100813	ACIN1	99	92.548	ENSOARG00000019368	ACIN1	100	89.732	Ovis_aries
ENSG00000100813	ACIN1	100	99.181	ENSPPAG00000041392	ACIN1	100	99.181	Pan_paniscus
ENSG00000100813	ACIN1	99	96.000	ENSPPRG00000006713	ACIN1	100	90.179	Panthera_pardus
ENSG00000100813	ACIN1	99	97.743	ENSPTIG00000021540	ACIN1	100	90.558	Panthera_tigris_altaica
ENSG00000100813	ACIN1	100	99.404	ENSPTRG00000006159	ACIN1	100	99.404	Pan_troglodytes
ENSG00000100813	ACIN1	99	100.000	ENSPANG00000019644	ACIN1	100	98.061	Papio_anubis
ENSG00000100813	ACIN1	66	56.359	ENSPMGG00000018777	acin1b	53	78.022	Periophthalmus_magnuspinnatus
ENSG00000100813	ACIN1	95	85.787	ENSPCIG00000027763	ACIN1	100	77.601	Phascolarctos_cinereus
ENSG00000100813	ACIN1	100	97.017	ENSPPYG00000005657	ACIN1	100	97.017	Pongo_abelii
ENSG00000100813	ACIN1	92	78.947	ENSPCAG00000006599	ACIN1	92	79.028	Procavia_capensis
ENSG00000100813	ACIN1	99	98.435	ENSPCOG00000002308	ACIN1	100	93.299	Propithecus_coquereli
ENSG00000100813	ACIN1	99	97.913	ENSPVAG00000013806	ACIN1	99	90.171	Pteropus_vampyrus
ENSG00000100813	ACIN1	96	84.925	ENSRNOG00000013533	Acin1	100	86.543	Rattus_norvegicus
ENSG00000100813	ACIN1	100	96.651	ENSRBIG00000031308	ACIN1	100	96.498	Rhinopithecus_bieti
ENSG00000100813	ACIN1	99	99.826	ENSRROG00000003676	ACIN1	100	97.539	Rhinopithecus_roxellana
ENSG00000100813	ACIN1	99	99.304	ENSSBOG00000032127	ACIN1	100	96.071	Saimiri_boliviensis_boliviensis
ENSG00000100813	ACIN1	99	98.087	ENSSSCG00000002034	ACIN1	100	92.148	Sus_scrofa
ENSG00000100813	ACIN1	65	87.770	ENSTBEG00000016605	-	92	94.231	Tupaia_belangeri
ENSG00000100813	ACIN1	96	90.909	ENSUAMG00000024475	ACIN1	99	90.799	Ursus_americanus
ENSG00000100813	ACIN1	99	98.087	ENSUMAG00000014156	ACIN1	100	91.308	Ursus_maritimus
ENSG00000100813	ACIN1	99	97.913	ENSVVUG00000019885	ACIN1	100	91.227	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	10490026.	NAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	18951082.20195357.	IPI	Function
GO:0005634	nucleus	10490026.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006397	mRNA processing	-	IEA	Process
GO:0008380	RNA splicing	-	IEA	Process
GO:0016607	nuclear speck	20966198.	IDA	Component
GO:0016887	ATPase activity	10490026.	NAS	Function
GO:0019899	enzyme binding	10490026.	NAS	Function
GO:0030218	erythrocyte differentiation	11208865.	IEP	Process
GO:0030263	apoptotic chromosome condensation	10490026.	IDA	Process
GO:0045657	positive regulation of monocyte differentiation	12393560.	IEP	Process
GO:0061574	ASAP complex	12665594.	IDA	Component